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Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1086-1100页

作者： yanli Liu Zhuqing Zheng Chaohui Wang Yumeng Wang Xi Sun Zhouzheng ren Xin Yang Xiaojun Yang College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Agricultural Biotechnology Jingchu University of TechnologyJingmen 448000China

Background Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality rate.Three-dimensional(3D)chromatin architecture takes part in disease processing by regulating tran-scriptional reprogramming.The study is carried out to investigate the alterations of hepatic 3D genome and H3K27ac profiling in early fatty liver(FLS)and reveal their effect on hepatic transcriptional reprogramming in laying hens.Results Results show that FLS model is constructed with obvious phenotypes including hepatic visible lipid deposi-tion as well as higher total triglyceride and cholesterol in serum.A/B compartment switching,topologically associat-ing domain(TAD)and chromatin loop changes are identified by high-throughput/resolution chromosome conforma-tion capture(HiC)technology.Targeted genes of these alternations in hepatic 3D genome organization significantly enrich pathways related to lipid metabolism and hepatic damage.H3K27ac differential peaks and differential expres-sion genes(DEGs)identified through RNA-seq analysis are also enriched in these pathways.Notably,certain DEGs are found to correspond with changes in 3D chromatin structure and H3K27ac binding in their promoters.DNA motif analysis reveals that candidate transcription factors are implicated in regulating transcriptional reprogram-ming.Furthermore,disturbed folate metabolism is observed,as evidenced by lower folate levels and altered enzyme expression.Conclusion Our findings establish a link between transcriptional reprogramming changes and 3D chromatin struc-ture variations during early FLS formation,which provides candidate transcription factors and folate as targets for FLS prevention or treatment.

关键词： 3D chromatin architecture Fatty liver disease Folate H3K27ac profiling Transcription reprogramming

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Fine-Grained and Fair Identity Authentication Scheme for Mobile Networks Based on Blockchain

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China Communications 2022年第6期19卷 35-49页

作者： Mengjuan Zhai yanli ren Guorui Feng Xinpeng Zhang School of Communication and Information Engineering Shanghai UniversityShanghai 200444China Zhengzhou Xinda Institute of Advanced Technology Zhengzhou 450001HenanChina

With the popularity of the internet,users hope to better protect their privacy while obtaining network services.However,in the traditional centralized authentication scheme,identity information such as the user's private key is generated,stored,and managed by the network operator.Users can't control their identity information,which will lead to a great threat to the privacy of users.Based on redactable blockchain,we propose a fine-grained and fair identity authentication scheme for mobile networks.In our proposed scheme,the user's identity information is generated and controlled by the users.We first propose a notion of score chameleon hash(SCH),which can delete or update the information of illegal users so as to dynamically update the status of users and provide users with more fine-grained and fair services.We propose another notion of self-updating secret sharing(SUSS),which allows users to update the trapdoor and the corresponding hash key after redacting the blockchain without requiring trusted authority to redistribute the trapdoor.Experimental results show that,compared with the immutable blockchain Bitcoin,the redactable blockchain in our identity authentication scheme provides users with fine-grained and fair redacting functions,and can be adopted with a small additional overhead.

关键词： identity authentication secret sharing chameleon hash redactable blockchain

The Knowledge on HCV:From the Discovery to the Elimination

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Infectious Microbes & Diseases 2022年第1期4卷 1-6页

作者： Jun Guan yanli ren Jing Wang Haihong Zhu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

From being described as“non-A,non-B”hepatitis in 1975 and being identified in 1989,to the emergence of direct-acting antiviral drugs(DAAs),knowledge on hepatitis C virus(HCV)has achieved a qualitative leap in recent decades.Although more than 95%of HCV patients can be cured by DAAs,the high detection rate,high treatment cost,and relative high recurrence rate for some subtypes(eg,type 3b)make it still a public health problem worldwide.Due to the widespread availability of DAAs,vaccine research has received relatively little attention.The purpose of this review is to look back to the discovery of the HCV,its life cycle,innate and adaptive immune responses,and the evolution of treatment options for HCV.

