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Biliatresone:progress in biliary atresia study

World Journal of Pediatrics 2023年第5期19卷 417-424页

作者： Jia‑Jie Zhu yi‑fan yang Rui Dong Shan Zheng Department of Pediatric Surgery Shanghai Key Laboratory of Birth Defectand Key Laboratory of Neonatal DiseaseMinistry of HealthChildren’s Hospital of Fudan University399 Wan Yuan RoadShanghai 201102China

Background Biliary atresia(BA)is one of the main causes of neonatal end-stage liver *** timely diagnosis and treatment,most children with BA will develop irreversible liver fibrosis within the first two *** current theorized causes of BA include viral infection,immune disorders,and genetic defects,the comprehensive etiology is still largely ***,biliatresone attracted much interest for its ability to induce BA in both zebrafish and mice,so we summarized the latest progress of biliatresone research in BA and tried to answer the question of whether it could provide further clues to the etiology of human *** sources We conducted a PubMed search for any published articles related to the topic using search terms including“biliary atresia”,“biliatresone”,“GSH”,and“HSP90”.Relevant data were extracted from the original text or supplementary materials of the corresponding *** Biliatresone had shown its unique toxicity in multiple species such as zebrafish and mice,and pathogenic factors involved included glutathione(GSH),heat shock protein 90(HSP90)and the related *** combination with epidemiological evidence and recent studies on the intestinal flora in biliary atresia,a new pathogenic hypothesis that the occurrence of biliary atresia is partly due to biliatresone or its structure-like compounds depositing in human body via vegetables or/and the altered intestinal flora structure can be tentatively *** Based on the existing evidence,we emphasized that GSH and HSP90 are involved in the development of BA,and the maternal diet,especially higher vegetable intake of Asian women of childbearing age,accompanied by the altered intestinal flora structure,may contribute to the occurrence of biliary atresia and the higher incidence in the Asia ***,the evidence from large sample epidemiological research is necessary.

关键词： Biliary atresia Biliatresone Glutathione Gut flora

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Using Network Pharmacology and Molecular Docking Tools to Investigate the Potential Mechanism of Ephedra-Gypsum in the Treatment of Respiratory Diseases

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World Journal of Traditional Chinese Medicine 2023年第2期9卷 150-159页

作者： Can Huang Ling Yuan yang Niu Ya-Ting yang yi-fan yang yi Nan Hong-Li Dou Joanna Japhet School of Chinese Medicine Ningxia Medical UniversityYinchuanNingxiaChina Pharmacy College of Ningxia Medical University YinchuanNingxiaChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuanNingxiaChina School of Marxism Shaanxi University of ChineseMedicineXianyangShaanxiChina

Objective:The objective of this study was to investigate the potential mechanisms of ephedra-gypsum in the treatment ofrespiratory diseases(RDs)using network pharmacology and molecular docking *** and Methods:The TCMSP and UniProt databases were used to mine the active components and targets of ephedra-gypsum,and the targets of RD were screened using the Online Mendelian Inheritance in Man(OMIM)and GeneCards *** protein-protein interaction network graph was created using the drug-disease intersection targets in the STRING *** network diagram was analyzed using Cytoscape 3.9.1's topology *** gene ontology(GO)and KEGG enrichment analyses were performed using the DAVID *** docking bioactivity validation of the main active components and core targets was performed using AutoDock and PyMOL ***:Twenty-four compounds were screened,and 113 drug-disease targets *** total,358 biological processes,67 molecular functions,38 cellular components of GO,and 139 pathways were *** docking analysis demonstrated the strong binding ability of tumor protein 53(TP53)-***:The core components of ephedra-gypsum,such as quercetin,luteolin,kaempferol,and CaSO_(4)·2H_(2)O,act on key targets,such as tumor necrosis factor(TNF),interleukin-6(IL-6),TP53,and IL-1β through cytokine-mediated signaling pathways,infiammatory responses,cell proliferation,and *** could be useful for the treatment of RD.

