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Glycyrrhizinate reduces portal hypertension in isolated perfused rat livers with chronic hepatitis

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World Journal of Gastroenterology 2013年第36期19卷 6069-6076页

作者： Xin Zhao Bo Deng Xue-Yan Xu Shi-jun Yang Tao Zhang yi-jun song Xiao-Ting Liu Yue-Qi Wang Da-Yong Cai Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College School of Basic Medicine Beijing University of Chinese Medicine

AIM:To investigate the effects of diammonium glycyrrhizinate(Gly)on portal hypertension(PHT)in isolated portal perfused rat liver(IPPRL)with carbon tetrachloride(CCl4)-induced chronic ***:PHT model was replicated with CCl4 in rats for 84 *** was identified by measuring the ascetic amounts,hepatic function,portal pressure in vivo,splenic index,and pathological *** nitric oxide synthase(iNOS)in liver was assessed by *** were performed at d0,d28,d56,and *** phenylephrine-induced constriction,Gly was geometrically used to reduce *** action was expressed as median effective concentration(EC50)and area under the curve(AUC).Underlying mechanism was exploited by linear correlation between AUC values of Gly and existed iNOS in portal ***:PHT model was confirmed with ascites,splenomegaly,serum biomarkers of hepatic injury,and elevated portal *** findings had shown normal hepatic structure at d0,degenerations at d28,fibrosis at d56,cirrhosis at d84in PHT *** lobule ratios decreased and collagen ratios increased progressively along with PHT *** does dose-dependently reduce PHT in IPPRLs with CCl4-induced chronic *** potencies were increased gradually along with PHT development,characterized with its EC50at 2.80×10-10,3.03×10-11,3.77×10-11and 4.65×10-11mol/L at d0,d28,d56and d84,*** iNOS was located at hepatocyte at d0,stellate cells at d28,stellate cells and macrophages at d56,and macrophages in portal triads at *** infiltrated more into portal triads and expressed more iNOS along with PHT *** values of Gly were positively correlated with existed iNOS levels in portal ***:Gly reduces indirectly PHT in IPPRL with CCl4-induced chronic *** underlying mechanisms may relate to rescue NO bioavailability from macrophage-derived peroxynitrite in portal triads.

关键词： Chronic hepatitis Portal hypertension Isolated portal perfused rat liver Diammonium glycyrrhizinate Inducible nitric oxide synthase

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对西方和马克思社会保障理论的现代诠释

马克思主义研究 2009年第12期 107-113页

作者：李怡宋军华南理工大学思想政治学院

为提供完善社会保障体系的理论参照和理论支撑,对西方和马克思的社会保障体系理论做了总结、比较研究及分析。并从方法论入手,比较分析了西方社会保障理论和马克思社会保障理论各自不同的理论视角。认为社会保障体系的理论支撑,借鉴马... 详细信息

为提供完善社会保障体系的理论参照和理论支撑,对西方和马克思的社会保障体系理论做了总结、比较研究及分析。并从方法论入手,比较分析了西方社会保障理论和马克思社会保障理论各自不同的理论视角。认为社会保障体系的理论支撑,借鉴马克思的实践理性方法论和世界观比借鉴西方经济理性的效率说和西方道德意志理性的公平说更具适用性,对西方社会保障理论的合理因素也要依据我国社会发展实际加以参考。

关键词：社会保障经济理性效率说道德意志理性公平说实践理性

Pregnancy Combined with Epilepsy and Cerebral Cavernous Malformation

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Chinese Medical Journal 2017年第5期130卷 619-620页

作者： Ya-Lan Xu jun-Tao Liu yi-jun song Xi-Ya Zhou Qing-Wei Qi Xu-Ming Bian Zhi-Qin Xu Lei Li Department of Obstetrics and Gynecology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Neurosurgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

INTRODUCTIOIN Cerebral cavernous malformation （CCM）, also known as cavernous angioma, is a type of vascular malformation in the central nervous system. To date, rare cases of CCM and seizure have been reported in pr... 详细信息

关键词： Cerebral Cavernous Malformation Delivery Hemorrhage Pregnancy

Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)

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Journal of Geriatric Cardiology 2021年第4期18卷 261-270页

