Biliatresone:progress in biliary atresia study
作者机构：Department of Pediatric SurgeryShanghai Key Laboratory of Birth Defectand Key Laboratory of Neonatal DiseaseMinistry of HealthChildren’s Hospital of Fudan University399 Wan Yuan RoadShanghai 201102China
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2023年第19卷第5期
页 面：417-424页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：This study received financial support from Shanghai Key Clinical Specialty(No.shslczdzk05703) National Natural Science Foundation of China(No.81974059) International Joint Laboratory Project of Haiju,National Children’s Medical Center(No.EK1125180104) Shenkang Three-year Action Plan of Precision Diagnosis and Treatment Project for Difficult Diseases(No.SHDC2020CR2009A) National Natural Science Foundation of China(No.82001595)
主 题：Biliary atresia Biliatresone Glutathione Gut flora
摘 要：Background Biliary atresia(BA)is one of the main causes of neonatal end-stage liver *** timely diagnosis and treatment,most children with BA will develop irreversible liver fibrosis within the first two *** current theorized causes of BA include viral infection,immune disorders,and genetic defects,the comprehensive etiology is still largely ***,biliatresone attracted much interest for its ability to induce BA in both zebrafish and mice,so we summarized the latest progress of biliatresone research in BA and tried to answer the question of whether it could provide further clues to the etiology of human *** sources We conducted a PubMed search for any published articles related to the topic using search terms including“biliary atresia,“biliatresone,“GSH,and“HSP90.Relevant data were extracted from the original text or supplementary materials of the corresponding *** Biliatresone had shown its unique toxicity in multiple species such as zebrafish and mice,and pathogenic factors involved included glutathione(GSH),heat shock protein 90(HSP90)and the related *** combination with epidemiological evidence and recent studies on the intestinal flora in biliary atresia,a new pathogenic hypothesis that the occurrence of biliary atresia is partly due to biliatresone or its structure-like compounds depositing in human body via vegetables or/and the altered intestinal flora structure can be tentatively *** Based on the existing evidence,we emphasized that GSH and HSP90 are involved in the development of BA,and the maternal diet,especially higher vegetable intake of Asian women of childbearing age,accompanied by the altered intestinal flora structure,may contribute to the occurrence of biliary atresia and the higher incidence in the Asia ***,the evidence from large sample epidemiological research is necessary.
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