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Transcriptomic and Macroscopic Architectures of Multimodal Covariance Network Reveal Molecular–Structural–Functional Co-alterations

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Research 2024年第1期2023卷 471-487页

作者： lin Jiang Yueheng Peng Runyang He Qingqing Yang Chanlin Yi Yuqin Li Bin Zhu Yajing Si Tao Zhang Bharat B.Biswal Dezhong yao Lan Xiong fali Li Peng Xu The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Life Science and Technology Center for Information in BioMedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Psychology Xinxiang Medical UniversityXinxiang 453003China School of Science Xihua UniversityChengdu 610039China Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJUSA School of Electrical Engineering Zhengzhou UniversityZhengzhou 450001China Research Unit of NeuroInformation Chinese Academy of Medical Sciences2019RU035ChengduChina Montreal Neurological Institute and Hospital McGill UniversityMontrealQCCanada Department of Electrical and Computer Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Radiation Oncology Key Laboratory of Sichuan Province 610041 ChengduChina Rehabilitation Center Qilu Hospital of Shandong UniversityJinan 250012China

Human cognition is usually underpinned by intrinsic structure and functional neural co-activation in spatially distributed brain regions.Owing to lacking an effective approach to quantifying the covarying of structure and functional responses,how the structural–functional circuits interact and how genes encode the relationships,to deepen our knowledge of human cognition and disease,are still unclear.Here,we propose a multimodal covariance network(MCN)construction approach to capture interregional covarying of the structural skeleton and transient functional activities for a single individual.We further explored the potential association between brain-wide gene expression patterns and structural–functional covarying in individuals involved in a gambling task and individuals with major depression disorder(MDD),adopting multimodal data from a publicly available human brain transcriptomic atlas and 2 independent *** analysis showed a replicable cortical structural–functional fine map in healthy individuals,and the expression of cognition-and disease phenotype-related genes was found to be spatially correlated with the corresponding MCN differences.Further analysis of cell type-specific signature genes suggests that the excitatory and inhibitory neuron transcriptomic changes could account for most of the observed correlation with task-evoked MCN differences.

关键词： alterations evoked spatially

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Will the Globe Encounter the Warmest Winter after the Hottest Summer in 2023?

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Advances in Atmospheric Sciences 2024年第4期41卷 581-586页

作者： Fei ZHENG Shuai HU Jiehua MA lin WANG Kexin LI Bo WU Qing BAO Jingbei PENG Chaofan LI Haifeng ZONG yao yao Baoqiang TIAN Hong CHEN Xianmei LANG fangxing faN Xiao DONG Yanling ZHAN Tao ZHU Tianjun ZHOU Jiang ZHU International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Nansen-Zhu International Research Centre(NZC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Monsoon System Research(CMSR) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China CAS Key Lab of Regional Climate-Environment for Temperate East Asia(RCE-TEA) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

In the boreal summer and autumn of 2023,the globe experienced an extremely hot period across both oceans and continents.The consecutive record-breaking mean surface temperature has caused many to speculate upon how the global temperature will evolve in the coming 2023/24 boreal winter.In this report,as shown in the multi-model ensemble mean(MME)prediction released by the Institute of Atmospheric Physics at the Chinese Academy of Sciences,a medium-to-strong eastern Pacific El Niño event will reach its mature phase in the following 2−3 months,which tends to excite an anomalous anticyclone over the western North Pacific and the Pacific-North American teleconnection,thus serving to modulate the winter climate in East Asia and North America.Despite some uncertainty due to unpredictable internal atmospheric variability,the global mean surface temperature(GMST)in the 2023/24 winter will likely be the warmest in recorded history as a consequence of both the El Niño event and the long-term global warming trend.Specifically,the middle and low latitudes of Eurasia are expected to experience an anomalously warm winter,and the surface air temperature anomaly in China will likely exceed 2.4 standard deviations above climatology and subsequently be recorded as the warmest winter since 1991.Moreover,the necessary early warnings are still reliable in the timely updated mediumterm numerical weather forecasts and sub-seasonal-to-seasonal prediction.