关键词： HCV discovery life cycle immune response therapy vaccination

Differential Expression Analysis of Proteins Regulated by Rare Earth Cerium in Soybean Leaves at Seedling Stage

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Journal of Northeast Agricultural University(English Edition) 2024年第1期31卷 42-52页

作者： ren Hongyu Zhang Tianren Miao yanli Li Haoyang Zhang Shuying Zhang Xingwen College of Resources and Environment Northeast Agricultural UniversityHarbin 150030China College of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China

This study was to explore the functional mechanism of rare earth regulating soybean leaves and the characteristics and functions of differentially expressed proteins under the regulation of rare earth. In this study, Dongnong 42 was used as material, and 30 mg·L^(-1) CeCl_(3) solution was sprayed on soybean leaves at the seedling stage. Tandem mass tag(TMT) quantitative proteomics technique and bioinformatics analysis were used to identify soybean leaf proteins. A total of 8 510 proteins were identified, and 127 differentially expressed proteins(DEPs) in response to rare earth cerium regulation were identified, among which 64 were upregulated and 63 were down-regulated. The gene ontology(GO) annotation indicated that DEPs were mainly involved in metabolic process, cellular process, response to stimulus, biological regulation, and response to a stimulus;DEPs in cell module categories were mainly involved in cells, cell part, organelle, membrane, membrane part, organelle par, and protein-containing complex;DEPs in molecular functional categories were mainly involved in catalytic activity, binding and antioxidant activity. Kyoto encyclopedia of genes and genomes(KEGG) pathway significantly enriched starch and sucrose metabolism, glycolysis/gluconeogenesis, galactose metabolism, pentose phosphate pathway, and MAPK signaling pathway-plant. These DEPs were mainly involved in photosynthesis, glucose metabolism and stress response. Forty-six differential protein interaction networks were identified by protein interaction network analysis. This experiment provided a reference for studies of the mechanism of rare earth cerium regulating soybean leaf function from the proteomic perspective.

关键词： rare earth soybean proteomics tandem mass tag(TMT)

Efficient and secure outsourcing of bilinear pairings with single server

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Science China(Information Sciences) 2018年第3期61卷 240-242页

作者： Min DONG yanli ren School of Communication and Information Engineering Shanghai University

Dear editor,Cloud computing is playing important role at the era of big data,and its availability makes outsourcing computations possible[1].By outsourcing computations,mobile devices with weak computational ability can outsource complex operations to powerful cloud servers so that the time cost can be greatly reduced[2].Despite of unique advantages,there are also some security challenges we need pay attention to.

关键词： Efficient and secure outsourcing of bilinear pairings with single server

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*-诣零McCoy环

浙江大学学报（理学版） 2024年第2期51卷 162-171页

作者：王尧李欣任艳丽南京信息工程大学数学与统计学院江苏南京210044 南京晓庄学院信息工程学院江苏南京211171

研究了具有对合映射*-诣零McCoy环的性质,给出了一批*-诣零McCoy环例子,并讨论了其扩张和*-斜多项式环的*-诣零McCoy性,证明了(1)设*-环R满足nil(R[x])=nil(R)[x],则环R是*-诣零McCoy环当且仅当环R[x]是*-诣零McCoy环;(2)设R[x;*]是*-... 详细信息

研究了具有对合映射*-诣零McCoy环的性质,给出了一批*-诣零McCoy环例子,并讨论了其扩张和*-斜多项式环的*-诣零McCoy性,证明了(1)设*-环R满足nil(R[x])=nil(R)[x],则环R是*-诣零McCoy环当且仅当环R[x]是*-诣零McCoy环;(2)设R[x;*]是*-斜多项式环,如果R是*-可逆环,则R[x;*]是*-诣零McCoy环。

