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评述天然橡胶中作促进剂的苯醛与苯酮衍生物

橡胶参考资料 1990年第2期20卷 4-8页

作者： A.A. yehia N.L. Doss 王瑞芝

合成了三个苯醛苯腙衍生物与三个苯酮胺衍生物,并且在天然橡胶胶料中作硫化促进剂进行了述评。配料的橡胶在液压式平板硫化机中在142℃下硫化。用振荡盘式流变计测试了流变性能。在制备的化合物存在时利用流变性能数据计算了其硫化反应... 详细信息

合成了三个苯醛苯腙衍生物与三个苯酮胺衍生物,并且在天然橡胶胶料中作硫化促进剂进行了述评。配料的橡胶在液压式平板硫化机中在142℃下硫化。用振荡盘式流变计测试了流变性能。在制备的化合物存在时利用流变性能数据计算了其硫化反应的动力学常数。所制备的化合物显示了优良的硫化促进效率,可与广泛用于橡胶工业中的巯基苯并噻唑(mBT)相媲美。

关键词：天然橡胶促进剂苯醛苯酮衍生物

Analysis of CANDU Reactor Performance Using Thorium Fuel:Comparison with Natural UO2 Case

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材料科学与工程（中英文B版） 2020年第4期10卷 139-147页

作者： Ali yehia Ellithi Afrah AL-Khawlani Faculty of Science Cairo UniversityCairo 12613Egypt Department of Alternative Energy Technology Philadelphia UniversityAmman 19392Jordan Physics Department Faculty of ScienceSana’a UniversitySana’a 72738Yemen

The purpose of the paper is to study the performance of the CANDU(Canada Deuterium Uranium)reactor when the reactor core is loaded with thorium fuel mixed with plutonium isotopes with ratio 3 and 5%.A three dimensional model is designed for the core of CANDU *** computer code mCNPX(monte Carlo N–Particle Transport)is used to calculate the processes in its *** results are compared with natural UO2 case which is the typical fuel of the *** results show that the multiplication factor of the reactor is higher even in the case of thorium fuel mixed with 3%plutonium isotopes,which indicates longer neutron life cycle length and more economic utilization of the reactor.

关键词： CANDU reactor mCNPX code reactor burn up natural uranium thorium fuel

Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1900-1912页

作者： Sirish Dharmapuri UmutÖzbek Hiren Jethra Tomi Jun Thomas U marron Anwaar Saeed Yi-Hsiang Huang mahvish muzaffar matthias Pinter Lorenz Balcar Claudia Fulgenzi Suneetha Amara Arndt Weinmann Nicola Personeni Bernhard Scheiner Tiziana Pressiani musharraf Navaid Bertram Bengsch Sonal Paul Uqba Khan Dominik Bettinger Naoshi Nishida yehia Ibrahim mohamed Arndt Vogel Anuhya Gampa James Korolewicz Antonella Cammarota Ahmed Kaseb Peter R Galle Anjana Pillai Ying-Hong Wan Alessio Cortellini masatoshi Kudo Antonio D’Alessio Lorenza Rimassa David James Pinato Celina Ang Tisch Cancer Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Population Health Science and Policy Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Data Analytics Harrisburg Harrisburg University of Science and TechnologyHarrisburdPA 17101United States SEmA4 StamfordCT 06902United States Division of medical Oncology Kansas University of Kansas Cancer CenterKansasMO 66160United States Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipei 11217Taiwan Department of Internal medicine Brody School of MedicineEast Carolina UniversityGreenvilleNC 27858United States Department of Internal medicine III Division of Gastroenterology and HepatologyMedical University of ViennaVienna 1090Austria Department of Surgery and Cancer Imperial College LondonHammersmith Hospital LondonLondon W120HSUnited Kingdom Department of Hepatology Johannes Gutenberg-University Medical CentreNiedersachsen 30625Germany medical Oncology Unit ASST GardaVia Lungomella ValsecchiBresciaManerbio 25025Italy medical Oncology and Hematology Unit Humanitas Cancer CenterIRCCS Humanitas Research HospitalMilanRozzano 20089Italy Department of medicine II Univ Med Ctr FreiburgHugstetter Str 55University Hospital FreiburgFreiburg D-79106Germany Department of Oncology Baltimore LifeBridge HealthBaltimoreMD 21215United States Division of Hematology and Oncology Weill Cornell Medical CollegeNY 10065United States Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka 577-8502Japan Department of Gastrointestinal medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastroenterology Hepatology and Endocrinology HannoverArndt VogelMedical School HannoverCarl-Neubergstr.Hannover 30659Germany Department of Hepatology Rush University Medical Group 1725 W Harrison St Ste 158ChicagoIL 60612United States Department of Biomedica

BACKGROUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontinuation of *** are reported inmarkers to predict the onset and severity of *** tested the association between neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)at baseline with development of clinically significant IrAEs(grade≥2)in hepatocellular carcinoma(HCC)patients treated with *** To test the association between NLR and PLR at baseline with development of clinically significant IrAEs(grade≥2)in HCC patients treated with *** Data was extracted from an international database from a consortium of 11 tertiary-care referral ***=absolute neutrophil count/absolute lymphocyte count(ALC)and PLR=platelet count/*** of 5 was used for NLR and 300 for PLR based on *** also tested the association between RESULTS Data was collected from 361 patients treated between 2016-2020 across the United States(67%),Asia(14%)and Europe(19%).most patients received Nivolumab(n=255,71%).One hundred sixty-seven(46%)patients developed at least one IrAE,highest grade 1 in 80(48%),grade≥2 in 87(52%)*** a univariable regression model PLR>300 was significantly associated with a lower incidence of grade≥2 IrAEs(OR=0.40;P=0.044).Similarly,a trend was observed between NLR>5 and lower incidence of grade≥2 IrAEs(OR=0.58;P=0.097).multivariate analyses confirmed PLR>300 as an independent predictive marker of grade≥2 IrAEs(OR=0.26;P=0.011),in addition to treatment with programmed cell death ligand 1(PD-1)/cytotoxic T lymphocyte-associated protein-4(OR=2.57;P=0.037)and PD-1/tyrosine kinase inhibitor(OR=3.39;P=0.01)*** use was not associated with IrAE incidence(OR=1.02;P=0.954).Patients treated with steroids had a>2-fold higher incidence of gr

关键词： Neutrophil-lymphocyte ratio Platelet-lymphocyte ratio Inflammatory biomarkers Immunotherapy Immune toxicity

Renal hilar paraganglioma: A case report

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World Journal of Radiology 2014年第1期6卷 15-17页

作者： Zeinab Ali Abou yehia Rashid Khalid Sayyid Ali Ahmad Haydar Department of Radiology AUBMC

Paragangliomas are extra-adrenal pheochromocytomas that derive from chromaffin cells and arise along the sympathetic paraganglia in the *** the majority of cases,they are secretory tumors and most commonly present with *** metanephrines are the standard screening tests for making the diagnosis which is confirmed by *** plays a very important role in establishing the ***,there is no specific feature on imaging for paragangliomas;the vascularity of the tumor should show as hyper-enhancing lesions but this is not always the *** diagnostic value of PET is yet a matter of *** present a very rare case of a paraganglioma arising at the renal hilum,splaying the renal artery and vein and causing vascular compromise to the left *** patient presented with an atypical presentation of unrelenting fever that was followed by acute colicky *** on imaging and blood metanephrine levels,the diagnosis of paraganglioma was *** of the tumor was achieved and the patient is now asymptomatic.

关键词： Renal Hilar Paraganglioma Pheochromo-cytoma Imaging

Biomarkers of Barrett's esophagus

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World Journal of Gastrointestinal Pathophysiology 2014年第4期5卷 450-456页

作者： Yasser mahrous Fouad Ibrahim mostafa Reem yehia Hisham El-Khayat Gastroenterology and Hepatology Unit Tropical Medicine Department Minia University Gastroenterology and Hepatology Department Theodore Research Institute

Barrett's esophagus is the strongest risk for esophageal adenocarcinoma(EAC). metaplasia in patients with BE may progress to dysplasia and then invasive carcinoma. Well-defined diagnostic, progressive, predictive, and prognostic biomarkers are needed to identify the presence of the disease, estimate the risk of malignant transformation, and predict the therapeutic outcome and survival of EAC patients. There are many predictive and prognostic markers that lack substantial validation, and do not allow stratification of patients with gastroesophageal reflux disease in clinical practice for outcome and effectiveness of therapy. In this short review we summarize the current knowledge regarding possible biomarkers, focusing on the pathophysiologic mechanisms to improve prognostic and therapeutic approaches.

