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Southwesterly Water Vapor Transport Induced by Tropical Cyclones over the Bay of Bengal during the South Asian Monsoon Transition Period

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Journal of Meteorological Research 2022年第1期36卷 140-153页

作者： Beiyao liU Ying Li State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 University of Chinese Academy of Sciences Beijing 100049

Based on best-track,outgoing longwave radiation,sea surface temperature,and reanalysis data during 1979-2018,statistical and composite analyses were performed to investigate characteristics of the southwesterly water vapor transport(WVT)induced by Bay of Bengal(BoB)tropical cyclones(TCs)during the South Asian summer monsoon(SASM)transition period.The results show that the BoB TCs mainly occur several days before/after the date of SASM onset(retreat)in May(October-November),thereby imposing an important impact on southwesterly WVT to China in those two periods.The WVT is significant in the middle and lower troposphere during the bimodal peak periods of BoB TCs,with large values over the east-central BoB,southeastern Tibetan Plateau,and Southwest and South China.The WVT is located more northward at 500 hPa than at 700 hPa,reaching close to 35°N and covering the southeastern Tibetan Plateau owing to weakening of the plateau’s blocking effect at upper levels.The BoB TCs mainly increase the northward and eastward WVT anomalies compared to the climatological mean.Furthermore,the large southerly WVT anomalies are located in the lower troposphere in low-latitude areas,while the large westerly WVT anomalies appear mainly in the middle troposphere in high-latitude areas.This indicates an enhanced WVT channel where the southwesterly moisture jet first climbs northwards to the southeastern Tibetan Plateau and then turns eastwards to East China under the influence of the BoB TCs.Besides,the southwesterly WVT during the TC period in May is stronger and more widespread than that in October-November,being about twice the latter in value.However,their maximum contributions to the climatological average do not differ much,with maximums of 12%and19%occurring in Southwest China during the bimodal periods,respectively,implying an important role played by the BoB TCs in the WVT.

关键词： tropical cyclones Bay of Bengal South Asian summer monsoon southwesterly water vapor transport anomalous characteristics

Climatology of Tropical Cyclone Extreme Rainfall over China from 1960 to 2019

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Advances in Atmospheric Sciences 2022年第2期39卷 320-332页

作者： Ying Li Dajun ZHAO National Climate Centre Beijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China

Tropical cyclone extreme rainfall(TCER)causes devastating floods and severe damage in China and it is therefore important to determine its long-term climatological distribution for both disaster prevention and operational forecasting.Based on the tropical cyclone(TC)best-track dataset and TC precipitation data from 1960 to 2019,the spatiotemporal distribution of TCER affecting China is analyzed.Results show that there were large regional differences in the threshold for TCER in China,decreasing from the southeastern coast to the northwest inland.TCER occurred infrequently in northern China but had a high intensity and was highly localized.The frequency and intensity of TCER showed slightly increasing trends over time and was most likely to occur in August(41.0%).Most of the TC precipitation processes with extreme rainfall lasted for four to six days,with TCER mainly occurring on the third to fourth days.TCER with wide areas showed a northwestward prevailing track and a westward prevailing track.Strong TCs are not always accompanied by extreme precipitation while some weak TCs can lead to very extreme rainfall.A total of 64.7%(35.3%)of the TCER samples occurred when the TC was centered over the land(sea).TCER≥250 mm was located within 3°of the center of the TC.When the center of the TC was located over the sea(land),the extreme rainfall over land was most likely to appear on its northwestern(northeastern)side with a dispersed(concentrated)distribution.TCER has unique climatic characteristics relative to the TC precipitation.

关键词： tropical cyclones extreme rainfall threshold track characteristics intensity characteristics

Writing perovskite optoelectronic devices with ballpoint pens

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Science China Materials 2023年第10期66卷 4135-4136页

作者： Ying Li Guozhen Shen School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China Institute of Flexible Electronics Beijing Institute of TechnologyBeijing 102488China

Flexible optoelectronic devices have wide application prospects in wearable and portable electronic products because of their advantages of high power per unit weight,high flexibility and low cost[1,2].Traditional preparation processes of flexible device such as spin-coating,vacuum-based evaporation/sputtering and etching,yield high reproducibility and device performance[3,4].

