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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu jing yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton

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Science China Life Sciences 2025年

作者： Yanlong Li Yinuo Fu Yaoyao Li Rui Zhang jing yang Huanhuan Ma Ling Min Xianlong Zhang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

High temperature (HT) stress causes male sterility,leading to reduced upland cotton ***,we identified a key gene,Casein Kinase I (GhCKI),that negatively regulates male fertility in upland cotton under ***,conventional genetic manipulations of GhCKI would result in male sterility,hindering its utilization in breeding ***,we engineered quantitative variation for anther thermotolerance-related traits in upland cotton by creating weak promoter alleles of GhCKI genes,using CRISPR/Cas9 and CRISPR/Cpf1genome ***,we screened and identified two new upland cotton plant lines exhibiting a HT-tolerant phenotype with edited GhCKI promoters,and characterized their corresponding heat-tolerant allelic *** research revealed that the primary reason for the HT tolerance of the GhCKI promoter editing mutants is that the trans-acting factors GhMYB73 and GhMYB4,which positively regulate GhCKI expression under HT,failed to bind and activate the expression of ***,our study not only provides a rapid strategy to generate new beneficial alleles but also offers novel germplasm resources and molecular insights for crop HT tolerance breeding.

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Pronounced impact of size and shape effects on creep rupture life of a K439B superalloy combustion chamber casting simulator

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China Foundry 2025年

作者： Wen-tong Liu Yi-dong Wu Lei Gao jing-yang Chen Cheng-bo Xiao Xi-dong Hui State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical Materials

The size and shape effect(SSE) of components has become a critical issue for mechanical properties, application reliability, and processing. In this study, the creep rupture life(CRL) of components with different wall thicknesses and positions in a combustion chamber casing simulator made of K439B superalloy was investigated. The intrinsic mechanisms of the SSE were explored from the dendrite structure, volume fraction and size of the γ' phase, and element segregation, etc. It is shown that this casting exhibits a strong SSE of creep rupture life, characterized by a significant difference in the CRL values up to 60% with the variation of wall thickness and position in the casing. In terms of casting technology, the influence of SSE on CRL is actually determined by the cooling rate. The SSE on the creep rupture life originates from the dendrite structure(such as the secondary dendrite arm spacing), volume fraction size of the γ' phase in the dendrite trunk, and elements segregation rate. This work may have implications for the design and application of engineering components with large sizes and complex structures.

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基于图像处理和BP神经网络的森林防火无人机系统

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农机化研究 2025年第2期47卷 205-209页

作者：杨静湖北警官学院武汉430034

对无人机设计方案、图像处理和火焰分割算法的技术原理进行了介绍,并利用BP神经网络对图像中的火焰面积变化率和火焰尖角等特征进行识别,实现了对森林火灾的快速监测。实验结果表明:系统的准确率为98.5%,比普通神经网络的84.5%更高;耗时... 详细信息

对无人机设计方案、图像处理和火焰分割算法的技术原理进行了介绍,并利用BP神经网络对图像中的火焰面积变化率和火焰尖角等特征进行识别,实现了对森林火灾的快速监测。实验结果表明:系统的准确率为98.5%,比普通神经网络的84.5%更高;耗时仅22 s,比普通神经网络159 s缩短很多。这表明,BP神经网络是更可靠且更有效率的火灾识别方案。

关键词：森林防火无人机图像处理 BP神经网络

Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： jing yang Hui Peng Sheng-Ke Tu Min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

“1+X”书证融通背景下高职院校人才培养模式探究

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黑龙江教师发展学院学报 2025年第1期44卷 81-86页

作者：杨晶尧朝阳师范学院辽宁朝阳122000

随着职业教育的持续推进与深化改革,“1+X”书证融通制度已成为高职院校人才培养的崭新范式。基于此,首先阐述1+X证书制度的概念和特点,其次分析高职院校人才培养模式的现状,再次探讨“1+X”制度实施的必要性和可行性,并基于“1+X”书... 详细信息

