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World Journal of Clinical Cases 2020年第16期8卷 3431-3439页

作者： Qi-Hang Su yan Zhang bin Shen Yong-Chao Li Jun Tan Department of Orthopedics Shanghai East HospitalTongji University School of MedicineShanghai 200120China

BACKGROUND Conventional plain X-ray images of rats,the most common animals used as degeneration models,exhibit unclear vertebral structure and blurry intervertebral disc spaces due to their small size,slender vertebral *** To apply molybdenum target X-ray photography in the evaluation of caudal intervertebral disc(IVD)degeneration in rat *** Two types of rat caudal IVD degeneration models(needle-punctured model and endplate-destructed model)were established,and their effectiveness was verified using nuclear magnetic resonance *** target inspection and routine plain X-ray were then performed on these ***,four observers were assigned to measure the intervertebral height of degenerated segments on molybdenum target plain X-ray images and routine plain X-ray images,*** degeneration was evaluated and statistical analysis was subsequently *** Nine rats in the needle-punctured model and 10 rats in the endplate-destructed model were *** with routine plain X-ray images,molybdenum target plain X-ray images showed higher clarity,stronger contrast,as well as clearer and more accurate structural *** McNemar test confirmed that the difference was statistically significant(P=0.031).In the two models,the reliability of the intervertebral height measured by the four observers on routine plain X-ray images was poor(ICChus ensuring a more accurate evaluation of degeneration.

关键词： Molybdenum target inspection Routine plain X-ray Intervertebral disc degeneration model Animal experiment Imaging analysis McNemar test

基于随机演化博弈的战略联盟稳定性分析和仿真

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系统工程理论与实践 2011年第5期31卷 920-926页

作者：徐岩胡斌钱任华中科技大学管理学院武汉430074

借助演化博弈论考虑了大群体成员下的战略联盟成员策略演化过程,建立了复制动态方程.指出了现有的确定性动态方程的不足,从人群工作互动角度探讨了策略演化过程中扰动的来源,在此基础上,对方程引入白噪声来反映过程所受到的随机干扰,建... 详细信息

借助演化博弈论考虑了大群体成员下的战略联盟成员策略演化过程,建立了复制动态方程.指出了现有的确定性动态方程的不足,从人群工作互动角度探讨了策略演化过程中扰动的来源,在此基础上,对方程引入白噪声来反映过程所受到的随机干扰,建立了随机动力系统,借鉴It随机微分方程理论来分析战略联盟演化过程中成员行为稳定性的问题.给出了联盟保持稳定的一个充分条件和解体的一个充分条件,以此来解释战略联盟的有效性问题.利用计算机进行了仿真,针对结果将本模型与现有确定性的动力模型进行了比较,两次仿真实验测度了联盟演化的随机动力模型的有效性.

关键词：战略联盟演化博弈 Ito随机微分方程稳定性

POLLEN STERILITY,a novel suppressor of cell division,is required for timely tapetal programmed cell death in rice

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Science China(Life Sciences) 2022年第6期65卷 1235-1247页

作者： Ronghui Che bin hu Wei Wang Yunhua Xiao Dapu Liu Wenchao Yin Hongning Tong Chengcai Chu State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biologythe Innovative Academy for Seed DesignChinese Academy of SciencesBeijing 100101China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China School of Biological and Science Technology University of JinanJinan 250022China College of Agriculture South China Agricultural UniversityGuangzhou510642China

Timely programmed cell death(PCD) of the tapetum supplying nutrients to microspores is a prerequisite for normal pollen *** we identified a unique mutant of rice(Oryza sativa L.),pollen sterility(post),which showed aborted pollens accompanied with extra-large *** to failure of timely PCD of tapetal cells,post exhibited abnormal pollen wall patterning and defective pollen *** map-based cloning,we identified a causal gene,POST,encoding a novel protein which is ubiquitously localized in *** in situ hybridization showed that POST is highly detected in the tapetum and microspores at stages 8 and *** analysis indicated that POST could function as an important regulator of the metabolic process involved in tapetal *** with wild-type rice,post mutant has an increased cell number resulting from elevated expression of cell cycle associated genes in grain *** of POST inhibits grain size in wild type,while appropriate expression of POST in post mutant can recover the seed fertility but has little effect on the large grains,illustrating that fine-tuning of POST expression could be a potential strategy for rice yield *** connection between cell division and cell death conferred by POST provides novel insights into the understanding of the tapetal PCD process.

