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Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese uygur ethnic minority

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第5期17卷 367-374页

作者： yu-xin GUO Jian-gang CHEN Yan WANG Jiang-wei YAN Jing CHEN Tian-hua YAO Li-ping ZHANG Guang yang Hao-tian MENG yu-dang ZHANG Ting MEI Yao-shun LIU Qian DONG Bo-feng ZHU Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University Xi 'an 710004 China Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases College of Stomatology Xi 'an liaotong University Xi 'an 710004 China Research Center of Stomatology Stomatological Hospital Xi'an Jiaotong University Xi 'an 710004 China Department of Biochemistry Preclinical Medicine College Xinjiang Medical University Urumqi 830011 China Criminal Police Detachment of Yili Public Security bureau Yili 835000 China Key Laboratory of Genome Sciences Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China Department of General Dentistry Stomatological Hospital Xi'an Jiaotong University Xi'an 710004 China Department of Pathology and Laboratory Medicine Loma Linda University Medical Center California 92354 USA

The population genetic data and forensic parameters of 19 X-chromosome short tandem repeat （X-STR） loci in Chinese uygur ethnic minority are presented. These loci were detected in a sample of 233 （94 males and 139 females） unrelated healthy individuals. We observed 238 alleles at the 19 X-STR loci, with the corresponding gene frequencies spanning the range from 0.0021 to 0.5644. After Bonferroni correction （P〉0.0026）, there were no signif- icant deviations from Hardy-Weinberg equilibrium. The cumulative power of discrimination in females and males, and the probability of exclusion of the 19 X-STR loci were 0.999 999 999 999 999 999 998 091,0.999 999 999 999 966, and 0.999 999 986 35, respectively. The cumulative mean exclusion chance was 0.999 999 992 849 in deficiency cases, 0.999 999 999 999 628 in normal trios, and 0.999 999 998 722 in duo cases. The high value of the forensic parameters mentioned above revealed that the novel panel of 19 loci had important values for forensic applications in the LJygur group.

关键词： X-chromosome Short tandem repeat (STR) uygur Genetic polymorphism Forensic

Protective effect and mechanism of dexmedetomidine on lung injury in diabetic mice with myocardial ischemia reperfusion

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Journal of Hainan Medical University 2021年第19期27卷 15-20页

作者： Ai-Mei Li Jia-xin Li Si-yu Chen Jiang Wang Department of Anesthesiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China

Objective:To evaluate the protective effect of dexmedetomidine and its mechanism on the lung after myocardial ischemia reperfusion in diabetic ***:Adult diabetic db/db mice aged 15 weeks were *** sham operation group(S group),ischemic reperfusion group(IR group),dexmedetomidine post-treatment group(POST-D)and dexmedetomidine pre-treatment group(PRE-D)were set *** IR group of mice underwent ligation of anterior descending branch of left coronary artery for 30min and readministration for *** post-D group and the pre-D group were intraperitoneally injected with 50 ug/kg DEX before surgery and during reperfusion,*** blood was extracted at 120min of reperfusion,serum levels of creatine kinase isoenzyme MB and inflammatory cytokines IL-6,IFN-γand IL-10 were detected,then mice were sacrificed and lung tissue was taken,the ratio of wet and dry weight(W/D)was determined,lung histopathological morphology was observed under light microscope,superoxide dismutase(SOD)and malondialdehyde(MDA)contents were determined,Western Blot was used to detect the expressions of Sirt1,GRP78 and CHOP in lung ***:Compared with the S group,the IR group rats had severe lung injury,including increased lung W/D value,increased serum CK-MB、IL-6 and IFN-γlevels,decreased serum IL-10,increased serum MDA content,decreased SOD activity,down-regulated Sirt1 expression,up-regulated GRP78 and CHOP *** with IR group,lung histopathological injury was reduced in post-D group and pre-D group,lung W/D value was decreased,serum CK-MB、IL-6 and IFN-γlevels were decreased,serum IL-10 was increased,serum MDA content was reduced,SOD activity was rised,the expression of Sirt1 was up-regulated,and GRP78 and CHOP were *** with the post-D group,the degree of lung tissue injury in the pre-D group was reduced,but the differences in various indicators were not statistically ***:Dexmedetomidine can allevia

