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A systematic review of metabolism of methionine sources in animals:One parameter does not convey a comprehensive story

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Animal Nutrition 2023年第2期13卷 31-49页

作者： Philippe Becquet Mercedes vazquez-Anon Yves Mercier Karen Wedekind Tahir Mahmood Dolores I.Batonon-Alavo Frances Yan International Methionine Analogue Association Regus Brussels City CentreStephanie SquareAvenue Louise65B-1050 BrusselsBelgium Novus International Inc. 20 Research Park DriveSaint CharlesMissouri 63304USA Adisseo France SAS Antony Parc II10 Place Du General de GaulleAntony 92160France

The goal of this review article,based on a systematic literature search,is to critically assess the state of knowledge and experimental methodologies used to delineate the conversion and metabolism of the 2 methionine(Met)sources DL-methionine(DL-Met)and DL-2-hydroxy-4-(methylthio)butanoic acid(HMTBa).The difference in the chemical structures of HMTBa and DL-Met indicates that these molecules are absorbed and metabolized differently in *** review explores the methodologies used to describe the 2-step enzymatic conversion of the 3 enantiomers(D-HMTBa,L-HMTBa and D-Met)to L-Met,as well as the site of conversion at the organ and tissue *** work was published documenting the conversion of HMTBa and D-Met into L-Met and,consequently,the incorporation into protein using a variety of in vitro techniques,such as tissue homogenates,cell lines,primary cell lines,and everted gut sacs of individual *** studies illustrated the role of the liver,kidney,and intestine in the con-version of Met precursors into L-Met.A combination of in vivo studies using stable isotopes and infusions provided evidence of the wide conversion of HMTBa to L-Met by all tissues and how some tissues are net users of HMTBa,whereas others are net secreters of L-Met derived from *** of D-Met to L-Met in organs other than the liver and kidney is poorly *** methodology cited in the literature to determine conversion efficiency ranged from measurements of urinary,fecal,and respiratory excretion to plasma concentration and tissue incorporation of isotopes after intraperitoneal and oral *** observed between these methodologies reflect differences in the metabolism of Met sources rather than differences in conversion *** factors affecting conversion efficiency are explored in this paper and are mostly associated with extreme dietary conditions,such as noncommercial crystalline diets that are very deficient in total sulfur amino a

关键词： DL-Methionine Hydroxy-analog of methionine 2-Hydroxy-4-(methylthio)butanoic acid Conversion Metabolism Methodology

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Protic ionic liquids/poly(vinylidene fluoride) composite membranes for fuel cell application

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Journal of Energy Chemistry 2021年第2期30卷 197-207,I0008页

作者： Isabel vazquez-Fernandez Mohamed Raghibi Adnane Bouzina Laure Timperman Janick Bigarre Meriem Anouti Laboratoire KM2E Parc de GrandmontUniversite de Tours37200ToursFrance CEA-DAM Le Ripault BP16F-37260MontsFrance

Poly(vinylidene fluoride), PVDF, membranes have attracted considerable attention as polymer electrolytes for fuel cells. This study explores the effect of solvent on the spherulite size and the crystallinity of the polymeric membranes. Based on Hansen solubility parameters theory, the mixture of DMC and DMSO was selected among a dozen of solvents for the preparation of PVDF membranes by thermally induced phase separation. The addition of two protic ionic liquids(PILs), bis(2-ethyl hexyl) ammonium hydrogen phosphate [EHNH_2][H_2PO_4], and imidazolium hexanoate [Im][Hex] to PVDF membranes at concentrations(10% < wP IL< 50%) has been investigated by SEM, FTIR, DSC, TGA, EIS, and DMA. The inclusion of ionic liquids into the polymer matrix influences structural parameters(degree of crystallinity and electroactive phases), thermal stability, proton conductivity and mechanical properties of the membranes. The membranes become transparent regardless type of ionic liquid employed. A small amount of ionic liquids increases the degree of crystallinity and facilitates the production of polar β and γ crystals. The proton conductivity mechanism(Grotthuss) is dependent on the ionic liquid structure(due to its selforganization in water) and the content in the PVDF membrane, as well as the membrane water *** behavior has been observed for the two ionic liquids, which stresses the challenge on selecting an appropriate cation and anion combination. The obtained composite membranes exhibited excellent mechanical performance and reduced elastic modulus, with respect to the pure polymer matrix. These results indicate that PVDF/IL composite membranes have a high potential for PEMFC applications.

