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Immunology reshapes neuroscience,and neuroscience reshapes immunology

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Fundamental Research 2024年第2期4卷 199-200页

作者： Bo Peng yanxia rao Yun Wang Shumin Duan Hai Qi Jing Yang Hongliang Zhang Department of Neurosurgery Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceMOE Innovative Center for New Drug Development of Immune Inflammatory DiseasesFudan UniversityShanghai 200040China Department of Laboratory Animal Science MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesKey Laboratory for NeuroscienceMinistry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Faculty of Medicine and Pharmaceutical Sciences Zhejiang UniversityHangzhou 310014China School of Medicine Tsinghua UniversityBeijing 100084China IDG/McGovern Institute for Brain Research Center for Life SciencesSchool of Life SciencesPeking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China Department of Life Sciences National Natural Science Foundation of ChinaBeijing 100085China

As a result of evolution,our body has evolved into a sophisticated system in which various tissues and organs cooperate in a highly orchestrated manner.Few tissues or organs operate in isolation.The brain serves as the command center of our body and is relatively isolated from the peripheral system due to the presence of the blood-brain barrier(BBB).This barrier prevents direct and extensive interaction between blood cells,plasma molecules,and brain cells,contributing to the longstanding perception of the brain as an“immune-privileged”area.Consequently,neuroscientists and immunologists historically conducted separate research with minimal overlap between these two disciplines.However,this perspective has undergone reconsideration over the past few decades.

关键词： organs overlap contributing

A revisit of rod microglia in preclinical studies

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Neural Regeneration Research 2017年第1期12卷 56-57页

作者： yanxia rao Yu-Xiang Liang Bo Peng Institute of Biomedical and Health Engineering ShenzhenInstitutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina

Microglial cells（or microglia）are the mononuclear phagocytes residing in the central nervous system（CNS）.In homeostasis,they showed ramified morphology with relative small cell bodies and long processes（Figure 1A... 详细信息

关键词： A revisit of rod microglia in preclinical studies Figure RGC

Combined treatment promotes the long-range axon regeneration to right brain targets

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Eye Science 2017年第1期32卷 4-8页

作者： Bo Peng yanxia rao Kwok-Fai So Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong St. John's College The University of Hong Kong Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan University Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong Kong State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong

Axons in the peripheral nervous system(PNS)can regenerate after injury.However,the adult mammalian central nervous system(CNS)loses the intrinsic regrowth ability.No robust axon regeneration occurs spontaneously after... 详细信息

关键词： RGCs TOR Rheb Combined treatment promotes the long-range axon regeneration to right brain targets

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应用型人才培养质量保障体系的建构策略

科教文汇 2024年第13期 9-13页

作者：饶志强张益农刘艳霞方建军北京联合大学城市轨道交通与物流学院北京100101

建构合理科学的人才培养质量保障体系是应用型人才培养的核心环节。以应用型高校为背景,该文系统阐述了高校人才培养质量保障体系建设的现状和必要性,针对高校人才培养质量标准体系、质量管理监测体系和质量评价体系存在的问题,在总结... 详细信息

建构合理科学的人才培养质量保障体系是应用型人才培养的核心环节。以应用型高校为背景,该文系统阐述了高校人才培养质量保障体系建设的现状和必要性,针对高校人才培养质量标准体系、质量管理监测体系和质量评价体系存在的问题,在总结经验和不足的同时,提出了相应的完善策略,建构了以质量标准为引领,检测、调控、评估环环相扣的人才培养质量保障体系,对应用型专业技术人才培养质量的提升具有战略意义。

关键词：应用型高校人才培养质量保障体系建构

Repopulated microglia are solely derived from the proliferation of residual microglia, not from de novo progenitor cells

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Repopulated microglia are solely derived from the proliferat...

中国神经科学学会第十二届全国学术会议

作者： Yubin Huang Shanshan Xiong Guangrong Qin Guanglei Hu Jingjing Wang Fangfang Sun Yu-Xiang Liang Zhen Xu Kwok-Fai So Tianzhun Wu Mark S.Humayun Ti-Fei Yuan yanxia rao Bo Peng Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shanghai Center for Bioinformation Technology City University of Hong Kong School of Psychology Nanjing Normal University State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Guangdong-Hong Kong-Macau Institute of CNS Regeneration Jinan University Department of Ophthalmology Keck School of Medicine University of Southern California School of Biomedical Sciences Li Ka Shing Faculty of Medicine The University of Hong Kong

Studies found new-born microglia replenished the whole brain after selective elimination of microglia（＞99%） in adult mice. Immunohistochemical evidences suggested that repopulated microglia were differentiated from de novo progenitors expressing Nestin in the brain, which raised the possibility that the cross-lineage differentiation occurs in the mature brain. However, the origin of repopulating microglia has been hotly debated. In the present study, we investigated the origin of repopulating microglia by fate mapping. We first excluded that repopulated microglia were from blood cells. We then identified that repopulated microglia were not differentiated from Nestinpositive cells. Next we demonstrated all new-born microglia were derived from the proliferation of surviving microglia（＜0.90%）. Moreover, we confirmed that the whole brain transcriptome were not largely altered among stages of microglial elimination and repopulation. In summary, we concluded that de novo microglial progenitor cells were not existed in the adult brain.