关键词： winter climate El Niño seasonal forecast GMST

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《理查二世》:素材来源与改编出新

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河南大学学报（社会科学版） 2024年第1期64卷 81-86,154页

作者：姚琳河南大学外语学院河南开封475001

莎士比亚的《理查二世》有着繁杂的素材来源。莎士比亚根据其写作目的,对相关史料进行选择性的安排和使用,对主要角色进行了立体刻画和明暗式处理,突出了角色的情感力量,建构了宏大的想象空间,缔造了一场伟大的道德和政治的因果盛宴。... 详细信息

莎士比亚的《理查二世》有着繁杂的素材来源。莎士比亚根据其写作目的,对相关史料进行选择性的安排和使用,对主要角色进行了立体刻画和明暗式处理,突出了角色的情感力量,建构了宏大的想象空间,缔造了一场伟大的道德和政治的因果盛宴。该剧对史料的创新改编凸显了作者对情感力量的认知和掌控,以及对君王德行、君臣关系等王权政治问题的严肃思考,表达了其对僭越行为的否定和对强大君主与国家的渴望。

关键词：《理查二世》素材来源改编出新

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Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： Xingyue Wu yao Chen Kangli Cao yao Shen Xueling Wu Yilin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei Wang Ye yao Ying Wang Shaodie Chen Zhigao Yu Wei Wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long Jian Sun lingyu Xing Jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna lin Xiaoyan Zhang Rong Zeng Jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co V-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COVID-19 during the Shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COVID-19cases identified between April and June of 2022, from four COVID-19 designated hospitals located in two areas of Shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： REPLICATION

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TCERG1L hypermethylation is a risk factor of diabetic retinopathy in Chinese children with type 1 diabetes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 537-544页

作者： Yu Qian Ying Xiao Qiu-Rong lin Zhao-Yu Xiang Li-Pu Cui Jia-Qi Sun Si-Cong Li Xin-Ran Qin Hai-Dong Zou Chen-Hao Yang Pei-yao Jin Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai First People’s HospitalShanghai 200080China Shanghai Eye Diseases Prevention&Treatment Center Shanghai Eye HospitalShanghai 200040China National Clinical Research Center for Eye Diseases Shanghai Clinical Research Center for Eye DiseasesShanghai Key Clinical SpecialtyShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology Children’s Hospital of Fudan UniversityShanghai 201102China

●AIM:To identify the differential methylation sites(DMS)and their according genes associated with diabetic retinopathy(DR)development in type 1 diabetes(T1DM)children.●METHODS:This study consists of two surveys.A total of 40 T1DM children was included in the first survey.Because no participant has DR,retina thinning was used as a surrogate indicator for DR.The lowest 25%participants with the thinnest macular retinal thickness were included into the case group,and the others were controls.The DNA methylation status was assessed by the Illumina methylation 850K array BeadChip assay,and compared between the case and control groups.Four DMS with a potential role in diabetes were identified.The second survey included 27 T1DM children,among which four had DR.The methylation patterns of the four DMS identified by 850K were compared between participants with and without DR by pyrosequencing.●RESULTS:In the first survey,the 850K array revealed 751 sites significantly and differentially methylated in the case group comparing with the controls(|Δβ|>0.1 and Adj.P0.05)between participants with and without DR.●CONCLUSION:The hypermethylation of the TCERG1L gene is a risk factor for DR development in Chinese children with T1DM.