关键词： PVDF Hansen solubility parameters PILs Proton conductivity

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Endosomal escape of protein nanoparticles engineered through humanized histidine-rich peptides

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Science China Materials 2020年第4期63卷 644-653页

作者： Hector Lopez-Laguna Rafael Cubarsi Ugutz Unzueta Ramon Mangues Esther vazquez Antonio Villaverde Institut de Biotecnologia i de Biomedicina Universitat Aut6noma de BarcelonaBellaterra08193 BarcelonaSpain Departament de Genetica i de Microbiologia Universitat Aut6noma de BarcelonaBellaterra08193 BarcelonaSpain CIBER de Bioingenieria Biomateriales y Nanomedicina(CIBER-BBN)C/Monforte de Lemos 3-528029 MadridSpain Departament de Matematiques Universitat Politecnica de Catalunya08034BarcelonaSpain Institut d'Investigacions Biomediques Sant Pau Hospital de la Santa Creu i Sant Pau08025 BarcelonaSpain

Poly-histidine peptides such as H6(HHHHHH)are used in protein biotechnologies as purification tags,protein-assembling agents and endosomal-escape *** pleiotropic properties of such peptides make them appealing to design protein-based smart materials or nanoparticles for imaging or drug delivery to be produced in form of recombinant ***,the clinical applicability of H6-tagged proteins is restricted by the potential immunogenicity of these *** this study,we have explored several humanized histidine-rich peptides in tumor-targeted modular proteins,which can specifically bind and be internalized by the target cells through the tumoral marker *** were particularly interested in exploring how protein purification,self-assembling and endosomal escape perform in proteins containing the variant histidine-rich *** the tested candidates,the peptide H5 E(HEHEHEHEH)is promising as a good promoter of endosomal escape of the associated fulllength protein upon endosomal *** numerical modelling of cell penetration and endosomal escape of the tested proteins has revealed a negative relationship between the amount of protein internalized into target cells and the efficiency of cytoplasmic *** fact demonstrates that the His-mediated,proton sponge-based endosomal escape saturates at moderate amounts of internalized protein,a fact that might be critical for the design of protein materials for cytosolic molecular delivery.

关键词： protein materials nanoparticles genetic design endosomal escape poly-histidines

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Nanostructured biohybrid material with wide-ranging antiviral action

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Nano Research 2023年第8期16卷 11455-11463页

作者： Noelia Losada-Garcia Angela vazquez-Calvo David Ortega-Alarcon Olga Abian Adrian Velazquez-Campoy Pilar Domingo-Calap Antonio Alcami Jose M.Palomo Instituto de Catálisis y Petroleoquímica(ICP) CSICC/Marie Curie 2.Madrid 28049Spain Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas(CSIC)-Universidad Autónoma de Madrid(UAM)Madrid 28049Spain Institute of Biocomputation and Physics of Complex Systems(BIFI) Joint Unit GBsC-CSIC-BIFIUniversity of ZaragozaZaragoza 50018Spain Fundación Instituto de Investigación Sanitaria de Aragón(IIS Aragón) Zaragoza 50009Spain CIBERehd Madrid 28029Spain Instituto de Biología Integrativa de Sistemas I2SyBioUniversitat de València-CSICValència E-46071Spain

Respiratory pathogens kill more people than any other infectious agent each year *** of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major ***,we describe a nanostructured material composed of very small crystalline phosphate copper nanoparticles synthesized using a new biohybrid technology that employs a biological agent for its formation at room temperature in aqueous *** evaluation of different enzymes in the final preparation of the nanomaterial or even in synthetic methods was *** characterization revealed the formation of Cu species in the protein *** best biomaterial synthesized using a lipase called BioCuNPs showed excellent inhibition capacity against functional proteins of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);for example,assent 3-chymotrypsin like protease(3CLpro)complete inhibition was achieved by using 5µg/mL,or acetone(ACE)–spike protein interaction was inhibited by more than 80%in the presence of 400µg/mL of *** these in vitro results into account,an efficacy analysis against human coronavirus 229E(HCoV-E229)coronavirus was performed.A virus reduction of 99%was obtained in 5 ***,SARS-CoV-2 virus was tested to demonstrate high efficiency,with>99%inhibition in 15 min using 500 microgram of *** determine the wide applicability of this nanohybrid against viruses,an evaluation was carried out against a non-enveloped virus such as Human Rhinovirus(HRV-14),obtaining a virus reduction of 99.9%in 5 ***,the virucidal capacity against different bacteriophages was also evaluated,obtaining an excellent inhibition effect against PhageΦX174(99.999%reduction in 5 min).