关键词： Ephedra-gypsum mechanistic studies molecular docking network pharmacology respiratory diseases

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Effect of Progestin-primed Ovarian Stimulation Protocol on Outcomes of Aged Infertile Women Who Failed to Get Pregnant in the First IVF/ ICSI Cycle： A Self-controlled Study

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Current Medical Science 2018年第3期38卷 513-518页

作者： yin-mei CHEN Qian-rong QI Qing-zhen XIE yi-fan yang yi XIA Xiao-dan ZHOU Center for Reproductive Medicine Renmin Hospital of Wuhan University Hubei Clinical Research Center for Assisted Reproductive Technology and Embryonic Development Wuhan 430060China

This study aimed to explore the outcomes of progestin-primed ovarian stimulation protocol （PPOS） in aged infertile women who failed to get pregnant in the first IVF/ICSI-ET cycles with GnRH-a long protocol. A self-controlled study was conducted to retrospectively investigate the clinical outcomes of 104 aged infertile patients who didn＇t get pregnant in the first IVF/ICSI-ET treatment by stimulating with GnRH-a long protocol （non-PPOS group）, and underwent PPOS protocol （PPOS group） in the second cycle between January 2016 and December 2016 in the Center for Reproductive Medicine, Renmin Hospital of Wuhan University. The primary outcomes included clinical pregnancy rate of frozen-thawed embryos transfer （FET） in PPOS group, and good-quality embryo rate in both groups. The secondary outcomes were fertilization rate, egg utilization rate and cycle cancellation rate. The results showed that there were no significant differences in basal follicle stimulating hormone （bFSH）, antral follicle count （AFC）, duration and total dosage of gonadotropin （Gn）, number of oocytes retrieved, intracytoplasmic sperm injection （ICSI） rate, fertilization rate, and cycle cancellation rate between the two groups （P〉0.05）. However, the oocyte utilization rate and good-quality embryo rate in PPOS group were significantly higher than those in non-PPOS group （P〈0.05）. By the end of April 2017, 62 FET cycles were conducted in PPOS group. The clinical pregnancy rate and embryo implantation rate were 22.58% and 12.70%, respectively. In conclusion, PPOS protocol may provide better clinical outcomes by improving the oocyte utilization rate and good-quality embryo rate for aged infertile patients who failed to get pregnant in the first IVF/ ICSI-ET cycles.

关键词： advanced age progestin-primed ovarian stimulation in vitro fertilization and embryo transfer

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Molecular mechanisms of Buqing granule for the treatment of diabetic retinopathy:Network pharmacology analysis and experimental validation

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World Journal of Diabetes 2024年第9期15卷 1942-1961页

作者： yi-fan yang Ling Yuan Xiang-yang Li Qian Liu Wen-Jie Jiang Tai-Qiang Jiao Jia-Qing Li Meng-yi Ye yang Niu yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes *** blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is ***,there are abundant and diverse research results on the treatment of DR by Chinese medicine Traditional Chinese medicine compounds are potentially advantageous for DR prevention and treatment because of its safe and effective therapeutic *** To investigate the effects of Buqing granule(BQKL)on DR and its mechanism from a systemic perspective and at the molecular level by combining network pharmacology and in vivo *** This study collected information on the drug targets of BQKL and the therapeutic targets of DR for intersecting target gene analysis and protein-protein interactions(PPI),identified various biological pathways related to DR treatment by BQKL through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,and preliminarily validated the screened core targets by molecular ***,we constructed a diabetic rat model with a high-fat and high-sugar diet and intraperitoneal streptozotocin injection,and administered the appropriate drugs for 12 weeks after the model was successfully *** mass and fasting blood glucose and lipid levels were measured,and pathological changes in retinal tissue were detected by hematoxylin and eosin *** was used to detect the oxidative stress index expression in serum and retinal tissue,and immunohistochemistry,real-time quantitative reverse transcription PCR,and western blotting were used to verify the changes in the expression of core *** Six potential therapeutic targets of BQKL for DR treatment,including Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3,were screened using *** analysis indicated that the MAPK signaling pathway might be the core target pathway of BQKL in DR *** docking prediction indica

关键词： Diabetic retinopathy Network pharmacology Animal models Oxidative stress Inflammatory

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Study of the retina algorithm on FPGA for fast tracking

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Nuclear Science and Techniques 2019年第8期30卷 84-91页

作者： Zi-Xuan Song Wen-Di Deng Gilles De Lentdecker Guang-Ming Huang Hua Pei yi-fan yang Dong Wang Frederic Robert Central China Normal University Wuhan 430079China Universite libre de Bruxelles Av.F.Roosevelt 501050 BrusselsBelgium

