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Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function

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Neural Regeneration Research 2023年第11期18卷 2497-2503页

作者： yeonghoon Son Hye-Jin Park ye Ji Jeong Hyung-Do Choi Nam kim Hae-June Lee Division of Radiation Biomedical Research Korea Institute of Radiological&Medical SciencesSeoulKorea Department of EMF Research Team Radio and Broadcasting Technology LaboratoryElectronics and Telecommunications Research InstituteDaejonKorea School of Electrical and Computer Engineering Chungbuk National UniversityCheongjuKorea

We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including *** examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 *** conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain *** confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-β*** expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed ***,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated *** radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by *** res

关键词： 5×FAD Alzheimer’s disease CSF1R long term exposure microglial function neuroinflammation radiofrequency electromagnetic fields therapeutic effect

Hemodynamic instability following intravenous dexmedetomidine infusion for sedation under brachial plexus block: Two case reports

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World Journal of Clinical Cases 2023年第30期11卷 7469-7474页

作者： ye Sull kim Chanhong Lee Jeongmin Oh seonhwa Nam A Ram Doo Department of Anesthesiology and Pain Medicine Jeonbuk National University HospitalJeonju 54907South Korea Department of Anesthesiology and Pain Medicine Jeonbuk National University Medical School and HospitalJeonju 54907South Korea Department of Anesthesiology and Pain Medicine Research Institute of Clinical Medicine-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND Dexmedetomidine(DMED)is frequently used as a sedative in several medical *** benefits of DMED include enhanced quality of regional anesthesia,prolonged analgesia,and postoperative opioid-sparing when administered intravenously or perineurally in combination with regional *** hemodynamic complications,such as profound bradycardia and hypotension,can occur after DMED administration in critically ill patients or overdosage;however,there are few reports of complications with DMED administration following brachial plexus block(BPB).CASE SUMMARY We present two cases of hemodynamic instability that occurred following the initial loading of DMED under supraclavicular BPB.A healthy 29-year-old man without any medical history showed profound bradycardia after receiving a loading dose of DMED 0.9μg/kg for 9 *** administration was promptly stopped,and after receiving a second dose of atropine,the heart rate recovered.A 62-year-old woman with a history of cardiomyopathy became hypotensive abruptly,requiring the administration of inotrope and vasopressors after receiving a reduced loading dose of 0.5μg/kg for 10 *** of the recommended loading dose of DMED was administered due to the underlying heart ***-sed blood pressure was maintained despite the intravenous administration of *** continuous infusion of dopamine and norepinephrine,the vital signs were maintained within normal *** and vasopressor support was required for over 6 h after the initial loading dose of *** DMED administration following BPB could trigger hemodynamic instability in patients with decreased cardiac function as well as in healthy individuals.

关键词： Dexmedetomidine Brachial plexus block Profound bradycardia Complication Hypotension Instability Case report

A Framework of Deep Learning and Selection-Based Breast Cancer Detection from Histopathology Images

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Computer Systems Science & Engineering 2023年第5期45卷 1001-1016页

作者： Muhammad Junaid Umer Muhammad Sharif Majed Alhaisoni Usman Tariq ye Jin kim Byoungchol Chang Department of Computer Science COMSATS University IslamabadWah CampusWah CanttPakistan Computer Sciences Department College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman University(PNU)P.O.BOX 84428Riyadh11671Saudi Arabia College of Computer Engineering and Science Prince Sattam Bin Abdulaziz UniversityAl-Kharaj11942Saudi Arabia Department of Computer Science Hanyang UniversitySeoul04763Korea Center for Computational Social Science Hanyang UniversitySeoul04763Korea

Breast cancer(BC)is a most spreading and deadly cancerous malady which is mostly diagnosed in middle-aged women worldwide and effecting beyond a half-million people every *** BC positive newly diagnosed cases in 2018 reached 2.1 million around the world with a death rate of 11.6%of total *** diagnosis and detection of breast cancer disease with proper treatment may reduce the number of *** gold standard for BC detection is biopsy analysis which needs an expert for correct *** diagnosis of BC is a complex and challenging *** work proposed a deep learning-based(DL)solution for the early detection of this deadly disease from histopathology *** evaluate the robustness of the proposed method a large publically available breast histopathology image database containing a total of 277524 histopathology images is *** proposed automatic diagnosis of BC detection and classification mainly involves three ***,a DL model is proposed for feature ***,the extracted feature vector(FV)is passed to the proposed novel feature selection(FS)framework for the best ***,for the classification of BC into invasive ductal carcinoma(IDC)and normal class different machine learning(ML)algorithms are *** outcomes of the proposed methodology achieved the highest accuracy of 92.7%which shows that the proposed technique can successfully be implemented for BC detection to aid the pathologists in the early and accurate diagnosis of BC.

