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The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar Science 2024年第1期35卷 63-77页

作者： Paula BONA Juliana STERlI Marcelo Saúl de la FuENTE Eduardo OlIVERO Marta S.FERNÁNDEZ Marcelo REGuERO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Austral de Investigaciones Científicas-CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian Sea and final dismemberment of Southern *** this context,Eocene marine vertebrates from Seymour(Marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic Coast of South *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the leticia Formation(late-mid Eocene)at Cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to Dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late Cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the la Meseta and Submeseta formations(Antarctica)and the Waihao and Burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles Dermochelyidae Paleogene la Meseta Formation Submeseta Formation leticia Formation

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Influence of ageing on oil degradation and gassing tendency under high-energy electrical discharge faults for mineral oil and synthetic ester

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High Voltage 2020年第6期5卷 731-738页

作者： l.loiselle u.Mohan Rao I.Fofana Research Chair on the Aging of Power Network Infrastructure(ViAHT) Universitédu QuébecàChicoutimiChicoutimiQCG7H 2B1Canada

In this work, mineral oil and synthetic esters were selected at different ageing factors (based on acidity values). Fresh and aged oils have been subjected to high-energy discharges (repeated 100 breakdowns) to simulate electric faults of highly vulnerable intensity. The intent of this work is to understand the influence of high-energy electric faults on oil degradation and gassing tendency at different ageing conditions. In this study, the influence of the high-energy discharges on degradation and gassing tendency at different ageing factors is reported for mineral oil and synthetic esters. Oil degradation is reported by adopting ultraviolet spectroscopy, turbidity and particle counter as per american society for testing and materials (ASTM) standard test methods. Gassing tendencies and fault gas analysis are understood by dissolved the gas analysis using Duval's triangle and Duval's pentagon methods for mineral and non-mineral oils. It is found that the influence of high-energy discharges on oil degradation is higher in mineral oils to that of the synthetic esters. The intensity of the gassing tendency is higher for ester fluids;however, as per the Duval methods, the faulty conditions are at lower levels as compared to mineral oils.

关键词： synthetic energy high

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Genes associated with Alzheimer's disease affecting ischemic neurodegeneration of the hippocampal CA3 region

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Neural Regeneration Research 2021年第7期16卷 1392-1393页

作者： Ryszard Pluta Marzena ułamek-Kozioł laboratory of Ischemic and Neurodegenerative Brain Research Mossakowski Medical Research CentrePolish Academy of SciencesWarsawPoland

Neurodegeneration in the brain after ischemia with reperfusion mimicking the neuropathology of Alzheimer's disease:Brain ischemia with reperfusion,which is one of the main causes of morbidity and mortality in the world,triggers various neuropathological changes characteristic for Alzheimer's disease(AD)such as increased blood-brain barrier permeability,excitotoxicity,necrosis,autophagy,mitophagy,apoptosis,neuroinflammation,amyloid plaques,neurofibrillary tangles,cerebral vessel pathology,and brain atrophy that lead to the death of neurons,deteriorating motor,sensory and cognitive functions(Figure 1)(Kato et al.,1988;Wisniewski et al.,1995;Van Groen et al.,2005;Kocki et al.,2015;ułamek-Koziołet al.,2016,2017,2019).Brain ischemia is recognized as a major contributor to the dysfunction of an aging brain and the development of neurodegenerative diseases,including AD(Pluta,2019).

关键词： Alzheimer ischemia cerebral

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Boosting Adaptive Weighted Broad learning System for Multi-label learning

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2204-2219页

作者： Yuanxin lin Zhiwen Yu Kaixiang Yang Ziwei Fan C.l.Philip Chen the School of Computer Science and Engineering in South China university of Technology IEEE the Pengcheng laboratory

Multi-label classification is a challenging problem that has attracted significant attention from researchers, particularly in the domain of image and text attribute annotation. However, multi-label datasets are prone to serious intra-class and inter-class imbalance problems, which can significantly degrade the classification performance. To address the above issues, we propose the multi-label weighted broad learning system(MlW-BlS) from the perspective of label imbalance weighting and label correlation mining. Further, we propose the multi-label adaptive weighted broad learning system(MlAW-BlS) to adaptively adjust the specific weights and values of labels of MlW-BlS and construct an efficient imbalanced classifier set. Extensive experiments are conducted on various datasets to evaluate the effectiveness of the proposed model, and the results demonstrate its superiority over other advanced approaches.

