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Circ_0004592:An auxiliary diagnostic biomarker for gastric cancer

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2757-2768页

作者： Shan Kong yan-Hua xu Ming Zheng Shao-Qing Ju Heng-Chuan Shi department of Laboratory Medicine Jiangsu Province Official HospitalNanjing 210000Jiangsu ProvinceChina department of Laboratory Medicine Northern Jiangsu People’s HospitalYangzhou 225000Jiangsu ProvinceChina department of Laboratory Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGrOUND Gastric cancer(GC)has a high mortality rate,and robust diagnostic biomarkers are currently ***,the clinical relevance of circular rNAs(circrNAs)as GC biomarkers remains largely *** To evaluate the potential of novel circrNA circ_0004592 in the early screening and prognosis of *** High-throughput sequencing of circrNAs was performed to screen for potential target ***_0004592 expression was examined in GC tissues,cells,and *** samples were collected from healthy subjects’patients,as well as from patients with benign lesions,precancerous lesions,and GC,whereafter the diagnostic accuracy of circ_0004592 was *** correlation between circ_0004592 levels in plasma and clinicopathological data of patients with GC was further *** Circ_0004592 was upregulated in both the tissue and plasma of patients with ***,circ_0004592 expression was higher in patients with precancerous lesions than in healthy controls while being highest in patients with *** the same patient,the postoperative plasma level of circ_0004592 was lower than that in the preoperative ***,circ_0004592 level was significantly correlated with tumor differentiation,tumor depth,and lymph node *** area under the curve(AUC)of plasma circ_0004592 exhibited high sensitivity and specificity for differentiating patients with GC from healthy *** based on circ_0004592,carcinoembryonic antigen,and cancer antigen 199 achieved a superior AUC and was highly *** plasma circ_0004592 may represent a potential non-invasive auxiliary diagnostic biomarker for patients with GC.

关键词： Biomarker Circular rNA Diagnosis Gastric cancer plasma

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An ultrathin and crack-free metal-organic framework film for effective polysulfide inhibition in lithium-sulfur batteries

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Interdisciplinary Materials 2024年第2期3卷 306-315页

作者： Cheng Zhou Chenxu Dong Weixiao Wang Yu Tian Chunli Shen Kaijian yan Liqiang Mai xu xu International School of Materials Science and Engineering Wuhan University of TechnologyWuhanHubeiPeople's Republic of China department of Chemical Engineering University of Massachusetts AmherstAmherstMassachusettsUSA

Due to their extensive microporous structure,metal-organic frameworks(MOFs)find widespread application in constructing modification layers,functioning as ion ***,the modification layers prepared by existing methods feature gaps between MOFs that are noticeably larger than the inherent MOF pore *** and lithium ions unavoidably permeate through these gaps,hindering the full exploitation of the structural ***,an ultrathin(20 nm)and crack-free MOF film is formed on the separator by atomic layer deposition for the first *** on the separator,the mechanism of different MOF layers has been verified by phase field simulation and in situ raman *** results accurately prove that the MOF particle layer can relieve the shuttle of polysulfides,but it does not have the effect of homogenizing lithium *** the ultrathin and crack-free MOF film with proper pore size can act as the ion sieve for both polysulfides and lithium *** a result,under the test condition of 2mA cm^(-2)-2 mAh cm^(-2),the overpotential of the Li/Li symmetric battery is only 18 mV after 2500 *** capacity retention rate of the lithium-sulfur battery is 95.6% after 500 cycles and 80% after 1000 cycles at 2 C.

关键词： crack-free film ion sieve lithium-sulfur battery metal-organic framework separator

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Association between childhood obesity and gut microbiota:16S rrNA gene sequencing-based cohort study

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World Journal of Gastroenterology 2024年第16期30卷 2249-2257页

作者： xu-Ming Li Qing Lv Ya-Jun Chen Lu-Biao yan Xin Xiong Laboratory department Nanjing Medical University Affiliated Obstetrics and Gynecology Hospital(Nanjing Maternal and Child Health Hospital)Nanjing 210004Jiangsu ProvinceChina department of pediatrics Shenzhen University General HospitalShenzhen 518055Guangdong ProvinceChina department of Inspection Division Women’s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital)Nanjing 210004Jiangsu ProvinceChina department of pediatrics Women’s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital)Nanjing 210004Jiangsu ProvinceChina department of Neonatology Chenzhou First People’s HospitalChenzhou 423000Hunan ProvinceChina

BACKGrOUND This study aimed to identify characteristic gut genera in obese and normal-weight children(8-12 years old)using 16S rDNA *** research aimed to provide insights for mechanistic studies and prevention strategies for childhood *** normal-weight and thirty age-and sex-matched obese children were *** and body measurements were collected,and fecal samples underwent 16S rDNA *** differences in body mass index(BMI)and body-fat percentage were observed between the *** of gut microbiota diversity revealed lowerα-diversity in obese *** in gut microbiota composition were found between the two *** and Firmicutes were more abundant in the obese group,while Bacteroides and Sanguibacteroides were more prevalent in the control *** To identify the characteristic gut genera in obese and normal-weight children(8-12-year-old)using 16S rDNA sequencing,and provide a basis for subsequent mechanistic studies and prevention strategies for childhood *** Thirty each normal-weight,1:1 matched for age and sex,and obese children,with an obese status from 2020 to 2022,were included in the control and obese groups,*** information was collected through questionnaires and body measurements were obtained from both obese and normal-weight *** samples were collected from both groups and subjected to 16S rDNA sequencing using an Illumina MiSeq sequencing platform for gut microbiota diversity *** Significant differences in BMI and body-fat percentage were observed between the two *** Ace and Chao1 indices were significantly lower in the obese group than those in the control group,whereas differences were not significant in the Shannon and Simpson ***-Wallis tests indicated significant differences in unweighted and weighted UniFrac distances between the gut microbiota of normal-weight and obese children(p<0.01),suggest

