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Gefapixant,a Novel P2X3 Antagonist,Protects against Post Myocardial Infarction Cardiac Dysfunction and Remodeling Via Suppressing NLRP3 Inflammasome

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Current Medical Science 2023年第1期43卷 58-68页

作者： yan-zhao WEI Shuang yanG Wei LI yan-hong tang Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan430060China Cardiovascular Research Institute Wuhan UniversityWuhan430060China Hubei Key Laboratory of Cardiology Wuhan430060China Department of Cardiology Wuhan No.1 HospitalWuhan Hospital of Traditional Chinese and Western MedicineWuhan430022China

Objective The ATP responsive P2 purinergic receptors can be subdivided into metabotropic P2X family and ionotropic P2Y *** these,P2X3 is a type of P2X receptor which is specifically expressed on nerves,especially on pre-ganglionic sensory *** study investigates whether gefapixant possesses the potential of inhibiting cardiac sympathetic hypersensitivity to protect against cardiac remodeling in the context of myocardial *** The Sprague-Dawley rats were divided randomly into three groups:sham group-myocardial infarction group,and myocardial infarction with gefapixant treatment *** infarction was induced by left anterior descending branch *** gefapixant solution was intraperitoneally injected each time per day for 7 days and the appropriate dosage of gefapixant was determined according to the results of hematoxylin-eosin(HE)staining and myocardial injury *** of cardiac function were assessed by echocardiograph and cardiac fibrosis was evaluated by Western blotting and immunofluorescence staining of collagen I and collagen *** sympathetic innervation was detected by norepinephrine concentration(pg/mL),in-vivo electrophysiology,and typical sympathetic *** cell infiltration was shown from immunofluorescence staining and pro-inflammatory signaling pathway activation was checked by immunohistology,quantitative realtime PCR(qPCR)and Western *** It was found that gefapixant injection of 10 mg/kg per day had the highest dosage-efficacy ***,gefapixant treatment improved cardiac pump function as shown by increased LVEF and LVFS,and decreased LVIDd and *** expression levels of collagen I and collagen III,and TNF-αwere all decreased by P2X3 ***,the decreased activation of nucleotide-binding and oligomerization domain-like receptors family pyrin-domain-containing 3(NLRP3)inflammasome and subsequent cleavage of caspase-1 which modula

关键词： myocardial infarction P2X3 inhibition gefapixant nucleotide-binding and oligomerization domain-like receptors family pyrin-domain-containing 3 inflammasome sympathetic nerve

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Synthesis and curing of a novel amino-containing phthalonitrile derivative

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Chinese Chemical Letters 2007年第5期18卷 523-526页

作者： Ke Zeng Ke Zhou Wen Rui tang yan tang hong Fei Zhou Tao Liu Yi Peng Wang Hai Bing Zhou Gang yang State Key Laboratory of Polymer Materials Engineering College of Polymer Science and Engineering Sichuan University Chengdu 610065 China

A novel phthalonitrile derivative containing an amino group, 3,5-bis（3,4-dicyanophenoxy）aniline （CPA）, was synthesized via a nucleophilic displacement of 4-nitrophthalonitrile and 5-aminoresorcinol hydrochloride. The structure of CPA was confirmed by Fourier transform infrared spectra （FT-IR） and nuclear magnetic resonance （^1H NMR）. Thermal analysis performed on CPA revealed that the novel phthalonitrile derivative showed a self-promotion curing behavior and the resulting polymer exhibited outstanding heat-resistance.

关键词： Phthalonitrfle derivative Amino group Self-promotion curing behavior

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Comparisons of{100}texture improvement and formability in hot-rolled non-oriented electrical steel by austenite-ferrite phase transformation and shear deformation

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Journal of Iron and Steel Research International 2025年第1期32卷 171-185页

作者： Chi-hao Yu hong-jiang Pan yan-ping Zhao De-ting tang Hai-jun Wang Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093YunnanChina School of Electronics and Information Engineering Anshun UniversityAnshun561000GuizhouChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina

Over the years,the high magnetic induction of industrial Mn-added electrical steel is assumed to be the enhancement of{100}texture derived from its austenite-ferrite phase transformation during hot rolling(phase transformation(PT)method).However,it is still undetermined without straightforward experimental *** reason for{100}texture improvement of Mn-added electrical steel is experimentally confirmed due to the recrystallization induced by the austenite-ferrite phase transformation during hot ***,a more promising methodology to further improve{100}texture and formability of hot-rolled electrical steel is promoted by the control of hot rolling deformation condition(shear deformation(SD)method).The results show that the nucleation mechanisms of{100}oriented recrystallized grains are different in the samples by SD and PT methods,which are in-depth shear deformation and austenite-ferrite phase transformation,*** this case,coarse{100}oriented recrystallized grains and low residual stress are obtained in the sample by SD method,which is responsible for its superior{100}texture and *** contrast,the sample by PT method forms fine recrystallized grains with random orientations and accumulates severe residual stress.