随着职业教育的持续推进与深化改革,“1+X”书证融通制度已成为高职院校人才培养的崭新范式。基于此,首先阐述1+X证书制度的概念和特点,其次分析高职院校人才培养模式的现状,再次探讨“1+X”制度实施的必要性和可行性,并基于“1+X”书证融通背景提出高职院校人才培养模式的构建策略,以期提高高职院校的教育品质,并显著增强毕业生的就业竞争力,使他们在日益激烈的职场竞争中脱颖而出。

关键词： “1+X”书证融通高职院校人才培养模式

铜基催化剂在乙炔氢氯化反应中的工业应用评估

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现代化工 2025年第1期45卷 72-76页

作者：代元元杨京林牛强内蒙古鄂尔多斯电力冶金集团股份有限公司内蒙古鄂尔多斯016064

概述了近年来国内外铜催化剂在乙炔氢氯化反应中的研究进展,综述了铜催化剂的几种改性手段,探讨了催化剂的工业应用情况,分析了铜催化剂工业应用的安全风险问题。研究表明,经过适当改性,铜催化剂具备工业应用潜力,且在实际工业生产中通... 详细信息

概述了近年来国内外铜催化剂在乙炔氢氯化反应中的研究进展,综述了铜催化剂的几种改性手段,探讨了催化剂的工业应用情况,分析了铜催化剂工业应用的安全风险问题。研究表明,经过适当改性,铜催化剂具备工业应用潜力,且在实际工业生产中通过严格控制工艺指标可避免铜工业应用的安全风险问题。

关键词：乙炔氢氯化铜催化剂工业化应用安全性

Excavator Energy-saving Efficiency Based on Diesel Engine Cylinder Deactivation Technology

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Chinese Journal of Mechanical Engineering 2012年第5期25卷 897-904页

作者： yang jing QUAN Long yang yang Key Laboratory of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology Taiyuan 030024 China The State Key Lab of Fluid Power Transmission and Control Zhejiang University Hangzhou 31002 7 China

The hydraulic excavator energy-saving research mainly embodies the following three measures： to improve the performance of diesel engine and hydraulic component, to improve the hydraulic system, and to improve the power matching of diesel-hydraulic system-actuator. Although the above measures have certain energy-saving effect, but because the hydraulic excavator load changes frequently and fluctuates dramatically, so the diesel engine often works in high-speed and light load condition, and the fuel consumption is higher. Therefore, in order to improve the economy of diesel engine in light load, and reduce the fuel consumption of hydraulic excavator, energy management concept is proposed based on diesel engine cylinder deactivation technology. By comparing the universal characteristic under diesel normal and deactivated cylinder condition, the mechanism that fuel consumption can be reduced significantly by adopting cylinder deactivation technology under part of loads condition can be clarified. The simulation models for hydraulic system and diesel engine are established by using AMESim software, and fuel combustion consumption by using cylinder-deactivation-technology is studied through digital simulation approach. In this way, the zone of cylinder deactivation is specified. The testing system for the excavator with this technology is set up based on simulated results, and the results show that the diesel engine can still work at high efficiency with part of loads after adopting this technology; fuel consumption is dropped down to 11% and 13% under economic and heavy-load mode respectively under the condition of driving requirements. The research provides references to the energy-saving study of the hydraulic excavators.

关键词： diesel engine cylinder deactivation hydraulic excavator energy-saving

An overview of cryptographic primitives for possible use in 5G and beyond

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Science China(Information Sciences) 2020年第12期63卷 5-26页

作者： jing yang Thomas JOHANSSON Department of Electrical and Information Technology Lund University

This survey overviews the potential use of cryptographic primitives in the fifth-generation mobile communications system(aka 5G) and beyond. It discusses the new security challenges that come with 5G and presents the upcoming security architecture. It shows the use of current cryptographic algorithms and discusses new algorithms or modifications of existing ones, that can be relevant. It also discusses the need for lightweight algorithms to meet the new use cases as well as the general demand for algorithms secure even when large quantum computers are available.

关键词： 5G cryptographic primitives lightweight cryptography post-quantum cryptography