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New Food Sources and Production Systems: A Comparison of International Regulations and China’s Advancements in Novel Foods with Synthetic Biology

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Food Science and Human Wellness 2024年

作者： Xin Liu Di Wu yi shao Yongning Wu Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education) College of Food Science and Engineering Wuhan Polytechnic University Institute for Global Food Security School of Biological Sciences Queen's University Belfast Department of Nutrition and Food Safety Peking Union Medical College Research Unit of Food Safety Chinese Academy of Medical Sciences NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk Assessment

The global shift towards sustainable food systems has sparked innovations in food sources and production systems， including cell-based meat， plant-based food products， precision fermentation， and 3D food printing. These advancements pose regulatory challenges and opportunities， with China emerging as a critical player in adopting and regulating new food technologies. This review explores the international landscape of new food sources and production systems， focusing on China’s role and regulatory approaches compared to global practices. Through this comparative analysis， we aim to contribute to the ongoing dialogue on food safety regulation， offering insights and recommendations for policymakers， industry stakeholders， and researchers engaged in the global food system’s evolution. This comprehensive overview underscores the dynamic nature of regulatory frameworks governing NFPS， highlighting the international efforts to ensure food safety， consumer protection， and the sustainable evolution of the food industry.

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采用有限元+边界元方法研究非饱和地基中群桩基础的动力阻抗

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岩土力学 2024年第3期45卷 895-907页

作者：李绍毅吉首大学土木工程与建筑学院湖南张家界427000

采用边界元结合有限元法研究了非饱和地基群桩基础动力阻抗。根据梁模型建立桩体动力控制方程,结合有限元方法建立群桩基础数值模型;基于非饱和多孔介质动力控制方程组,采用加权残余法和拉普拉斯变换,推导非饱和地基边界元法控制方程,...

采用边界元结合有限元法研究了非饱和地基群桩基础动力阻抗。根据梁模型建立桩体动力控制方程,结合有限元方法建立群桩基础数值模型;基于非饱和多孔介质动力控制方程组,采用加权残余法和拉普拉斯变换,推导非饱和地基边界元法控制方程,根据伴随矩阵性质推导其Green函数基本解答。基于桩体和地基土接触面作用力平衡条件和位移相容原理,建立非饱和地基边界元模型和群桩基础有限元模型的耦合数值模型;研究土体饱和度、桩体间距、长度、数目和地基分层等参数对群桩基础动力阻抗的影响。研究发现:地基饱和度增加可降低群桩基础刚度系数;荷载频率较低时增大饱和度可减小群桩基础阻尼系数。增加桩基数目和地基饱和度可增大桩基与地基土相互作用。下卧基岩分层地基可提高桩基与土体的相互作用,且对群桩水平阻抗影响显著。

关键词：非饱和介质群桩基础动力阻抗有限元+边界元方法分层地基

Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina

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World Journal of Diabetes 2024年第3期15卷 519-529页

作者： Jian Tan Ang Xiao Lin Yang Yu-Lin Tao yi shao Qiong Zhou Department of Ophthalmology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is a major ocular complication of diabetes mellitus,leading to visual *** pigment epithelium(RPE)injury is a key component of the outer blood retinal barrier,and its damage is an important indicator of *** for activated C kinase 1(RACK1)activates protein kinase C-ε(PKC-ε)to promote the generation of reactive oxygen species(ROS)in RPE cells,leading to ***,we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS,thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of *** To investigate the role and associated underlying mechanisms of RACK1 in the development of early *** In this study,Sprague-Dawley rats and adult RPE cell line-19(ARPE-19)cells were used as in vivo and in vitro models,respectively,to explore the role of RACK1 in mediating PKC-εin early ***,the impact of RACK1 on apoptosis and barrier function of RPE cells was also investigated in the former *** Streptozotocin-induced diabetic rats showed increased apoptosis and upregulated expression of RACK1 and PKC-εproteins in RPE cells following a prolonged ***,ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RACK1 and PKC-ε,accompanied by an increases in ROS production,apoptosis rate,and monolayer ***,silencing RACK1 significantly downregulated the expression of PKC-εand ROS,reduced cell apoptosis and permeability,and protected barrier *** RACK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.

