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局部一致性主动学习的源域无关开集域自适应

软件学报 2024年第4期35卷 1651-1666页

作者：王帆韩忠义苏皖尹义龙山东大学软件学院山东济南250101

无监督域自适应在解决训练集(源域)和测试集(目标域)分布不一致的问题上已经取得了一定的成功.在面向低能耗场景和开放动态任务环境时,在资源约束和开放类别出现的情况下,现有的无监督域自适应方法面临着严峻的挑战.源域无关开集域自适... 详细信息

无监督域自适应在解决训练集(源域)和测试集(目标域)分布不一致的问题上已经取得了一定的成功.在面向低能耗场景和开放动态任务环境时,在资源约束和开放类别出现的情况下,现有的无监督域自适应方法面临着严峻的挑战.源域无关开集域自适应(SF-ODA)旨在将源域模型中的知识迁移到开放类出现的无标签目标域,从而在无源域数据资源的限制下辨别公共类和检测开放类.现有的源域无关开集域自适应的方法聚焦于设计准确检测开放类别的源域模型或增改模型的结构.但是,这些方法不仅需要额外的存储空间和训练开销,而且在严格的隐私保护场景下难以实现.提出了一个更加实际的场景:主动学习的源域无关开集域自适应(ASF-ODA),目标是基于一个普通训练的源域模型和少量专家标注的有价值的目标域样本来实现鲁棒的迁移.为了达成此目标,提出了局部一致性主动学习(LCAL)算法.首先,利用目标域中局部特征标签一致的特点,LCAL设计了一种新的主动选择方法:局部多样性选择,来挑选更有价值的阈值模糊样本来促进开放类和公共类分离.接着,LCAL基于信息熵初步筛选出潜在的公共类集合和开放类集合,并利用第一步得到的主动标注样本对这两个集合进行匹配纠正,得到两个对应的可信集合.最后,LCAL引入开集损失和信息最大化损失来进一步促使公共类和开放类分离,引入交叉熵损失来实现公共类的辨别.在Office-31、Office-Home和VisDA-C这3个公开的基准数据集上的大量实验表明:在少量有价值的目标域样本的帮助下,LCAL不仅显著优于现有的源域无关开集域自适应方法,还大幅度超过了现有的主动学习方法的表现,在某些迁移任务上可以提升20%.

关键词：资源约束开集识别源域无关域自适应开集域自适应主动学习

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN Shuo CHEN You-yi HUANG Lan-Jin WU Zhi-Qing QIN ying HUANG wan-Zhong HUANG Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a

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World Journal of Stem Cells 2024年第2期16卷 191-206页

作者： Fan Yang wan-Qi Xiong Chen-Zhi Li Ming-Jian Wu Xiu-Zhi Zhang Chun-Xiao Ran Zhen-Hao Li Yan Cui Bao-yi Liu De-Wei Zhao Department of Orthopedics Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina

BACKGROUND Knee osteoarthritis(KOA)is a common orthopedic condition with an uncertain etiology,possibly involving genetics and *** like changes in chondrocyte microenvironment,oxidative stress,inflammation,and immune responses affect KOA ***-stage treatment options primarily target symptom *** stem cells(MSCs)show promise for treatment,despite *** research highlights microRNAs(miRNAs)within MSC-released extracellular vesicles that can potentially promote cartilage regeneration and hinder KOA *** suggests exosomes(Exos)as a promising avenue for future *** these findings emphasize the need for effective KOA progression management,further safety and efficacy validation for Exos is *** To explore miR-29a’s role in KOA,we’ll create miR-29a-loaded vesicles,testing for early treatment in rat *** Extraction of bone marrow MSC-derived extracellular vesicles,preparation of engineered vesicles loaded with miR-29a using ultrasonication,and identification using quantitative reverse transcription polymerase chain reaction;after establi-shing a rat model of KOA,rats were randomly divided into three groups:Blank control group injected with saline,normal extracellular vesicle group injected with normal extracellular vesicle suspension,and engineered extrace-llular vesicle group injected with engineered extracellular vesicle *** three groups evaluation,histological detection,and immunohistochemical detection to compare and evaluate the progress of various forms of *** General behavioral observation results showed that the extracellular vesicle group and engineered extracellular vesicle group had better performance in all four indicators of pain,gait,joint mobility,and swelling compared to the blank control ***,the engineered extracellular vesicle group had better pain relief at 4 wk and better knee joint mobility at 8 wk compared to the nor

