Microbiome changes in esophageal cancer:implications for pathogenesis and prognosis
作者机构:Department of Molecular PathologyClinical Pathology CenterAffiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450003China Henan Key Laboratory of Molecular PathologyZhengzhou 450003China Henan Key Laboratory of Helicobacter pylori&Microbiota and Gastrointestinal CancerMarshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China
出 版 物:《Cancer Biology & Medicine》 (癌症生物学与医学(英文版))
年 卷 期:2024年第21卷第2期
页 面:163-174页
核心收录:
学科分类:1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金:supported by grants from the Health Commission of Henan Province(Grant No.SBGJ20211008) the Henan Provincial Department of Science and Technology(Grant No.222300420574)
主 题:Esophageal cancer microbiome dysbiosis microenvironment carcinogenesis
摘 要:Esophageal cancer(EC)is an aggressive malignancy with a poor *** factors,including dietary habits,and antacid and antibiotic use,have been shown to influence the esophageal ***,enrichment and diversity of the esophageal microbiome can also impact its *** studies have revealed prevalent changes in the esophageal microbiome among patients with EC,thus suggesting the potential contribution of the esophageal microbiome to EC ***,distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy,indicating the role of the esophageal microbiome in modulating treatment *** this review,we have examined previous studies on the esophageal microbiome in healthy individuals and patients with EC or other esophageal diseases,with a focus on identifying microbial communities associated with EC pathogenesis and *** the role of the microbiome in EC may aid in early detection and optimized treatment strategies,ultimately leading to better outcomes for patients.