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Prevalence and Patterns of Multimorbidity Among Adults Aged 18 years and Older—China,2018

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China CDC weekly 2023年第2期5卷 35-39,I0004,I0005页

作者： ye geng Wan Jie Yuan He Xiaolong Zhou Sijia Zhang Wenlan Dong Zhenping Zhao Xiaoguang Cheng Jing Wu School of Public Health China Medical UniversityShenyang CityLiaoning ProvinceChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Baotou Medical College Baotou CityInner Mongolia Autonomous RegionChina Department of Radiology Beijing Jishuitan HospitalBeijingChina.

Summary What is already known about this topic?Multimorbidity is becoming more common and poses a major challenge to healthcare systems.However,the prevalence and patterns of multimorbidity among Chinese adults aged≥18 years are largely unknown.What is added by this report?This study found that 46.5% of Chinese adults had multimorbidity in 2018.And the prevalence of multimorbidity prevalence is increased with age.Prevalence of multimorbidity was higher among men,Han Chinese,adults with lower educational level,and those with lower household income.The most common multimorbidity pattern is a combination of three chronic conditions,hypertension,dyslipidemia,and obesity.

关键词： morbidity prevalence obesity

排放源废气CO_(2)连续监测分析方法解析

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环境与发展 2024年第1期36卷 38-42页

作者：耿晔王鹏王刚山东省济南生态环境监测中心山东济南250101 山东城控检测技术有限公司山东济南250014

为解决我国CO_(2)连续监测在排放源废气监测体系中的缺失,完成碳中和、碳达峰远景目标,系统的梳理了NDIR、TDLAS、FTIR等常见的排放源废气中CO_(2)连续监测分析方法,同时分析了国内外相关的监测标准的差异性,提出了加强CO_(2)连续监测... 详细信息

为解决我国CO_(2)连续监测在排放源废气监测体系中的缺失,完成碳中和、碳达峰远景目标,系统的梳理了NDIR、TDLAS、FTIR等常见的排放源废气中CO_(2)连续监测分析方法,同时分析了国内外相关的监测标准的差异性,提出了加强CO_(2)连续监测设备研发和优化设备选型,以设备性能约束指标为依托,尽快建立完善的排放源CO_(2)连续监测体系等方面的建议。

关键词：二氧化碳可调谐半导体激光吸收光谱法零点漂移示值误差

TP53突变和缺失对弥漫大B细胞淋巴瘤患者预后影响的研究

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现代肿瘤医学 2024年第3期32卷 518-523页

作者：古佳白斯君耿晔贺建霞晋城市人民医院血液科山西晋城048000 山西医科大学第五临床医学院山西省人民医院血液科山西太原030012

目的:探讨TP53突变和缺失对弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma, DLBCL)患者预后的影响。方法:收集我院2017至2020年94例初发DLBCL患者的石蜡病理组织,应用免疫组化及二代测序检测TP53突变,FISH技术检测TP53缺失,分析TP5... 详细信息

目的:探讨TP53突变和缺失对弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma, DLBCL)患者预后的影响。方法:收集我院2017至2020年94例初发DLBCL患者的石蜡病理组织,应用免疫组化及二代测序检测TP53突变,FISH技术检测TP53缺失,分析TP53突变、缺失与临床病理及分子分型的相关性,以及对生存的影响。应用COX回归分析DLBCL的生存影响因素。结果:27.7%(26/94)患者过表达p53,23.5%(19/81)患者存在TP53突变,16.0%(15/94)患者TP53缺失,结外受累(P=0.027)、MUM-1(P=0.04)及p53蛋白(P<0.01)表达在在TP53突变和/或缺失及TP53正常两组中存在明显差异。生存分析显示,“双阳性(TP53突变合并缺失)”组生存最差,“双阴性(无TP53突变及缺失)”组预后最好,TP53突变或缺失则次之,其中单突变与单缺失两组总生存无明显统计学差异(P=0.689),其余各组之间生存有显著差异(P<0.05)。GCB中,TP53突变组预后较差(P=0.046)。多因素分析显示合并B症状、TP53异常及双表达是影响DLBCL生存的独立危险因素。结论:TP53突变或缺失,特别是同时合并突变和缺失是DLBCL的不良预后因素,在新的分子分型中,其预后意义仍值得进一步的深入研究。

关键词：弥漫大B细胞淋巴瘤 TP53 突变缺失预后

A frequency servo SoC with output power stabilization loop technology for miniaturized atomic clocks

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Journal of Semiconductors 2024年第6期45卷 13-22页

作者： Hongyang Zhang Xinlin geng Zonglin ye Kailei Wang Qian Xie Zheng Wang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

A frequency servo system-on-chip(FS-SoC)featuring output power stabilization technology is introduced in this study for high-precision and miniaturized cesium(Cs)atomic clocks.The proposed power stabilization loop(PSL)technique,incorporating an off-chip power detector(PD),ensures that the output power of the FS-SoC remains stable,mitigating the impact of power fluctuations on the atomic clock's stability.Additionally,a one-pulse-per-second(1PPS)is employed to syn-chronize the clock with GPS.Fabricated using 65 nm CMOS technology,the measured phase noise of the FS-SoC stands at-69.5 dBc/Hz@100 Hz offset and-83.9 dBc/Hz@1 kHz offset,accompanied by a power dissipation of 19.7 mW.The Cs atomic clock employing the proposed FS-SoC and PSL obtains an Allan deviation of 1.7×10^(-11) with 1-s averaging time.