Real-time track reconstruction in high-energy physics experiments at colliders running at high luminosity is very challenging for trigger systems. To perform pattern recognition and track fitting, artificial retina or Hough transformation algorithms have been introduced to the field typically implemented on state-of-the-art field programmable gate array(FPGA) devices. In this paper, we report on two FPGA implementations of the retina algorithm: one using a mixed Floating-Point core and the other using Fixed-Point and Look-Up Table, and detailed measurements of the retina performance are investigated and compared. So far, the retina has mainly been used in a detector configuration comprising parallel planes, and the goal of our work is to study the hardware implementation of the retina algorithm and estimate the possibility of using such a method in a real experiment.

关键词： Fast tracking Field programmable gate array Trigger

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Daixian:An Ancient Border Town

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China Today 2007年第12期56卷 72-73页

作者： yi fan & yang JIXING

DAIXIAN is an ancient town in central Shanxi Province,just a few hours by expressway from *** have been living here since the New Stone Age in around 7,000 *** the border between ancient China and the northern lands of nomadic tribes,it was once a place of considerable stra- tegic importance that witnessed many significant *** times of peace, it was a prosperous nexus of trade

关键词：古城代县山西经济发展

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Laparoscopic splenectomy by secondary pedicle division strategy： a highly cost-effective method

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Chinese Medical Journal 2008年第2期121卷 105-107页

作者： CAI Xiu-jun SHEN Bo YU Hong LIANG Xiao ZHU Lin-hua WANG yi-fan DAI yi yang Jin Institute of Micro-Invasive Surgery of Zhejiang University Department of General Surgery Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou Zhejiang 310016 China

Background Laparoscopic splenectomy （LS） shows many advantages compared with open surgery except for the high cost. This study was aimed to recommend secondary pedicle division strategy as a method with high cost-effectiveness. Methods From January 2003 to June 2005, 14 consecutive patients underwent laparoscopic splenectomy. The splenic pedicle was controlled by secondary pedicle division strategy in 8 cases and by Endo-GIA in the other 6 cases. A retrospective study was carried out to evaluate the operative time, blood loss, time to diet, operative morbidity, postoperative stay, and operative cost.Results LS was performed successfully in a total of 14 cases. There was no significant difference between the two strategies in operative time, blood loss, time to diet, operative morbidity and postoperative stay. The operative cost of secondary pedicle division strategy group （RMB 8354.38±752,10） was significantly lower than that of Endo-GIA group （RMB 11053.33±602.27）（P〈0.01）.Conclusions Laparoscopic splenectomy by secondary pedicle division strategy is a safe, effective and economical procedure with the value of popularization in developing countries.

关键词： laparoscopic surgery splenectomy spleen

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Water quality model with multiform of N/P transport and transformation in the yangtze River Estuary

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Journal of Hydrodynamics 2016年第3期28卷 423-430页

作者：王彪卢士强林卫青杨漪帆王道增 Shanghai Academy of Environmental Sciences Shanghai 200233 China Institute of Applied Mathematics and Mechanics and Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University Shanghai 200072 China

As the yangtze River Estuary and adjacent sea have been classified as a problem area with regard to eutrophication, it is important to explore the spatial and temporal variations of nitrogen and phosphorus （N/P） nutrients in this area. Based on danish hydraulic institute （DHI）＇s open platform Ecolab, a hydrodynamic and water quality model was developed for the yangtze River Estuary, in which the transport and transformation processes of different forms of N/P nutrients were considered. Validations against measured data show that the model is overall reliable. Preliminary application of the model suggests that the model can simulate the characteristics of high phosphorus concentration area in the yangtze River Estuary, and the high concentration area is closely related to the resuspension process of particulate phosphorus.