关键词： Non-oriented electrical steel {100}texture Formability Austenite-ferrite phase transformation Shear deformation

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Foliar-applied zinc promotes cadmium allocation from leaf surfaces to grains in rice

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Journal of Environmental Sciences 2025年第5期151卷 582-593页

作者： Ya-Ting Liu Bo-Fang yan Xuan Cai hong-Xiang Zheng Rong-Liang Qiu Ye-Tao tang School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China Institute of Facility Agriculture Guangdong Academy of Agricultural SciencesGuangzhou 510640China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Agricultural&Rural Pollution Abatement and Environmental Safety College of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China

The accumulation of Cd by rice poses significant health *** fertilizationwith Zn can reduce grain Cd contents in rice grown in Cd-contaminated ***,atmospheric deposition on leaves is another vector of Cd contamination,and it remains unclear how Zn application affects the allocation of such *** conducted an experiment where the flag leaves of rice plants were treated with solutions with various Zn concentrations and a constant Cd *** 111Cd stable isotope was used to trace the flux of foliarapplied *** levels of foliar-applied Zn enhanced Cd efflux and grain *** is attributed to limited sequestration of foliar-applied Cd in the leaf cell symplasm and increased Cd desorption from leaf cell walls when a high Zn^(2+)concentration occurs in the *** Zn oxide nanoparticlesmitigated these ***,the expressions of OsLCT1 and OsZIP7 in flag leaves and OsHMA2 and OsZIP7 in the uppermost nodes were upregulated under high-Zn^(2+)treatment,which may facilitate Cd phloem loading and grain *** is advised in using foliar Zn in areas with high atmospheric Cd due to potential grain-contamination risks.

关键词： Atmospheric deposition Isotope labelling Metal interaction Phloem Cell wall

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A novel supramolecular assembly based on nor-seco-cucurbit[10]uril for spermine sensing and artificial light-harvesting

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Chinese Chemical Letters 2025年第1期36卷 262-266页

作者： Ran Cen yan-yan tang Li-Xia Chen Zhu Tao Xin Xiao National Key Laboratory of Green Pesticide State Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationKey Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou ProvinceGuizhou UniversityGuiyang 550025China

A supramolecular assembly composed of perylene diimide derivative(PDI-nm)and nor-secocucurbit[10]uril(ns-Q[10])was *** excellent host-guest interaction between PDI-nm and nsQ[10]prevented the aggregation-caused quenching(ACQ)effect of PDI-nm,resulting in a luminescent *** addition of spermine to the PDI-nm/ns-Q[10]assembly restored the ACQ of PDI-nm due to the competitive binding of spermine to ns-Q[10],which released *** assembly based on this principle showed ultra-high sensitivity for the detection of spermine with a detection limit as low as7.84×10^(-7)mol/L in aqueous solution and 3.69×10^(-7)mol/L in plasma ***,an artificial light-harvesting system based on this assembly was proposed,benefiting from its good luminescent *** red(Ni R)functioned as an acceptor loaded into assembly,and a highly efficient energy transfer process occurred from PDI-nm/ns-Q[10]to Ni R,with an efficiency up to 87%.