关键词： programmed cell death tapetum pollen sterility grain size rice

Analysis of χ Phase Precipitation in Aged 2205 Duplex Stainless Steel

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Journal of Wuhan University of Technology(Materials Science) 2015年第3期30卷 591-595页

作者：刘和平 SUN hu'er LIU bin LI Dazhao SUN Fenger ZHANG Yongtao School of Materials Science and Engineering North University of China School of Machinery Shanghai Dian Ji University

Analysis ofZ phase precipitation in 2205 duplex stainless steel aged at 700 and 750 ~C has been investigated systematically. The experimental results showed that X phase forms prior to the precipitation of δ phase and disappears once tr phase starts to precipitate. This phenomenon indicates that a phase nucleated and consumed the Z phase. The δ phase nucleated mairdy at ferrite/austenite interface and grew inwards into the ferrite phase. The morphology of a phase reveals a coral-like structure at the temperature of 700 ℃ for 120 min followed by quenching in water. The decomposition of ferrite occurs via the following eutectoid reaction： F---＊o＇＋y2. The selected area diffraction pattern of zone axes is[3 1 3-][3 1 3], indicating a characteristic orientation relationship between X phase and δ-ferrite.

关键词： duplex stainless steel X phase tr phase microstructure analysis

基于HS-SPME-GC-MS和化学计量学对不同产地红枣香气成分的分析

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食品工业科技 2024年第6期45卷 265-271页

作者：胡航伟张仁堂张楠楠梁辰游新侠孔欣欣朱玲闫信想刘云国郑州科技学院食品科学与工程学院河南郑州450064 山东农业大学食品科学与工程学院山东泰安271018 临沂大学生命科学学院山东临沂276000

为了比较不同产地红枣的挥发性风味特征,采用顶空固相微萃取结合气相色谱质谱技术对5个产地(新郑、灵宝、榆林、和田、德州)枣果的挥发性香气成分进行分析。结果表明:共鉴定出化合物51种,其中,新疆和田大枣中所含挥发性化合物的种类最... 详细信息

为了比较不同产地红枣的挥发性风味特征,采用顶空固相微萃取结合气相色谱质谱技术对5个产地(新郑、灵宝、榆林、和田、德州)枣果的挥发性香气成分进行分析。结果表明:共鉴定出化合物51种,其中,新疆和田大枣中所含挥发性化合物的种类最多。结合多元统计学分析,不同产地红枣的整体挥发性风味物质的差异得以很好区分。在满足预测变量重要性投影>1、P<0.05的条件下,从红枣样品中筛选出13种差异性特征香气物质,包括己酸甲酯、癸酸甲酯、己醛、苯甲醛等,赋予红枣独特的杏仁味、甜味、水果味。本研究结果明确了不同产地红枣香气品质的化学物质基础,为红枣产地溯源研究提供一种新思路,进一步对枣果资源的合理加工利用提供科学依据。

关键词：红枣化学计量学固相微萃取风味物质地理来源

Visible-light-promoted radical alkylation/cyclization of allylic amide with N-hydroxyphthalimide ester: Synthesis of oxazolines

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Chinese Chemical Letters 2022年第4期33卷 1997-2000页

