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Risk factors for neoplastic progression in Barrett's esophagus

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World Journal of Gastroenterology 2011年第32期17卷 3672-3683页

作者： Elizabeth F Wiseman yeng s ang Department of Gastroenterology Royal Albert Edward Infirmary Wigan Lane Wigan Greater Manchester WN1 2NN United Kingdom Faculty of Medical and Human sciences School of Translational Medicine The University of Manchester Oxford Road Manchester M13 9PL United Kingdom

Barrett's esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a "metaplasia-dysplasia-carcinoma" (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.

关键词： Barrett’s esophagus Esophageal adeno-carcinoma Metaplasia-dysplasia-carcinoma Neoplastic progression Risk factors

Targeting key signalling pathways in oesophageal adenocarcinoma:A reality for personalised medicine?

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World Journal of Gastroenterology 2011年第23期17卷 2781-2790页

作者： Richard R Keld yeng s ang Department of Gastroenterology Royal Albert Edward InfirmaryWigan LaneWiganGreater ManchesterWN1 2NNUnited Kingdom school of Translational Medicine Faculty of Medical and Human SciencesThe University of ManchesterManchesterM13 9PLUnited Kingdom

Cancer treatments are rapidly *** treatment for oesophageal adenocarcinoma currently involves surgery and cytotoxic chemotherapy or *** for both regimes are generally poor as a result of tumor *** have reviewed the key signalling pathways associated with oesophageal adenocarcinomas and discussed the recent trials of novel agents that attempt to target these *** are many trials underway with the aim of improving survival in oesophageal ***,phase 2 and 3 trials are focused on MAP kinase inhibition,either through inhibition of growth factor receptors or signal transducer *** order to avoid tumor resistance,it appears to be clear that targeted therapy will be needed to combat the multiple signalling pathways that are in operation in oesophageal *** may be achievable in the future with the advent of gene signatures and a combinatorial approach.

关键词： Oesophageal adenocarcinoma signallingpathways MAP and PI3 Kinase pathways Wnt signalling Transforming growth factor-13 pathway Nuclear factor-KBpathways Transcription factors Tyrosine kinase receptors

Impact of Bubbles on Mechanical Performances in a Borosilicate Glass

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Journal of Wuhan University of Technology(Materials science) 2025年第1期40卷 25-29页

作者： LI Chengxing LI Dongfeng MA shilong QIAO ang ZHENG Qingshuang China Helicopter Research and Development Institute Jingdezhen 333001China state Key Laboratory of silicate Materials for Ar-chitectures Wuhan University of TechnologyWuhan 430070China

To analyze the impact of bubbles on the mechanical behavior of glasses,by controlling the refining time,we prepared three borosilicate glasses with the same composition and different *** the analysis software integrated within the optical microscope,the diameter and number of the bubbles on the surface of three borosilicate glasses were *** the hardness and crack initiation resistance(CR),we built the relationship between the porosity and the mechanical performance of these borosilicate glasses.

关键词： bubbles oxide glass hardness creak initiation resistance

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Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population

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World Journal of Gastroenterology 2014年第34期20卷 12212-12216页

作者： Richard Keld Manyi Thian Chia Hau Jamil sajid Narveen Kumar yeng ang Department of Gastroenterology Royal Albert Edward InfirmaryWiganLancashire WN1 2NNUnited Kingdom Faculty of Human and Medical sciences University of ManchesterManchesterSalford M6 8HDUnited Kingdom

AIM: To identify if methylene tetra-hydrofolatereductase (MTHFR) C677T polymorphisms are associated with oesophageal adenocarcnomas in a Caucasian population and to test whether folic acid and homocysteine levels are ... 详细信息

关键词： Polymorphisms of 5,10-methylenetetrahydrofolate reductase Oesophageal adenocarcinoma Caucasian population Helicobacter pylori Polymorphism

溶解有机质N/C比值的分布格局及其对湖泊增温和营养富集的响应

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湖泊科学 2025年第1期37卷 97-111页

作者：陈铭胡盎韩磊王建军湖南农业大学资源学院长沙410128 中国科学院南京地理与湖泊研究所湖泊与流域水安全重点实验室南京211135

溶解有机质(DOM)是水生生态系统的重要能量和营养源,其N/C等元素化学计量学能够反映湖泊沉积物营养物质来源,相关研究有助于揭示全球变暖和水体富营养化的影响机制。本研究聚焦高分辨率质谱技术所获DOM的N/C比值,通过Meta分析从宏观角... 详细信息