关键词： perovskite optoelectronic portable

Anomalies of Precipitation over China on Days with Tropical Cyclone Activity over the Bay of Bengal: Role of Moisture Transport

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Journal of Meteorological Research 2024年第2期38卷 368-382页

作者： Na WEI Ying Li Xiaoting FAN Nanjing Joint Institute for Atmospheric Sciences Nanjing 210041 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200433

Tropical cyclones over the Bay of Bengal(BoBTC)affect the precipitation over China,with distinct seasonal and daily variabilities.This study quantitatively examines the daily standardized precipitation anomalies(SPAs)over China on the days with BoBTC activities(storm-days)and related circulations,based on rainfall measurements at surface meteorological stations and ECMWF reanalysis data on a 0.25°×0.25°resolution during 1979-2019.Significant positive SPA is found over the stations in the two adjacent regions around BoB(Southwest China in May/November and southern Tibetan Plateau in October)and three distant regions(Southeast China and the northeastern boundary of the Qinghai-Tibet Plateau in May,and central North China in October).The SPA distributions are remarkably consistent with the integrated water vapor transport(IVT)anomalies.Enhanced IVT is found associated with the interaction between southwesterly(southerly)of the BoBTC circulation and low-level monsoonal flow in May(midlevel westerly in winter months).The probabilities of extreme precipitation(EP)occurrences over the above regions all increase on storm-days.For adjacent regions,EP is significantly correlated with the northward IVT anomalies to the east of BoBTC circulation,which strengthen the water vapor input through the southern border.Such IVT anomalies are stronger in May,benefited by the deep monsoonal southwesterlies than those in November.For distant regions,EP is more closely related to the IVT anomaly extending back from BoB.Enhanced moisture from BoB concentrates along a local low-level convergence line over Southeast China,being further facilitated by coexistence of the BoBTC depression and midlevel westerly trough in midlatitudes.Our results highlight the interactions between BoBTCs and local weather systems that influence the general precipitation anomalies and occurrence of EP over China,especially over distant regions.

关键词： tropical cyclone Bay of Bengal precipitation anomaly moisture transport

Characteristics of Precipitation in China Associated with Tropical Cyclones over the Bay of Bengal

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Journal of Meteorological Research 2023年第3期37卷 417-430页

作者： Xiaoting FAN Ying Li Yan liU State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200433 CMA Earth System Modeling and Prediction Centre China Meteorological Administration(CMA)Beijing 100081

In comparison with the number of studies into the impact on precipitation in China of tropical cyclones(TCs)over the western North Pacific,investigation of the effect of TCs in the Bay of Bengal(BoB)on precipitation in China is lacking.In this study,precipitation in China associated with TCs over the BoB was divided into direct rainfall induced by TC cloud clusters and indirect rainfall related to the long-distance transport of TC water vapor.We partitioned the BoB TC-related rainfall that occurred during 2000–2018 in China and analyzed its statistical features.It was found that 40 of the 67(60%)TCs that occurred over the BoB exerted influence on rainfall in China.Direct rainfall was mainly distributed over the southeastern Tibetan Plateau and Southwest China,while indirect rainfall was distributed widely with two high-value centers:one over Yunnan Province and the other over the area south of the middle–lower reaches of the Yangtze River.The highest mean daily rainfall amount of direct TC precipitation appeared in northern Yunnan Province and southeastern Tibet,while that of indirect TC precipitation occurred eastward of 110°E.During the bimodal period of peak occurrence of BoB TCs in May and October–November,the annual mean amount,intensity,and number of days of rainfall in China related to BoB TCs were generally greater in May,e.g.,the mean daily rainfall amount was twice that in October–November,except at stations in southeastern Tibet.In comparison with the BoB TCs that induced heavy rainfall in China in early summer,the TCs in autumn had a more southwestward mean position and a more asymmetric structure,with the long axis oriented in the northeast–southwest direction.Heavy rainfall induced by BoB TCs occurred mainly over southeastern Tibet and provinces south of the middle–lower reaches of the Yangtze River in early summer and over Yunnan and Sichuan provinces in autumn,mostly in response to circulation patterns of a“northern trough with a southern TC”and of“convergence of two high pressure systems,”respect

关键词： tropical cyclone Bay of Bengal precipitation in China statistical characteristics

Electro-acupuncture promotes gut motility and alleviates functional constipation by regulating gut microbiota and increasing butyric acid generation in mice

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Journal of Integrative Medicine 2023年第4期21卷 397-406页

