Application of molybdenum target X-ray photography in imaging analysis of caudal intervertebral disc degeneration in rats
作者机构：Department of OrthopedicsShanghai East HospitalTongji University School of MedicineShanghai 200120China
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2020年第8卷第16期
页 面：3431-3439页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：Supported by the National Key Research and Development Program of China No.2017YFA0105404
主 题：Molybdenum target inspection Routine plain X-ray Intervertebral disc degeneration model Animal experiment Imaging analysis McNemar test
摘 要：BACKGROUND Conventional plain X-ray images of rats,the most common animals used as degeneration models,exhibit unclear vertebral structure and blurry intervertebral disc spaces due to their small size,slender vertebral *** To apply molybdenum target X-ray photography in the evaluation of caudal intervertebral disc(IVD)degeneration in rat *** Two types of rat caudal IVD degeneration models(needle-punctured model and endplate-destructed model)were established,and their effectiveness was verified using nuclear magnetic resonance *** target inspection and routine plain X-ray were then performed on these ***,four observers were assigned to measure the intervertebral height of degenerated segments on molybdenum target plain X-ray images and routine plain X-ray images,*** degeneration was evaluated and statistical analysis was subsequently *** Nine rats in the needle-punctured model and 10 rats in the endplate-destructed model were *** with routine plain X-ray images,molybdenum target plain X-ray images showed higher clarity,stronger contrast,as well as clearer and more accurate structural *** McNemar test confirmed that the difference was statistically significant(P=0.031).In the two models,the reliability of the intervertebral height measured by the four observers on routine plain X-ray images was poor(ICC0.4),while the data obtained from the molybdenum target plain X-ray images were more *** target inspection can obtain clearer images and display fine calcification in the imaging evaluation of caudal IVD degeneration in rats,thus ensuring a more accurate evaluation of degeneration.
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