关键词： learning systems Adaptation models Correlation Adaptive systems Annotations Boosting Classification algorithms Broad learning system label correlation mining label imbalance weighting multi-label imbalance ClASSIFICATION ENSEMBlE

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新辅助免疫治疗联合化疗联合或不联合其他疗法治疗可切除局部进展期胃癌或胃食管结合部癌疗效和安全性的Meta分析

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中国肿瘤临床与康复 2024年第1期31卷 17-29页

作者：田青怡德吉央宗张丽娜义西求措迪吉青海大学附属医院肿瘤内科西宁810012 青海省玉树州玉树市人民医院内科玉树815099

目的评估新辅助程序性死亡受体1(PD-1)/程序性死亡配体1(PD-l1)单抗+化疗±其他疗法治疗可切除局部进展期胃癌(GC)或胃食管结合部癌(GEJC)患者的疗效和安全性。方法检索了建库至2023年7月28日的Pubmed、Embase、Cochrane library和Web o... 详细信息

目的评估新辅助程序性死亡受体1(PD-1)/程序性死亡配体1(PD-l1)单抗+化疗±其他疗法治疗可切除局部进展期胃癌(GC)或胃食管结合部癌(GEJC)患者的疗效和安全性。方法检索了建库至2023年7月28日的Pubmed、Embase、Cochrane library和Web of Science数据库中的相关研究,提取疾病控制率(DCR)、客观缓解率(ORR)、1年总生存率、1年无病生存率、3年总生存率、3年无病生存率、病理学完全缓解(pCR)率、主要病理学缓解(MPR)率、R0切除率等疗效数据,以及1~2级治疗相关不良反应(TRAE)发生率、≥3级TRAE发生率和免疫相关不良反应(irAE)发生率等安全性数据。通过纽卡斯尔-渥太华量表(NOS)和亚乔安娜布里格斯研究所(JBI)关键评价清单评估纳入研究的质量。结果共纳入10项研究,10项研究均发表于2022-2023年,共纳入353例患者,中位年龄为57.9~65.5岁。NOS和JBI关键评价清单评价结果显示,纳入文献质量较好。在疗效方面,汇总后的DCR、ORR、1年总生存率、1年无病生存率、3年总生存率、3年无病生存率、pCR率、MPR率、R0切除率分别为92%(95%CI:85%~99%)、61%(95%CI:50%~72%)、95%(95%CI:91%~98%)、93%(95%CI:89%~97%)、90%(95%CI:83%~97%)、83%(95%CI:74%~92%)、22%(95%CI:18%~27%)、44%(95%CI:33%~55%)和95%(95%CI:92%~98%)。在安全性方面,大多数患者出现了1~2级TRAE。最常见的血液系统1~2级TRAE为白细胞减少(47%,95%CI:38%~56%),最常见的消化系统1~2级TRAE为呕吐(20%,95%CI:10%~30%)。≥3级TRAE发生率低,均l1单抗+化疗±阿帕替尼对可切除局部进展期GC或GEJC患者的疗效确切,不良反应可耐受。

关键词：胃肿瘤胃食管结合部癌程序性死亡受体1/程序性死亡配体1 新辅助治疗 Meta分析

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系统免疫炎症指数对腹腔镜胰十二指肠切除术后胰瘘发生的诊断价值