关键词： Dexmedetomidine Sirt1 Endoplasmic reticulum stress Lung injury

硝酸钕28 d经口毒性试验ICR小鼠组织脏器中钕含量及其分布研究

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毒理学杂志 2024年第4期38卷 257-264页

作者：张慧敏黄蕊芳丁瑜徐菁成雪晴刘君丽李元香钱科蕾郑志清王宁洪新宇上海市疾病预防控制中心化学品毒性检定所动物毒理检测与评价室上海200336 新疆维吾尔自治区疾病预防控制中心毒理科新疆乌鲁木齐830002

目的用电感耦合等离子体质谱法(ICP-MS)对28 d经口染毒试验ICR小鼠全血和脏器中钕含量进行测定。方法全血和脏器样品经硝酸微波消解、ICP-MS测定,用外标法定量,评价稀土钕元素在小鼠全血和脏器中的含量。结果钕元素的检出限为0.0018μg... 详细信息

目的用电感耦合等离子体质谱法(ICP-MS)对28 d经口染毒试验ICR小鼠全血和脏器中钕含量进行测定。方法全血和脏器样品经硝酸微波消解、ICP-MS测定,用外标法定量,评价稀土钕元素在小鼠全血和脏器中的含量。结果钕元素的检出限为0.0018μg/L,回收率为97.2%~111.0%,相对标准偏差为1.63%~7.93%,线性相关系数为0.9993,该方法各项指标均符合相关检测要求;硝酸钕连续给药28 d后,心钕含量、肝钕含量和肾钕含量雌性小鼠从12 mg/kg·bw开始明显上升(F值分别为2289.00、37.09和903.50,P<0.05),雄性小鼠从7 mg/kg·bw开始明显上升(F值分别为895.40、38.51和465.30,P<0.05);肺和脾的钕含量雌性小鼠从24 mg/kg·bw开始明显上升(F值分别为3702.00、94.66,P<0.05),雄性小鼠从14 mg/kg·bw开始明显上升(F值分别为4988.00、104.00,P<0.05);脑钕含量雄性小鼠从27 mg/kg·bw开始,明显上升(F值为3.48,P<0.05);睾丸钕含量雄性小鼠从14 mg/kg·bw开始,明显上升(F值为8.28,P<0.05)。血钕含量、脑钕含量、心钕含量、肺钕含量、肝钕含量、脾钕含量、肾钕含量和给药剂量有统计学意义上的相关性[雌性小鼠r值分别为0.85、0.94、0.81、0.97、0.97、0.99、0.93,雄性小鼠r值分别为0.95、0.97、0.81、0.91、0.96、0.97、0.95和0.98(睾丸钕含量),P<0.05]。结论所建立的检测方法准确灵敏,硝酸钕经口摄入可在小鼠体内经血液分布于全身各脏器,其中分布最多的是心脏、肝和肾,其次是肺、脾和睾丸,脑中钕含量较低。不同脏器钕含量与给药剂量有显著的相关性。

关键词：微波消解电感耦合等离子体质谱法稀土元素钕

Treatment satisfaction with rheumatoid arthritis in patients with different disease severity and financial burden:A subgroup analysis of a nationwide survey in china

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Chinese Medical Journal 2020年第8期133卷 892-898页

作者： Hong-Bin Li Li-Jun Wu Nan Jiang Ping-Ting yang Sheng-yun Liu Xiao-Fei Shi Yong-Fei Fang Yi Zhao Jian Xu Zhen-yu Jiang Zhen-Biao Wu xin-Wang Duan Qian Wang Meng-Tao Li xin-Ping Tian Xiao-Feng Zeng Department of Rheumatology Affiliated Hospital of Inner Mongolia Medical CollegeHohhotInner Mongolia 010050China Department of Rheumatology&Immunology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Rheumatology Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesKey Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Rheumatology and Immunology First Affiliated HospitalChina Medical UniversityShenyangLiaoning 110001China Department of Rheumatology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Rheumatology and Immunology The First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and TechnologyLuoyangHenan 471003China Department of Rheumatology Southwest HospitalThird Military Medical UniversityChongqing 400038China Department of Rheumatology and Immunology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Rheumatology and Immunology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Rheumatology The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Clinical Immunology and Rheumatology Xijing Hospital Affiliated to Air ForceMedical UniversityXi’anShaanxi 710032China Department of Rheumatology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Background:Despite the recent advances in treatments for rheumatoid arthritis (RA), there are still unmet needs in disease outcomes. This study aimed to analyze the satisfaction with drug therapies for RA according to the levels of disease severity (patientassessed) and proportions of treatment cost to household ***:This was a subgroup study of a cross-sectional study in patients with RA and their physicians. The patients were subdivided into different subgroups based on their self-assessed severity of RA and on the proportions of treatment cost to household income (50%). The Treatment Satisfaction Questionnaire for Medication version II was used to assess patients’ treatment ***:When considering all medications, effectiveness, convenience, and global satisfaction scores were lower in the severe and moderate RA subgroups than those in the mild and extremely mild RA subgroups (all P 50% subgroup (all P 50% subgroups ( F = 12.646, P = 0.005). Global satisfaction score was higher in the <10% subgroup than that in the 31% to 50% subgroup ( F = 8.794, P = 0.032). Conclusion:Higher disease severity and higher financial burden were associated with lower patient satisfaction.

