检索结果-南通市图书馆

Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway

引用

Acta Pharmacologica Sinica 2019年第8期40卷 1010-1018页

作者： ying-luo liu Xiao-yu Zhou Li-jiang Xuan State Key Laboratory of Drug Research Shanghai Institute of Materia Medica School of Pharmacy University of Chinese Academy of Sciences

Microcirculation morphologically refers to the blood flow in vessels of less than 150 pm in diameter,including arterioles,capillaries and venules,which provides nutrients and removes metabolic byproducts within *** dysfunction is involved in the pathological progress of many diseases,such as obesity,hypertension,and insulin *** this study we investigated the effects of magnesium lithospermate B(MLB), an active compound of the traditional Chinese medicine Slavia miltiorrhiza,on the microcirculation dysfunction in rats and the underlying molecular *** effects of MLB on microcirculation were assessed in vivo by measuring the hindlimb blood perfusion in dextran-induced microcirculation dysfunction rats and mesentery blood flow in anesthetized *** demonstrated that administration of MLB restored the impaired rat hindlimb blood flow and promoted the mesenteric micoperfusion in *** further revealed in these two animal models that MLB treatment significantly increased the production of total nitrite in vascular tissues(mesentery,aorta,and heart),which was confirmed in human microvascular endothelial cells(HMEC-1)treated with MLB in ***,we showed that MLB treatment significantly increased the phosphorylation of endothelium nitric oxide synthase(eNOS)via inducing AKT phosphorylation in vivo and in ***-administration of the eNOS inhibitor L-NAME(20 mg/kg)abolished the protective effects of MLB against dextran-induced microcirculation dysfunction in rats,whereas pretreatment with PI3K inhibitor LY294002(10 μM)prevented eNOS activation in MLBtreated HMEC-1 *** results suggest that MLB can restore the microcirculation dysfunction via activating eNOS,and in turn enhancing the vascular nitric oxide production,which is medicated by MLB-caused activation of the PI3K/AKT pathway.

关键词： traditional Chinese medicine Salvia miltiorrhiza magnesium lithospermate B microcirculation dysfunction NO endothelium nitric oxide synthase PI3K/AKT pathway

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease

引用

World Journal of Gastroenterology 2025年第2期31卷 138-143页

作者： ying Wang Jie liu Department of Life Sciences and Medicine South District of Endoscopic CenterThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

Inflammatory bowel disease,particularly Crohn's disease(CD),has been linked to modifications in mesenteric adipose tissue(MAT)and the phenomenon known as"creeping fat"(CrF).The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with ***,the incorporation of the mesentery during ileocolic resection for CD has been correlated with a decrease in surgical recurrence,indicating the significant role of MAT in the pathogenesis of *** numerous studies have indicated that dysbiosis of the gut microbiota is a critical factor in the development of CD,the functional implications of translocated microbiota within the MAT of CD patients remain *** manuscript commentary discusses a recent basic research conducted by Wu et *** their study,intestinal bacteria from individuals were transplanted into CD model mice,revealing that fecal microbiota trans-plantation(FMT)from healthy donors alleviated CD symptoms,whereas FMT from CD patients exacerbated these ***,FMT was found to affect intestinal permeability,barrier function,and the levels of proinflammatory factors and ***,these findings suggest that targeting MAT and CrF may hold therapeutic potential for patients with ***,the study did not evaluate the composition of the intestinal microbiota of the donors or the subsequent alterations in the gut ***,the gut microbiota plays a crucial role in the histopathology of CD,and thus,targeting MAT and CrF may represent a promising avenue for treatment in this patient population.

关键词： Crohn's disease Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation Gut microbiota

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preparation and piezoelectric properties of a novel PZT fiber ceramic

Preparation and piezoelectric properties of a novel PZT fibe...

引用

2011年全国压电和声波理论及器件应用研讨会

作者： Cai-feng CHEN~* Xiao-li Han ying luo Jiu liu School of Materials Science and Engineering,Zhenjiang,Jiangsu.212013

＜正＞PZT nano piezoelectric fibers were prepared by hydrothermal-template *** effects of some reaction conditions on preparation were investigated,such as PH value,reaction temperature and *** optimal hydrothermal co... 详细信息

关键词： Piezoelectric fiber Hydrothermal method Template Ceramic

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Multiple liver metastases of unknown origin:A case report

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： ying-Jin Wang Ze-Chuan liu Jian Wang Yin-Mo Yang Department of Hepatobiliary Pancreatic Surgery Peking University First HospitalBeijing 100034China Department of Interventional and Vascular Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive system tumor metastasis,but not all liver metastases can be traced back to the primary *** it is unusual,syphilis can impact the liver,manifesting as syphilitic hepatitis with inflammatory nodules,which might be misdiagnosed as *** SUMMARY This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy scan without evidence of primary *** positive serological tests for syphilis and a biopsy of the liver nodules,a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis *** Clinicians must be aware of the possibility that syphilis can cause hepatic inflam-matory masses,especially when liver metastasis is suspected without evidence of primary lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.

