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Coach Simplified Structure Modeling and Optimization Study Based on the PBM Method

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Chinese Journal of Mechanical Engineering 2016年第5期29卷 1010-1018页

作者： ZHANG Miaoli REN Jindong yin ying DU Jian State Key Lab of Automotive Simulation and Control Jilin University Hyundai Motor Technology & Engineering Center (China) Ltd. R&D Center FAW Group

For the coach industry, rapid modeling and efficient optimization methods are desirable for structure modeling and optimization based on simplified structures, especially for use early in the concept phase and with capabilities of accurately expressing the mechanical properties of structure and with flexible section forms. However, the present dimension-based methods cannot easily meet these requirements. To achieve these goals, the property-based modeling （PBM） beam modeling method is studied based on the PBM theory and in conjunction with the characteristics of coach structure of taking beam as the main component. For a beam component of concrete length, its mechanical characteristics are primarily affected by the section properties. Four section parameters are adopted to describe the mechanical properties of a beam, including the section area, the principal moments of inertia about the two principal axles, and the torsion constant of the section. Based on the equivalent stiffness strategy, expressions for the above section parameters are derived, and the PBM beam element is implemented in HyperMesh software. A case is realized using this method, in which the structure of a passenger coach is simplified. The model precision is validated by comparing the basic performance of the total structure with that of the original structure, including the bending and torsion stiffness and the first-order bending and torsional modal frequencies. Sensitivity analysis is conducted to choose design variables. The optimal Latin hypercube experiment design is adopted to sample the test points, and polynomial response surfaces are used to fit these points. To improve the bending and torsion stiffness and the first-order torsional frequency and taking the allowable maximum stresses of the braking and left turning conditions as constraints, the multi-objective optimization of the structure is conducted using the NSGA-II genetic algorithm on the ISIGHT platform. The result of the Paret

关键词： coach structure property-based modeling (PBM) simplification modeling multi-objective optimization

Edge detection of magnetic tile cracks,based on wavelet

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High Technology Letters 2015年第3期21卷 276-281页

作者：林丽君 He Mingge yin ying yin Xiangyun yin Guofu School of Manufacturing Science and Engineering Sichuan University Gas Production Engineering Research Institute Petro China Southwest Oil & Gas Field Co.

In order to extract the defect edge information on the magnetic tile surface with low contrast and textured background,an edge detection algorithm based on image weighted information entropy and wavelet modulus maxima is *** first,a new Butterworth high pass filter(BHPF) with adaptive cutoff frequency is produced,because the clarity and complexity of the textured background are described by the weighted information entropy of the image gradient variance quantitatively,and the filter can change its parameters through matching the non-linear relationship between the information entropy and the cutoff *** then,the best decomposition scale is obtained by the level determination function to prevent edge information from *** last,edge points are got by double threshold after obtaining the wavelet modulus maxima,and then the edge image is linked by the edge points to ensure the edge continuity and *** results indicate that the proposed algorithm outperforms the conventional Canny and Sobel algorithm,and the edge detection algorithm can also detect other defects,and lays the foundation for defecting auto- recognition.

关键词： edge detection wavelet transform textures processing magnetic tile informationentropy

Identification of Rice Al-responsive Genes by Semi-quantitative Polymerase Chain Reaction using Sulfite Reductase as a Novel Endogenous Control

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Journal of Integrative Plant Biology 2010年第5期52卷 505-514页

作者： Jianjun Zhang ying yin Yuqi Wang Xinxiang Peng Laboratory of Molecular Plant Physiology College of Life Sciences South China Agricultural University Guangzhou 510642 China Key Laboratory of Plant Functional Genomics and Biotechnology Education Department of Guangdong Province College of LifeSciences South China Agricultural University Guangzhou 510642 China Laboratory of Biochemistry and Molecular Biology College of Life Sciences South China Agricultural University Guangzhou 510642 China

Based on the evidence that Al resistance is an inducible process and rice is an Al-resistant crop, identification of Al-responsive genes from rice may help to further clone *** genes in plants. Semi-quantitative and real-time polymerase chain reaction （PCR） is widely applied in gene transcrip- tional analyses, particularly for those genes with low transcript abundance. Normalization with proper endogenous control （EC） genes is critical for these two approaches in terms of reliability and precision. We first noticed that the expression of several commonly-used EC genes was depressed under AI stress, while sulfite reductase gene （SR） was stable throughout the AI treatment. The reliability of SR as an EC gene was further tested by analyzing the expression of a number of genes in response to Al challenge. Except for the consistent results obtained for the four previously-identified genes, nine additional genes were newly defined as Al-responsive in this study. Collectively, our results suggest that SR can be used as a novel EC gene for semi-quantitative and real-time PCR analysis of Al responsive genes, and that activated transport of silicon and stimulated metabolism of carotenoid and terpenoid could be involved in Al resistance in rice plants.

