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Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

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Journal of Pharmaceutical Analysis 2024年第4期14卷 601-614页

作者： Bei Li Yong Zhang Xinyuan Liu Ziyang Zhang Shuqing Zhuang Xiaoli Zhong Wenbo Chen yilin hong Pingli Mo Shuhai Lin Shicong Wang Chundong Yu State Key Laboratory of Cellular Stress Biology School of Life SciencesXiamen UniversityXiamen361102China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian363000China Xiang'an Hospital of Xiamen University School of MedicineXiamen UniversityXiamen361005China Department of Cardiology Xiamen Key Laboratory of Cardiac ElectrophysiologyXiamen Institute of Cardiovascular DiseasesThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361003China

Pien Tze Huang(PZH),a class-1 nationally protected traditional Chinese medicine(TCM),has been used to treat liver diseases such as hepatitis;however,the effect of PZH on the progression of sepsis is ***,we reported that PZH attenuated lipopolysaccharide(LPS)-induced sepsis in mice and reduced LPS-induced production of proinflammatory cytokines in macrophages by inhibiting the activation of mitogen-activated protein kinase(MAPK)and nuclear factor-kappa B(NF-κB)***,PZH stimulated signal transducer and activator of transcription 3(STAT3)phosphorylation to induce the expression of A20,which could inhibit the activation of NF-κB and MAPK *** of the bile acid(BA)receptor G protein-coupled bile acid receptor 1(TGR5)in macrophages abolished the effects of PZH on STAT3 phosphorylation and A20 induction,as well as the LPS-induced inflammatory response,suggesting that BAs in PZH may mediate its anti-inflammatory effects by activating ***,deprivation of BAs in PZH by cholestyramine resin reduced the effects of PZH on the expression of phosphorylated-STAT3 and A20,the activation of NF-κB and MAPK signalling,and the production of proinflammatory cytokines,whereas the addition of BAs to cholestyramine resin-treated PZH partially restored the inhibitory effects on the production of proinflammatory ***,our study identifies BAs as the effective components in PZH that activate TGR5-STAT3-A20 signalling to ameliorate LPS-induced sepsis.

关键词： Pien Tze Huang Bile acids Sepsis Inflammation TGR5 STAT3-A20 signalling

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不同介质环境样品的符合修正方法研究

核电子学与探测技术 2024年第3期44卷 542-548页

作者：顾先宝於国兵卞岍雨程李迅许丰张健军盛六四洪义麟中国科学技术大学合肥230027 安徽省辐射环境监督站合肥230071 中国科学技术大学附属第一医院合肥230001 哈尔滨工程大学哈尔滨150001

使用γ能谱测量放射性核素活度时,级联发射的γ射线会发生符合效应,影响测量结果。为了得到不同环境介质样品的符合修正因子,研究了简单级联发射模式的核素在不同介质中符合修正因子之间的关系,提出了利用水代替其他环境介质的符合修正... 详细信息

使用γ能谱测量放射性核素活度时,级联发射的γ射线会发生符合效应,影响测量结果。为了得到不同环境介质样品的符合修正因子,研究了简单级联发射模式的核素在不同介质中符合修正因子之间的关系,提出了利用水代替其他环境介质的符合修正因子计算方法。实验结果表明,使用该方法所得结果的最大偏差为2.8%。使用此方法不需要逐一制备不同介质标准源,它为多介质的辐射环境监测提供了一种简单的符合修正方法。

关键词：环境介质符合修正标准源

Encoding innumerable charge density waves of FeGe into polymorphs of LiFe_(6)Ge_(6)

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 126-132页

作者： yilin Wang School of Emerging Technology University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China New Cornerstone Science Laboratory University of Science and Technology of ChinaHefei 230026China

Kagome metals exhibit rich quantum states by the intertwining of lattice,charge,orbital and spin degrees of ***,a novel charge density wave(CDW)ground state was discovered in kagome magnet FeGe and was revealed to be driven by lowering magnetic energy via large ***,based on DFTcalculations,we show that such mechanism will yield infinitely many metastable CDWs in FeGe due to different ways to arrange the Ge1-dimerization in enlarged ***,utilizing these metastable CDWs,innumerable polymorphs of kagome magnet LiFe_(6)Ge_(6) can be stabilized by filling Li atoms in the voids right above/below the dimerized Ge1-sites in the CDW *** polymorphs are very stable due to the presence of magnetic-energy-saving mechanism,in sharp contrast to the non-magnetic“166”kagome *** this way,a one-to-one mapping of the metastable CDWs of FeGe to stable polymorphs of LiFe_(6)Ge_(6) is *** one hand,the fingerprints of these metastable CDWs,i.e.,the induced in-plane atomic distortions and band gaps,are encoded into the corresponding stable polymorphs of LiFe_(6)Ge_(6),such that further study of their properties becomes *** the other hand,such innumerable polymorphs of LiFe_(6)Ge_(6) offer great degrees of freedom to explore the rich physics of magnetic kagome *** thus reveal a novel connection between the unusually abundant CDWs and structural polymorphism in magnetic kagome materials,and establish a new route to obtain structural polymorphism on top of CDW states.