关键词： Disease severity Rheumatoid arthritis Treatment cost Treatment satisfaction

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改进的蚁群优化算法求解旅行商问题

计算机工程与设计 2022年第4期43卷 962-968页

作者：赵鑫杨雄飞钱育蓉新疆大学软件学院新疆乌鲁木齐830046 新疆大学软件工程重点实验室新疆乌鲁木齐830046 新疆维吾尔自治区信号检测与处理重点实验室新疆乌鲁木齐830046

针对基本蚁群算法在求解旅行商问题时表现的停滞和早熟现象,提出一种带遗忘因子的蚁群优化算法。通过在人工蚂蚁中加入遗忘因子,建立新的状态转移公式,修改信息素更新策略,蚂蚁按照基本蚁群算法的搜索方式工作,结合当前解的最优值误差率... 详细信息

针对基本蚁群算法在求解旅行商问题时表现的停滞和早熟现象,提出一种带遗忘因子的蚁群优化算法。通过在人工蚂蚁中加入遗忘因子,建立新的状态转移公式,修改信息素更新策略,蚂蚁按照基本蚁群算法的搜索方式工作,结合当前解的最优值误差率,对状态转移方程进行调整,新公式可用于降低最优值误差、提高最优值跟踪能力、修正路径评价模型、计算每条路径到当前最优解的概率。对TSP实例的仿真结果表明,改进算法耗时更短,路径寻优结果更优。

关键词：蚁群优化算法优化组合问题启发式算法旅行商问题信息素更新

Impact of the interval after endoscopic dacryocystorhinostomy on the outcomes of intraocular surgery: a 4-year retrospective study

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Annals of Eye Science 2021年第3期6卷 7-12页

作者： Wen-yu Wu Rong-xin Chen Hui-Ying yu Jun Mao xin-yue yu Shu-Juan Cao Yan-Dong Wang Xuan-Wei Liang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouChina Ophthalmologic Center First People’s Hospital in KashgarKashgarChina

Background:Patients with dacryocystitis should be treated for their infection by endoscopic dacryocystorhinostomy(EN-DCR)before any intraocular ***,there is no unified standard for the specific time interval between the two *** study aimed to determine the appropriate interval for intraocular surgery in patients with previous EN-DCR for chronic ***:The medical files of all patients who underwent intraocular surgery after EN-DCR surgery in our hospital from 2016 to 2019 were *** EN-DCR data of patients undergoing intraocular surgery at different time intervals and the incidence of endophthalmitis after intraocular surgery were ***:A total of 116 patients(92 females and 24 males,mean age 64.06±7.78 years)underwent EN-DCR and intraocular surgery met the inclusion *** interval between EN-DCR and intraocular surgery varied from 5-475 *** number of patients undergoing cataract surgery after EN-DCR is the largest(75,64.7%).All patients(100%)who had previously undergone EN-DCR did not develop endophthalmitis infection after intraocular surgery at a follow-up of 12 ***:For patients with dacryocystitis who have undergone EN-DCR surgery,there is no time limit when choosing the timing of intraocular *** patients requiring intraocular surgery,operation can be arranged as soon as possible to solve their problems as long as the patients had patency on lacrimal passage irrigation and no secretions.