关键词： antiviral compound coronaviruses copper nanoparticles nanobiotechnology viruses

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The Future Of BRICS

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Beijing Review 2021年第37期64卷 22-23页

作者： Karin Costa vazquez the Center for BRICS Studies at Fudan University the Center for African Latin American and Caribbean Studies at O.P.Jindal Global University

As the BRICS group enters its second decade,the collective is now ready to consolidate its early *** this context,the leaders of Brazil,Russia,India,China,and South Africa met virtually on September 9 for their13th su... 详细信息

关键词： BRICS collective Continuity

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Recent Advances on Early-Stage Fire-Warning Systems: Mechanism, Performance, and Perspective

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Nano-Micro Letters 2022年第12期14卷 106-136页

作者： Xiaolu Li Antonio vazquez-Lopez Jose Sanchez del Rio Saez De-Yi Wang IMDEA Materials Institute C/Eric Kandel228906 GetafeMadridSpain E.T.S.de Ingenieros de Caminos Universidad Politecnica de MadridCalle Profesor Aranguren 328040 MadridSpain Departamento de Ingenieria Electrica Electronica Automatica y Fisica AplicadaETSIDIUniversidad Politecnica de MadridRonda de Valencia 328012 MadridSpain

Early-stage fire-warning systems(EFWSs)have attracted significant attention owing to their superiority in detecting fire situations occurring in the pre-combustion *** progress on EFWSs has been achieved recently,and they have presented a considerable possibility for more evacuation time to control constant unintentional fire hazards in our daily *** review mainly makes a comprehensive summary of the current EFWSs,including the working mechanisms and their *** to the different working mechanisms,fire alarms can be classified into graphene oxide-based fire alarms,semiconductor-based fire alarms,thermoelectric-based fire alarms,and fire alarms on other working ***,the challenge and prospect for EFWSs are briefly provided by comparing the art of state of fire *** work can propose a more comprehensive understanding of EFWSs and a guideline for the cutting-edge development direction of EFWSs for readers.

关键词： Smart thermosensitive fire sensors Working mechanism Response time Signal conversion

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ISCHEMIA trial:How to apply the results to clinical practice

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World Journal of Cardiology 2021年第8期13卷 237-242页

作者： Rafael Vidal-Perez Alberto Bouzas-Mosquera Jesus Peteiro Jose Manuel vazquez-Rodriguez Servicio de Cardiologia Unidad de Imagen y Funcion CardiacaComplexo Hospitalario Universitario A Coruna(CHUAC)Centro de Investigacion Biomedica en Red(CIBERCV)-Instituto de Salud Carlos IIIA Coruna 15006Spain Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006Spain

During the last years two questions have been continuously asked in chronic coronary syndromes:(1)Do revascularization procedures(coronary artery bypass grafting or percutaneous coronary intervention)really improve symptoms of angina?and(2)Do these techniques improve outcomes,*** they prevent new myocardial infarction events and cardiovascular death?Therefore,there was a need for a large definitive *** study was the ISCHEMIA trial,a large,multicentric trial sponsored by the National Heart,Lung,and Blood *** main trial compared coronary revascularization and optimal medical treatment(OMT)vs OMT alone in 5179 patients enrolled after a stress *** a median 3.2-year follow-up,318 primary outcome events occurred;the adjusted hazard ratio for the invasive strategy as compared with the conservative strategy was 0.93(95%confidence interval 0.80-1.08,P=0.34).The ISCHEMIA trial deeply disrupted many of our prior attitudes regarding management strategies for patients with stable coronary artery *** findings underscore the benefits of disease-modifying OMT for stable coronary artery disease *** main purposes of ischemia assessment before this trial were:Diagnostic purposes,assessment of outcome,and adding to decision-making ***,this changed after the trial *** results of ISCHEMIA might challenge the current diagnostic approach for stable angina patients recommended in the last European Society of Cardiology guidelines on chronic coronary disease that were based on studies published before the ISCHEMIA *** this editorial we propose our approach based on the ISCHEMIA study and the pretest probability for a positive test in patients with chronic coronary syndromes.

