Risk factors for neoplastic progression in Barrett's esophagus

作     者：Elizabeth F Wiseman Yeng S Ang 

作者机构：Department of Gastroenterology Royal Albert Edward Infirmary Wigan Lane Wigan Greater Manchester WN1 2NN United Kingdom Faculty of Medical and Human Sciences School of Translational Medicine The University of Manchester Oxford Road Manchester M13 9PL United Kingdom 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第32期

页      面：3672-3683页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Barrett’s esophagus Esophageal adeno-carcinoma Metaplasia-dysplasia-carcinoma Neoplastic progression Risk factors 

摘      要：Barrett s esophagus (BE) confers a significant increased risk for development of esophageal adenocarcinoma (EAC), with the pathogenesis appearing to progress through a metaplasia-dysplasia-carcinoma (MDC) sequence. Many of the genetic insults driving this MDC sequence have recently been characterized, providing targets for candidate biomarkers with potential clinical utility to stratify risk in individual patients. Many clinical risk factors have been investigated, and associations with a variety of genetic, specific gastrointestinal and other modifiable factors have been proposed in the literature. This review summarizes the current understanding of the mechanisms involved in neoplastic progression of BE to EAC and critically appraises the relative roles and contributions of these putative risk factors from the published evidence currently available.