关键词： Exosomes Osteoarthritis Mesenchymal stem cells MicroRNA-29a Intra-articular injection

Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

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Asian Journal of Andrology 2024年第1期26卷 41-45页

作者： Shun Bai Ming-Zhen Li Yang-Yang wan Xue-Chun Hu yi-Xun Liu Xian-Hong Tong Tong-Hang Guo Lu Zong Ran Liu Yuan-Qi Zhao Ping Xiang Bo Xu Xiao-Hua Jiang Department of Gynecology and Obstetrics Reproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHC Key Laboratory of Male Reproduction and Genetics Guangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of Urology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China wannan Medical College Wuhu 241002China

Genetic risk factors have been shown to contribute to the development of sexual ***,the role of methylenetetrahydrofolate reductase(MTHFR)gene variants in the risk of erectile dysfunction(ED)remains *** this study,we recruited 1254 participants who underwent ED assessed by the International Index of Erectile *** MTHFR c.677C>T variant was also measured by fluorescence polymerase chain reaction(PCR).No significant difference in the genotypic frequency of the MTHFR C677T polymorphism(CC,CT,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic regression analysis,both crude and adjusted models showed that the risk of ED was not significantly associated with the C677T ***,a significantly higher frequency of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive correlation between the MTHFR 677TT polymorphism and severe ED was confirmed by logistic regression analysis,even after adjusting for potential confounders(odds ratio[OR]=2.46,95%confidence interval[CI]:1.15-5.50,P=0.02).These findings suggest a positive correlation between the MTHFR 677TT polymorphism and the risk of severe *** of MTHFR gene polymorphisms may provide complementary information for ED patients during routineclinicaldiagnosis.

关键词： erectile dysfunction gene variant genetic risk factors methylenetetrahydrofolate reductase sexual function

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阅核制述评

法学 2024年第3期 140-157页

作者：万毅四川大学法学院

当前法院系统所推行的阅核制本质上仍然是院庭长行使审判监督、管理权的一种形式,差别在于其在司法责任制改革的“四类案件”外,还覆盖了原本属于独任法官和合议庭“自留地”的“非四类案件”。阅核在形式上虽然仍属文书签发制,却只是... 详细信息

当前法院系统所推行的阅核制本质上仍然是院庭长行使审判监督、管理权的一种形式,差别在于其在司法责任制改革的“四类案件”外,还覆盖了原本属于独任法官和合议庭“自留地”的“非四类案件”。阅核在形式上虽然仍属文书签发制,却只是一项程序启动权,而非实体处分权,因此并非个案审批制的翻版。从改革背景看,阅核制的出台主要是为弥补“四类案件”监管机制的不足,这表现为:一是“四类案件”本身难以发现和识别,二是考核压力下院庭长和承办法官缺乏动力启动监管程序,三是院庭长对于“非四类案件”的脱管导致裁判文书质量下滑。关于阅核制的发展,在政策层面,由于司法责任愈加向院庭长集中,改革可能导致其脱离办案岗位或者选择尽量将案件提交审委会讨论,这与司法责任制改革关于院庭长亲自、带头办案以及审委会的定位之间产生背反现象。在法律层面,为保障改革的合法性,可以考虑对院庭长启动审委会的权限进行适当限制。在法理层面,为尊重法官独立办案权,院庭长在阅核过程中应当保持谦抑,慎用部分监管措施,并限缩监管方式。

关键词：阅核制司法责任制审判监督管理 “四类案件”

Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

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Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze wan Hung Massimiliano Gaetani yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man Tao Zhang yi Song Yao wang Jacqueline Pui Wah Chung Tak Hang Chan Roman A.Zubarev Chi Chiu wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome Integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis

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程朱理学王道论的三个基本主题

社会科学战线 2024年第4期346卷 32-41,281页

作者：敦鹏河北大学哲学与社会学学院河北保定071002

宋代儒学是宋学的主流,程朱理学又是宋代儒学的主流。作为宋代新儒学的主要流派,程朱理学及其王道论不仅奠定了中国封建社会后期政治意识形态的理论基础,也成为儒家王道思想最成熟最具代表性的理论形态。程朱理学王道论的基本面向与主题... 详细信息