作者： Yu-Qi LIU Dan-Dan LI Meng CHAI Hong-Liang CONG Xiao-Qiang CONG jun DAI Rong-Pin DU Ming GAO Jin-Cheng GUO Yan-Qing GUO Xiao-Jian HONG Rong-Chong HUANG Feng-Shun JIA Jia-Yu LI Qing LI Jia-Mei LIU Xin-Ping LIU Yu-Guo LIU Hong-Gang NIE Bing SHAO Xiao-Yu SHEN Hai-Qing song yi-jun song Li-jun WANG Shuo WANG Dong-Mei WU Jing XIA Zhi-Yong YANG Hong-ying YU Hui ZHANG Tie-Mei ZHANG Ji-yi ZHAO Liang-Chen ZHAO Ming-Qi ZHENG Yun-Dai CHEN Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina Department of Cardiology Tianjin Chest HospitalTianjinChina Department of Cardiology the First Hospital of Jilin UniversityChangchunChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Hebei People’s HospitalShijiazhuangChina Department of Cardiology Kailuan General HospitalHebei Union UniversityTangshanChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology Shanxi Cardiovascular HospitalTaiyuanChina Department of Cardiology the Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Tangshan Worker’s HospitalTangshanChina Department of Cardiology China-Japan Friendship Hospital Affiliated Jilin UniversityChangchunChina Department of Cardiology Handan Central HospitalHebeiChina Heart Center Beijing Key Laboratory of HypertensionBeijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Department of Cardiology the First Affiliated Hospital of Dalian Medical UniversityLiaoningChina Department of Cardiology the Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology the Second Affiliated Hospital of Shenyang Medical CollegeShenyangChina Department of Cardiology the Second Hospital of Shanxi Medical UniversityTaiyuanChina Department of Neurology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Neurology Tianjin Medical University Gen

BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to june in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for *** In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real

关键词： LDL RWE-PCSK study Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high r

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng yi Jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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碳毡/碳复合材料超高温力学性能实验研究

无机材料学报 2001年第6期16卷 1229-1234页

作者：易法军孟松鹤韩杰才杜善义哈尔滨工业大学复合材料研究所哈尔滨150001

利用改进的快速通电加热测试技术，模拟碳毡／碳复合材料的超高温工作环境，对其高温下的拉伸、压缩力学性能进行了全面的测试，并计算了材料在不同温度下的抗热应力系数．结果表明，材料的模量和强度在一定范围内随温度的升高而增加．... 详细信息

利用改进的快速通电加热测试技术，模拟碳毡／碳复合材料的超高温工作环境，对其高温下的拉伸、压缩力学性能进行了全面的测试，并计算了材料在不同温度下的抗热应力系数．结果表明，材料的模量和强度在一定范围内随温度的升高而增加．材料的拉伸性能ＸＹ向优于Ｚ向，而压缩性能Ｚ向优于ＸＹ向．材料的抗热震性能随温度升高变化平稳，ＸＹ向的抗热震性能优于Ｚ向．

关键词：碳毡/碳复合材料超高温力学性能抗热应力系数

基于马尔可夫网络排队论的电梯交通建模及应用

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天津大学学报（自然科学与工程技术版） 2005年第1期38卷 9-13页

作者：宗群魏利剑程义菊宋军远天津大学电气与自动化工程学院天津300072

为优化电梯配置,分析了电梯交通流.利用马尔可夫网络排队论对电梯交通流建模,并求解该模型,然后将求解结果应用到电梯配置中,通过实例与传统的电梯配置作比较.根据两种配置结果,分别求得并分析了相应的性能指标.结果表明,基于新模型的... 详细信息

为优化电梯配置,分析了电梯交通流.利用马尔可夫网络排队论对电梯交通流建模,并求解该模型,然后将求解结果应用到电梯配置中,通过实例与传统的电梯配置作比较.根据两种配置结果,分别求得并分析了相应的性能指标.结果表明,基于新模型的电梯配置可有效降低乘客平均候梯时间和电梯平均载荷,从而证明了利用马尔可夫网络排队论建立电梯交通模型的可行性和优越性.

关键词：电梯交通马尔可夫排队论网络排队模型电梯配置

Two new C-15 enolic acyl phragmalin-type limonoids from Chukrasia tabularis ***

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Two new C-15 enolic acyl phragmalin-type limonoids from Chuk...

Synthesis and Structure of a novel Lead（Ⅱ） Carboxylate-Arsonates

中药与天然药高峰论坛暨第十二届全国中药和天然药物学术研讨会

作者： jun Luo~a,yi Li~b,jun-song Wang~a,and Ling-yi Kong~(a*) a Department of Natural Medicinal Chemistry,China Pharmaceutical University, 24 Tong Jia Xiang,Nanjing 210009,China b Testing & Analysis Center,Nanjing Normal University,Nanjing 210046,China

Two new C-15 enolic acyl phragmalin-type limonoid orthoesters,chukvelutilide G(1)and chukrasine F(2),were isolated from the stem barks of Chukrasia tabularis *** structures were elucidated by their extensive HR-ESI-MS... 详细信息

关键词： Chukrasia tabularis var.velutina C-15 enolic phragmalin-type limonoid orthoester

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Synthesis and Structure of a novel Lead（Ⅱ） Carboxylate-Ar...