Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

作     者：Xingyue Wu Yao Chen Kangli Cao Yao Shen Xueling Wu Yilin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei Wang Ye Yao Ying Wang Shaodie Chen Zhigao Yu Wei Wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long Jian Sun Lingyu Xing Jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna Lin Xiaoyan Zhang Rong Zeng Jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Xingyue Wu;Yao Chen;Kangli Cao;Yao Shen;Xueling Wu;Yilin Yang;Zhongshu Kuang;Qingrun Li;Zhenzhen Lu;Yichen Jia;Mian Shao;Guorong Gu;Xiangwei Wang;Ye Yao;Ying Wang;Shaodie Chen;Zhigao Yu;Wei Wei;Longfei Ding;Lulu Lan;Tianwen Gu;Xiangyu Long;Jian Sun;Lingyu Xing;Jiayuan Shen;Yi Han;Yue Luo;Sucheng Mu;Mengna Lin;Xiaoyan Zhang;Rong Zeng;Jianqing Xu;Guoping Zhao;Lihong Huang;Zhenju Song

作者机构：Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of PulmonologyRenji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2024年第11卷第4期

页      面：24-27页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2021YFC2501800 and 2023YFC0872500) the National Natural Science Foundation of China(82273733 and 92169206) the Science and Technology of Shanghai Committee (22YJ1400100,21MC1930400 and 20Z11901004) the Science and Technology Development Fund of Shanghai Pudong New Area (PK2021-Y35) ‘Leading Goose’ R&D Program of Zhejiang Province(2023C03045) 

主　　题：sars-cov-2 effectiveness epidemic shanghai integrated spring clinical variant virus account 

摘      要：The emergence of SARS-Co V-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COVID-19 during the Shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COVID-19cases identified between April and June of 2022, from four COVID-19 designated hospitals located in two areas of Shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).