关键词： CMOS technology atomic clock phase-locked loop output power stabilization 1PPS

Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex,mesocortex,and cerebellum

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Genes & Diseases 2024年第1期11卷 53-56页

作者： ye Cheng Lei Zhang Xiaolong Wu Hiroaki Wakimoto Haoming geng Yukui Wei geng Xu Xinru Xiao Jie Bai Yaming Wang Zeliang Hu Leiming Wang Qingtang Lian Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Brain Tumor Research Center Massachusetts General HospitalDepartment of NeurosurgeryHarvard Medical SchoolBostonMA02134USA Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Gliomas originating from anatomically and developmentally distinct brain regions have different clinical outcomes.However,the molecular landscape underlying this difference remains largelyunknown.We analyzed key molecular mutations via sequencing and correlated them with clinical characteristics in 180 adult patients with gliomas originating from the neocortex,mesocortex,and cerebellum.Cases of cerebellar origin had significantly longer survival than those of supratentorial origin,consistent with higher rates of mutation in key genes associated with supratentorial gliomas.

关键词： clinical cortex glioma

地西他滨联合阿霉素对TP53突变弥漫大B淋巴瘤细胞株的影响及临床意义研究

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临床血液学杂志 2024年第1期37卷 56-61页

作者：郑艳丽贺建霞白斯君耿晔高轶男张彩霞山西医科大学第五临床医学院太原030012 山西省人民医院血液科

目的:观察地西他滨对TP53突变弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)细胞株DB增殖、凋亡及周期的影响,并评估地西他滨联合治疗TP53突变DLBCL患者的疗效及安全性。方法:体外培养细胞,不同浓度(5~80μmol/L)地西他滨和... 详细信息

目的:观察地西他滨对TP53突变弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)细胞株DB增殖、凋亡及周期的影响,并评估地西他滨联合治疗TP53突变DLBCL患者的疗效及安全性。方法:体外培养细胞,不同浓度(5~80μmol/L)地西他滨和阿霉素作用于DB细胞后采用CCK-8法计算增殖抑制率;地西他滨(20μmol/L)和阿霉素(12μmol/L)作用于DB细胞24/48 h,采用Annexin V-FITC/PI及流式细胞术检测凋亡率及细胞周期;比较不同组间细胞增殖、凋亡及周期的差异。另收集5例地西他滨联合治疗TP53突变DLBCL患者的临床资料进行回顾性总结。结果:对DB细胞的增殖抑制作用随着地西他滨浓度的增加(5、10、20、40、80μmol/L)而增强,联合阿霉素(12μmol/L)后抑制率较单药明显增大[(78.51±1.19)%vs(40.80±1.62)%,(87.48±0.29)%vs(46.83±1.47)%,(92.59±0.15)%vs(47.07±1.50)%,(94.57±0.58)%vs(52.68±0.84)%,(95.56±0.53)%vs(54.95±1.07)%,P<0.01];采用IC50浓度(20μmol/L地西他滨、12μmol/L阿霉素)药物处理细胞,抑制率随时间增加(12、24、48 h)而增大[(50.40±0.19)%、(61.65±0.16)%、(85.08±0.78)%,P<0.01]。与空白对照组比较,地西他滨作用于DB细胞24 h显示S期细胞比例增加[(10.54±0.40)%vs(2.03±0.01)%,P<0.01],48 h显示G2/M期细胞比例增加[(17.45±0.19)%vs(3.69±0.09)%,P<0.01]。5例复发/难治TP53突变DLBCL患者使用含有地西他滨方案治疗后,总有效率为40%(2/5),主要不良反应为骨髓抑制,未出现治疗相关死亡。结论:地西他滨可增强阿霉素对TP53突变DLBCL细胞株的增殖抑制作用,阻滞细胞周期。含地西他滨方案治疗TP53突变DLBCL显示出一定疗效,安全性良好,值得进一步探索。

关键词：弥漫大B细胞淋巴瘤复发/难治 TP53突变阿霉素地西他滨

TRD在某垃圾填埋场垂直防渗工程中的应用研究

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地基处理 2024年第3期6卷 284-295页

作者：刘晨阳叶更强徐晓兵胡琦丁继民薛道寒浙江工业大学土木工程学院浙江杭州310014 中国电建集团华东勘测设计研究院有限公司浙江杭州311122 广西大学土木建筑工程学院广西南宁530004 东通岩土科技股份有限公司浙江杭州310020

