Non-proteolytic ubiquitination of HBx controls HBV replication
作者机构：State Key Laboratory for Animal Disease Control and PreventionHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China State Key Laboratory of Molecular BiologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Key Laboratory of Systems Health Science of Zhejiang ProvinceSchool of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Thoracic SurgeryRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Plant Molecular SciencesCollege of Life SciencesShanghai Normal UniversityShanghai 200234China Department of Pathogenic BiologyWest China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China School of MedicineGuizhou UniversityGuiyang 550025China Key Laboratory of Medical Molecular Virology(MOE&MOH)School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Hospital Infection ManagementDepartment of Infectious DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200240China
出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)
年 卷 期：2024年第39卷第2期
页 面：338-342页
核心收录：
学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：funded by the National Science and Technology Innovation 2030 Major Project of China(No.2021ZD0203900) the Ministry of Science and Technology of China(No.2019YFA0802103) the National Natural Science Foundation of China(No.92253302) the Department of Science and Technology of Zhejiang Province(No.2021C03104) the Guangzhou Science Innovation and Development Program(No.201803010092) athe Shenzhen-Hong Kong Institute of Brain Science(No.NYKFKT2019006)
摘 要：Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health *** HBV infection remains the principal cause of liver cirrhosis and hepatocellular carcinoma(HCC).HBV is a small DNA virus,owning a~3.2 kb genome that encodes several proteins:viral DNA polymerase,core antigen(HBcAg),E antigen(HBeAg),three surface antigens(PreS1/PreS2/HBsAg),and a regulatory X protein(HBx)(Lamontagne et al.,2016).X protein,named for its lack of homology with any known proteins,is a 154 aa protein that plays an essential role in HBV biology and regulates the development of HCC(Yang et al.,2022).Although previous studies have strongly expanded our understanding of HBx,the regulation of HBx is not completely elucidated.
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