作者： Zhiyang yan bin Sun Panyi huang Haiyun Zhao Hao Ding Weike Su Can Jin Collaborative Innovation Center of yangtze River Delta Region Green Pharmaceuticals Zhejiang University of TechnologyHangzhou 310014China College of Pharmaceutical Sciences Zhejiang University of TechnologyHangzhou 310014China

An efficient photocatalytic alkylation/cyclization of allylic amide with N-hydroxyphthalimide ester has been developed. The transformation is taken advantage of alkyl radicals to attack allylic amide with the assist of inexpensive rose bengal as photocatalyst to prepare a series of alkyl substituted oxazolines in moderate to excellent yields. High regioselectivity, operational safety, mild conditions and excellent substrate generality give this protocol broad application prospects.

关键词： Photocatalysis Oxazolines Allylic amide N-Hydroxyphthalimide ester Alkylation/cyclization Decarboxylation

^(32)P不同温度不同照射剂量对SD大鼠放射性皮肤损伤初步研究

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临床军医杂志 2024年第5期52卷 479-482页

作者：郭佳程凤曹滨验游平飞王秋北部战区总医院核医学科辽宁沈阳110016 北部战区总医院急诊医学科辽宁沈阳110016 大连医科大学辽宁大连116000 中国医科大学辽宁沈阳110000

目的探讨^(32)P不同温度不同照射剂量造成SD大鼠放射性皮肤损伤的病理状态。方法选取48只6~8周雄性SD清洁级大鼠为研究对象。采用随机数字表法将48只大鼠随机分为A组(室温下10 Gy)、B组(低温下10 Gy)、C组(室温下30 Gy)、D组(低温下30 ... 详细信息

目的探讨^(32)P不同温度不同照射剂量造成SD大鼠放射性皮肤损伤的病理状态。方法选取48只6~8周雄性SD清洁级大鼠为研究对象。采用随机数字表法将48只大鼠随机分为A组(室温下10 Gy)、B组(低温下10 Gy)、C组(室温下30 Gy)、D组(低温下30 Gy)、E组(室温下60 Gy)、F组(低温下60 Gy),每组各8只。采用^(32)P发射的β射线进行照射。计算大鼠皮肤损伤面积、进行皮肤损伤评分及病理切片苏木素伊红染色。比较各组大鼠不同照射时间皮肤损伤面积百分比、皮肤损伤评分及病理学变化。结果F组大鼠不同照射时间的皮肤损伤面积百分比均高于E组,差异均有统计学意义(P<0.05)。D组照射后1周、照射后2周的皮肤损伤评分均高于C组,差异均有统计学意义(P<0.05)。低温中的B组、D组、F组大鼠受照皮肤的病理改变均早于室温下的A组、C组、E组,且损伤程度较重。结论低温环境下的皮肤β射线损伤发生早、损伤进展快,且其损伤程度随照射剂量增加而加重。

关键词：照射剂量放射性皮肤损伤 β射线皮肤损伤评分

ADA2基因变异与腺苷脱氨酶2缺乏症的研究进展

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中国中西医结合儿科学 2024年第2期16卷 102-106页

作者：付彬李海波叶启东闫露露宁波大学医学部浙江宁波315000 宁波市妇女儿童医院出生缺陷综合防治中心宁波大学附属第一医院

腺苷脱氨酶2缺乏症是一种罕见的常染色体隐性遗传的自身炎症性疾病,是由ADA2基因纯合或复合杂合变异导致腺苷脱氨酶2活性低下或缺乏而致病。该缺乏症主要临床表现为儿童期起病的全身性炎症、血管炎、体液免疫缺陷和血液学异常等,早期诊... 详细信息

