Marginal zone lymphoma with severe rashes: A case report

作     者：Si-Jun Bai Ye Geng Yi-Nan Gao Cai-Xia Zhang Qian Mi Chen Zhang Jia-Ling Yang Si-Jie He Zhen-YingYan Jian-Xia He 

作者机构：Department of HematologyShanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2024年第12卷第3期

页      面：565-574页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Marginal zone lymphoma Mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab,Obinutuzumab Zanubrutinib Case report 

摘      要：BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial *** SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent ***-line treatment with rituximab combined with zanubrutinib had poor ***,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes *** For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be *** approach may provide a new perspective in the treatment of MZL.