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Atmospheric and Oceanic Science Letters 2022年第5期15卷 8-13页

作者： yating nan Jianqi Sun Mengqi Zhang Haixu Hong Junpeng Yuan Department of Atmospheric Sciences Yunnan UniversityKunmingChina nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina

The relationship between variations in the East Asian trough(EAT)intensity and spring extreme precipitation over Southwest China(SWC)during 1961-2020 is *** results indicate that there is an interdecadal increase in the relationship between the EAT and spring extreme precipitation over eastern SWC around the late1980 *** the latter period,the weak(strong)EAT corresponds to a strong and large-scale anomalous anticyclone(cyclone)over the East Asia-Northwest Pacific *** EAT-related anomalous southerlies(northerlies)dominate eastern SWC,leading to significant upward(downward)motion and moisture convergence(divergence)over the region,providing favorable(unfavorable)dynamic and moisture conditions for extreme precipitation over eastern *** contrast,during the former period,the EAT-related circulation anomalies are weak and cover a relatively smaller region,which cannot significantly affect the moisture and dynamic conditions over eastern SWC;therefore,the response in extreme precipitation over eastern SWC to EAT is weak over the *** interdecadal change in the relationship between eastern SWC spring extreme precipitation and the EAT could be related to the interdecadal change in the EAT *** large(small)variability of the EAT is associated with significant(insignificant)changes in spring extreme precipitation over eastern SWC during the latter(former)period.

关键词： Spring extreme precipitation Southwest China East Asian trough

Measurement of air exchange rates in different indoor environments using continuous CO_2 sensors

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Journal of Environmental Sciences 2012年第4期24卷 657-664页

作者： Yan You Can Niu Jian Zhou yating Liu Zhipeng Bai Jiefeng Zhang Fei He nan Zhang State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control College of Environmental Sciences and EngineeringNankai UniversityTianjin 300071China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China

A new air exchange rate （AER） monitoring method using continuous CO2 sensors was developed and validated through both laboratory experiments and field studies. Controlled laboratory simulation tests were conducted in a 1-m3 environmental chamber at different AERs （0.1-10.0 hr-1）. AERs were determined using the decay method based on box model assumptions. Field tests were conducted in classrooms, dormitories, meeting rooms and apartments during 2-5 weekdays using CO2 sensors coupled with data loggers. Indoor temperature, relative humidity （RH）, and CO2 concentrations were continuously monitored while outdoor parameters combined with on-site climate conditions were recorded. Statistical results indicated that good laboratory performance was achieved： duplicate precision was within 10%, and the measured AERs were 90%-120% of the real AERs. Average AERs were 1.22, 1.37, 1.10, 1.91 and 0.73 hr-l in dormitories, air-conditioned classrooms, classrooms with an air circulation cooling system, reading rooms, and meeting rooms, respectively. In an elderly particulate matter exposure study, all the homes had AER values ranging from 0.29 to 3.46 hr-1 in fall, and 0.12 to 1.39 hr-1 in winter with a median AER of 1.15.

关键词： air exchange rate continuous CO2 sensor steady-state method decay method particulate matter indoor-outdoorconcentration relationship

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

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Frontiers of Medicine 2023年第5期17卷 924-938页

作者： Pengfei Zhao yating Wang Xiao Yu Yabing nan Shi Liu Bin Li Zhumei Cui Zhihua Liu State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Department of Gynecological Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Department of Obstetrics and Gynecology The Affiliated Hospital of Qingdao UniversityQingdao266000China

Long noncoding RNAs(lncRNAs)play a crucial regulatory role in the development and progression of multiple ***,the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains *** the current study,the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary ***-and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation,invasiveness,and metastasis of ovarian cancer cells in vivo and in ***,the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor ***,LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1,which is necessary for suppressing tumor metastasis and inhibiting KRAS ***,our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer,which may be a potential prognostic biomarker.

关键词： 0varian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1

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Maternal Bisphenol B Exposure and Mammary Gland Development of Offspring:A Time-Series Analysis

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Environment & Health 2023年第4期1卷 278-290页

作者： Xiaotong Ji Peiyun Jiang yating Li Lihong Su Huifeng Yue nan Sang Department of Environmental Health School of Public HealthShanxi Medical UniversityTaiyuanShanxi 030001P.R.China Key Laboratory of Coal Environmental Pathogenicity and Prevention(Shanxi Medical University) Ministry of EducationTaiyuanShanxi 030001P.R.China Department of Pathology Shanxi Provincial People’s HospitalTaiyuanShanxi 030001P.R.China College of Environment and Resource Research Center of Environment and HealthShanxi UniversityTaiyuanShanxi 030006P.R.China

