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Chinese Medical Sciences Journal 2009年第4期24卷 231-235页

作者： Jia-he Wang yi-jun zhoux yi-jun Zhou Li Tian Ping He Department of Geriatrics Shengjing Hospital China Medical University Shenyang 110004 China Department of Endocrinology and Metabolism the Fourth Affiliated Hospital China Medical University Shenyang 110032 China

Objective To explore the mechanisms involved in Staphylococcus aureus （S. aureus） invading human monocytic U937 cells. Methods S. aureus were added to U937 cells at multiplicity of infections （MOI） of 20：1 for 0, 15, 30, 60, and 90 minutes, respectively. Cell apoptosis was analyzed with Hoechst 33258 staining and Annexin V-fluorescein isothiocyanate （FITC）/propidium iodide （PI） flow cytometry analysis. Akt and nuclear factor-κB （NF-κB） activities were detected by Western blotting. Results Infection of U937 cells with S. aureus induced rapid cell death in a time-dependent manner, and the cells displayed characteristic features of apoptosis. S. aureus-induced apoptosis was associated with a prominent downregulation of activated （phosphorylated） Akt and NF-κB. The inhibition of phosphorylated Akt by LY294002 led to the inhibition of NF-κB in a dose-dependent manner. Inhibition of Akt with LY294002 caused further increase in apoptosis of U937 cells. Conclusions S. aureus can stimulate the apoptosis of U937 ceils. S. aureus induces apoptosis of U937 cells by inhibiting Akt-regulated NF-κB.

关键词： Staphylococcus aureus apoptosis U937 cells phosphoinositide 3-kinase nuclear factor-κB

Some Convergence Properties for Weighted Sums of Martingale Difference Random Vectors

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1127-1142页

作者： yi WU Xue jun WANG School of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000P.R.China School of Big Data and Statistics Anhui UniversityHefei 230601P.R.China

Let{X_(ni),F_(ni);1≤i≤n,n≥1}be an array of R^(d)martingale difference random vectors and{A_(ni),1≤i≤n,n≥1}be an array of m×d matrices of real *** this paper,the Marcinkiewicz-Zygmund type weak law of large numb... 详细信息

关键词： Martingale difference random vectors weighted sums Marcinkiewicz–Zygmund type weak law of large numbers complete convergence strong law of large numbers multivariate simple linear regression model

Microglia Suppresses Breast Cancer Brain Metastasis via a Pro-inflammatory Response

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Neuroscience Bulletin 2024年第7期40卷 1034-1036页

作者： Shengbo Chen yi-jun Liu Department of Neurobiology of Affiliated Mental Health Center and Hangzhou Seventh People's Hospital and School of Brain Science and Brain Medicine Zhejiang University School of MedicineHangzhou 310058China Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain-machine IntegrationState Key Laboratory of Brain-machine IntelligenceZhejiang University1369 West Wenyi RoadHangzhou 311121China NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang UniversityHangzhou 310058China

Due to the obstacle of the blood-brain barrier(BBB)for drug delivery[1],breast cancer brain metastasis(BCBM)represents a worldwide health challenge with high *** BCBM formation and progression,brain metastases(BrMs)secret various factors,including cytokines and exosomes,and trigger the infiltration of tumours-associated macrophages(TAMs),which in turn become important components of brain tumour microenvironments(TME).

关键词： mortality tumour Breast

Cooperative enhancement of mechanical and tribological properties through tailoring TiN transition interface in boron nitride nanosheets reinforced copper composites

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Rare Metals 2024年第10期43卷 5202-5215页

作者： Zhong-Hua Li Liang Liu Xin You Jian-Hong yi Rui Bao Ming-yi Zhu Song Lu jun-jun Pai Faculty of Materials Science and Engineering Kunming University of Science and Technology Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and Technology

