Microbiome changes in esophageal cancer:implications for pathogenesis and prognosis

作     者：Yi Li Bing Wei Xia Xue Hongle Li Jun Li Yi Li;Bing Wei;Xia Xue;Hongle Li;Jun Li

作者机构：Department of Molecular PathologyClinical Pathology CenterAffiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450003China Henan Key Laboratory of Molecular PathologyZhengzhou 450003China Henan Key Laboratory of Helicobacter pylori&Microbiota and Gastrointestinal CancerMarshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2024年第21卷第2期

页      面：163-174页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Health Commission of Henan Province(Grant No.SBGJ20211008) the Henan Provincial Department of Science and Technology(Grant No.222300420574) 

主　　题：Esophageal cancer microbiome dysbiosis microenvironment carcinogenesis 

摘      要：Esophageal cancer(EC)is an aggressive malignancy with a poor *** factors,including dietary habits,and antacid and antibiotic use,have been shown to influence the esophageal ***,enrichment and diversity of the esophageal microbiome can also impact its *** studies have revealed prevalent changes in the esophageal microbiome among patients with EC,thus suggesting the potential contribution of the esophageal microbiome to EC ***,distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy,indicating the role of the esophageal microbiome in modulating treatment *** this review,we have examined previous studies on the esophageal microbiome in healthy individuals and patients with EC or other esophageal diseases,with a focus on identifying microbial communities associated with EC pathogenesis and *** the role of the microbiome in EC may aid in early detection and optimized treatment strategies,ultimately leading to better outcomes for patients.