关键词： Nor-seco-cucurbituril Perylene diimide derivative Spermine Light-harvesting

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Dual Control of Macrolithotype and Coal Structure on the Pore Parameters of Middle Jurassic Coals in the Southern Junggar Basin,NW China

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 194-211页

作者： HOU Haihai LIANG Guodong SHAO Longyi tang Yue yan Zhifeng College of Mining Liaoning Technical UniversityFuxinLiaoning 123000China College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing 100083China Oil&Gas Resource Survey Center China Geological SurveyMinistry of Natural ResourcesBeijing 100029China

Coal pore parameters are closely related to macrolithotypes and coal structures,having a large influence over the gas potential and productivity of coalbed methane(CBM).The Middle Jurassic Xishanyao Formation,located in the southern Junggar Basin of northwestern China,has geological conditions with rich CBM *** 46 Xishanyao coal samples gathered from the drilling cores and coal mines cover 4 types of macrolithotypes(bright coal 1,semi-bright coal 2,semi-dull coal 3,and dull coal 4)and 2 types of coal structures(primary coal I and cataclastic coal II).Based on a range of pore testing experiments and analytical methods,the dual effects of different macrolithotypes and coal structures on pore structures were intensely *** results showed that the specific surface area(SSA)and total pore volume(TPV)of coal samples increased gradually from bright to dull *** the same macrolithotypes,the SSA and TPV of the primary coals were lower than those of the cataclastic ***,the pore structures of bright and semi-bright coals are simpler when compared to semi-dull and dull coals with the same coal structure,whereas cataclastic coals have more complicated pore structure systems than primary coals with the same *** bright and semi-bright coals have higher vitrinite contents and more endogenous fractures,whereas well-developed structural fractures were identified in cataclastic ***,bright and semi-bright coals have better pore connectivity than semi-dull and dull coals with the same coal structure,the pore connectivity of cataclastic coals being slightly better than that of primary coals under the same *** terms of the CBM adsorption conditions,the eight type samples formed a descending order:Ⅱ-4>I-4>Ⅱ-3>Ⅰ-3>Ⅱ-2>Ⅰ-2>Ⅱ-1>Ⅰ-1,while they ranked as follows when consideration was given to the CBM seepage capacities:II-2>Ⅱ-1>Ⅰ-2>Ⅰ-1>Ⅰ-3>Ⅰ-4>Ⅱ-3>Ⅱ-*** a result,it could be determined that the bright and semi-bright

关键词： coalbed methane macrolithotype coal structure pore structure Southern Junggar Basin

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Atomic-scale insights into microscopic mechanisms of grain boundary segregation in Al−Cu alloys

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中国有色金属学报 2025年第1期35卷 1-12页

作者： Xiong SHUAI hong MAO Sai tang Yi KONG Yong DU State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China College of Mechanical Engineering Hunan Institute of Science and TechnologyYueyang 414006China National Key Laboratory of Science and Technology on High-strength Structural Materials Central South UniversityChangsha 410083China

This study aims to clarify the mechanisms for the grain boundary(GB)segregation through investigating the absorption of excess solute atoms at GBs in Al−Cu alloys by using the hybrid molecular dynamics/Monte Carlo *** segregation mechanisms,substitutional and interstitial mechanisms,are *** intergranular defects,including dislocations,steps and vacancies,and the intervals in structural units are conductive to the prevalence of interstitial *** substitutional mechanism is favored by the highly ordered twin ***,the two mechanisms affect the GB structure *** is quantified that interstitial mechanism is less destructive to GB structure than substitutional one,and often leads to a segregation level being up to about 6 times higher than the *** findings contribute to atomic scale insights into the microscopic mechanisms about how solute atoms are absorbed by GB structures,and clarify the correlation among intergranular structures,segregation mechanisms and kinetics.

关键词： grain boundaries segregation Al−Cu alloy intergranular structure molecular dynamics simulation Monte Carlo simulation

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Thermoelectric Modulation of Neat Ti_(3)C_(2)T_(x) MXenes by Finely Regulating the Stacking of Nanosheets

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Nano-Micro Letters 2025年第4期17卷 347-362页

作者： Junhui tang Renyang Zhu Ya-Hsin Pai yan Zhao Chen Xu Ziqi Liang Department of Materials Science Fudan UniversityShanghai 200433People’s Republic of China Spine Center Department of OrthopedicsShanghai Changzheng HospitalNaval Medical UniversityShanghai 200003People’s Republic of China