关键词： DNA methylation 850K array pyrosequencing diabetic retinopathy type 1 diabetes children

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Study on the Efficacy Claim and Evaluation Method of Lip Cosmetics

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China Detergent & Cosmetics 2024年第1期9卷 54-62页

作者： Wu fan Pan yao Zhao Hua Zhu Wei lin lin fan Yangyi Department of Cosmetics College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityChina Beijing Key Laboratory of Plant Resources Research and Development China Shanghai Corday Biotechnology Co. Ltd.China

To study the efficacy of lip moisturizing cosmetics and explore the methods for evaluating their efficacy.The claimed efficacy and number of claimed efficacy of 44 lip moisturizing cosmetics were investigated,and a combination of in vitro and human testing was used to evaluate the efficacy of the lip moisturizing cosmetics.The efficacy claims of lip cosmetics mainly included 4 categories of moisturizing,repairing,soothing and anti-wrinkle,with 79.55%of the products claiming 3~4 categories of efficacy.In the in vitro test,the cell morphology of the skin damage model improved and the secretion of pro-inflammatory factors decreased significantly.In the human trial,the water content,skin softness and brightness L value of the cuticle of the lips increased significantly in 31 subjects,and the transepidermal water loss,redness a value,and the area and volume of lip wrinkles decreased significantly;the dryness of the lip skin and the uniformity of the skin texture improved significantly.The dryness of lip skin and the uniformity of skin texture were significantly improved.The results show that the moisture content of the stratum corneum can be used to evaluate the moisturizing efficacy of lip products.The transepidermal water loss,skin color,skin softness and expert assessment can be used to evaluate the repairing efficacy.The observation of cell morphology of skin damage models and the detection of pro-inflammatory factor content can be used to evaluate the soothing efficacy.The area and volume of lip wrinkles can be used to evaluate the anti-wrinkle efficacy of products.

关键词： lip cosmetic efficacy claim clinical trial in vitro test

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Emerging role of vitamin D3 in alleviating intestinal structure injury caused by Aeromonas hydrophila in grass carp（Ctenopharyngodon idella）

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Animal Nutrition 2024年第1期16卷 202-217页

作者： yao Zhang Xiao-Qiu Zhou Wei-Dan Jiang Pei Wu Yang Liu Hong-Mei Ren Lu Zhang Hai-Feng Mi ling Tang Cheng-Bo Zhong lin Feng Animal Nutrition Institute Sichuan Agricultural University Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural University Key Laboratory for Animal Disease-Resistant Nutrition of China Ministry of Education Sichuan Agricultural University Healthy Aquaculture Key Laboratory of Sichuan Province Tongwei Co. Ltd. Sichuan Animal Science Academy Sichuan Animtech Feed Co. Ltd.

Bacterial pathogens destroy the structural integrity of functional organs in fish, leading to severe challenges in the aquaculture industry. Vitamin D3（VD3） prevents bacterial infections and strengthens immune system function via vitamin D receptor（VDR）. However, the correlation between VD3/VDR and the structural integrity of functional organs remains unclarified. This study aimed to investigate the influence of VD3supplementation on histological characteristics, apoptosis, and tight junction characteristics in fish intestine during pathogen infection. A total of 540 healthy grass carp（257.24 ± 0.63 g） were fed different levels of VD3（15.2, 364.3, 782.5, 1,167.9, 1,573.8, and 1,980.1 IU/kg） for 70 d. Subsequently, fish were challenged with Aeromonas hydrophila, a pathogen that causes intestinal inflammation. Our present study demonstrated that optimal supplementation with VD3（1） alleviated intestinal structural damage, and inhibited oxidative damage by reducing levels of oxidative stress biomarkers;（2） attenuated excessive apoptosisrelated death receptor and mitochondrial pathway processes in relation to p38 mitogen-activated protein kinase signaling（P ling（P < 0.05）; and（4） elevated VDR isoform expression in fish intestine（P < 0.05）.Overall, the results demonstrated that VD3alleviates oxidative injury, apoptosis, and the destruction of tight junction protein under pathogenic infection, thereby strengthening pathogen defenses in the intestine. This finding supports the rationale for VD3intervention as an essential practice in sustainable aquaculture.

