what drives progressive motor deficits in patients with acute pontine infarction?

作     者：Jue-bao Li Rui-dong Cheng Liang Zhou Wan-shun Wen Gen-ying Zhu Liang Tian Xiang-ming Ye 

作者机构：Department of Rehabilitation MedicineZhejiang Provincial People’s Hospital 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第3期

页      面：501-504页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：nerve regeneration pontine infarction progressive motor deficits basilar artery pene-trating artery corticospinal tract Wallerian degeneration review neural regeneration 

摘      要：Progressive motor deficits are relatively common in acute pontine infarction and frequently associated with increased functional disability. However, the factors that affect the progression of clinical motor weakness are largely unknown. Previous studies have suggested that pontine infarctions are caused mainly by basilar artery stenosis and penetrating artery disease. Recently, lower pons lesions in patients with acute pontine infarctions have been reported to be related to progressive motor deficits, and ensuing that damage to the corticospinal tracts may be respon- sible for the worsening of neurological symptoms. Here, we review studies on motor weakness progression in pontine infarction and discuss the mechanisms that may underlie the neurologic worsening.