Breast cancer incidence has increased and become the world’s most prevalent cancer,which is related to abnormal development of mammary glands and thought to be influenced by environment endocrine disruptors such as bisphenol A(BPA).However,whether its substitution,bisphenol B(BPB),has similar effects remains a *** the present study,a maternal exposure model of ICR mice combined time-series RNA-seq analysis was established to explore the underlying correlation among maternal BPB exposure(300μg/kg body weight),mammary gland development,and long-term breast health in *** results showed that BPB exposure disrupted hormonal homeostasis of the female offspring but did not affect the branch development of mammary glands in a time-dependent ***,at postnatal day 90(PND90),BPB exposure resulted in duct dilatation,lobular hyperplasia,and inflammatory cell infiltration and increased the number of hormone receptor-expressing(HR+)luminal cells in ***,the differentially expressed genes in time-series analysis of RNA-seq for mammary glands of the female offspring were enriched in the morphogenesis of branching structures,branching epithelium,and branching morphogenesis of epithelial tubes,which are always considered gland ***,the results of RNA-seq also suggested that progesterone receptor(Pgr)mRNA expression in the BPB group was elevated at PND90,and breast cancer related genes such as GATA binding protein 3(Gata3)and epidermal growth factor receptor(Egfr)were also *** findings suggested that maternal BPB exposure did not accelerate mammary gland development or lead to obvious morphological anomalies of offspring,but it induced pathological changes and altered cancer related gene expression in adult offspring breast.

关键词： Bisphenol B Maternal exposure Mammary gland development Hormonal homeostasis Progesterone receptor

FvWRKY50 is an important gene that regulates both vegetative growth and reproductive growth in strawberry

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Horticulture Research 2023年第7期10卷 280-292页

作者： yating Chen Liping Liu Qianqian Feng Chuang Liu Yujuan Bao nan Zhang Ronghui Sun Zhaonan Yin Chuanfei Zhong Yuanhua Wang Qian Li Bingbing Li Department of Pomology College of HorticultureChina Agricultural UniversityBeijing10093China Beijing Engineering Research Center for Strawberry Institute of Forestry and PomologyBeijing Academy of Agriculture and Forestry SciencesBeijing100093China Department of Agronomy and Horticulture Jiangsu Vocational College of Agriculture and ForestryJiangsu212400China Engineering and Technical Center for Modern Horticulture Jiangsu212400China

The WRKY transcription factors play important roles in plant growth and resistance,but only a few members have been identified in *** we identified a WRKY transcription factor,FvWRKY50,in diploid strawberry which played essential roles in strawberry vegetative growth,and reproductive *** out FvWRKY50 by genome editing accelerated flowering time and leaf senescence but delayed anthocyanin accumulation in *** analysis showed that FvWRKY50 acted as a transcriptional repressor to negatively regulate the expression of flowering-and leaf senescence-related genes,including FvFT2,FvCO,FvFT3,and ***,FvWRKY50 directly upregulated the expression of FvCHI and FvDFR by binding their promoter under normal conditions,but at low temperature FvWRKY50 was phosphorylated by FvMAPK3 and then induced protein degradation by ubiquitination,delaying anthocyanin *** addition,the homozygous mutant of FvWRKY50 was smaller while the biallelic mutant showed normal *** new findings provide important clues for us to further reveal the regulatory mechanisms of strawberry growth and fruit ripening.

关键词： straw vegetative berry

异钩藤碱减轻帕金森病小鼠多巴胺能神经元损伤的作用机制

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安徽医药 2025年第1期29卷 23-28页

作者：刘崇刘亚婷张壮周国平南阳市第一人民医院神经内二科河南南阳473000 南阳市中心医院神经外科河南南阳473000

目的探讨异钩藤碱对帕金森病(PD)小鼠多巴胺能神经元损伤及凋亡的影响及其可能作用机制。方法2020年6月至2022年6月选取40只小鼠建立PD模型,造模成功小鼠按照随机数字表法分为模型组、异钩藤碱低、中和高剂量组,每组各10只,另设对照组1... 详细信息