Strengthening interface bonding between boron nitride nanosheets(BNNS) and copper matrix is an essential prerequisite for exploiting a new generation of copper matrix composites(CMCs) with high strength and wear resistance. Herein, BNNS/Cu composites were fabricated by the powder metallurgy route, matrix-alloying(adding 1.0 wt% Ti) strategy was adopted to improve the interfacial wettability and strengthen interface adhesion. A typical "sandwich"-like multiply interface structure involving TiN transition layers, BNNS and Cu matrix had been well constructed through the rational heat treatment(900℃for 120 min). Additionally, nano-sized TiB whisker was in situ formed in the vicinity of the interface, it had linked the BNNS-Cu-TiN multiply interface, which played a role of "threading the needle" and significantly strengthened the multi-interfaces bonding. This specific interface structure was finely characterized, and the formation mechanism of solid-state interfacial reaction feature was proposed. The results demonstrated that the ultimate tensile strength(UTS) of BNNS/Cu-(Ti)-900℃ increased from 248 to 530 MPa(increased by 114%), and the coefficient of friction(COF) decreased from 0.51 to 0.28 than pure Cu. This work highlights the importance of interface configuration design, which contributes to the development of CMCs with prominent comprehensive properties.

关键词： Boron nitride nanosheets Copper matrix composites Interface structure Mechanical and frictional properties

On the Difference Between the Skew-rank of an Oriented Graph and the Rank of Its Underlying Graph

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 129-136页

作者： Jia-min Zhu Bo-jun Yuan yi Wang School of Mathematical Sciences Anhui UniversityHefei230601China School of Science Zhejiang University of Science and TechnologyHangzhou310023China

Let G be a simple graph and G~σ be the oriented graph with G as its underlying graph and orientation σ.The rank of the adjacency matrix of G is called the rank of G and is denoted by r(G).The rank of the skew-adjacency matrix of G~σ is called the skew-rank of G~σ and is denoted by sr(G~σ).Let V(G)be the vertex set and E(G) be the edge set of *** cyclomatic number of G,denoted by c(G),is equal to |E(G)|-|V(G)|+ω(G),where ω(G) is the number of the components of *** is proved for any oriented graph G~σ that-2c(G)≤sr(G~σ)-r(G)≤2c(G).In this paper,we prove that there is no oriented graph G~σwith sr(G~σ)-r(G)=2c(G)-1,and in addition,there are infinitely many oriented graphs G~σ with connected underlying graphs such that c(G)=k and sr(G~σ)-r(G)=2c(G)-l for every integers k,l satisfying 0 ≤l≤4k and l≠1.

关键词： cyclomatic number rank skew-rank

Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu jun-Xiu Shi yi-Ming Ou Hua-Jie Jiang yi-jun Fang Qi-Ming Wang Quan Gao Jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

Small-signal Stability Constrained Optimal Power Flow Considering Eigenvalue Distribution

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1052-1062页

作者： Zheng Huang Kewen Wang yi Wang Jing Han jun Liang the School of Electrical and Information Engineering Zhengzhou UniversityZhengzhou 450001China Cardiff University Cardiff CF243AAU.K.

In the existing small-signal stability constrained optimal power flow(SSSC-OPF)algorithms,only the rightmost eigenvalue or eigenvalues that do not satisfy a given threshold,e.g.,damping ratio threshold and real-part threshold of eigenvalue,are considered in the small-signal stability *** effect of steady-state,i.e.,operating point,changes on eigenvalues is not fully taken into *** this paper,the small-signal stability constraint that can fully reflect the eigenvalue change and system dynamic performance requirement is formed by analyzing the eigenvalue distribution on the complex *** small-signal stability constraint is embedded into the standard optimal power flow model for generation *** simultaneous solution formula of the SSSC-OPF is established and solved by the quasi-Newton approach,while penalty factors corresponding to the eigenvalue constraints are determined by the stabilization degree of constrained *** improve the computation speed,a hybrid algorithm for eigenvalue computation in the optimization process is proposed,which includes variable selection for eigenvalue estimation and strategy selection for eigenvalue *** effectiveness of the proposed algorithm is tested and validated on the New England 10-machine 39-bus system and a modified practical 68-machine 2395-bus system.