腺苷脱氨酶2缺乏症是一种罕见的常染色体隐性遗传的自身炎症性疾病,是由ADA2基因纯合或复合杂合变异导致腺苷脱氨酶2活性低下或缺乏而致病。该缺乏症主要临床表现为儿童期起病的全身性炎症、血管炎、体液免疫缺陷和血液学异常等,早期诊断困难,发病机制尚不完全清楚。全身性炎症表型患者治疗首选肿瘤坏死因子α受体拮抗剂,其次为沙利度胺。造血干细胞移植主要用于严重血液学表型患者或对肿瘤坏死因子α受体拮抗剂治疗无效患者。本文对腺苷脱氨酶2缺乏症的临床特征、人口学特征、基因型以及与临床表型相关性、可能的发病机制和诊疗策略进行阐述。

关键词：腺苷脱氨酶2缺乏症 ADA2基因自身炎症性疾病血管炎

Role of epithelial-mesenchymal transition in gastric cancer initiation and progression

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World Journal of Gastroenterology 2014年第18期20卷 5403-5410页

作者： Zhao Peng Chen-Xiao Wang Er-hu Fang Guo-bin Wang Qiang Tong Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

Gastric cancer is one of the most common malignant tumors *** to its intricate initiation and progression mechanisms,early detection and effective treatment of gastric cancer are difficult to *** epithelial-mesenchymal transition(EMT)is characterized as a fundamental process that is critical for embryonic development,wound healing and fibrotic *** evidence has established that aberrant EMT activation in the human stomach is closely associated with gastric carcinogenesis and tumor *** activation endows gastric epithelial cells with increased characteristics of mesenchymal cells and reduces their epithelial ***,mesenchymal cells tend to dedifferentiate and acquire stem cell or tumorigenic phenotypes such as invasion,metastasis and apoptosis resistance as well as drug resistance during EMT *** are a number of molecules that indicate the stage of EMT(e.g.,E-cadherin,an epithelial cell biomarker);therefore,certain transcriptional proteins,especially E-cadherin transcriptional repressors,may participate in the regulation of *** addition,EMT regulation may be associated with certain epigenetic *** aforementioned molecules can be used as early diagnostic markers for gastric cancer,and EMT regulation can provide potential targets for gastric cancer ***,we review the role of these aspects of EMT in gastric cancer initiation and development.

关键词： Epithelial-mesenchymal transition Gastric cancer Tumorigenesis Tumor progression Cancer stem cells

Response of aerobic sludge to AHL-mediated QS:Granulation,simultaneous nitrogen and phosphorus removal performance

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Chinese Chemical Letters 2021年第11期32卷 3402-3409页

作者： Jia Shuai Xiaoling hu bin Wang Wanlin Lyu Rongfan Chen Wenbin Guo Hongyu Wang Dao Zhou School of Civil Engineering Wuhan UniversityWuhan 430072China

The effects of different species and concentrations’signal molecules on aerobic activated sludge system were investigated through batch *** showed that the fastest NH^(+)_(4)-N oxidization rate and the most extracellular polymeric substances(EPS)secretion were obtained by adding 5 nmol/L N-hexanoyl-l-homoserine lactone(C_(6)-HSL)into the aerobic activated *** study investigated the correlation among N-acyl-homoserine lactones-mediated quorum sensing(AHLs-mediated QS),nutrient removal performances and microbial communities with the long-term addition of 5 nmol/L C_(6)-*** was found that C_(6)-HSL-manipulation could enhance the stability and optimize the decontamination performance of aerobic granular sludge(AGS)*** compositions considerably shifted with long-term C_(6)-*** C_(6)-HSL-manipulation inhibited quorum quenching-related(QQ-related)activities and enhanced QS-related activities during the stable *** proposed C_(6)-HSL-manipulation might be a potential technology to inhibit the growth of harmful bacteria in AGS,which could provide a theoretical foundation for the realization of more stable biological wastewater treatments.

关键词： Quorum sensing(QS) Aerobic granular sludge(AGS) Simultaneous nitrogen and phosphorus removal(SNDPR) N-acyl-homoserine lactones(AHLs) N-hexanoyl-L-homoserine lactone(C_(6)-HSL) Nitrogen transformation