宋代儒学是宋学的主流,程朱理学又是宋代儒学的主流。作为宋代新儒学的主要流派,程朱理学及其王道论不仅奠定了中国封建社会后期政治意识形态的理论基础,也成为儒家王道思想最成熟最具代表性的理论形态。程朱理学王道论的基本面向与主题,表现在:一是将形上的“天理”论运用于现实政治,得出“循天理以治国”的主张;二是把“正君心”摆在更重要的位置,丰富和发展了传统儒家的内圣外王之道;三是旗帜鲜明地坚持“以义为先”“藏富于民”的治道理念,彰显着关心普通百姓生活和人间疾苦的民生旨趣。程朱理学不仅是修身之学,更是治世之学,它涵括了仁政、礼治、民本等多重思想维度,代表着王权与民利的最佳契合状态,是儒家经世致用的典型形态。因此,研究理学王道论具有拓展和深化宋代理学研究的意义和价值。

关键词：程朱理学王道论天理内圣外王民生

Non-proteolytic ubiquitination of HBx controls HBV replication

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Virologica Sinica 2024年第2期39卷 338-342页

作者： Xiangpeng Sheng yi Yang Min Zhu Linlin Zhou Fang Zhu Yuanfei Zhu Siying Dong Hui Kong Honghua wang Ji Jiang Mingyue wan Mingyang Feng Qiang Deng Yumin Xu Qing You Ronggui Hu State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Thoracic Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China Department of Pathogenic Biology West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China School of Medicine Guizhou UniversityGuiyang 550025China Key Laboratory of Medical Molecular Virology(MOE&MOH) School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Hospital Infection Management Department of Infectious DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health *** HBV infection remains the principal cause of liver cirrhosis and hepatocellular carcinoma(HCC).HBV is a small DNA virus,owning a~3.2 kb genome that encodes several proteins:viral DNA polymerase,core antigen(HBcAg),E antigen(HBeAg),three surface antigens(PreS1/PreS2/HBsAg),and a regulatory X protein(HBx)(Lamontagne et al.,2016).X protein,named for its lack of homology with any known proteins,is a 154 aa protein that plays an essential role in HBV biology and regulates the development of HCC(Yang et al.,2022).Although previous studies have strongly expanded our understanding of HBx,the regulation of HBx is not completely elucidated.

关键词： infection cirrhosis

基于数据失真的雷达通信一体化OFDM波形设计方法

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雷达学报（中英文） 2024年第1期13卷 160-173页

作者：刘燕万显荣易建新武汉大学电子信息学院武汉430072

正交频分复用(OFDM)波形设计是实现雷达通信一体化的物理层关键技术之一。OFDM波形通常存在峰均功率比(PAPR)高,以及波形自相关旁瓣电平高的问题。该文针对现有联合降低PAPR和自相关旁瓣方法存在的通信速率下降问题,提出了一种基于数据... 详细信息

正交频分复用(OFDM)波形设计是实现雷达通信一体化的物理层关键技术之一。OFDM波形通常存在峰均功率比(PAPR)高,以及波形自相关旁瓣电平高的问题。该文针对现有联合降低PAPR和自相关旁瓣方法存在的通信速率下降问题,提出了一种基于数据失真的一体化波形设计方法。该文还将通信数据的误差矢量幅度作为优化目标之一,降低了数据失真引起的通信误码率。首先,构建了PAPR约束下最小化积分旁瓣比和误差矢量幅度的优化模型。其次,根据调制星座图特点,通过外围星座调制的数据失真和所有调制数据失真,将多目标高维非凸优化问题转化为两个单目标优化子问题,分别采取凸松弛操作和交替方向乘子法(ADMM)求解简化后的子问题,得到低积分旁瓣比波形和PAPR约束下的低误差矢量幅度波形。仿真结果表明该方法设计的一体化波形可满足PAPR要求,同时具有良好的感知和通信性能。

关键词：波形设计雷达通信一体化正交频分复用(OFDM) 峰均功率比(PAPR) 旁瓣误差矢量幅度