关键词： Breast cancer deep learning FS IDC ML SVM

Apalutamide for patients with metastatic castrationsensitive prostate cancer in East Asia:a subgroup analysis of the TITAN trial

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Asian Journal of Andrology 2022年第2期24卷 161-166页

作者： Byung Ha Chung Jian Huang Zhang-Qun ye Da-Lin He Hirotsugu Uemura Gaku Arai Choung Soo kim Yuan-Yuan Zhang Yusoke Koroki Suyeon Jeong Suneel Mundle Spyros Triantos Sharon McCarthy kim N Chi Ding-Wei ye Department of Urology Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-roGangnam-guSeoul 135-271Korea Sun Yat-Sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China Wuhan Tongji Hospital Tongji Medical CollegeWuhan 430030China First Affiliated Hospital of Xi’an Jiaotong University Xi’an 719054China Kindai University Hospital Ōsakasayama 589-8511Japan Dokkyo Medical University Saitama Medical Center Saitama 2-1-50Japan Asian Medical Center University of UlsanSeoul 138-040Korea Janssen Medical Affairs Department Beijing 100025China Janssen Medical Affairs Department Tokyo 101-0065Japan Janssen Medical Affairs Department Seoul 140-012Korea Janssen Global Medical Affairs Department HorshamPA 08869USA Janssen Research and Development Spring HousePA 19477USA Janssen Research and Development RaritanNJ 08869USA BC Cancer and Vancouver Prostate Centre VancouverBC V5Z 1G1Canada Fudan University Shanghai Cancer Center Shanghai 200032China

Ethnicity might be associated with treatment outcomes in advanced prostate *** study aimed to evaluate the efficacy and safety of androgen deprivation therapy(ADT)combined with apalutamide in East Asians with metastatic castration-sensitive prostate cancer(mCSPC).The original phase 3 Targeted Investigational Treatment Analysis of Novel Anti-androgen(TITAN)trial was conducted at 260 sites in 23 *** subgroup analysis included patients enrolled in 62 participating centers in China,Japan,and *** progression-free survival(PFS),time to prostate-specific antigen(PSA)progression,and PSA changes from baseline were compared between groups in the East Asian *** intent-to-treat East Asian population included 111 and 110 participants in the apalutamide and placebo groups,*** 24-month radiographic PFS rates were 76.1%and 52.3%in the apalutamide and placebo groups,respectively(apalutamide vs placebo:hazard ratio[HR]=0.506;95%confidence interval[CI],0.302–0.849;P=0.009).Median time to PSA progression was more favorable with apalutamide than placebo(HR=0.210;95%CI,0.124–0.357;P<0.001).Median maximum percentages of PSA decline from baseline were 99.0%and 73.9%in the apalutamide and placebo groups,*** most common adverse event(AE)was rash in the apalutamide group,with a higher rate than that in the placebo group(37.3%vs 9.1%).The most common grade 3 or 4 AEs were rash(12[10.9%])and hypertension(12[10.9%])for *** efficacy and safety of apalutamide in the East Asian subgroup of the TITAN trial are consistent with the global results.