关键词： Syphilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preparation and Characterization of piezoelectric fibers

Preparation and Characterization of piezoelectric fibers

引用

2011年全国压电和声波理论及器件应用研讨会

作者： Xiao-li Han Cai-feng Chen~* ying luo Jun liu School of Materials Science and Engineering,Jiangsu University,Zhenjiang 212013,Jiangsu,China

＜正＞In this work,a new fabrication method of piezoelectric fibers was developed,the fibers were extruded into a carbon template with aligned gapes through a reduction *** they were sintered at 1100℃using Ar atmosphere after drying,during the whole process fibers were held by the template to make sure the fibers with no deformation and

关键词： Piezoelectric fibers Extrusion Template Single fibers

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

预浸泡对桃金娘果汁中抗氧化物质和抗氧化活性的影响

引用

食品工业科技 2017年第1期38卷 75-80,86页

作者：邹雨辰罗爽妍段翰英刘柳罗尧欣王超暨南大学食品科学与工程系广东广州510632

本研究将桃金娘整果分别浸泡在不同温度的水、盐酸、柠檬酸、抗坏血酸和亚硫酸氢钠溶液中10、20、30 min,分析不同处理对桃金娘果汁中总多酚、总花青素、总黄酮和抗氧化活性的影响。结果表明,在40~60℃水中浸泡,桃金娘果汁中总多酚、总... 详细信息

本研究将桃金娘整果分别浸泡在不同温度的水、盐酸、柠檬酸、抗坏血酸和亚硫酸氢钠溶液中10、20、30 min,分析不同处理对桃金娘果汁中总多酚、总花青素、总黄酮和抗氧化活性的影响。结果表明,在40~60℃水中浸泡,桃金娘果汁中总多酚、总花青素、总黄酮含量和抗氧化活性显著降低,然而在80℃热水和1%盐酸中预浸泡可保持或增加抗氧化物含量。柠檬酸、抗坏血酸或NaHSO_3溶液能降低抗氧化物质的损失程度。同时研究了桃金娘中多酚氧化酶(PPO)和过氧化酶(POD)在不同pH和温度下的稳定性。温度达到100℃、pH小于2时PPO和POD活性才被完全抑制。因此不同的预浸泡方式影响桃金娘果汁PPO和POD的酶活,而抗氧化物质和抗氧化活性的稳定性与PPO和POD的活性负相关。

关键词：桃金娘果汁预浸泡抗氧化物质多酚氧化酶过氧化酶

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

引用

Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli Si Naijia Xue Yi liu Ran Zheng ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

引用

Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi luo Wanguo liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of community public health care on treatment effect,health cognition,and self-management in patients with type 2 diabetes

引用

World Journal of Clinical Cases 2025年第5期13卷 22-29页

作者： Hong Shi Chun liu Hong-Yan luo Department of Infrastructure Operation West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Public Health Minzu Street Community Health Service CenterWuhan 430000Hubei ProvinceChina Caotang Community Health Service Center Chengdu 610031Sichuan ProvinceChina

BACKGROUND At present,China has become the country with the largest number of individuals with diabetes mellitus(DM)in the world,with a total of approximately 140 million patients,the majority of whom have type 2 DM(T2DM).Based on conven-tional nursing methods,community home care has important clinical significance in controlling blood sugar and disease *** To explore the impact of community public health nursing on treatment effect,health cognition,and self-management in patients with *** One hundred patients with T2DM were selected as the research *** patients were divided into either a conventional nursing group or community nursing(CN)group using the random number table *** conventional nursing group(50 cases)received routine care,while the CN group(50 cases)received community public health care in addition to routine care as that for the conventional nursing *** rate of excellent and good blood glucose control,fasting blood glucose before and after care,2-h postprandial blood glucose,health cognition,and self-management ability,and patient satisfaction were compared between the two *** The CN group had a higher rate of excellent blood sugar control than the conventional nursing group(88%vs 70%,P0.05).After nursing,fasting blood glucose and 2-h postprandial blood glucose were reduced to varying degrees in both groups,and both blood glucose levels in the CN group were lower than those of the conventional nursing group(P<0.05).Compared with the scores before care,the cognitive level score for diabetes and self-management ability score improved after care in both *** cognitive level and self-management ability of patients in the CN group were higher than those of the conventional nursing group(P<0.05).The overall satisfaction of the CN group was better than

关键词： Community public health care Type 2 diabetes Blood sugar control Self-management ability Cognition level

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： Chen Chen Hongyu Xue Qilin Hu Mengfan Wang Pan Shang Ziyan liu Tao Peng Deyang Zhang Yongsong luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：