关键词： kagome magnet unconventional charge density wave structural polymorphism magnetic energy saving

Fabrication of the beam splitters for soft X-ray laser application

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Chinese Science Bulletin 2003年第18期48卷 1930-1933页

作者： WANG Zhanshan WU Yonggang TANG Weixing QIN Shuji CHEN Lingyan XU Xiangdong hong yilin FU Shaojun ZHU Jie CUI Mingqi Institute of Precision Optical Engineering Department of PhysicsTongji UniversityShanghai 200092China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of High Energy Physics Beijing 100039China

The soft X-ray interferometry is completed by the Mach-Zehnder interferometer using a soft X-ray laser, and it is also an important method to measure the electron densities of a laser-produced plasma near the critical surface. It is apparently demonstrated in this paper that the incident angle of each optical element in the soft X-ray Mach- Zehnder interferometer should be near normal incidence based on the polarized characteristics of the soft X-ray mul-tilayers, and the product of reflectivity and transmission of the beam splitter should be taken as a standard of design according to the structure of the soft X-ray Mach-Zehnder interferometer. The beam splitters used in the soft X-ray interferometry at 13.9 nm are fabricated using the ion beam sputtering. The figure error of the beam splitter has reached the nanometer magnitude, in which the product of reflectiv-ity and transmission of the beam splitter is more than 1.6%.

关键词： soft X-ray beam splitter multilayer interference.

Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications

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Nano-Micro Letters 2024年第10期16卷 403-434页

作者： yilin Sun Huaipeng Wang Dan Xie School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People's Republic of China School of Integrated Circuits Beijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijing 100084People's Republic of China

Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial ***,great efforts have been devoted to exploring biomimetic mechanisms of plasticity simulation in the last few *** progress in various plasticity modulation techniques has pushed the research of synaptic electronics from static plasticity simulation to dynamic plasticity modulation,improving the accuracy of neuromorphic computing and providing strategies for implementing neuromorphic sensing ***,several fascinating strategies for synap-tic plasticity modulation through chemical techniques,device structure design,and physical signal sensing are *** chemical techniques,the underly-ing mechanisms for the modification of functional materials were clarified and its effect on the expression of synaptic plasticity was also *** on device structure design,the reconfigurable operation of neuromorphic devices was well demonstrated to achieve programmable neuromorphic ***,integrating the sensory units with neuromorphic processing circuits paved a new way to achieve human-like intelligent perception under the modulation of physical signals such as light,strain,and ***,considering that the relevant technology is still in the basic exploration stage,some prospects or development suggestions are put forward to promote the development of neuromorphic devices.

关键词： Plasticity modulation Dynamic plasticity Chemical techniques Programmable operation Neuromorphic sensing

Bispecific antibody drug conjugates:Making 1+1>2

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1965-1986页

作者： yilin Gu Zhijia Wang Yuxi Wang Targeted Tracer Research and Development Laboratory Institute of Respiratory HealthFrontiers Science Center for Disease-Related Molecular NetworkNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu 610212China

Bispecific antibody‒drug conjugates(BsADCs)represent an innovative therapeutic category amalgamating the merits of antibody‒drug conjugates(ADCs)and bispecific antibodies(BsAbs).Positioned as the next-generation ADC approach,BsADCs hold promise for ameliorating extant clinical challenges associated with ADCs,particularly pertaining to issues such as poor internalization,off-target toxicity,and drug ***,ten BsADCs are undergoing clinical trials,and initial findings underscore the imperative for ongoing *** review initially delves into specific design considerations for BsADCs,encompassing target selection,antibody formats,and the linker–payload *** sections delineate the extant progress and challenges encountered by BsADCs,illustrated through pertinent case *** amalgamation of BsAbs with ADCs offers a prospective solution to prevailing clinical limitations of ***,the symbiotic interplay among BsAb,linker,and payload necessitates further optimizations and coordination beyond a simplistic“1+1”to effectively surmount the extant challenges facing the BsADC domain.