关键词： Diabetic retinopathy Receptor for activated C kinase 1 Protein kinase C-ε Adult retinal pigment epithelium cell line-19

Emotional differences based on comments on doctor-patient disputes with varying levels of severity

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World Journal of Psychiatry 2024年第7期14卷 1068-1079页

作者： Jing-Ru Lu Yu-Han Wei Xin Wang Yu-Qing Zhang Jia-yi shao Jiang-Jie Sun School of Health Care Management Anhui Medical UniversityHefei 230032Anhui ProvinceChina School of Management Hefei University of TechnologyHefei 230039Anhui ProvinceChina

BACKGROUND The risks associated with negative doctor-patient relationships have seriously hindered the healthy development of medical and healthcare and aroused wide-spread concern in *** number of public comments on doctor-patient relationship risk events reflects the degree to which the public pays attention to such *** incidents of doctor-patient disputes were collected from Weibo and TikTok,and 3655 related comments were *** number of comment sentiment words was extracted,and the comment sentiment value was *** Kruskal-Wallis H test was used to compare differences between each variable group at different levels of ***’s correlation analysis was used to examine associations between *** analysis was used to explore factors influencing scores of comments on *** The study results showed that public comments on media reports of doctor-patient disputes at all levels are mainly dominated by“good”and“disgust”emotional *** was a significant difference in the comment scores and the number of partial emotion words between comments on varying levels of severity of doctor-patient *** comment score was positively correlated with the number of emotion words related to positive,good,and happy)and negatively correlated with the number of emotion words related to negative,anger,disgust,fear,and *** The number of emotion words related to negative,anger,disgust,fear,and sadness directly influences comment scores,and the severity of the incident level indirectly influences comment scores.

关键词： Doctor-patient relationship Doctor-patient dispute Comments Emotional differences Weibo TikTok

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费雪货币论述与清代北京虚数钱计物价

清华大学学报（哲学社会科学版） 2024年第2期39卷 201-217,240页

作者：邵义中国香港999077

清代北京流通的钱币主要有制钱、当十钱和当十铜元。这三种不同钱币流通的时间分别为1644年—1856年、1853年—1907年、1901年—1935年。如何将历史文献中的钱计物价折合成当时流通钱币的文数并非易事,其原因是清代北京的钱计物价有虚...

清代北京流通的钱币主要有制钱、当十钱和当十铜元。这三种不同钱币流通的时间分别为1644年—1856年、1853年—1907年、1901年—1935年。如何将历史文献中的钱计物价折合成当时流通钱币的文数并非易事,其原因是清代北京的钱计物价有虚实之分。北京的虚数物价具有以下的特征:第一,当制钱流通时,1文制钱作虚数2文,虚数1吊钱等于500文制钱;第二,咸丰七年至光绪三十一年,1枚当十钱作虚数20文,虚数1吊钱等于50枚当十钱;第三,光绪三十一年后,1枚当十铜元文作虚数100文,虚数1吊钱折合10枚当十铜元;第四,文献中虚数与实数的出现毫无规律可言。与以往的研究不同,运用费雪的货币论述可证明清代北京物价虚数的产生与演变,很可能是朝廷决策的经济后果。

关键词：清代北京虚数物价制钱京钱费雪

Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations:a functional magnetic resonance imaging study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1665-1674页

作者： Xue-Lin Wang Xu-Jun Zheng Li-Juan Zhang Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen yi-Xin Wang Xu Chen yi shao Department of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina Jiangxi Medical College Shangrao 334000Jiangxi ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiff CF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands

AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)***:Twenty HR patients and 20 healthy controls(HCs)were respectively *** age,gender,and educational background characteristics of the two groups were *** functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF *** operating characteristic(ROC)curve analysis was used to classify the ***,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with ***:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual *** contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR *** results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P0.0001)and depression scores(r=0.9682;P0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR.

关键词： hypertensive retinopathy fractional amplitude of low-frequency fluctuation brain region magnetic resonance imaging

Identification and distribution of 13003 landslides in the northwest margin of Qinghai-Tibet Plateau based on human-computer interaction remote sensing interpretation

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China Geology 2024年第2期7卷 171-187页

作者： Wei Wang Yuan-dong Huang Chong Xu Xiao-yi shao Lei Li Li-ye Feng Hui-ran Gao Yu-long Cui Shuai Wu Zhi-qiang Yang Kai Ma National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of Chin12eijing 100085China School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China School of Civil Engineering and Architecture Anhui University of Science and TechnologyHuainan 232001China No.3 Bureau of China Metallurgical Geology Bureau Taiyuan 030031China