关键词： Stable angina Chronic coronary syndrome ISCHEMIA Stress testing Therapy Diagnosis

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Public "Cloud" Provisioning for Venus Express VMC Image Processing

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Communications on Applied Mathematics and Computation 2019年第2期1卷 253-261页

作者： J.L.vazquez-Poletti M.P.Velasco S.Jimenez D.Usero I.M.Llorente L.vazquez O.Korablev D.Belyaev M.V.Patsaeva I.V.Khatuntsev Instituto de Matematica Interdisdiciplinar (IMI) Universidad Complutense de Madrid28040 MadridSpain Universidad Politdcnica de Madrid 28040 MadridSpain Space Research Institute of Russian Academy of Sciences (IKI) 117997 MoscowRussia

In this paper,we consider the implementation of the “cloud" computing strategy to study data sets associated to the atmospheric exploration of the planet Venus. More concretely,the Venus Monitoring Camera (VMC) onboard Venus Express orbiter provided the largest and the longest so far set of ultraviolet (UV),visible and near-IR images for investigation of the atmospheric circulation. To our best knowledge,this is the first time where the analysis of data from missions to Venus is integrated in the context of the "cloud" computing. The followed path and protocols can be extended to more general cases of space data analysis,and to the general framework of the big data analysis.

关键词： Retrieval Data integration Cloud computing Big data

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具有温度梯度的电流体动力学传导的数值研究

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Acta Mechanica Sinica 2023年第11期39卷 15-25页

作者：杜中林 Pedro A.vazquez 吴健 School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Heilongjiang Key Laboratory of Micro-and Nano-scale Fluid Flow and Hea Transfer Harbin 150001China Departamento de Fisica Aplicada Ⅱ SUniversidad de SeillaCamino de los Descubrimientos s/nSevilla 41092Spain

本文模拟研究了温度梯度对电传导现象的流动特性的影响,通过有量纲模拟研究了温度对介电液体物性及介电力的影响.为了更好地辨别不同力的影响,本文考虑了具有温度梯度的二维非对称平行电极配置,研究了介电力对电传导机制的流动模式和强... 详细信息

本文模拟研究了温度梯度对电传导现象的流动特性的影响,通过有量纲模拟研究了温度对介电液体物性及介电力的影响.为了更好地辨别不同力的影响,本文考虑了具有温度梯度的二维非对称平行电极配置,研究了介电力对电传导机制的流动模式和强度的影响.为此,我们通过增大施加的电场强度和温度梯度来改变作用在流场上的介电力.在此过程中,我们同样讨论了介电力方向对流场的影响.结果表明,与流场中单独存在库仑力的情况相比,介电力的存在显着改变了系统的流动模式和强度随着施加的电场强度和温度梯度的增大,介电力对电传导机制的流动特性的影响增强.

关键词：电流体动力学温度梯度电场强度流动模式流动特性电传导库仑力平行电极

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A study of chlorophyll-like and phycobilin pigments in the C endosymbiont of the apple- snail Pomacea canaliculata

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BIOCELL 2012年第2期36卷 47-55页

作者： ISRAEL A.VEGA FEDERICO A.DELLAGNOLA JORGE A.HURST MARTÍN S.GODOY ALFREDO CASTRO-vazquez Laboratorio de Fisiologia(IHEM-CONICET) and Departamento de Morfología y Fisiología(Facultad de Ciencias MédicasUniversidad Nacional de Cuyo)Casilla de Correo 335500 MendozaArgentina Instituto de Ciencias Básicas-Universidad Nacional de Cuyo.Padre Jorge Contreras 1300.Parque Gral.San Martín 5500 Mendoza Departamento de Química Biológica.Facultad de Farmacia y Bioquímica Universidad de Buenos Aires.Present address:Instituto de Botánica Darwinion.Labardén 200B1642HYD Buenos Aires

Pigments present in the brown-greenish C morph of an intracellular endosymbiont of Pomacea canaliculata were *** extracts of the endosymbiotic corpuscles showed an absorption spectrum similar to that of *** fractions obtained from silica gel column chromatography of the acetone extracts(CI,CII and CIII),were studied by positive ion fast atom bombardment-mass spectrometry(FAB–MS)and hydrogen-nuclear magnetic resonance(H-NMR).Results indicated the presence of(1)a sterol in the yellow colored CI fraction;(2)a mixture of pheophorbides a and b in the major green fraction,CII;and(3)a modified pheophorbide a in the smaller green fraction,*** extracts of the C endosymbiont did not show evidence of the occurrence of C-phycocyanin,allophycocyanin or phycoerithrin(light absorption,fluorescence emission,and electrophoresis of the protein moieties)while cyanobacterial cells(Nostoc sp.)showed evidence of C-phycocyanin and *** possible phylogenetic and functional significance of the pigments present in the C endosymbiont is discussed.

关键词： symbiosis Cyanobacteria chloroplast photosynthetic pigments phylogeny

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