Nanostructured biohybrid material with wide-ranging antiviral action
作者机构：Instituto de Catálisis y Petroleoquímica(ICP)CSICC/Marie Curie 2.Madrid 28049Spain Centro de Biología Molecular Severo OchoaConsejo Superior de Investigaciones Científicas(CSIC)-Universidad Autónoma de Madrid(UAM)Madrid 28049Spain Institute of Biocomputation and Physics of Complex Systems(BIFI)Joint Unit GBsC-CSIC-BIFIUniversity of ZaragozaZaragoza 50018Spain Fundación Instituto de Investigación Sanitaria de Aragón(IIS Aragón)Zaragoza 50009Spain CIBERehdMadrid 28029Spain Instituto de Biología Integrativa de SistemasI2SyBioUniversitat de València-CSICValència E-46071Spain
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第8期
页 面：11455-11463页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：supported by the Spanish National Research Council(CSIC)(projects Intramural Grant 202020E254) CSIC PTI-Global Health SGL2103036(J.M.P) European Union(Nextgeneration EU).Authors thank Dr.Martinez from Novozymes was supported by Fundación hna(A.V-C.and O.A.).P.D-C.was financially supported by a Ramón y Cajal contract RYC2019-028015-I funded by MCIN/AEI
主 题：antiviral compound coronaviruses copper nanoparticles nanobiotechnology viruses
摘 要：Respiratory pathogens kill more people than any other infectious agent each year *** of novel,economically friendly,sustainable,and highly efficient materials against viruses is a major ***,we describe a nanostructured material composed of very small crystalline phosphate copper nanoparticles synthesized using a new biohybrid technology that employs a biological agent for its formation at room temperature in aqueous *** evaluation of different enzymes in the final preparation of the nanomaterial or even in synthetic methods was *** characterization revealed the formation of Cu species in the protein *** best biomaterial synthesized using a lipase called BioCuNPs showed excellent inhibition capacity against functional proteins of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);for example,assent 3-chymotrypsin like protease(3CLpro)complete inhibition was achieved by using 5µg/mL,or acetone(ACE)–spike protein interaction was inhibited by more than 80%in the presence of 400µg/mL of *** these in vitro results into account,an efficacy analysis against human coronavirus 229E(HCoV-E229)coronavirus was performed.A virus reduction of 99%was obtained in 5 ***,SARS-CoV-2 virus was tested to demonstrate high efficiency,with99%inhibition in 15 min using 500 microgram of *** determine the wide applicability of this nanohybrid against viruses,an evaluation was carried out against a non-enveloped virus such as Human Rhinovirus(HRV-14),obtaining a virus reduction of 99.9%in 5 ***,the virucidal capacity against different bacteriophages was also evaluated,obtaining an excellent inhibition effect against PhageΦX174(99.999%reduction in 5 min).
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