关键词： Damping ratio eigenvalue optimal power flow quasi-Newton approach sensitivity small-signal stability

Heterogeneous engineering of MnSe@NC@ReS_(2) core-shell nanowires for advanced sodium-/potassium-ion batteries

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Rare Metals 2024年第8期43卷 3713-3723页

作者： Sheng-jun Lu Jin-yi Lin Cai-Hong Wang Yu-Fei Zhang yi Zhang Hao-Sen Fan College of Materials Science and Metallurgy Engineering Guizhou University Guiyang 550025China School of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China

Sodium-ion batteries(SIBs) and potassium-ion batteries(PIBs) have been attracting great attentions and widely been exploited due to the abundant sodium/potassium ***,the preparation of high-powered anode materials for SIBs/PIBs plays a decisive role for the commercial applications of SIBs/PIBs in the *** selenides are a class of potential anode materials for SIBs/PIBs because of their small band gap and high electrical *** this work,MnSe and ReS_(2) core-shell nanowires connecting by polydopamine derived carbon nanotube(MnSe@NC@ReS_(2)) have been successfully synthesized from growing ReS_(2) nanosheets array on the surface of MnSe@NC nano wires,which present excellent Na^(+)/K^(+) storage *** applied as SIBs anode,the specific capacity of 300 mAh·g^(-1) was maintwined after 400 cycles at the current density of 1.0 A·g^(-1).Besides,it could also keep 120 mAh·g^(-1) specific capacity after 900 cycles at 1.0 A·g^(-1) for the anode of *** heterogeneous engineering and one-dimensional-two-dimensional(1D-2D) hybrid strategies could provide an ideal strategy for the synthesis of new hetero-structured anode materials with outstanding battery performance for SIBs and PIBs.

关键词： Heterogeneous engineering Core-shell nanowires MnSe@NC@ReS_(2)nanowires Na^(+)batteries K^(+)batteries

Microbiome changes in esophageal cancer:implications for pathogenesis and prognosis

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Cancer Biology & Medicine 2024年第2期21卷 163-174页

作者： yi Li Bing Wei Xia Xue Hongle Li jun Li Department of Molecular Pathology Clinical Pathology CenterAffiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450003China Henan Key Laboratory of Molecular Pathology Zhengzhou 450003China Henan Key Laboratory of Helicobacter pylori&Microbiota and Gastrointestinal Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Esophageal cancer(EC)is an aggressive malignancy with a poor *** factors,including dietary habits,and antacid and antibiotic use,have been shown to influence the esophageal ***,enrichment and diversity of the esophageal microbiome can also impact its *** studies have revealed prevalent changes in the esophageal microbiome among patients with EC,thus suggesting the potential contribution of the esophageal microbiome to EC ***,distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy,indicating the role of the esophageal microbiome in modulating treatment *** this review,we have examined previous studies on the esophageal microbiome in healthy individuals and patients with EC or other esophageal diseases,with a focus on identifying microbial communities associated with EC pathogenesis and *** the role of the microbiome in EC may aid in early detection and optimized treatment strategies,ultimately leading to better outcomes for patients.

关键词： Esophageal cancer microbiome dysbiosis microenvironment carcinogenesis

Visualisation and Heat Transfer Performance of Mini-Channel Flat Heat Pipe with a Binary Mixture

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Journal of Thermal Science 2024年第5期33卷 1712-1725页

作者： FAN Gaoting TANG Aikun CAI Tao SHAN Chunxian PAN jun JIN yi School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Jiangsu Jinhe Energy Technology Co.Ltd Zhenjiang 212400China

To unravel the intricacies of two-phase gas-liquid flow characteristics and heat transfer behavior,an array mini-channel gravity plate heat pipe(AMGPHP)is proposed in this work,which allows for observing the internal changes in the state of the working *** flow patterns such as pool flow,columnar flow,and slug flow,are experimentally explored and analyzed in *** is found that the optimal volume fill ratio is 20%by utilizing start-up time and thermal resistance as performance evaluation *** this fill ratio,a medium optimization strategy by blending ethanol within R141b is proposed and *** comparison to pure working fluids,the heat transfer performance of AMGFHP in the binary fluid has been significantly augmented due to temperature and concentration shifts resulting from disparate boiling *** the 10%volume fraction ethanol blending condition,the equivalent thermal conductivity of the heat pipe is dramatically elevated,with a value of 3110 W/(m·℃),along with the reduction of the minimum start-up power to 4 *** general,applying such a medium to heat pipes has considerable potential in practical applications.

关键词： flat heat pipe mini-channel visualisation two-phase flow binary mixtures thermal performance