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Combustion characteristics of low-quality lignite for different bed material sphericities in a circulating fluidized bed boiler:A numerical study

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Particuology 2024年第7期90卷 364-382页

作者： Barış Gürel Gülşah Karaca Dolgun Osman İpek Ali Keçebaş Department of Mechanical Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study delves into the combustion behavior of various lignite types within a circulating fluidized bed boiler(CFBB),with a primary focus on the impact of different bed material sphericity ratios(0.5,0.7,and 0.9).Utilizing bed material with a sphericity ratio of 0.9 sourced from theÇan power plant and verified through experimentation,the research reveals several key ***,furnace temperatures tended to rise with higher sphericity ratios,albeit with variations between lignite types,particularly highlighting the complexity of this relationship in the case of GLI-Tunçbilek *** levels in the combustion chamber remained consistent across different sphericity ratios,indicating minimal influence on pressure *** combustion efficiency,especially at the bottom of the boiler,was observed at lower sphericity levels(0.5 and 0.7)forÇan lignite,as reflected in CO_(2) mole *** NO_(x) emissions generally decreased with lower sphericity,the sensitivity to sphericity varied by lignite type,with Ilgın lignite showcas.ng low NO_(x) but high sO_(2) emissions,underscoring the intricate interplay between lignite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights valuable for optimizing performance and emissions control,particularly in lignite-based power.

关键词： Circulating fluidized bed boiler Computational particle fluid dynamics method Particle sphericity ratios NO_(x)and sO_(2)emissions Energy production efficiency

A Nonstandard Lévy-Khintchine Formula and Lévy Processes

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Acta Mathematica sinica,English series 2008年第2期24卷 241-252页

作者： siu ah ng school of Mathematical sciences University of KwaZulu-Natal Pietermaritzburg 3209 South Africa

We use methods from nonstandard analysis to obtain a short and simple derivation of the Levy-Khintchine formula via an explicit construction of certain laws of the infinitesimal increments. Consequently, any arbitrary... 详细信息

关键词： Levy processes Levy-Khintchine formula nonstandard analysis infinitesimal hyperfinite

Natural dietary anti-cancer chemopreventive compounds:redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells

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Acta Pharmacologica sinica 2007年第4期28卷 459-472页

作者： sujit NAIR ah-ng Tony KOng Graduate Program in Pharmaceutical sciences Department of Pharmaceutics Ernest Mario School of PharmacyRutgersThe StateUniversity of New JerseyPiscatawayNew Jersey 08854USA

Many dietary phytochemicals exhibit health-beneficial effects including preven-tion of diseases such as cancer,as well as neurological,cardiovascular,inflam-matory,and metabolic ***,herbivorous and omnivorousanimals have been ingesting *** interaction between"animal-plant"ecosystems has resulted in an elaborate system of detoxification and defensemechanisms evolved by animals including *** cells,includinghuman cells,respond to these dietary phytochemicals by"non-classical receptorsens.ng"mechanisms of electrophilic chemical-stress typified by"thiol-modu-lated"cellular signaling events primarily leading to the gene expression of phar-macologically beneficial effects,but sometimes unwanted cytotoxicity *** has been studying two groups of dietary phytochemical cancer-chemopreventive compounds (isothiocyanates and polyphenols),which areeffective in chemical-induced,as well as genetically-induced,animal carcinogen-esis *** compounds typically generate"cellular stress"and modulategene expression of phase Ⅱ detoxifying/antioxidant ***,reac-tive oxygen species,and reactive nitrogen species are known to act as secondmess.ngers in the modulation of many cellular signaling pathways leading togene expression changes and pharmacological ***-sensitive tran-scription factors such as nuclear factor-E2-related factor 2 (Nrf2),AP-1,NF-κB,tocite a few examples,sense and transduce changes in the cellular redox status andmodulate gene expression responses to oxidative and electrophilic stresses,pre-sumably via sulfhydryl modification of critical cysteine residues found on theseproteins and/or other upstream redox-sensitive molecular *** the currentreview,we will explore dietary cancer chemopreventive phytochemicals,discussthe link between oxidative/electrophilic stresses and the redox circuitry,and con-sider different redox-sensitive transcription *** will also discuss thekelch-l

关键词： redox Nrf2 Keapl NEs NLs gene expression profiles

Defining and tracing subtypes of patient-derived xenograft models in pancreatic ductal adenocarcinoma

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Cancer Communications 2024年第8期44卷 915-920页

作者： s.ngyeop Hyun Youngmin Han Jae Yun Moon Young-ah suh Won-Gun Yun Wooil Kwon Jong-Eun Lee Daeun Kim Ja-Lok Ku Jin-Young Jang Daechan Park Department of Molecular science and Technology Ajou UniversitySuwonRepublic of Korea Department of surgery and Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Molecular science and Technology Research Center Ajou UniversitySuwonRepublic of Korea DNA Link Inc. SeoulRepublic of Korea Korean Cell Line Bank Laboratory of Cell BiologyCancer Research InstituteSeoul National University College of MedicineSeoulRepublic of Korea