关键词： POLYMERASE chain reaction RICE PLANT genetics GENE expression GENETIC engineering

Review of Molecular Simulation Method for Gas Adsorption/desorption and Diffusion in Shale Matrix

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Journal of Thermal Science 2019年第1期28卷 1-16页

作者： WANG Hui QU Zhiguo yin ying BAI Junqiang YU Bo School of Aeronautics Northwestern Polytechnical University MOE Key Laboratory of Thermo-Fluid Science and Engineering School of Energy and Power Engineering Xi'an Jiaotong University Mechanical Engineering College Beijing Institute of Petrochemical Technology

Shale gas is becoming an increasingly promising alternative energy resource because of its high efficiency and environment-friendly characteristic. The amount of adsorbed gas on the shale matrix surfaces and dissolved gas in the shale matrix bulk is the dominant factor in the long-term productivity of shale reservoir. Although experimental measurements have been extensively carried out to investigate the gas adsorption and diffusion properties in the shale matrix, they cannot provide the detailed information on the microscopic transport mechanism of shale gas during the gas production process. Molecular simulation can accurately visualize the gas adsorption/desorption and diffusion processes in the shale matrix. In the present study, the recent research advances of molecular simulation on gas adsorption/desorption and diffusion in the shale matrix are reviewed. Firstly, the density functional theory(DFT) for shale gas molecule desorption/adsorption on the surface of the matrix crystal is illustrated. Then, the grand canonical Monte Carlo(GCMC) method predicting the amount of shale gas desorption/adsorption in the shale matrix crystal is introduced. Finally, molecular dynamics simulation(MD) for gas diffusion in the shale matrix is elucidated. Further developments of the molecular simulation method in shale gas production are also discussed.

关键词： shale gas molecular simulation adsorption/desorption diffusion

Robust temporal changes of cellular senescence and proliferation after sciatic nerve injury

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Neural Regeneration Research 2022年第7期17卷 1588-1595页

作者： yin-ying Shen Rui-Rui Zhang Qian-Yan Liu Shi-ying Li Sheng Yi Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina

Cellular senescence and proliferation are essential for wound healing and tissue ***,senescence-proliferation cell fate after peripheral nerve injury has not been clearly ***,post-injury gene expression patterns in rat sciatic nerve stumps(SRP113121)and L4–5 dorsal root ganglia(SRP200823)obtained from the National Center for Biotechnology Information were analyzed to decipher cellular senescence and proliferation-associated genetic *** first constructed a rat sciatic nerve crush ***,β-galactosidase activities were determined to indicate the existence of cellular senescence in the injured sciatic ***67 and EdU immunostaining was performed to indicate cellular proliferation in the injured sciatic *** cellular senescence and proliferation were less vigorous in the dorsal root ganglia than in sciatic nerve *** results reveal the dynamic changes of injury-induced cellular senescence and proliferation from both genetic and morphological aspects,and thus extend our understanding of the biological processes following peripheral nerve *** study was approved by the Animal Ethics Committee of Nantong University,China(approval No.20190226-001)on February 26,2019.

关键词： bioinformatic analysis cellular senescence dorsal root ganglia p16 peripheral nerve regeneration peripheral nerve trauma proliferation rat sciatic nerves sciatic nerve crush β-galactosidase activities

Proteome changes in the plasma of Papilio xuthus (Lepidoptera:Papilionidae):effect of parasitization by the endoparasitic wasp Pteromalus puparum (Hymenoptera:Pteromalidae)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第6期10卷 445-453页

作者： Jia-ying ZHU Gong-yin YE Qi FANG Cui HU State Key Laboratory of Rice Biology Institute of Insect Sciences Zhejiang University Hangzhou 310029 China

Although the biochemical dissection of parasitoid-host interactions is becoming well characterized, the molecular knowledge concerning them is minimal. In order to understand the molecular bases of the host immune response to parasitoid attack, we explored the response of Papilio xuthus parasitized by the endoparasitic wasp Pteromalus puparum using proteomic approach. By examining the differential expression of plasma proteins in the parasitized and unparasitized host pupae by two-dimensional (2D) electrophoresis, 16 proteins were found to vary in relation to parasitization compared with unparasitized control samples. All of them were submitted to identification by mass spectrometry coupled with a database search. The modulated proteins were found to fall into the following functional groups: humoral or cellular immunity, detoxification, energy metabolism, and others. This study contributes insights into the molecular mechanism of the relationships between parasitoids and their host insects.