关键词： Aeromonas hydrophila Antibacterial property Grass carp ( Ctenopharyngodon idella ) Intestinal health Vitamin D 3

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支持等式测试及密码逆向防火墙的SM9标识加密方案

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计算机研究与发展 2024年第4期61卷 1070-1084页

作者：熊虎林烨姚婷电子科技大学信息与软件工程学院成都610054 网络与数据安全四川省重点实验室(电子科技大学) 成都610054

支持等式测试的标识加密(identity-based encryption with equality test, IBEET)体制解决了传统等式测试方案中证书管理的问题,得到了广泛的关注.但现有的IBEET体制难以抵抗渗透攻击,且都是基于国外密码算法设计,不具有自主知识产权.... 详细信息

支持等式测试的标识加密(identity-based encryption with equality test, IBEET)体制解决了传统等式测试方案中证书管理的问题,得到了广泛的关注.但现有的IBEET体制难以抵抗渗透攻击,且都是基于国外密码算法设计,不具有自主知识产权.基于此,提出一种支持等式测试并具有密码逆向防火墙的SM9标识加密方案(SM9 identity-based encryption scheme with equality test and cryptographic reverse firewalls, SM9-IBEET-CRF).该方案在用户与云服务器的上行信道间部署密码逆向防火墙(cryptographic reverse firewalls,CRF),对用户发出的信息执行重随机化以达到抵抗渗透攻击的作用.该方案拓展国密算法SM9至IBEET领域中,提升其运行效率并丰富国密算法在云计算领域的研究.给出了SM9-IBEET-CRF的形式化定义和安全模型,并在随机预言机模型中考虑2种不同的敌手将此方案在选择密文攻击下的不可区分性与单向性分别形式化地规约到BDH困难假设上.同时,该方案通过考虑第3种敌手证明CRF的部署为其带来维持功能性、保留安全性以及抵抗渗透性.实验仿真和分析结果展示了该方案的有效性.

关键词： SM9 等式测试密码逆向防火墙标识加密渗透攻击

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Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： Qing Tang Xiao-Yong Dai Qiang lin Zhi-Peng ling Yi-Kun Hao Tian-Xi Zhu Ji-Hui Zhang Yi-Bo Hou yao-Lan Li Lai-Qiang Huang Jing-Hao Wang Guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum calycinum.Compound 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring system.Compound 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of 2.Compound 4 is the second example of c-22-nor yuzurimine-type alkaloids.Their structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray diffraction.Moreover,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

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Graphene-anchored sodium single atoms:A highly active and stable catalyst for transesterification reaction

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Nano Research 2024年第6期17卷 4979-4985页

作者： Song-Song Peng yao Nian Xing-Ru Song Xiang-Bin Shao Chen Gu Zhi-Wei Xing Shi-Chao Qi Peng Tan You Han Xiao-Qin Liu lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech University30 South Puzhu RoadNanjing 211816China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Solid strong base catalysts have received considerable attention in various organic reactions due to their facile separation,neglectable corrosion,and environmental friendliness.Although great progress has been made in the preparation of solid strong base catalysts,it is still challenging to avoid basic sites aggregation on support and active sites loss in reaction system.Here,we report a tandem redox strategy to prepare Na single atoms on graphene,producing a new kind of solid strong base catalyst(Na1/G).The base precursor NaNO_(3)was first reduced to Na2O by graphene(400℃)and successively to single atoms Na anchored on the graphene vacancies(800℃).Owing to the atomically dispersed of basicity,the resultant catalyst presents high activity toward the transesterification of methanol and ethylene carbonate to synthesize dimethyl carbonate(turnover frequency(TOF)value:125.7 h^(−1)),which is much better than the conventional counterpart Na2O/G and various reported solid strong bases(TOF:1.0-90.1 h^(−1)).Furthermore,thanks to the basicity anchored on graphene,the Na1/G catalyst shows excellent durability during cycling.This work may provide a new direction for the development of solid strong base catalysts.

关键词： solid strong base catalyst basic sites redox graphene single Na atoms

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