溶解有机质(DOM)是水生生态系统的重要能量和营养源,其N/C等元素化学计量学能够反映湖泊沉积物营养物质来源,相关研究有助于揭示全球变暖和水体富营养化的影响机制。本研究聚焦高分辨率质谱技术所获DOM的N/C比值,通过Meta分析从宏观角度考察全球湖泊、河流、海洋和泥炭地等多生境N/C比值的全球分布情况。结果表明,河流水体、沉积物和污水等生境的N/C均值(分别为0.050±0.062、0.050±0.014和0.083±0.084)均显著高于泥炭地(0.026±0.037);水体N/C比值主要受海拔(即温度)、pH、氨氮和溶解有机碳等显著影响,而泥炭地等陆地N/C比值主要受pH、总溶解有机氮和溶解有机碳的影响。进一步,依托云南老君山海拔梯度开展模拟温度变化和营养富集的微宇宙实验定量解析其影响机制,并根据沉积物DOM分子转换数将总分子划分为高活性和低活性两类,探究总分子及其两类组分的N/C比值对温度和营养富集的响应规律。溶解有机质N/C均值为0.112±0.020,其中高活性分子(0.119±0.017)显著高于低活性分子(0.109±0.034)。总分子N/C比值主要受亚硝酸盐和硝酸盐等营养盐的影响,相对总贡献率为63.43%;高活性分子N/C比值主要受营养盐和能量供应(比如溶解有机碳、总有机碳和叶绿素a等)的影响,而低活性分子N/C比值主要受营养盐的影响。结构方程模型分析表明,营养富集对总分子N/C比值的影响高于温度,主要通过能量供应和营养盐的间接作用而产生影响;对于高活性分子,营养盐主要通过能量供应的间接作用影响N/C比值;而对于低活性分子,主要通过营养盐发挥直接作用。本研究结果首次探讨了全球不同生境N/C比值的分布格局,揭示了沉积物溶解有机质N/C比值对全球变暖和营养富集的响应规律和机制,为更好理解和预测未来全球变化背景下溶解有机碳稳定性提供科学参考。

关键词：溶解有机质氮碳比湖泊沉积物全球变暖富营养化

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Immunohistochemical assessment of NY-EsO-1 expression in esophageal adenocarcinoma resection specimens

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World Journal of Gastroenterology 2014年第14期20卷 4011-4016页

作者： stephen J Hayes Keng Ngee Hng Peter Clark Fiona Thistlethwaite Robert E Hawkins yeng ang Department of Histopathology Salford Royal NHS Foundation Trust Faculty of Medical and Human sciences University of Manchester Department of Gastroenterology Salford Royal NHS Foundation Trust Department of Medical Oncology The Christie NHS Foundation Trust Department of Medical Oncology Paterson Institute of Cancer ResearchUniversity of Manchester

AIM: To assess NY-EsO-1 expression in a cohort of esophageal adenocarcinomas.

关键词： Esophageal adenocarcinoma Immunohistochemistry NY-EsO-1 stem cells Vesicle trafficking

Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-ang Nan Qing Li Xiufang Li Zi-Xiu Lu Linzhe Lü Jin Liu Luyao Liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang state Key Laboratory of structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences state Key Laboratory of Physical Chemistry of solid surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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Detection of Perfect stealthy Attacks on Cyber-Physical systems subject to Measurement Quantizations: A Watermark-Based strategy

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IEEE/CAA Journal of Automatica sinica 2025年第1期 114-125页

作者： Yu-ang Wang Zidong Wang Lei Zou Bo shen Hongli Dong the College of Information science and Technology Donghua University the Engineering Research Center of Digitalized Textile and Fashion Technology Ministry of Education IEEE the College of Electrical Engineering and Automation Shandong University of Science and Technology the Department of Computer science Brunel University London Uxbridge the sanya Offshore Oil and Gas Research Institute Northeast Petroleum University the Artificial Intelligence Energy Research Institute Northeast Petroleum University Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast Petroleum University

In this paper, the attack detection problem is investigated for a class of closed-loop systems subjected to unknownbutbounded noises in the presence of stealthy attacks. The measurement outputs from the sensors are quantized before transmission.A specific type of perfect stealthy attack, which meets certain rather stringent conditions, is taken into account. such attacks could be injected by adversaries into both the sensor-toestimator and controller-to-actuator channels, with the aim of disrupting the normal data flow. For the purpose of defending against these perfect stealthy attacks, a novel scheme based on watermarks is developed. This scheme includes the injection of watermarks(applied to data prior to quantization) and the recovery of data(implemented before the data reaches the estimator).The watermark-based scheme is designed to be both timevarying and hidden from adversaries through incorporating a time-varying and bounded watermark signal. subsequently, a watermark-based attack detection strategy is proposed which thoroughly considers the characteristics of perfect stealthy attacks,thereby ensuring that an alarm is activated upon the occurrence of such attacks. An example is provided to demonstrate the efficacy of the proposed mechanism for detecting attacks.

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An Overview of self-piercing Riveting Process with Focus on Joint Failures, Corrosion Issues and Optimisation Techniques

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Chinese Journal of Mechanical Engineering 2021年第1期34卷 89-113页

作者： Hua Qian ang school of Engineering RMIT UniversityBundooraVictoria 3083Australia

self-piercing riveting(sPR)is a cold forming technique used to fasten together two or more sheets of materials with a rivet without the need to predrill a *** application of sPR in the automotive sector has become increasingly popular mainly due to the growing use of lightweight materials in transportation ***,sPR joining of these advanced light materials remains a challenge as these materials often lack a good combination of high strength and ductility to resist the large plastic deformation induced by the sPR *** this paper,sPR joints of advanced materials and their corresponding failure mechanisms are discussed,aiming to provide the foundation for future improvement of sPR joint *** paper is divided into three major sections:1)joint failures focusing on joint defects originated from the sPR process and joint failure modes under different mechanical loading conditions,2)joint corrosion issues,and 3)joint optimisation via process parameters and advanced techniques.

关键词： self-piercing riveting Mechanical joining Joint defects Failure mechanisms Corrosion Joint optimisation

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