Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

作     者：Pengfei Zhao Yating Wang Xiao Yu Yabing Nan Shi Liu Bin Li Zhumei Cui Zhihua Liu Pengfei Zhao;Yating Wang;Xiao Yu;Yabing Nan;Shi Liu;Bin Li;Zhumei Cui;Zhihua Liu

作者机构：State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Department of Gynecological OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Department of Obstetrics and GynecologyThe Affiliated Hospital of Qingdao UniversityQingdao266000China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2023年第17卷第5期

页      面：924-938页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key R&D Program of China (No.2021YFC2501000) the CAMS Innovation Fund for Medical Sciences (Nos.2021-I2M-1-018 and 2021-12M-1-067) 

主　　题：0varian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1 

摘      要：Long noncoding RNAs(lncRNAs)play a crucial regulatory role in the development and progression of multiple ***,the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains *** the current study,the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary ***-and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation,invasiveness,and metastasis of ovarian cancer cells in vivo and in ***,the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor ***,LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1,which is necessary for suppressing tumor metastasis and inhibiting KRAS ***,our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer,which may be a potential prognostic biomarker.