Emerging two-dimensional MXenes have been extensively studied in a wide range of fields thanks to their superior electrical and hydrophilic attributes as well as excellent chemical stability and mechanical *** them,the ultrahigh electrical conductivity(σ)and tunable band structures of benchmark Ti_(3)C_(2)T_(x) MXene demonstrate its good potential as thermoelectric(TE)***,both the large variation ofσreported in the literature and the intrinsically low Seebeck coefficient(S)hinder the practical ***,this study has for the first time systematically investigated the TE properties of neat Ti_(3)C_(2)T_(x) films,which are finely modulated by exploiting different dispersing solvents,controlling nanosheet sizes and constructing ***,deionized water is found to be superior for obtaining closely packed MXene sheets relative to other polar ***,a simultaneous increase in both S andσis realized via elevating centrifugal speed on MXene aqueous suspensions to obtain small-sized nanosheets,thus yielding an ultrahigh power factor up to~156μW m^(-1) K^(-2).Third,S is significantly enhanced yet accompanied by a reduction inσwhen constructing MXene-based nanocomposites,the latter of which is originated from the damage to the intimate stackings of MXene ***,a correlation between the TE properties of neat Ti_(3)C_(2)T_(x) films and the stacking of nanosheets is elucidated,which would stimulate further exploration of MXene TEs.

关键词： MXene Nanosheet stacking Electrical conductivity Seebeck coefficient Thermoelectrics

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Effect of Shensong yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity

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Chinese Medical Journal 2017年第2期130卷 171-178页

作者： hong-Yi Zhao Shu-Di Zhang Kai Zhang Xi Wang Qing-yan Zhao Shu-Juan Zhang Zi-Xuan Dai Yong-Sheng Qian You-Jing Zhang Hao-Tian Wei yan-hong tang Cong-Xin Huang Department of Cardiology Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Cardiovascular Research Institute Wuhan University Wuhan Hubei 430060 China Hubei Key Laboratory of Cardiology Wuhan Hubei 430060 China Department of Neurosurgery Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Oncology The Affiliated Hospital of Guizhou Medical University Guiyang Guizhou 550000 China

Background： Shensong yangxin （SSYX）, a traditional Chinese herbal medicine, has long been used clinically to treat arrhythmias in China. However, the mechanism of SSYX on atrial fibrillation （AF） is unknown. In this study, we tested the hypothesis that the effect of SSYX on the progression of paroxysmal AF is correlated with the regulation of autonomic nerve activity. Methods： Eighteen mongrel dogs were randomly divided into control group （n = 6）, pacing group （n = 6）, and pacing ＋ SSYX group （n = 6）. The control group was implanted with pacemakers without pacing; the pacing group was implanted with pacemakers with long-term intermittent atrial pacing; the pacing ＋ SSYX group underwent long-term intermittent atrial pacing and SSYX oral administration. Results： Compared to the pacing group, the parameters of heart rate variability were lower after 8 weeks in the pacing ＋ SSYX group （low-frequency [LF] component： 20.85± 3.14 vs. 15.3±1.89 ms2, P =0.004; LF component/high-frequency component： 1.34 ± 0.33 vs. 0.77± 0.15, P 〈 0.001 ）. The atrial effective refractory period （AERP） was shorter and the dispersion of the AERP was higher after 8 weeks in the pacing group, while the changes were suppressed by SSYX intake. The dogs in the pacing group had more episodes and longer durations of AF than that in the pacing ＋ SSYX group. SSYX markedly inhibited the increase in sympathetic nerves and upregulation of tumor necrosis factor-alpha and interleukin-6 expression in the pacing ＋ SSYX group. Furthermore, SSYX suppressed the decrease of acetylcholine and α7 nicotinic acetylcholine receptor protein induced by long-term intermittent atrial pacing. Conclusions： SSYX substantially prevents atrial electrical remodeling and the progression of AF. These effects of SSYX may have association with regulating the imbalance of autonomic nerve activity and the cholinergic anti-inflammatory pathway.

关键词： Atrial Fibrillation Autonomic Nerve Cholinergic Anti-inflammatory Pathway Inflammatory Cytokines Shensongyangxin

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On the existence of solutions for prescribing fractional Q-curvature problem on S~n

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Acta Mathematica Sinica,English Series 2025年

作者： yan LI Zhongwei tang College of Science China University of Petroleum(Beijing) School of Mathematical Sciences Laboratory of Mathematics and Complex Systems MOEBeijing Normal University

The aim of this paper is to investigate the existence of solutions to the prescribing fractional Q-curvature problem on S~n under some reasonable assumption of the Laplacian sign at the critical point of prescribing curvature function K. Due to the lack of compactness, we choose to return to the basic elements of variational theory and study the deformation along the flow lines. The novelty of the paper is that we obtain the existence without assuming any symmetry and periodicity on K. In addition,to overcome the loss of compactness for high-order operator problem, we need more delicate estimates with the second order cases.

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