关键词： apalutamide East Asia metastasis prostatic neoplasm survival

Alternating current electrolysis:A photoredox catalysis mimic and beyond

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Green Synthesis and Catalysis 2022年第1期3卷 4-10页

作者： Junsong Zhong Chenglin Ding Hyunwoo kim Terry McCallum Keyin ye Institute of Pharmaceutical Science and Technology College of ChemistryFuzhou UniversityFuzhou 350108China Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul 03760South Korea The Canadian Bank Note Company OttawaOntario 91758Canada State Key Laboratory of Physical Chemistry of Solid Surfaces Xiamen UniversityXiamen 361005China

Alternating current electrolysis(ACE)is an emerging powerful synthetic tool,which principally resembles photoredox catalysis *** periodically alternating polarity feature allows oxidation and reduction processes to take place on the same electrode surface in a well-controlled manner via the fine-tuning of current frequency along with other reaction ***,many challenging transformations in typical direct electrolysis,including constant current electrolysis or constant potential electrolysis,could be achieved via *** recent advances in the organic synthesis using this emerging technology and its advantages over direct electrolysis are highlighted.

关键词： Electrochemistry Photoredox catalysis Alternating current electrolysis Green chemistry Selectivity

Human Gait Recognition Based on Sequential Deep Learning and Best Features Selection

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Computers, Materials & Continua 2023年第6期75卷 5123-5140页

作者： Ch Avais Hanif Muhammad Ali Mughal Muhammad Attique Khan Usman Tariq ye Jin kim Jae-Hyuk Cha Department of Electrical Engineering HITEC UniversityTaxilaPakistan Department of Computer Science HITEC UniversityTaxilaPakistan College of Computer Engineering and Science Prince Sattam Bin Abdulaziz UniversityAl-Kharaj11942Saudi Arabia Department of Computer Science Hanyang UniversitySeoul04763Korea

Gait recognition is an active research area that uses a walking theme to identify the subject *** Gait Recognition(HGR)is performed without any cooperation from the ***,in practice,it remains a challenging task under diverse walking sequences due to the covariant factors such as normal walking and walking with wearing a ***,over the years,have worked on successfully identifying subjects using different techniques,but there is still room for improvement in accuracy due to these covariant *** paper proposes an automated model-free framework for human gait recognition in this *** are a few critical steps in the proposed ***,optical flow-based motion region esti-mation and dynamic coordinates-based cropping are *** second step involves training a fine-tuned pre-trained MobileNetV2 model on both original and optical flow cropped frames;the training has been conducted using static *** third step proposed a fusion technique known as normal distribution serially *** the fourth step,a better optimization algorithm is applied to select the best features,which are then classified using a Bi-Layered neural *** publicly available datasets,CASIA A,CASIA B,and CASIA C,were used in the experimental process and obtained average accuracies of 99.6%,91.6%,and 95.02%,*** proposed framework has achieved improved accuracy compared to the other methods.

关键词： Human gait recognition optical flow deep learning features fusion feature selection

Survival improvement and prognostic factors in recent management of extrahepatic cholangiocarcinoma:A single-center study

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 153-156页

作者： Jung Wan Choe Hyo Jung kim Jae seon kim Division of Gastroenterology Department of Internal MedicineKorea University Ansan HospitalKorea University College of Medicine516 Gojan-dongDanwon-guAnsan-siGyeonggi-do15355Korea Division of Gastroenterology Department of Internal MedicineKorea University Guro HospitalKorea University College of Medicine148 Gurodong-roGuro-guSeoul 08308Korea

Background:Cholangiocarcinoma was considered as a dismal disease with very poor prognosis until *** is increasingly found due to increased life *** surgical and medical management were advanced recently,data on the prognosis,especially extrahepatic cholangio-carcinoma(ECC),were *** study aimed to identify clinicopathologic features and prognosis of patients with ***:Patients followed up and diagnosed with ECC between January 2014 and December 2016 at a tertiary hospital were included,whereas those with intrahepatic cholangiocarcinoma,gallbladder cancer,and ampullary cancer were ***:A total of 83 patients were followed after the treatment(49 men and 34 women;median age 73.3 years).Cancer location was classified as distal common bile duct(25 patients),proximal com-mon bile duct(24 patients),common hepatic duct(20 patients),and hilar(14 patients).About 14.5%of patients had history of another malignant neoplasm,and 24.1%patients had chronic ***-cal resection was performed in 54 patients(65%)and dysplasia was combined in 63%(34/54).Adjuvant chemotherapy was performed in 54%(29/54),but only 7 underwent palliative chemotherapy in 29 non-surgical *** median overall survival in all patients was 30.9 *** analyzing the treatment modality,median survival of adjuvant chemotherapy,surgery only,palliative chemotherapy,and support-ive care groups were 42.9,30.9,12.0,and 8.9 months,respectively(P<0.05).In the Cox regression analy-sis of survival,age,surgical resection,chemotherapy,and comorbidity were significant prognostic factors,and the comorbidity was the only significant prognostic factor in the multivariable analysis(hazard ratio[HR]=2.80;95%CI:1.32–5.95;P=0.007).In a subgroup analysis of surgical patients,the presence of dysplasia was a favorable prognostic factor in the multivariable analysis(HR=0.29;95%CI:0.09–0.91;P=0.033).Conclusions:The overall survival of patients with ECC wa