关键词： Bispecific antibody drug conjugates Antibody drug conjugates Bispecific antibody Targeted therapy Safety HER2 EGFR

Event-triggered predefined-time control for full-state constrained nonlinear systems: A novel command filtering error compensation method

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Science China(Technological Sciences) 2024年第9期67卷 2867-2880页

作者： PAN YingNan CHEN yilin LIANG hongJing College of Control Science and Engineering Bohai UniversityJinzhou 121013China School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Laboratory of Electromagnetic Space Cognition and Intelligent Control Beijing 100089China

In this paper, a command filter-based adaptive fuzzy predefined-time event-triggered tracking control problem is investigated for uncertain nonlinear systems with time-varying full-state constraints. By designing a sliding mode differentiator, the inherent computational complexity problem within the predefined-time backstepping framework is solved. Different from the existing command filter-based finite-time and fixed-time control strategies that the convergence time of the filtering error is adjusted through the system initial value or numerous parameters, a novel command filtering error compensation method is presented,which tunes one control parameter to make the filtering error converge in the predefined time, thereby reducing the complexity of design and analysis of processing the filtering error. Then, an improved event-triggered mechanism(ETM) that builds upon the switching threshold strategy, in which an inverse cotangent function is designed to replace the residual term of the ETM,is proposed to gradually release the controller's dependence on the residual term with increasing time. Furthermore, a tan-type nonlinear mapping technique is applied to tackle the time-varying full-state constraints problem. By the predefined-time stability theory, all signals in the uncertain nonlinear systems exhibit predefined-time stability. Finally, the feasibility of the proposed algorithm is substantiated through two simulation results.

关键词： predefined-time control command filtering error compensation method event-triggered mechanism time-varying full-state constraints uncertain nonlinear systems

Regulation of Tumor Microenvironment Under Malignant Conditions:Application of nMOFs in Sonodynamic Therapy

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Chemical Research in Chinese Universities 2024年第4期40卷 611-626页

作者： YANG yilin YAN Fei SHI Zhan State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun130012P.R.China

In this review,we delve into the intricate regulation of the tumor microenvironment(TME)under malignant conditions and explore the transformative potential of nanoscale metal-organic frameworks(nMOFs)in the realm of sonodynamic therapy(SDT).The TME serves as a dynamic milieu influencing tumor progression and therapeutic response,presenting formidable challenges,such as hypoxia,acidity,excess hydrogen peroxide,high expression of glutathione,and *** the exceptional attributes of nMOFs,including their tunable structures and biocompatibility,holds immense promise for enhancing SDT efficacy and reshaping the TME *** integrating nMOFs with SDT,researchers aim to assemble multiple functionalities in a single platform that enhance tumor cell eradication while counteracting unfavorable TME conditions and immune *** potential of nMOFs to revolutionize tumor therapies by precisely targeting TME and overcoming therapeutic barriers is underscored by an in-depth analysis of recent breakthroughs in the use of nMOFs-based sonosensitizers to remodulate TME to amplify the efficacy of SDT.

关键词： Sonodynamic therapy Metal-organic framework Tumor microenvironment Modification of sonosensitizer

Hadoop-based secure storage solution for big data in cloud computing environment

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Digital Communications and Networks 2024年第1期10卷 227-236页

作者： Shaopeng Guan Conghui Zhang yilin Wang Wenqing Liu School of Information and Electronic Engineering Shandong Technology and Business UniversityYantai264003China

In order to address the problems of the single encryption algorithm,such as low encryption efficiency and unreliable metadata for static data storage of big data platforms in the cloud computing environment,we propose a Hadoop based big data secure storage ***,in order to disperse the NameNode service from a single server to multiple servers,we combine HDFS federation and HDFS high-availability mechanisms,and use the Zookeeper distributed coordination mechanism to coordinate each node to achieve dual-channel ***,we improve the ECC encryption algorithm for the encryption of ordinary data,and adopt a homomorphic encryption algorithm to encrypt data that needs to be *** accelerate the encryption,we adopt the dualthread encryption ***,the HDFS control module is designed to combine the encryption algorithm with the storage *** results show that the proposed solution solves the problem of a single point of failure of metadata,performs well in terms of metadata reliability,and can realize the fault tolerance of the *** improved encryption algorithm integrates the dual-channel storage mode,and the encryption storage efficiency improves by 27.6% on average.

关键词： Big data security Data encryption Hadoop Parallel encrypted storage Zookeeper