目的探讨异钩藤碱对帕金森病(PD)小鼠多巴胺能神经元损伤及凋亡的影响及其可能作用机制。方法2020年6月至2022年6月选取40只小鼠建立PD模型,造模成功小鼠按照随机数字表法分为模型组、异钩藤碱低、中和高剂量组,每组各10只,另设对照组10只。异钩藤碱低、中和高剂量组小鼠分别灌胃给药20、40、80 mg/kg的异钩藤碱混悬液(0.9%氯化钠溶液配制),对照组及模型组给予等量0.9%氯化钠溶液。采用爬杆实验和旷场实验评定各组小鼠行为学变化;ELISA法检测小鼠血清中白细胞介素-1β(IL-1β)和肿瘤坏死因子α(TNF-α)水平以及脑组织中多巴胺(DA)水平;TUNEL法检测黑质区神经细胞凋亡;逆转录聚合酶链式反应(RT-PCR)法检测黑质区微RNA-376b-3p(miR-376b-3p)、转录因子SP1(SP1)和亮氨酸重复序列激酶2(LRRK2)的mRNA相对表达量;蛋白质印迹法检测黑质区SP1、LRRK2、α-突触核蛋白(α-syn)和酪氨酸羟化酶(TH)蛋白表达情况。结果与对照组(4.58±0.27)μg/L比较,模型组(1.35±0.13)μg/L小鼠DA水平显著降低(P<0.05)。与模型组比较,异钩藤碱低剂量组(1.86±0.17)μg/L、中剂量组(2.56±0.21)μg/L和高剂量组(3.40±0.29)μg/L小鼠DA水平显著升高(均P<0.05),且以异钩藤碱高剂量组最佳。与模型组比较,异钩藤碱低、中和高剂量组小鼠爬杆时间、IL-1β、TNF-α水平、神经细胞凋亡率、SP1和LRRK2 mRNA和蛋白表达水平、α-syn蛋白水平降低,运动总距离、miR-376b-3p以及TH蛋白水平升高(P<0.05),且以异钩藤碱高剂量组效果最佳(P<0.05)。结论异钩藤碱能够在一定程度上改善PD小鼠运动功能障碍,减轻神经炎症反应,降低神经细胞凋亡率,可能是通过影响miR-376b-3p/SP1/LRRK2信号系统发挥作用。

关键词：钩藤属帕金森病异钩藤碱神经元损伤转录因子SP1 亮氨酸重复序列激酶2

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烟草镰刀菌根腐病根际土壤微生物群落结构及多样性

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浙江农业科学 2025年第2期66卷 411-420页

作者：何晓冰黄昆鹏李俊营卜亚艇赵浪王明鑫张富生阴广宇杨楠许跃奇河南省烟草公司平顶山市公司河南平顶山467000 红云红河烟草(集团)有限责任公司红河卷烟厂云南弥勒652399 河南农业大学烟草学院河南郑州450000

研究烟草镰刀菌根腐病对根际土壤微生物群落结构及多样性的影响,探讨其与烟草病害发生的关系,为防治病害的发生提供理论依据。利用Illumina MiSeq高通量测序技术,比较健康株与病株烟草根际土壤微生物群落结构及多样性差异。镰刀菌根腐... 详细信息

研究烟草镰刀菌根腐病对根际土壤微生物群落结构及多样性的影响,探讨其与烟草病害发生的关系,为防治病害的发生提供理论依据。利用Illumina MiSeq高通量测序技术,比较健康株与病株烟草根际土壤微生物群落结构及多样性差异。镰刀菌根腐病使烟株根际土壤真菌种类的丰富程度和种群多样化发生改变,病株根际土壤真菌的辛普森指数、ACE和Chao1等指标均低于健康株;病株和健康株根际土壤微生物种群的优势种群具有明显差异。与对照相比,门水平上,病株绿弯菌门、浮霉菌门、芽单胞菌门和酸杆菌门的相对丰度降低,变形菌门的相对丰度增加;属水平上,细菌属有益菌属链霉菌属、土壤红杆菌属、加氏菌属相对丰度降低。烟草植株根际土壤中真菌群落结构改变及物种多样性降低是烟草镰刀菌根腐病发生的重要特征,为该病害的早期预防提供一定的理论依据。

关键词：烟草镰刀菌根腐病根际微生物高通量测序

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佐匹克隆的物理化学性质和生物药剂学分类系统属性研究

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药物评价研究 2021年第6期44卷 1171-1180页

作者：尹婕白雅婷南楠陈华中国食品药品检定研究院国家药品监督管理局化学药品质量研究与评价重点实验室北京102629

目的研究佐匹克隆的生物药剂学分类系统(BCS),并对原研和3家仿制企业原料的关键理化性质进行对比评价,为佐匹克隆片剂的一致性评价提供依据。方法检测pH 6.8和pH 7.4的磷酸盐缓冲液中佐匹克隆的固有溶出速率;分别采用差示扫描量热法(DSC... 详细信息