Patient-derived xenograft(PDX)models have been used to explore therapeutic opportunities for pancreatic ductal adenocarcinoma(PDAC)[1].Although original tumor characteristics are altered by cancer-stromal interactions... 详细信息

关键词： adenocarcinoma ductal xenograft

Pharmacometrics of nutraceutical sulforaphane and its implications in prostate cancer prevention

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Journal of Chinese Pharmaceutical sciences 2016年第1期25卷 12-22页

作者： sujit Nair ah-ng Tony Kong Amrita Cancer Discovery Biology Laboratory Amrita Vishwa Vidyapeetham University Center for Cancer Chemoprevention Research and Department of Pharmaceutics Rutgers The State University of New Jersey

sulforaphane(sFN), found in broccoli and other cruciferous vegetables, has a beneficial effect in chemoprevention of prostate cancer, whose incidence and associated mortality have gradually increased worldwide. There is great enthusiasm for bench-to-bedside development of sFN as a potent chemopreventive agent, possibly alone or as an adjunct to existing chemotherapy regimens, in the oncology care setting to reduce toxicity of chemotherapeutics and potentially enhance their cancer cell-kill efficacy. In this review, we appreciate existing knowledge on sFN us.ng a pharmacometrics approach, which is fast becoming a gold standard in discovery research and validation of New Chemical Entities and New Biological Entities in pharmaceutical industry. We discuss the epistemology of sFN target engagement and quantitative systems pharmacology with due emphasis on mechanistic pharmacology, pharmacodynamics, pharmacogenomics and metabolism of sFN. In addition, we explore the quantitative freeway to sFN translational medicine by assess.ng the preclinical and clinical PK/metabolism aspects of sFN that form the cornerstone of sFN pharmacometric evaluation, as well as the promise of sFN in prostate cancer. Taken together, we share perspectives on the exciting developments in translational cancer chemoprevention, with emphasis on the pharmacometric aspects, of the nutraceutical sFN which is currently in clinical trials, and suggest that the pharmacometric approach holds great promise in the sFN translational pharmacology paradigm for prostate cancer.

关键词： Pharmacometrics Pharmacokinetics Quantitative systems pharmacology Target engagement Metabolism Pharmacogenomics Chemoprevention sulforaphane Isothiocyanate Prostate cancer

Development and validation of a rapid UPLC/Ms method for the simultaneous determination of I3C, DIM, and related metabolites and its application to pharmacokinetics studies

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Journal of Chinese Pharmaceutical sciences 2016年第7期25卷 477-488页

作者： Yury Gomez Hu Wang ah-ng Tony Kong Graduate Program in Pharmaceutical science Ernest Mario School of Pharmacy Rutgers The State University of New Jersey Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey

Indole-3-carbinol(I3C) and diindolylmethane(DIM) are naturally derived dietary phytochemicals with promis.ng anti-cancer properties that have been demonstrated both in vitro and in vivo. Us.ng reversed-phase ultra-performance liquid chromatography(UPLC) coupled with mass spectrometry(Ms), a rapid, specific, and high throughput method was developed and validated for the quantification and identification of I3 C, DIM, and other I3 C metabolites in plasma. samples containing I3 C or DIM and the internal standard 4-methoxy indole(Is) were extracted us.ng a liquid-liquid extraction technique. The mean recovery was 96.21% for I3 C and 108.5% for DIM. separation was achieved us.ng a Waters Acquity UPLC Hss T3, 1.8 μm, 2.1 mm×150 mm column and acetonitrile–water gradient elution. The flow rate was 0.3 m L/min and the run time was 9 min. The limits of detection and quantification for I3 C and DIM were 15 ng/m L and 25 ng/m L, respectively. Calibration curves for I3 C and DIM were linear(r2>0.99) over a concentration range of 0.025–20 μg/m L. Precision, accuracy, and stability analysis fulfilled the CDER guidelines criteria. The method was successfully applied to the determination of the pharmacokinetic parameters of I3 C or DIM after oral, intravenous, or intraperitoneal administration to sprague Dawley rats. The method described here is superior over existing analytical methods for I3 C and its metabolites in terms of sensitivity, speed, and separation.

