The expression and distribution of α-Gal gene in various species ocular surface tissue
The expression and distribution of α-Gal gene in various species ocular surface tissue作者机构：Department of Ophthalmology the First Affiliated Hospital of Nanchang University Nanchang 330006 Jiangxi Province China Department of Endocrinology the Third Hospital of Nanchang the Affiliated Nanchang Hospital of Southern Medical University Nanchang 330009 Jiangxi Province China Cullen Eye Institute of Baylor Universit Houston Texas 77030 USA
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2012年第5卷第5期
页 面：543-548页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：National Natural Science Foundation of China (No. 81160118) Natural Science Foundation of Jiangxi Province (No. 20114BAB215029) Technology Foundation of Jiangxi Province (No. 20111BBG70026-2) Health Department Science and Technology Foundation(No.20121026) Education Department Youth Scientific Research Foundation (No. JJJ12158) National High Technology Research of China (863 project) (No. 2006AA02A131)
主 题：α-Gal xenotransplantation animal ocular surface tissue engineering
摘 要：OBJECTIVE:To examine the α-Gal gene expression and distribution in the different species/genus and developing phase animal ocular surface tissue.;METHODS:α-Gal binding assay were carried out on various animal eye sections. Photograph, slit-lamp observation on various eye showed normal corneal transparence.;RESULTS:A strong α-Gal expression in invertebrates and some vertebrates ocular tissue, but no α-Gal binding in birds, fish and mammal. α-Gal expression change in the development of mice ocular surface tissue (except sclera) and display genus dependency in the different murine ocular surface tissue.;CONCLUSIONS:This study identified specific α-Gal epitopes binding area in the ocular surface of several species and may solve the problem that naive ocular surface may be used as natural α-Gal gene knockout model/high risk immunologic rejection model or ocular surface scaffold material.
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