Association between MTHFR c.677C>T variant and erectile dysfunction among males attending fertility clinic

作     者：Shun Bai Ming-Zhen Li Yang-Yang Wan Xue-Chun Hu Yi-Xun Liu Xian-Hong Tong Tong-Hang Guo Lu Zong Ran Liu Yuan-Qi Zhao Ping Xiang Bo Xu Xiao-Hua Jiang Shun Bai;Ming-Zhen Li;Yang-Yang Wan;Xue-Chun Hu;Yi-Xun Liu;Xian-Hong Tong;Tong-Hang Guo;Lu Zong;Ran Liu;Yuan-Qi Zhao;Ping Xiang;Bo Xu;Xiao-Hua Jiang

作者机构：Department of Gynecology and ObstetricsReproductive and Genetic HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China NHC Key Laboratory of Male Reproduction and GeneticsGuangdong Provincial Reproductive Science Institute(Guangdong Provincial Fertility Hospital)Guangzhou 510600China Department of UrologyThe First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Wannan Medical CollegeWuhu 241002China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2024年第26卷第1期

页      面：41-45页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(No.81901543,No.82071709,No.81901545,No.81971333,and No.82171599) the Key Research and Development Project of Anhui Province(2022e07020014) the Key Laboratory of Male Reproduction and Genetics of NHC(KF202003) the Joint Fund for Medical Artificial Intelligence(MAI2022Q010) the Joint Research Center for Genomic Resources(2017B01012-2021K001) 

主　　题：erectile dysfunction gene variant genetic risk factors methylenetetrahydrofolate reductase sexual function 

摘      要：Genetic risk factors have been shown to contribute to the development of sexual ***,the role of methylenetetrahydrofolate reductase(MTHFR)gene variants in the risk of erectile dysfunction(ED)remains *** this study,we recruited 1254 participants who underwent ED assessed by the International Index of Erectile *** MTHFR c.677CT variant was also measured by fluorescence polymerase chain reaction(PCR).No significant difference in the genotypic frequency of the MTHFR C677T polymorphism(CC,CT,and TT)was observed between men from the ED and non-ED *** addition,on binary logistic regression analysis,both crude and adjusted models showed that the risk of ED was not significantly associated with the C677T ***,a significantly higher frequency of the 677TT polymorphism was found in severe and moderate ED(P=O.02).The positive correlation between the MTHFR 677TT polymorphism and severe ED was confirmed by logistic regression analysis,even after adjusting for potential confounders(odds ratio[OR]=2.46,95%confidence interval[CI]:1.15-5.50,P=0.02).These findings suggest a positive correlation between the MTHFR 677TT polymorphism and the risk of severe *** of MTHFR gene polymorphisms may provide complementary information for ED patients during routineclinicaldiagnosis.