关键词： UPLC/Ms Indole-3-Carbinol Diindolylmethane Pharmacokinetics s.ngle-dose administration sprague-Dawley Rats

Cancer chemoprevention by phytochemicals:potential molecular targets,biomarkers and animal models

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Acta Pharmacologica sinica 2007年第9期28卷 1409-1421页

作者： Ki Han KWON Avantika BARVE siwang Yu Mou-Tuan HUAng ah-ng Tony KOng Center for Cancer Prevention Research Department of Pharmaceutics Center for Cancer Prevention Research Graduate Program in Pharmaceutical science Center for Cancer Prevention Research susan Lehman Cullman Laboratory for Cancer Research Center for Cancer Prevention Research Department of Pharmaceutics Department of Chemical Biology Ernest Mario School of Pharmacy RutgersThe State University of New JerseyPiscatawayNJ 08854USA

Recent studies have strongly indicated that certain daily-consumed dietaryphytochemicals could have cancer protective effects against transgenic mice can-cer models and cancers mediated by carcinogens,irradiations and carcinogenicmetabolites derived from exogenous or endogenous *** cancer-protec-tive effects elicited by these dietary compounds are believed to be due at least inpart to the induction of cellular defense systems including the detoxifying andantioxidant enzymes system,as well as the inhibition of anti-inflammatory andanti-cell growth signaling pathways culminating in cell cycle arrest and/or cell-death,in this review,we summarize the potential mechanisms including the modu-lation of nuclear factor kappaB (NF-kB),cyclooxygenases-2 (COX-2),activatorprotein-1 (AP-1),mitogen-activated protein kinases (MAPKs) and the inductionof phase Ⅱ cellular detoxifying and antioxidant enzymes mediated mainly by theantioxidant response elements (ARE) within the promoter regions of these genesthrough nuclear factor-erythroid 2-related factor 2 (Nff2),a member of the Cap‘n’collar (CNC) family of the basic region-leucine zipper transcription ***,we also review several animal models of carcinogenesis and cancerchemopreventive efficacy studies of these animal models us.ng dietarychemopreventive ***,we discuss the cellular signaling cascadesmediated by Nrf2,NF-kB,AP-1,MAPKs and COX-2,which have been consideredto play pivotal roles in tumor initiation,promotion and progression processes,and could be promis.ng molecular targets for the design of drugs targeting cancerprevention and therapy.

关键词： chemoprevention dietary cancer chemopreventive compounds nuclear factor E2related factor 2 nuclear factor-kappaB activator protein-l mitogen-activated protein kinases

Cancers chemoprevention by dietary phytochemicals and traditional Chinese medicines: epigenetics and cellular signaling pathways

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Journal of Chinese Pharmaceutical sciences 2016年第4期25卷 233-234页

作者： ah-ng Tony Kong siwang Yu Department of Pharmaceutics Earnest Mario School of Pharmacy Rutgers The State University of New Jersey school of Pharmaceutical sciences Peking University Health Science Center

The incidence and mortality of cancer have been increas.ng alarmingly in China and *** other chronic diseases such as metabolic,cardiovascular,and neuropathies,most cancers,especially metastatic ones,are still essenti... 详细信息

关键词： epigenetics medicines dietary cardiovascular metastatic spite mortality carcinogenesis incidence alterations

Differential signaling regulatory networks governing hormone refractory prostate cancers

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Journal of Chinese Pharmaceutical sciences 2014年第8期23卷 511-524页

作者： sujit Nair Celine Liew Tin Oo Khor Li Cai ah-ng Kong Amrita Cancer Discovery Biology Laboratory and Amrita school of Pharmacy Amrita Vishwa Vidyapeetham UniversityPonekkara P.O. Kochi-682041 Kerala India Department of Pharmaceutics Rutgers The State University of New Jersey Piscataway NJ-08854 USA Department of Pharmacy National University of Singapore Singapore-117543 Republic of Singapore Department of Biomedical Engineering Rutgers The State University of New Jersey Piscataway NJ-08854 USA

To understand the organization of the biological networks that might potentially govern the pathogenesis of hormone refractory prostate cancer （HRPC）, we investigated the transcriptional circuitry and signaling in androgen-dependent 22Rvl and MDA PCa 2b cells, androgen- and estrogen-dependent LNCaP cells, and androgen-independent DU 145 and PC-3 prostate cancer （PCa） cell lines. We used microarray analyses, quantitative real-time PCR, pathway prediction analyses, and determination of Transcription Factor Binding site （TFBs） signatures to dissect HRPC regulatory networks. We generated graphical representations of global topology and local network motifs that might be important in prostate carcinogenesis. Many important putative biomarker ＇target hubs＇ were identified in the current study including AP-1, NF-KB, EGFR, ERK1/2, JNK, p38 MAPK, TGF beta, VEGF, PDGF, CD44, Akt, PI3K, NOTCH1, CAsP1, MMP2 and AR. Our results suggest that complex cellular events including autoregulation, feedback loops and cross-talk might govern progression from early lesion to clinically diagnosed PCa, as well as metastatic potential of pre-existent high-grade prostate intraepithelial neoplasia （HG-PIN） and/or advancement to HRPC. The identification of TFBs signatures for TCF/LEF, sOX9 and ELK1 in the regulatory elements suggests additional biomarkers for the potential development of chemopreventive/therapeutic strategies against PCa. Taken together, in this study, we have identified putative biomarker ＇target hubs＇ in the architecture of PCa signaling networks, and investigated TFBs signatures that might enhance our understanding of key regulatory nodes in the progression and pathogenesis of HRPC.

关键词： Prostate cancer signaling network Target hub Regulatory network Biomarker Transcription Factor Binding site