在垃圾填埋场垂直防渗工程中,渠式切割水泥土连续墙(Trench Cutting Re-Mixing Deep Wall,TRD)作为防渗墙,其设计方法、施工控制要点和实施效果仍缺乏足够的研究。本文依托滨海平原地区某垃圾填埋场封场覆盖及生态修复工程,根据项目工... 详细信息

在垃圾填埋场垂直防渗工程中,渠式切割水泥土连续墙(Trench Cutting Re-Mixing Deep Wall,TRD)作为防渗墙,其设计方法、施工控制要点和实施效果仍缺乏足够的研究。本文依托滨海平原地区某垃圾填埋场封场覆盖及生态修复工程,根据项目工程地质特点,比较不同防渗墙的适用性,设计了TRD联合高压旋喷桩的施工方案,在两幅TRD之间搭接一排高压旋喷桩,搭接宽度为300 mm。通过试成墙试验,确定了TRD的施工参数,并对其成墙质量进行了原位降水头注水试验、钻孔取芯试验、水泥土试块试验。原位降水头注水试验结果表明:防渗墙渗透系数为1.13×10^(−8)~6.67×10^(−7) cm/s;钻孔取芯试验结果表明:钻孔取芯芯样率较高,墙体沿深度均一性较好,芯样无侧限抗压强度为0.77~1.76 MPa,渗透系数为1.61×10^(−8)~9.96×10^(−7) cm/s;水泥土试块试验结果表明:无侧限抗压强度为4.7~23.1 MPa,渗透系数为1.6×10^(−8)~9.0×10^(−8) cm/s。检测结果表明,TRD垂直防渗墙在滨海平原地区垃圾填埋场工程中施工效果较好,满足垃圾填埋场垂直防渗墙的设计要求。

关键词：填埋场垂直防渗渠式切割水泥土连续墙无侧限抗压强度渗透系数

Enemies atpeace:Recentprogressin Agrobacterium-mediated cereal transformation

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The Crop Journal 2024年第2期12卷 321-329页

作者： Shaoshuai Liu Ke Wang Shuaifeng geng Moammar Hossain Xingguo ye Aili Li Long Mao Karl-Heinz Kogel State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Institute of Phytopathology Centre for BioSystemsLand Use and NutritionJustus Liebig UniversityHeinrich Buff-Ring 26-32D-35392GiessenGermany

Agrobacterium tumefaciens mediated plant transformation is a versatile tool for plant genetic engineering following its discovery nearly half a century ago.Numerous modifications were made in its application to increase efficiency,especially in the recalcitrant major cereals plants.Recent breakthroughs in transformation efficiency continue its role as a mainstream technique in CRISPR/Cas-based genome editing and gene stacking.These modifications led to higher transformation frequency and lower but more stable transgene copies with the capability to revolutionize modern agriculture.In this review,we provide a brief overview of the history of Agrobacterium-mediated plant transformation and focus on the most recent progress to improve the system in both the Agrobacterium and the host recipient.A promising future for transformation in biotechnology and agriculture is predicted.

关键词： Agrobacterium tumefaciens Cereal species Genome editing Genetic engineering Plant breeding

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Protective effects and microarray-based mechanism of sea cucumber hydrolysates against high-glucose induced nephrotoxicity in mouse glomerulus mesangial cells

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未来食品学报(英文) 2024年第3期4卷 233-240页

作者： Lingxin geng Jiaojiao Han Jun Zhou ye Li Tinghong Ming Zhen Zhang Chenyang Lu Xiurong Su State Key Laboratory for Quality and Safety of Argo-products School of Marine ScienceNingbo UniversityNingbo 315211China

Diabetic nephropathy(DN)is a common type of end-stage renal disease and glomerular mesangial cells(GMCs)are widely used as a cell model for DN.This study firstly investigated the inhibitory effects of the Apostichopus japonicus and Acaudina leucoprocta hydrolysates on cellular growth under high-glucose treatment,better inhibitory effect of A.japonicus hydrolysate was observed compared to that of A.leucoprocta hydrolysate.Subsequently,the global transcription profiles obtained via microarray analysis showed that 6070 and 7015 genes were identified in the A.japonicus and A.leucoprocta groups compared with the model group,respectively.Among them,transcriptions of the slc30a4,slc35dl,tppp3,tp53inpl,bcl-2,apafl,alox12b and adrala genes were restored from the levels of the model group to those of the control group,contributed to cell mitosis and proliferation in both treatment groups.In addition,other apoptosis-related genes,such as bcl-6,clu,foxo3 and akt,showed opposite trends between two groups,which might cause the difference in inhibitory effect.We preliminarily proposed that the regulation effects of A.japonicus and A.leucoprocta on the genes involved in cellular mitosis,proliferation and apoptosis,might contribute to their inhibitory activity on GMCs under high-glucose environment.

关键词： Diabetic nephropathy Apostichopus japonicus Acaudina leucoprocta Hydrolysate Rat mesangial cell Microarray