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中国医药导报 2024年第16期21卷 17-20页

作者：汪栋张轶西林华骏管成剑张小东郭伟首都医科大学附属北京友谊医院普通外科北京100050

目的分析系统免疫炎症指数(SII)对腹腔镜胰十二指肠切除术(lPD)后胰瘘发生的诊断价值。方法选取2018年1月至2023年6月首都医科大学附属北京友谊医院普通外科接受lPD的患者306例。统计患者的基本资料、根据公式(血小板计数×中性粒细胞计... 详细信息

目的分析系统免疫炎症指数(SII)对腹腔镜胰十二指肠切除术(lPD)后胰瘘发生的诊断价值。方法选取2018年1月至2023年6月首都医科大学附属北京友谊医院普通外科接受lPD的患者306例。统计患者的基本资料、根据公式(血小板计数×中性粒细胞计数/淋巴细胞计数)计算患者术前3 d的SII;按照2016年国际胰腺外科研究组胰瘘诊断标准和分级依据分为临床相关胰瘘(CRPF)组31例与非CRPF组275例。通过单因素及多因素回归分析筛选出影响患者发生术后胰瘘的危险因素,并通过甘油三酯(TG)、血清白蛋白(Alb)及SII的指标对术后胰瘘进行受试者操作特征(ROC)曲线绘制并评估其诊断价值。结果本研究中31例(10.2%)发生CRPF,其中24例为B级胰瘘,7例为C级胰瘘。单因素分析发现,CRPF组中性粒细胞率(NEu-R)和TG水平高于非CRPF组,血清Alb水平低于非CRPF组(Plb、TG和SII是lPD术后胰瘘发生的危险因素,Alb是lPD术后胰瘘的发生的独立保护因素(PuC值为0.945。TG的AuC值为0.911,95%CI(0.918~0.971),约登指数为0.733,截断值为5.62 mmol/l,(Z=4.78,Plb的AuC值为0.771,95%CI(0.674~0.867),约登指数为0.515,截断值为35.1 g/l,Z=4.34,Plb,SII曲线下面积最大,且具有更高的预测效能。ROC曲线来确定SII最佳临界值为984.6×10^(9)/l,灵敏度为0.782,特异度为0.736。结论SII是lPD术后的胰瘘的独立危险因素,并且相比于TG及血清Alb,SII具有更高的诊断价值。

关键词：腹腔镜胰十二指肠切除术胰瘘系统免疫炎症指数 C反应蛋白

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Inquiries and Confession before the Cross： An Interpretation of Wang Guilin＇s My Jerusalem

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Frontiers of literary Studies in China-Selected Publications from Chinese universities 2015年第2期9卷 318-336页

作者： l.u Yan Institute for Trans-cul.ural Studies Beijing Intemational Studies University Beijing 100024China

This essay employs the approach of New Criticism close reading to interpret My Jerusalem by a contemporary Chinese poet, Wang Guilin, from the dialogic perspective of＂I and Thou.＂ From a dimension of faith beyond daily life, the poet narrates his astonishment, historical reflection and spiritual transformation during a visit to Jerusalem. For him, the journey to Jerusalem was also a pilgrimage to a spiritual homeland, self-achievement, and peace and love.

关键词： Jerusalem Bible I and Thou the Cross

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In vitro expression of gelatinases in reconstructed melanoma model composited MV3 cells

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Chinese Medical Journal 2013年第16期126卷 3196-3197页

作者： l.u) Yu ZHANG Wei lu Hong-guang Department of Dermatology Affiliated Hospital of Guiyang Medical UniversityGuiyang Guizhou 550001 China