目的研究佐匹克隆的生物药剂学分类系统(BCS),并对原研和3家仿制企业原料的关键理化性质进行对比评价,为佐匹克隆片剂的一致性评价提供依据。方法检测pH 6.8和pH 7.4的磷酸盐缓冲液中佐匹克隆的固有溶出速率;分别采用差示扫描量热法(DSC)和X射线粉末衍射法对佐匹克隆的晶型进行考察;采用高效液相色谱(HPLC)法测定佐匹克隆不同pH介质中的平衡溶解度及表观油水分配系数;分别采用平行人工膜渗透性模型(PAMPA)和Caco-2细胞模型,考察佐匹克隆的有效渗透性。对佐匹克隆的BCS进行初步判定,并考察原研与仿制企业原料的差异。结果原研与仿制企业的佐匹克隆晶型为同一晶型,为对映异构体形成的无水非中心对称的正交晶型化合物;佐匹克隆在酸性介质中溶解度最高,为高溶解度药物;表观油水分配系数结果表明,佐匹克隆在胃内几乎无吸收,在不同肠段存在不同程度的吸收;PAMPA和Caco-2细胞模型均判定佐匹克隆为高渗透性药物,P-gp转运体参与佐匹克隆的肠道转运过程。原研与仿制企业原料的固有溶出速率、晶型、溶解度、表观油水分配系数和有效渗透性基本一致。结论佐匹克隆为BCSⅠ类药物;原研与仿制企业原料的关键理化性质基本一致;为佐匹克隆片的体外溶出行为评价和体内外相关性研究提供数据支撑。

关键词：佐匹克隆理化性质生物药剂学分类系统仿制药一致性评价溶解性渗透性平行人工膜渗透性模型 Caco-2细胞模型

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直播电商虚假宣传的法律规制

知识产权 2021年第5期31卷 68-82页

作者：刘雅婷李楠对外经济贸易大学法学院北京金融法院立案庭

直播电商中的虚假宣传现象日益凸显和严峻。《反不正当竞争法》和《广告法》作为治理虚假宣传的主要法律规范,在对直播电商虚假宣传的法律规制中存在以下问题:从《反不正当竞争法》上,“引人误解”作为虚假宣传行为的认定标准,常被弱化... 详细信息

直播电商中的虚假宣传现象日益凸显和严峻。《反不正当竞争法》和《广告法》作为治理虚假宣传的主要法律规范,在对直播电商虚假宣传的法律规制中存在以下问题:从《反不正当竞争法》上,“引人误解”作为虚假宣传行为的认定标准,常被弱化或虚置。直播电商虚假宣传行为的几种类型化表现中,对商品或服务本身、直播流量数据的虚假宣传已有相应的法律规范,但我国目前没有对表明身份和立场“实质性关联”的强制披露要求,对包装、装潢、店铺名、域名等商业标识的混淆行为潜在着知识产权侵权风险,相关法律规制也面临着新的挑战;从《广告法》上,一是直播电商的法律属性存在争议,二是主播的身份认定及法律责任不明确。此外,《反不正当竞争法》与《广告法》存在着竞合与适用的问题。为完善对直播电商虚假宣传的法律规制,应在《反不正当竞争法》中突出“引人误解”标准的核心地位,建立“实质性关联”的强制披露制度,强化知识产权保护的主体责任;从《广告法》上,应细化直播电商的法律属性,明确“广告荐证人”的身份及法律责任。在实务中,也需要灵活适用《反不正当竞争法》和《广告法》的相关规则。

关键词：直播电商虚假宣传反不正当竞争法广告法实质性关联广告荐证人

基于第一性原理的无铅无机钙钛矿Cs_(3)Bi_(2)X_(9)(X=Cl、Br、I)光电性能表面效应研究

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无机化学学报 2024年第3期40卷 555-560页

作者：彭程韦建卫陈亚婷胡南曾晖重庆理工大学理学院重庆400052 南京理工大学电子工程与光电技术学院南京210094

用基于第一性原理的密度泛函理论方法,对Cs_(3)Bi_(2)X_(9)(X=Cl、Br、I)的光电特性进行理论计算,并系统阐述这3种晶体的表面效应对光电性能的影响。结果表明,3种材料的光学特性由铋原子和卤素原子最外层p轨道上的价电子主导。在可见光... 详细信息

用基于第一性原理的密度泛函理论方法,对Cs_(3)Bi_(2)X_(9)(X=Cl、Br、I)的光电特性进行理论计算,并系统阐述这3种晶体的表面效应对光电性能的影响。结果表明,3种材料的光学特性由铋原子和卤素原子最外层p轨道上的价电子主导。在可见光区中,材料的吸收峰会随卤素原子序数的增加呈现红移,其中一维结构的Cs_(3)Bi_(2)Cl_(9)表面结构在光吸收能力上尤为特别且敏感;二维结构的Cs_(3)Bi_(2)Br_(9)光吸收能力会受厚度影响;零维结构的Cs_(3)Bi_(2)I_(9)非常稳定,且几乎不受表面特性和晶体厚度的影响。

关键词：表面效应 Cs_(3)Bi_(2)X_(9) 钙钛矿第一性原理