作者： Ming-min Xu Yu Guo ying Chen Wei Zhang Lu Wang Ying Li School of Acupuncture-Moxibustion and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Office of Educational Administration Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina

Objective:Abnormalities in the gut microbiota and intestinal short-chain fatty acid(SCFA)levels are implicated in the pathogenesis of functional constipation(FC).Electro-acupuncture(EA)has been shown to improve constipation-related symptoms and rebalance the gut microbiota.However,it is currently unknown whether the gut microbiota is a key mechanistic target for EA or how EA promotes gut motility by regulating the gut microbiota and SCFAs.Therefore,we assessed the effects of EA in FC mice and pseudo-germfree(PGF)mice to address these questions.Methods:Forty female Kunming mice were randomly separated into a normal control group(n=8),an FC group(n=8),an FC+EA group(n=8),a PGF group(n=8)and a PGF+EA group(n=8).The FC group and FC+EA group were treated with diphenoxylate to establish the FC model;the PGF group and PGF+EA group were given an antibiotic cocktail to initiate the PGF model.After maintaining the model for 14 d,mice in the FC+EA and PGF+EA groups received EA stimulation at the ST25 and ST37 acupoints,once a day,5 times per week,for 2 weeks.Fecal parameters and intestinal transit rate were calculated to assess the efficacy of EA on constipation and gastrointestinal motility.Colonic contents were used to quantify gut microbial diversity using 16S rRNA sequencing,and measure SCFA concentrations using gas chromatography-mass spectrometry.Results:EA significantly shortened the first black stool defecation time(Plity and alleviated constipation.However,EA treatment did not reverse slow-transit colonic motility in PGF mice(P>0.05),demonstrating that the gut microbiota may play a mechanistic role in the EA treatment of constipation.In addition,EA treatment restored the Firmicutes to Bacteroidetes ratio and significantly increased butyric acid generation in FC mice(Plikely due to the upregulation of Staphy

关键词： Electro-acupuncture Functional constipation Gut microbiota Firmicutes/Bacteroidetes ratio Intestinal short-chain fatty acid

Synergistic Effects of Bay of Bengal Tropical Cyclones and Tibetan Plateau Vortices on Water Vapor Transport over the Tibetan Plateau in Early Summer

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Journal of Meteorological Research 2024年第2期38卷 383-398页

作者： Jialu liN Ying Li Beiyao liU Pengchao AN State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 University of Chinese Academy of Sciences Beijing 100049 Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200433

The Bay of Bengal(BoB)tropical cyclones(TCs)and the Tibetan Plateau vortices(TPVs)are two crucial weather systems influencing the Tibetan Plateau(TP).Their synergistic effects can lead to widespread heavy precipitation events on the TP.In this study,we employ the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPliT)model to track the trajectory of water vapor transport during three large-scale precipitation events on the TP under the combined influence of BoB TCs and TPVs.The results indicate that low-level water vapor from the BoB under the influence of BoB TCs was cyclonically entangled into the cyclonic circulation,lifted and transported northward by southwesterly flow to the southeastern part of the TP,which contributes to the moistening of the entire troposphere there.Additionally,convergence of the cyclonic circulation of the TPVs on the northern TP further transports water vapor collected in the southeastern TP northward,conducive to the maintenance and development of precipitation systems,thus inducing widespread heavy precipitation events over the TP.

关键词： Bay of Bengal(BoB) tropical cyclones(TCs) Tibetan Plateau vortices(TPVs) trajectory tracing water vapor transport

慢病毒介导星形胶质细胞活化基因-1沉默对葡萄膜黑色素瘤生物学行为的影响

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中华实验眼科杂志 2018年第10期36卷 748-755页

作者：毛英白海霞畅颖李彬首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所眼科学与视觉科学北京市重点实验室北京100005

目的探讨星形胶质细胞活化基因-1（AEG-1）对葡萄膜黑色素瘤（UM）生物学行为的影响。方法培养不同侵袭转移潜能的MUM-2B和MUM-2C细胞系，根据AEG-1基因序列设计出有效RNA干扰（RNAi）靶点序列及RNAi阴性对照scramble序列进行慢病毒载... 详细信息