To the editor：It has been known that invasion and metastasis of skin melanoma in situ is a complex multi-step process involving in the interaction between melanoma cells and the adjacent stromal cells and basement membrane （BM）.1 Over the years,the process of melanoma invasion from epidermis to dermis was observed using animal models or human cutaneous melanoma lesions removed.2,3As for the deleted human pathological specimens,it is difficult to completely restore invasion system in ***,experimental animal is subjected to a damage or death in animal *** the animal in vivo,it contains various indefinite factors to influence tumor-cell invasion and *** the general enhance on awareness of animal protection,organized and realistic artificial tumor model is an acceptable alternative to animal melanoma research in this field,which is an important progress in observing skin melanoma *** in vitro reconstructed melanoma models made by different melanoma cell lines cul.ured on dermal substitute *** matrices were reported to study melanoma invasion.1 For instance,Eves et al4 reported that melanoma cells with invasive growth on acel.ular dermis expressed gelatinases （MMP-2,MMP-9）.However,both invasive behavior of melanoma cells and those proteases activity correlated with the invasion seem wide variations in different melanoma cell lines.4 Hence,more experiments on invasion assay in those models would be required in this field.

关键词： expression gelatinases reconstructed

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Plastic deformation of a Zr-based bulk metallic glass fabricated by selective laser melting

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Journal of Materials Science & Technology 2021年第1期60卷 139-146页

作者： l.Deng K.Kosiba R.limbach l.Wondraczek u.Kühn S.Pauly IFW Dresden Institute for Complex MaterialsHelmholtzstraße 20D-01069DresdenGermany Otto Schott Institute of Materials Research University of JenaFraunhoferstraße 6D-07743JenaGermany university of Applied Sciences Aschaffenburg Würzburger Straße 45D-63743AschaffenburgGermany

Fully amorphous Zr_(52.5)Cu_(17.9)Ni_(14.6)Al_(10)Ti_(5) bulk metallic glass(BMG) samples with a relative density exceeding 98% were fabricated via selective laser melting(SlM).High fracture stresses of around1700 MPa and a reproducible plastic strain of about 0.5% were obtained for cylindrical SlM *** analysis of the observed serrations during compressive loading implies that the shear-band dynamics in the additively manufactured samples distinctly differ from those of the as-cast *** phenomenon appears to originate from the presence of uniformly dispersed spherical pores as well as from the more pronounced heterogeneity of the glass itself as revealed by instrumented *** these heterogeneities,the shear bands are straight and form in the plane of maximum shear *** manufacturing,hence,might not only allow for producing large BMG samples with complex geometries but also for manipulating their deformation behaviour through tailoring porosity and structural heterogeneity.

关键词： Powder bed fusion Selective laser melting Bulk metallic glass Serrated flow Heterogeneity

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Recent advances in the understanding and management of chronic pancreatitis pain

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Journal of Pancreatology 2024年第1期7卷 35-44页

作者： Jessica Walker Olivia l.Babyok Jami l.Saloman Anna Evans Phillips Department of Internal Medicine University of Pittsburgh Medical CenterPittsburghPAUnited States Division of Gastroenterology Hepatology and NutritionDepartment of MedicineSchool of MedicineUniversity of PittsburghPittsburghPAUnited States Center for Pain Research Center for NeuroscienceSchool of MedicineUniversity of PittsburghPittsburghPAUnited States

Abdominal pain is the most common symptom of chronic pancreatitis(CP)and is often debilitating for patients and very difficult to *** date,there exists no cure for the *** strategies focus on symptom management and on mitigation of disease progression by reducing toxin exposure and avoiding recurrent inflammatory *** treatment protocols start with medical management followed by consideration of procedural or surgical intervention on selected patients with severe and persistent *** incorporation of adjuvant therapies to treat comorbidities including psychiatric disorders,exocrine pancreatic insufficiency,mineral bone disease,frailty,and mal.utrition,are in its early *** clinical studies and animal models have been designed to improve investigation into the pathophysiology of CP pain,as well as to improve pain *** the array of tools available,many therapeutic options for the management of CP pain provide incomplete *** still remains much to discover about the neural regulation of pancreas-related *** this review,we will discuss research from the last 5 years that has provided new insights into novel methods of pain phenotyping and the pathophysiology of CP *** discoveries have led to improvements in patient selection for optimization of outcomes for both medical and procedural management,and identification of potential future therapies.

关键词： Central sensitization Chronic pancreatitis Pain phenotyping Peripheral sensitization

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