关键词： Barrett’s esophagus Esophageal adenocarcinoma Biomarkers

新一代羟乙基淀粉与人血白蛋白在活体肝移植中安全性的比较

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麻醉与镇痛 2011年第1期7卷 84-91页

作者： Ahmed mukhtar Fawzia Aboulfetouh Gihan Obayah maged Salah mohamed Emam yehia Khater Ramzia Akram Aly Hoballah mohamed Bahaa 沈文振(译) 岳云(校) Department of Anesthesia and Intensive Care Cairo University Giza Wadi-Alneel Liver Transplant Center Cairo Egypt Department of Surgery Ain Shams University Cairo Egypt 不详

背景血容量替代治疗是肝移植围手术期管理的重要部分。目前尚缺乏羟乙基淀粉（HES）应用于肝移植患者的相关安全性数据。我们评估了新一代羟乙基淀粉130／0．4应用于肝移植围手术期管理的安全性，并着重分析了其对肾功能的影响。方法行... 详细信息

背景血容量替代治疗是肝移植围手术期管理的重要部分。目前尚缺乏羟乙基淀粉（HES）应用于肝移植患者的相关安全性数据。我们评估了新一代羟乙基淀粉130／0．4应用于肝移植围手术期管理的安全性，并着重分析了其对肾功能的影响。方法行活体肝移植的40例患者被预先随机分成两组。ALB组患者（n=20）给予5％人血自蛋白，HES组（n=20）给予第三代羟乙基淀粉（6％HES130／0．4）。胶体总量被限制在50ml·kg^-1·d^-1，容量输注使肺小动脉楔压或中心静脉压维持在5—7mmHg。如需要额外的液体，则用平衡盐溶液替代。麻醉和手术操作过程均被标准化。分别测定麻醉诱导后、手术结束时、手术后前4天的动脉血肌酐和血清半胱氨酸蛋白酶抑制剂C（cystatin C）血浆水平。结果所有40例登记患者完成了研究。两组患者的人口统计学及手术中变量均具有可比性。手术后胶体液输入量分别是HES组6229±1140ml和ALB组4636±1153ml（P=0．003）。与ALB组（1100±900m1）相比，HES组（3047±2000ml）有更大的净累积液体平衡量（P=0．029）。两组血肌酐水平、肌酐清除率、cystafin C血浆水平差异无显著性。每组各有一例患者合并急性肾功能衰竭需行肾脏替代治疗。结论HES130／0．4做为人血白蛋白的替代品对肝移植术后肾功能的影响与后者相似。

关键词：羟乙基淀粉130 人血白蛋白活体肝移植安全性急性肾功能衰竭半胱氨酸蛋白酶抑制剂围手术期管理肝移植患者

Exploring the factors influencing nurses' work motivation during the COVID-19 pandemic in King Faisal Hospital in makkah al-mukarramah, Saudi Arabia

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Nursing Communications 2022年第1期6卷 148-155页

作者： Albandre Alenezi mari Almutairi mohammed Saleh Alshmemri maram Taher Alghabbashi Hala yehia Faculty of Nursing Umm Al-Qura UniversityMakkah 24382Saudi Arabia ministry of health The Directorate of Health affairs in Northern ProvinceAr a r 91471Saudi Arabia

Background:At this time of severe budgetary constraints and worldwide nursing shortages,the nursing profession is already facing challenges in keeping its professionals motivated to work during the COVID-19 *** study explores the factors influencing nurses’work motivation during the COVID-19 pandemic in Saudi *** s:A descriptive quantitative cross-sectional study was conducted at King Faisal Hospital in makkah al-mukarramah,Saudi Arabia.A convenience sample of 184 nurses participated in the *** electronic self-administrative questionnaire in the English language was used to collect *** comprises two parts:demographic data and the multidimensional Work motivation Scale(mWmS)using a 7-point Likert *** of variance(ANOVA)and t-tests were utilized to identify the differences in mWmS scores among participants’***:The study found that the overall mean score for the mWmS scale accounted for m=81.32,SD=18.66,with the highest mean score reported for interjected regulation(m=20.19,SD=5.59).moreover,the results revealed that 62%of the participants attained an average level on the overall *** addition,the ANOVA and t-test showed a significant overall effect of the duration of nurses’work experience,the unit of care,the number of working hours per week and salary on nurses’work motivation during COVID-19 at Pministrators and nursing managers should pay careful attention to nurses’work motivation and related factors to increase nurses’quality performance,retention and satisfaction.

关键词： nurses work satisfaction motivation COVID-19 Saudi Arabia