关键词： Cholangiocarcinoma Survival Prognosis

Inorganic Halide Perovskite Quantum Dots:A Versatile Nanomaterial Platform for Electronic Applications

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Nano-Micro Letters 2023年第2期15卷 1-31页

作者： Chien‑Yu Huang Hanchen Li ye Wu Chun‑Ho Lin Xinwei Guan Long Hu Jiyun kim Xiaoming Zhu Haibo Zeng Tom Wu School of Materials Science and Engineering University of New South WalesSydney 2052Australia MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics and NanomaterialsCollege of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094People’s Republic of China

Metal halide perovskites have generated significant attention in recent years because of their extraordinary physical properties and photovoltaic *** these,inorganic perovskite quantum dots(QDs)stand out for their prominent merits,such as quantum confinement effects,high photoluminescence quantum yield,and defect-tolerant ***,ligand engineering and an all-inorganic composition lead to a robust platform for ambient-stable QD *** review presents the state-of-the-art research progress on inorganic perovskite QDs,emphasizing their electronic *** detail,the physical properties of inorganic perovskite QDs will be introduced first,followed by a discussion of synthesis methods and growth ***,the emerging applications of inorganic perovskite QDs in electronics,including transistors and memories,will be ***,this review will provide an outlook on potential strategies for advancing inorganic perovskite QD technologies.

关键词： Inorganic perovskite Quantum dots Electronics Nanocrystals Quantum confinement effects

WiMA:Towards a Multi-Criterion Association in Software Defined Wi-Fi Networks

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Computers, Materials & Continua 2023年第5期75卷 2347-2363页

作者： Sohaib Manzoor Hira Manzoor Saddaf Rubab Muhammad Attique Khan Majed Alhaisoni Abdullah Alqahtani ye Jin kim Byoungchol Chang Department of Electrical Engineering Mirpur University of Science and Technology(MUST)Mirpur-10250(AJK)Pakistan Faculty of Electronics Telecommunications and InformaticsGdansk University of Technology80-233 GdanskPoland Department of Computer Engineering College of Computing and InformaticsUniversity of SharjahSharjah27272United Arab Emirates National University of Sciences and Technology(NUST) Islamabad44000Pakistan Department of Computer Science HITEC UniversityTaxilaPakistan Computer Sciences Department College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia College of Computer Engineering and Sciences Prince Sattam bin Abdulaziz UniversityAl-KharjSaudi Arabia Department of Computer Science Hanyang UniversitySeoul04763Korea Center for Computational Social Science Hanyang UniversitySeoul04763Korea

Despite the planned installation and operations of the traditional IEEE 802.11 networks,they still experience degraded performance due to the number of *** of the main reasons is the received signal strength indicator(RSSI)association problem,in which the user remains connected to the access point(AP)unless the RSSI becomes too *** this paper,we propose a multi-criterion association(WiMA)scheme based on software defined networking(SDN)in Wi-Fi *** association solution based on multi-criterion such as AP load,RSSI,and channel occupancy is proposed to satisfy the quality of service(QoS).SDNhaving an overall view of the network takes the association and reassociation decisions making the handoffs smooth in throughput *** implementWiMA extensive simulations runs are carried out on Mininet-NS3-Wi-Fi network *** performance evaluation shows that the WiMA significantly reduces the average number of retransmissions by 5%–30%and enhances the throughput by 20%–50%,hence maintaining user fairness and accommodating more wireless devices and traffic load in the network,when compared to traditional client-driven(CD)approach and state of the art Wi-Balance approach.

关键词： Association multi-criterion SDN Wi-Fi