关键词： Dacryocystitis intraocular surgery endophthalmitis endoscopic dacryocystorhinostomy(EN-DCR) interval

Dynamic Observation of Cartilage Damage and Serum IL-1β, TNF-α, IL-6 and IL-17 in Post-traumatic Rat Osteoarthritis Model

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Journal of Northeast Agricultural University(English Edition) 2022年第3期29卷 59-65页

作者： Lv Liang-yu Ma Tian-wen yu yue Jia Li-na Xu xin-yu Zhao Ming-chao Chen Hong Sheng Xuan-bo Li Ting Xiao Jian-hua Gao Li College of Veterinary Medicine Northeast Agricultural UniversityHeilongjiang Key Laboratory Animals and Comparative MedicineHarbin 150030China

The pathogenesis of animal osteoarthritis(OA)is not *** aim of this study was to investigate the dynamic changes of cartilage lesions and serum IL-1β,TNF-α,IL-6 and IL-17 inflammatory factors in a post-traumatic osteoarthritis model in rats,and to explore their values in monitoring the progression of *** male SD rats were randomly divided into the control group(n=20)and the model group(n=20).The OA model was established by anterior cruciate ligament transection combined with partial medial meniscus resection(ACLT+PMMx)in the model group,and sham operation was performed in the control *** the 0th,10th,20th and 30th days after modeling,the degree of joint swelling and the number of white blood cells in the peripheral blood were evaluated,and tibia samples were taken for macroscopic observation score and pathological *** serum levels ofIL-1β,TNF-α,IL-6 and IL-17 concentration were detected by enzyme-linked immunosorbent assay(ELISA).The results showed that the cartilage damage in the tibial surface and pathological observations of rats in the model group gradually increased with time,the eye scores increased and increased significantly on the 20th and 30th days(P<0.01),and the joints of the rats were *** the swelling was extremely significant on the 30th day(P<0.01).Compared with the control group,the number of white blood cells in the peripheral blood of the model group gradually increased,and the increase was extremely significant on the 20th and 30th days(P<0.01).The serum IL-17 concentration in the model group tended to increase,and the increase was significant on the 20th day(P<0.05)and extremely significant on the 30th day(P<0.01);the serum TNF-αand IL-1βconcentrations in the model group showed an increasing trend,and the increase was extremely significant on the 10th,20th and 30th days(P<0.01);IL-6 concentration in the serum of the model group showed an increasing trend,and it increased significantly on the 30th da

关键词： osteoarthritis inflammatory factor cartilage injury rat

E ect of Optical Depth on Study of Chemical Properties of Massive Star Forming Clumps

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Chinese Journal of Chemical Physics 2020年第1期33卷 114-118页

作者： Jian-jun Zhou Run-xia Li Donghui Quan Jarken Esimbek yu-xin He Da-lei Li xin-di Tang Gang Wu Wei-guang Ji Zheng-xue Chang Xia Zhang xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of the Chinese Academy of Sciences Beijing 100080China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China Department of Chemistry Eastern Kentucky UniversityRichmond KY 40475USA

Here we present the study on chemical properties of massive star forming clumps using N2H^+(1-0),H^13CO+(1-0),HCN(1-0)and HN^13C(1-0)data from the literature[***.563,A97(2014)].We found that abundances of H^13CO+ and HN^13C are a ected by H2 column *** the median values of these two abundances increase by nearly 10 times from stages A to B,H^13CO+and HN^13C are suitable for tracing the evolution of massive star forming *** order of rapidity in growth of abundances of all the four studied molecules from stages A to B,is H^13CO^+,HCN,HN^13C,and N2H^+,from the highest to the *** results suggest that the observing optically thin molecular lines with high angular resolution are necessary to study the chemical evolution of massive star forming clumps.

关键词： Stars formation Clumps Molecules Radio lines

双钩细蠓新种描述及其飞舞活动的初步观察(双翅目:蠓科)

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昆虫学报 1989年第1期32卷 97-100页

作者：虞以新军事医学科学院微生物流行病研究所

1985年7月,在新疆克拉玛依市北,乌尔禾镇河滩发现有细蠓刺叮,从而进行了成蠓飞舞活动数量动态的初步观察。观察之日天晴无风,用60目绢纱制作的气网,每小时作交叉挥网采集5分钟,自清晨6时至下午22时,共采获细蠓雌性成虫443只,雄虫227只... 详细信息

1985年7月,在新疆克拉玛依市北,乌尔禾镇河滩发现有细蠓刺叮,从而进行了成蠓飞舞活动数量动态的初步观察。观察之日天晴无风,用60目绢纱制作的气网,每小时作交叉挥网采集5分钟,自清晨6时至下午22时,共采获细蠓雌性成虫443只,雄虫227只。经分类鉴定,所捕细蠓均为一新种。根据特征命名为双钩细蠓Leptoconops(Holoconops)binangulus ***.

关键词：双钩细蠓新种描述飞舞活动