关键词： Proteomics Plasma Parasitism Immune response Pteromaluspuparum Papilio xuthus

Biological characteristics of dynamic expression of nerve regeneration related growth factors in dorsal root ganglia after peripheral nerve injury

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Neural Regeneration Research 2020年第8期15卷 1502-1509页

作者： yin-ying Shen Xiao-Kun Gu Rui-Rui Zhang Tian-Mei Qian Shi-ying Li Sheng Yi Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Hand Surgery Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

The regenerative capacity of peripheral nerves is limited after nerve injury.A number of growth factors modulate many cellular behaviors,such as proliferation and migration,and may contribute to nerve repair and *** previous study observed the dynamic changes of genes in L4–6 dorsal root ganglion after rat sciatic nerve crush using transcriptome *** current study focused on upstream growth factors and found that a total of 19 upstream growth factors were dysregulated in dorsal root ganglions at 3,9 hours,1,4,or 7 days after nerve crush,compared with the 0 hour ***-six rat models of sciatic nerve crush injury were prepared as described ***,they were divided into six groups to measure the expression changes of representative genes at 0,3,9 hours,1,4 or 7 days post *** current study measured the expression levels of representative upstream growth factors,including nerve growth factor,brain-derived neurotrophic factor,fibroblast growth factor 2 and amphiregulin genes,and explored critical signaling pathways and biological process through bioinformatic *** data revealed that many of these dysregulated upstream growth factors,including nerve growth factor,brain-derived neurotrophic factor,fibroblast growth factor 2 and amphiregulin,participated in tissue remodeling and axon growth-related biological processes Therefore,the experiment described the expression pattern of upstream growth factors in the dorsal root ganglia after peripheral nerve *** analysis revealed growth factors that may promote repair and regeneration of damaged peripheral *** animal surgery procedures were performed in accordance with Institutional Animal Care Guidelines of Nantong University and ethically approved by the Administration Committee of Experimental Animals,China(approval No.20170302-017)on March 2,2017.

关键词： axon growth bioinformatic analysis dorsal root ganglia growth factors Ingenuity Pathway Analysis nerve regeneration peripheral nerve injury rat sciatic nerve crush injury transcriptome sequencing upstream regulators

Improved Electrochemical Synthesis of Nitro-substituted 1-Aryl-2-pyrrolidinecarbonitriles

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Chinese Chemical Letters 2006年第6期17卷 736-738页

作者： Wei LIU Yuan MA ying Wu yin Yu Fen ZHAO The Key Laboratory for Bioorganic Phosphorus Chemistry ＆ Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 Department of Chemistry Tsinghua UniversityBeijing 100084 Beijing TH-UNIS Insight Co.Ltd. Beijing 100084

In this paper, we described an improved electrochemical method for synthesis of some 1-aryl-2-pyrrolidinecarbonitrile derivatives bearing an electron-withdrawing group （NO2）. The electrochemical synthesis of titile ... 详细信息

关键词： Anodic cyanation nitrile pyrrolidine electrochemistry.

Crystallographic orientation dependence on nanoscale friction behavior of energetic β-HMX crystal

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Friction 2023年第12期11卷 2264-2277页

作者： ying yin Hongtao LI Zhihong CAO Binghong LI Qingshan LI Hongtu HE Jiaxin YU Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999China Key Laboratory of Testing Technology for Manufacturing Process in Ministry of Education State Key Laboratory of Environment-friendly Energy MaterialsSouthwest University of Science and TechnologyMianyang 621010China

Tribology behaviors of energetic crystals play critical roles in the friction-induced hotspot in highenergy explosive,however,the binder and energetic crystals are not distinguished properly in previous *** this study,for the first time,the nanoscale friction ofβ-octahydro-1,3,5,7-tetranitro1,3,5,7-tetrazocine(β-HMX)crystal is studied with nanoscratch tests under the ramping load *** results show that the nanoscale friction and wear ofβ-HMX crystal,as a typical energetic material,is highly depended on the applied *** friction coefficient ofβ-HMX crystal is initially high when no discernible wear is observed,and then it decreases to a stable value which varies from~0.2 to~0.7,depending on the applied load,scratch direction,and crystal ***β-HMX(011)surfaces show weakly friction and wear anisotropy behavior;in contrast,theβ-HMX(110)surfaces show strongly friction and wear anisotropy behavior where the friction coefficient,critical load for the elastic–plastic deformation transition and plastic–cracking deformation transition,and deformation index at higher normal load are highly depended on the scratch *** analyses indicate the slip system and direction ofβ-HMX surfaces play key roles in determining the nanoscale friction and wear ofβ-HMX *** obtained results can provide deeper insight into the friction and wear of energetic crystal materials.

关键词： β-octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(β-HMX) nanoscratch friction wear plastic deformation