关键词： water quality model yangtze River Estuary N/P transport and transformation

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Silencing novel long non-coding RNA FKBP9P1 represses malignant progression and inhibits PI3K/AKT signaling of head and neck squamous cell carcinoma in vitro

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Chinese Medical Journal 2020年第17期133卷 2037-2043页

作者： yi-fan yang Ling Feng Qian Shi Hong-Zhi Ma Shi-Zhi He Li-Zhen Hou Ru Wang Ju-Gao fang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100005China Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology Beijing 100730China

Background:Long non-coding RNAs(lncRNAs)play key roles in human *** our previous study,we demonstrated that lncRNA FKBP prolyl isomerase 9 pseudogene 1(FKBP9P1)was highly expressed in head and neck squamous cell cancer(HNSCC)***,its functional significance remains poorly *** the present study,we identify the role and potential molecular biologic mechanisms of FKBP9P1 in ***:Quantitative real-time polymerase chain reaction was used to detect the expression of FKBP9P1 in HNSCC tissues,matched adjacent normal tissues,human HNSCC cells(FaDu,Cal-27,SCC4,and SCC9),and human immortalized keratinocytes cell HaCaT(normal control).Cal-27 and SCC9 cells were transfected with sh-FKBP9P1-1,sh-FKBP9P1-2,and normal control(sh-NC)*** counting kit-8 assay,colony formation assay,wound healing assay,and trans-well assay were used to explore the biologic function of FKBP9P1 in HNSCC ***,western blotting was used to determine the mechanism of FKBP9P1 in HNSCC ***-squared test was performed to assess the clinical significance among FKBP9P1 high-expression and low-expression *** analyses were performed using the Kaplan-Meier method and assessed using the log-rank *** comparison between two groups was analyzed by Student t test,and comparisons among multiple samples were performed by one-way analysis of variance and a Bonferroni post hoc ***:FKBP9P1 expression was significantly up-regulated in HNSCC tissues(tumor ***,1.914 vs.0.957,t=7.746,P<0.001)and cell lines(P<0.01 in all HNSCC cell lines).Besides,the median FKBP9P1 expression of HNSCC tissues(1.677)was considered as the *** FKBP9P1 level was correlated with advanced T stage(P=0.022),advanced N stage(P=0.036),advanced clinical stage(P=0.018),and poor prognosis of HNSCC patients(overall survival,P=0.002 and disease-free survival,P<0.001).Knockdown of FKBP9P1 led to marked repression in proliferation,migration,and invas

关键词： Head and neck squamous cell carcinoma Long non-coding RNA FKBP prolyl isomerase 9 pseudogene 1 PI3K/AKT signaling pathway

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Research trends in exercise therapy for the treatment of pain in postmenopausal osteoporosis over the past decade:A bibliometric analysis

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World Journal of Orthopedics 2024年第10期15卷 950-964页

作者： Zhao-Qiu Dai Xiao-Yan Gong Rong Zhang Mei-Qin Jin Wei Lu Wen Wen Jie Chen fang-Jie Lu yi-fan yang Lei Wang Xiao-Jin He Changshu Hospital Affiliated with Nanjing University of Chinese Medicine Changshu 215500Jiangsu ProvinceChina Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Nanjing University of Chinese Medicine Nanjing 210023Jiangsu ProvinceChina

BACKGROUND Postmenopausal osteoporosis(PMOP)is the most common form of primary osteoporosis among women,and the associated pain often drives patients to seek clinical *** studies have highlighted the unique clinical benefits of exercise therapy(ET)in alleviating PMOP-related ***,bibliometric analyses examining collaboration,development trends,and research frontiers in the field of ET for PMOP pain remain *** To explore the research trends in ET for pain treatment in PMOP patients over the past *** All scholarly works were meticulously sourced from the Science Citation Index-Expanded within the prominent Web of Science Core *** the capabilities of CiteSpace 6.2.R5,we conducted a thorough analysis of publications,authors,frequently cited scholars,contributing nations,institutions,journals of significant citation,comprehensive references,and pivotal ***,our examination explored keyword cooccurrences,detailed timelines,and periods of heightened citation *** comprehensive search,from 2014 through 2023,was completed within a single day,on October 11,*** In total,2914 articles were ultimately included in the *** was a rapid increase in annual publication output in 2015,followed by stable growth in subsequent ***,Michael L,is the most prolific author,whereas Ware JE has the most *** United States’global influence is significant,surpassing all other *** University of California System and Harvard University are the most influential academic institutions.J Bone Joint Surg Am is the most influential journal in this field.“Spinal cord injury”is the keyword that has garnered the most attention from *** developmental pattern in this field is characterized by interdisciplinary fusion,with different disciplines converging to drive *** The academic development of the field of ET for pain in PMOP has matured and stabili

关键词： Exercise therapy Pain Postmenopausal osteoporosis CiteSpace Bibliometric analysis Web of Science

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