关键词：对合 McCoy环 *-诣零McCoy环 *-斜多项式环

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一种委员会机制的可编辑区块链方案

北京邮电大学学报 2024年第1期47卷 120-126页

作者：刘亚李昌辉赵逢禹任艳丽上海理工大学光电信息与计算机工程学院上海200093 上海出版印刷高等专科学校信息与智能工程系上海200093 上海大学通信与信息工程学院上海200444

区块链具有去中心化、可追溯、不可篡改等特性,但其不可篡改性使得链上一些违法信息被永久保留。针对这一问题,提出基于委员会机制的可编辑区块链方案。首先,通过随机抽签算法选取委员会成员;接着,结合基于权益证明共识机制,对用户编辑... 详细信息

区块链具有去中心化、可追溯、不可篡改等特性,但其不可篡改性使得链上一些违法信息被永久保留。针对这一问题,提出基于委员会机制的可编辑区块链方案。首先,通过随机抽签算法选取委员会成员;接着,结合基于权益证明共识机制,对用户编辑请求采用投票共识的去中心化编辑策略;最后,利用变色龙哈希函数修改链上数据;此外,引入问责机制防止用户作恶,论证了该方案的安全性和收敛性。模拟实验验证,所提方案能够在去中心化的环境下高效地修改区块内容,且不影响区块链的一致性。

关键词：区块链可编辑委员会机制加密抽签

Two New 2D POMs-Based Inorganic-Organic Hybrid Compounds Constructed from the Proline and 4,4＇-Bipy Mixed Ligands

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Chinese Journal of Chemistry 2017年第3期35卷 347-353页

作者： yanli ren Dandan Yang Na Li Rudan Huang Key Laboratory of Cluster Science of Ministry of Education School of Chemistry Beo'ing Institute of Technology Beijing 100081 China

Two new 2D hybrid compounds derived from Keggin‐type [BW 12 O 40 ] 5− anion, proline and 4,4’‐bipy were synthesized, namely, [Co II 2 (proline)(4,4’‐bipy)(H4,4’‐bipy) 2 (OH)(H 2 O) 2 ][BW 12 O 40 ]•3H 2 O ( 1 ) and [Co II 3 (proline) 2 (4,4’‐ bipy) 2 (H4,4’‐bipy) 4 (OH) 2 (H 2 O) 4 ][BW 12 O 40 ] 2 •6H 2 O ( 2 ). They are characterized by single‐crystal X‐ray diffraction, FT‐IR spectra, powder X‐ray diffraction (PXRD), thermogravimetric analyses (TGA) and XPS spectra. All compounds represent 2D framework, but the structures possess some distinctions to a certain degree. In compound 1 , 1D wave‐like chains are formed. The chains and polyanions are stacked each other in an ABAB fashion to yield a 2D network. However, compared with compound 1 , compound 2 exhibits the same construction except for the opposite arrangement mode. Moreover, their electrochemical behaviors and fluorescence properties have been investigated. The electrochemical properties show that compounds 1 , 2 display good electrocatalytic activities for the reduction of nitrite.

关键词： [BW12O40]5− anion proline 4,4’‐bipy hybrid compound electrochemical property

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*-zip环

山东大学学报（理学版） 2024年第2期59卷 1-7页

作者：王尧李欣任艳丽南京信息工程大学数学与统计学院江苏南京210044 南京晓庄学院信息工程学院江苏南京211171

提出*-zip环的概念,给出一些*-zip环的例子,研究它们的扩张性质。证明:(1)设*是环R上的一个对合,n∈N且n≥2,则R是*-zip环当且仅当Vn(R)是■环;(2)设R是一个*-斜Armendariz环,则R是*-zip环当且仅当*-斜多项式环R[x;*]是*-zip环。

关键词：对合 *-zip环环的扩张 *-斜多项式环