Cancer chemoprevention by phytochemicals:potential molecular targets,biomarkers and animal models

作     者：Ki Han KWON Avantika BARVE Siwang Yu Mou-Tuan HUANG Ah-Ng Tony KONG 

作者机构：Center for Cancer Prevention Research Department of Pharmaceutics Center for Cancer Prevention Research Graduate Program in Pharmaceutical Science Center for Cancer Prevention Research Susan Lehman Cullman Laboratory for Cancer Research Center for Cancer Prevention Research Department of Pharmaceutics Department of Chemical BiologyErnest Mario School of Pharmacy RutgersThe State University of New JerseyPiscatawayNJ 08854USA 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2007年第28卷第9期

页      面：1409-1421页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported in part by Institutional Funds and by RO1-CA094828 RO1CA092515 RO1-CA073674 and R01CA118947 to Dr Ah-Ng Tony KONG from the National Institutes of Health(NIH) 

主　　题：chemoprevention dietary cancer chemopreventive compounds nuclear factor E2related factor 2 nuclear factor-kappaB activator protein-l mitogen-activated protein kinases 

摘      要：Recent studies have strongly indicated that certain daily-consumed dietaryphytochemicals could have cancer protective effects against transgenic mice can-cer models and cancers mediated by carcinogens,irradiations and carcinogenicmetabolites derived from exogenous or endogenous *** cancer-protec-tive effects elicited by these dietary compounds are believed to be due at least inpart to the induction of cellular defense systems including the detoxifying andantioxidant enzymes system,as well as the inhibition of anti-inflammatory andanti-cell growth signaling pathways culminating in cell cycle arrest and/or cell-death,in this review,we summarize the potential mechanisms including the modu-lation of nuclear factor kappaB (NF-kB),cyclooxygenases-2 (COX-2),activatorprotein-1 (AP-1),mitogen-activated protein kinases (MAPKs) and the inductionof phase Ⅱ cellular detoxifying and antioxidant enzymes mediated mainly by theantioxidant response elements (ARE) within the promoter regions of these genesthrough nuclear factor-erythroid 2-related factor 2 (Nff2),a member of the Cap‘n’collar (CNC) family of the basic region-leucine zipper transcription ***,we also review several animal models of carcinogenesis and cancerchemopreventive efficacy studies of these animal models using dietarychemopreventive ***,we discuss the cellular signaling cascadesmediated by Nrf2,NF-kB,AP-1,MAPKs and COX-2,which have been consideredto play pivotal roles in tumor initiation,promotion and progression processes,and could be promising molecular targets for the design of drugs targeting cancerprevention and therapy.