关键词： Microglia repopulation CSF1R fate mapping parabiosis

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偏头痛的脑磁共振成像研究进展

影像研究与医学应用 2022年第2期6卷 4-6页

作者：饶艳霞张佳鑫谭颖孙兴龙川北医学院四川南充637000 广元市中心医院影像科四川广元628000

偏头痛是一种易反复发作的神经内科疾病,在受到光、声音和其他刺激后敏感性增强,严重影响患者的生活质量。磁共振成像(magnetic resonance imaging,MRI)已在探索神经系统疾病的病理生理机制方面取得突破性进展,现阶段磁共振成像评估偏... 详细信息

偏头痛是一种易反复发作的神经内科疾病,在受到光、声音和其他刺激后敏感性增强,严重影响患者的生活质量。磁共振成像(magnetic resonance imaging,MRI)已在探索神经系统疾病的病理生理机制方面取得突破性进展,现阶段磁共振成像评估偏头痛多方面参数的潜力尚未被临床医生熟知,本文以不同的MRI技术综述偏头痛多模态磁共振的最新研究进展。

关键词：偏头痛基于体素的形态测量静息态功能磁共振动脉自旋标记磁共振波谱

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乙醇电催化氧化

化学进展 2014年第5期26卷 727-736页

作者：饶路姜艳霞张斌伟游乐星李崭虹孙世刚固体表面物理化学国家重点实验室厦门大学化学化工学院化学系厦门361005

乙醇作为典型的可再生绿色环保型能源,具有易储存和携带、较高的能量密度、易生产等优点而备受关注。本文详细介绍了近年来国内外乙醇电催化氧化研究的重要进展,着重叙述了乙醇电催化氧化的反应机理,不同催化剂材料对乙醇电氧化的优缺点... 详细信息

乙醇作为典型的可再生绿色环保型能源,具有易储存和携带、较高的能量密度、易生产等优点而备受关注。本文详细介绍了近年来国内外乙醇电催化氧化研究的重要进展,着重叙述了乙醇电催化氧化的反应机理,不同催化剂材料对乙醇电氧化的优缺点,进一步探讨了影响乙醇电氧化反应活性和选择性的因素,总结了提高乙醇电氧化活性和选择性的策略,最后,对其今后可能的研究方向进行了展望。

关键词：乙醇燃料电池催化剂电氧化反应机理影响因素

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尿酸水平与认知功能障碍的研究进展

黑龙江科学 2023年第4期14卷 113-114,117页

作者：张佳鑫谭颖饶艳霞王曼玲孙兴龙川北医学院四川南充637000 广元市中心医院医学影像科四川广元628000

尿酸作为人体重要的抗氧化剂,可能具有神经保护作用。但有研究表明,尿酸的氧化应激特性是认知功能异常的主要原因之一,关于尿酸在认知功能方面的作用存在很多争议。对尿酸代谢与认知功能的相关机制、尿酸与认知功能的脑功能成像及尿酸... 详细信息

尿酸作为人体重要的抗氧化剂,可能具有神经保护作用。但有研究表明,尿酸的氧化应激特性是认知功能异常的主要原因之一,关于尿酸在认知功能方面的作用存在很多争议。对尿酸代谢与认知功能的相关机制、尿酸与认知功能的脑功能成像及尿酸的性别差异性与认知减退的相关研究进展作了初步探究与综述,希望未来能有更多的纵向研究进行准确分类和筛选研究人群,以便更好地了解高/低SUA水平对认知功能的长期影响。

关键词：尿酸水平认知功能障碍脑功能成像性别差异性

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阿海水电站工程施工总布置综述

水力发电 2012年第11期38卷 38-41页

作者：李宏祥杨燕峡饶建勇郭必文中国水电顾问集团昆明勘测设计研究院云南昆明650051

阿海水电站实施的施工总布置方案交通规划较优,施工场地布置合理,大型生产设施采用最优,渣场布置及容量合适,且施工过程中建设征地范围未产生变化,仅在工程实施过程中针对现场条件变化对油库的位置作了调整,施工总布置方案与工程相适应。

关键词：施工总布置交通运输料源规划渣场规划阿海水电站