The periphery of the Qinghai-Tibet Plateau is renowned for its susceptibility to ***,the northwestern margin of this region,characterised by limited human activities and challenging transportation,remains insufficiently explored concerning landslide occurrence and *** the planning and construction of the Xinjiang-Tibet Railway,a comprehensive investigation into disastrous landslides in this area is essential for effective disaster preparedness and mitigation *** using the human-computer interaction interpretation approach,the authors established a landslide database encompassing 13003 landslides,collectively spanning an area of 3351.24 km^(2)(36°N-40°N,73°E-78°E).The database incorporates diverse topographical and environmental parameters,including regional elevation,slope angle,slope aspect,distance to faults,distance to roads,distance to rivers,annual precipitation,and *** statistical characteristics of number and area of landslides,landslide number density(LND),and landslide area percentage(LAP)are *** authors found that a predominant concentration of landslide origins within high slope angle regions,with the highest incidence observed in intervals characterised by average slopes of 20°to 30°,maximum slope angle above 80°,along with orientations towards the north(N),northeast(NE),and southwest(SW).Additionally,elevations above 4.5 km,distance to rivers below 1 km,rainfall between 20-30 mm and 30-40 mm emerge as particularly susceptible to landslide *** study area’s geological composition primarily comprises Mesozoic and Upper Paleozoic *** fault and human engineering activities have different degrees of influence on landslide ***,the significance of the landslide database,the relationship between landslide distribution and environmental factors,and the geometric and morphological characteristics of landslides are *** landslide H/L ratios in the study area are

关键词： Landslides Human-computer interaction interpretation Landslide database Spatial distribution Earthquake Rainfall Human engineering activity Qinghai-Tibet Plateau Geological hazards survey engineering

美国眼科学会干眼临床实践指南解读(2023)

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眼科新进展 2024年第9期44卷 673-678页

作者：邵毅陈程魏红南昌大学第一附属医院眼科江西省南昌市330006

2024年2月美国眼科学会发布了2023版的干眼临床实践指南,与2018版相比,该指南主要新增了三种获得美国食品药品监督管理局批准的干眼治疗药物(全氟己基辛烷、伐尼克兰和血制品)的使用推荐以及其他药物使用间期的临床证据,详细阐述了干眼...

2024年2月美国眼科学会发布了2023版的干眼临床实践指南,与2018版相比,该指南主要新增了三种获得美国食品药品监督管理局批准的干眼治疗药物(全氟己基辛烷、伐尼克兰和血制品)的使用推荐以及其他药物使用间期的临床证据,详细阐述了干眼与角膜屈光手术和白内障手术的相互影响,干眼的定义、诊断和检测方法、分类分级以及治疗等。本文将对该指南进行全面解读。

关键词：干眼诊断治疗指南

冷却速率对La基非晶合金β弛豫行为和应力弛豫的影响

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物理学报 2024年第3期73卷 188-198页

作者：孟绍怡郝奇王兵段亚娟乔吉超西北工业大学力学与土木建筑学院西安710072 西北工业大学物理科学与技术学院西安710072 西北工业大学重庆科创中心重庆401135

β弛豫行为及应力弛豫是探索非晶合金微观结构非均匀性的重要切入口.β弛豫行为及应力弛豫与非晶合金扩散、玻璃转变行为以及塑性变形等密切相关,探究它们之间关联有重要科学意义.本文以典型的La基非晶合金作为研究载体,系统地探究了通...

β弛豫行为及应力弛豫是探索非晶合金微观结构非均匀性的重要切入口.β弛豫行为及应力弛豫与非晶合金扩散、玻璃转变行为以及塑性变形等密切相关,探究它们之间关联有重要科学意义.本文以典型的La基非晶合金作为研究载体,系统地探究了通过不同冷却速率所得块体样品与条带样品的β弛豫特征及应力弛豫行为.结果表明,冷却速率是控制玻璃体系能量状态,进而影响其物理力学性能的重要参数.冷却速率越大,低温内耗更大,对应β弛豫激活能更小,β弛豫行为在温度谱中展宽更大,表明高冷却速率导致原子移动性更大,微观尺度结构非均匀程度更高.基于应力弛豫测量与分析,发现高冷却速率变形特征时间减小,归一化应力衰减幅度更大,在外加力场作用下更易变形,变形单元更易激活以容纳结构形变.本研究为进一步厘清非晶合金β弛豫、变形及微观结构非均匀性之间关联提供了思路.

关键词：非晶合金 β弛豫冷却速率应力弛豫微观结构非均匀性

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