目的探讨星形胶质细胞活化基因-1（AEG-1）对葡萄膜黑色素瘤（UM）生物学行为的影响。方法培养不同侵袭转移潜能的MUM-2B和MUM-2C细胞系，根据AEG-1基因序列设计出有效RNA干扰（RNAi）靶点序列及RNAi阴性对照scramble序列进行慢病毒载体的制备和病毒包装。在2株细胞系中，经AEG-1-RNAi慢病毒感染的细胞作为慢病毒感染组，空白慢病毒载体感染的细胞作为阴性对照组，未处理的细胞作为正常对照组。采用Real-time PCR、Western blot法分别检测各组细胞中AEG-1转录水平和蛋白表达水平；采用MTT法、Annexin V-APC法、细胞侵袭试验和细胞Transwell试验检测慢病毒介导AEG-1沉默对人UM细胞系生物学行为的影响。结果成功制备RNAi慢病毒载体而进行病毒包装，然后分别转染对数生长期的MUM-2B、MUM-2C细胞系，2株细胞系中的正常对照组、阴性对照组和慢病毒感染组间细胞中AEG-1 mRNA相对表达量总体比较差异均有统计学意义（F=130.02，P0.05）。Western blot法检测结果显示，AEG-1蛋白表达水平在2株细胞系中的各组比较，差异均有统计学意义（F=146.17，P<0.01；F=156.79，P<0.01），其中慢病毒感染组较阴性对照组蛋白相对表达均显示下调，差异均有统计学意义（均P<0.01）。MTT法检测发现，2株细胞系实验第2～5天，慢病毒感染组细胞增生倍数较阴性对照组明显下降，差异均有统计学意义（t=5.78、30.68、23.99、29.40，均P<0.01；t=7.88、7.09、5.56、6.60，均P<0.01）；Annexin V-APC法检测发现，2株细胞系中慢病毒感染组凋亡率明显高于阴性对照组，差异均有统计学意义（t=54.34，P＜0.01；t=11.68，P＜0.01）；细胞侵袭试验发现，在2株细胞系中慢病毒感染组侵袭倍数明显低于阴性对照组，差异均有统计学意义（t=16.04，P＜0.01；t=13.98，P＜0.01）；细胞Transwell试验发现，在2株细胞系中慢病毒感染组转移倍数均明显低于阴性对照组，差异均有统计学意义（t=12.04，P＜0.01；t=22.43，P＜0.01）。结论慢病毒介导AEG-1沉默后，通过抑制UM细胞AEG-1的转录水平和蛋白表达水平，从而改变UM细胞的生物学行为，一定程度上减缓细胞增生，促进细胞凋亡并降低细胞侵袭和转移的能力。

关键词：葡萄膜黑色素瘤星形胶质细胞活化基因-1 慢病毒载体细胞增生凋亡侵袭转移

Clinical implications of forkhead box M1, cyclooxygenase-2, and glucose-regulated protein 78 in breast invasive ductal carcinoma

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World Journal of Clinical Cases 2023年第30期11卷 7284-7293页

作者： Jie Bai Ying Li li Cai Department of Clinical Laboratory Joint Logistics Support Unit 940 HospitalLanzhou 730030Gansu ProvinceChina Department of Breast Surgery The Fourth Hospital of ShijiazhuangShijiazhuang 050032Hebei ProvinceChina Department of Pathology Huai’an Maternal and Child Health Care CenterHuai’an 223002Jiangsu ProvinceChina

BACKGROUND Breast infiltrating ductal carcinoma(BIDC)represents the largest heterotypic tumor group,and an in-depth understanding of the pathogenesis of BIDC is key to improving its prognosis.AIM To analyze the expression profiles and clinical implications of forkhead box M1(FOXM1),cyclooxygenase-2(COX-2),and glucose-regulated protein 78(GRP78)in BIDC.METHODS A total of 65 BIDC patients and 70 healthy controls who presented to our hospital between August 2019 and May 2021 were selected for analysis.The peripheral blood FOXM1,COX-2,and GRP78 levels in both groups were measured and the association between their expression profiles in BIDC was examined.Additionally,we investigated the diagnostic value of FOXM1,COX-2,and GRP78 in patients with BIDC and their correlations with clinicopathological features.Furthermore,BIDC patients were followed for 1 year to identify factors influencing patient prognosis.RESULTS The levels of FOXM1,COX-2,and GRP78 were significantly higher in BIDC patients compared to healthy controls(Plignant tumor development and closely correlating with prognosis.These findings hold significant research implications for the future diagnosis and treatment of BIDC.

关键词： Diagnostic value Forkhead box M1 Cyclooxygenase-2 Glucose-regulated protein 78 Clinical implications