Biomarkers of Barrett's esophagus

作     者：Yasser Mahrous Fouad Ibrahim Mostafa Reem Yehia Hisham El-Khayat 

作者机构：Gastroenterology and Hepatology Unit Tropical Medicine Department Minia University Gastroenterology and Hepatology Department Theodore Research Institute 

出 版 物：《World Journal of Gastrointestinal Pathophysiology》 (世界胃肠病理生理学杂志（英文版）（电子版）)

年 卷 期：2014年第5卷第4期

页      面：450-456页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Barrett’s esophagus Esophageal adenocarcinoma Biomarkers 

摘      要：Barrett s esophagus is the strongest risk for esophageal adenocarcinoma(EAC). Metaplasia in patients with BE may progress to dysplasia and then invasive carcinoma. Well-defined diagnostic, progressive, predictive, and prognostic biomarkers are needed to identify the presence of the disease, estimate the risk of malignant transformation, and predict the therapeutic outcome and survival of EAC patients. There are many predictive and prognostic markers that lack substantial validation, and do not allow stratification of patients with gastroesophageal reflux disease in clinical practice for outcome and effectiveness of therapy. In this short review we summarize the current knowledge regarding possible biomarkers, focusing on the pathophysiologic mechanisms to improve prognostic and therapeutic approaches.