关键词： Childhood obesity Gut microbiota 16S rDNA sequencing Diversity analysis Genus identification Body mass index

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Mottled dolomite in the lower Cambrian Longwangmiao formation in the Northern Sichuan Basin,South china

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petroleum 2024年第1期10卷 19-29页

作者： xuefei yang Hao Tang Junyi Zhang Yao Du ruifeng Tang Shuang pan Xiang Zhou yan xu State Key Laboratory of Oil and Gas reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Sichuan provincial Key Laboratory of Gas Geology Southwest Petroleum UniversityChengdu610500China CCDC Chuandong Drilling Company Chongqing401120China Exploration department Petrochina Southwest Oil&Gasfield CompanyChengdu610051China

At the end of Early Cambrian time,the Sichuan basin(South china)was located in a wide carbonate platform,with hundreds of meters of carbonate *** Longwangmiao Formation carbonate in Sichuan basin is partially to completely dolomitized,displaying a mottled texture in the northern area of the *** mottled dolomitic limestone developed parallel to bedding,with shape irregular boundaries with limestone that has not been *** mottled dolomite is composed of powder crystalline and finely crystalline dolomite,while the matrix limestone is composed of micritic *** isotopic composition of mottled dolomite(δ^(13)C=+0.29‰pDB,δ^(18)O=1.15‰pDB)is similar to that of micrite calcite(δ^(13)C=0.49‰pDB,δ^(18)O=1.45‰pDB).Both isotopic values and trace element data indicate that the dolomitized fluid is originated from sea *** beds contain gypsum pseudomorphs and mud cracks,indicating a shallow and evaporative environment with local high salinity during *** likely took place early,in part as a result of sea water salinity *** fossils thalassinoides horizontalis,thalassinoides callianassa and planolites developed in the Longwangmiao Formation,and the sharp edges of mottled dolomite are similar to these trace *** beds are intensely *** the burrow network,the sediments and burrow fill were coarse and loose with little clay,and it is interpreted here as being easier to be dolomitized than the surrounding *** dolomitization is thus interpreted to have occurred in the burrow system,and the degree of dolomitization was related to the degree of bioturbation,which is controlled by the trace-making creatures.

关键词： Mottled dolomite Dolomitization Longwangmiao Formation Early Cambrian Northern Sichuan basin

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Alanine aminotransferase as a risk marker for new-onset metabolic dysfunction-associated fatty liver disease

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World Journal of Gastroenterology 2024年第25期30卷 3132-3139页

作者： Di Wang Bing-yan Zhou Lei Xiang xu-Yong Chen Jie-Xiong Feng department of pediatric Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

In this editorial,we comment on the article by Chen et *** dysfunction-associated fatty liver disease(MAFLD)is a global public health burden whose incidence has risen concurrently with overweight and *** its detri-mental health impact,early identification of at-risk individuals is *** diagnosis is based on evidence of hepatic steatosis indicated by liver biopsy,imaging,or blood biomarkers,and one of the following conditions:Overweight/obesity,type 2 diabetes mellitus,or metabolic ***,in large-scale epidemiological studies,liver biopsies are not *** application of techniques such as ultrasonography,computed tomography,magnetic resonance imaging,and magnetic resonance spectroscopy is restricted by their limited sensitivity,low effectiveness,high costs,and need for specialized *** biomarkers offer several advantages,particularly in large-scale epidemiological studies or clinical scenarios where traditional imaging techniques are *** of cumulative effects of excess high-normal blood alanine aminotrans-ferase(ALT)levels of blood ALT levels could facilitate identification of at-risk patients who might not be detected through conventional imaging ***,investigating the utility of blood biomarkers in MAFLD should enhance early detection and monitoring,enabling timely inter-vention and management and improving patient outcomes.

关键词： Nonalcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Alanine aminotransferase Screening risk marker

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Addison's disease caused by adrenal tuberculosis may lead to misdiagnosis of major depressive disorder: A case report

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World Journal of Clinical Cases 2024年第1期12卷 217-223页

作者： Tian-Xiang Zhang Hong-yan xu Wei Ma Jian-Bao Zheng department of Tuberculosis The Tuberculosis Hospital of Shaanxi ProvinceXi’an 710100Shaanxi ProvinceChina department of General Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGrOUND Addison’s disease(AD)is a rare but potentially fatal disease in Western countries,which can easily be misdiagnosed at an early *** adrenal tuberculosis(TB)may lead to depression in *** SUMMArY We report a case of primary adrenal insufficiency secondary to adrenal TB with TB in the lungs and skin in a 48-year-old *** patient was misdiagnosed with depression because of her depressed *** had hyperpigmentation of the skin,nails,mouth,and *** final diagnosis was adrenal TB that resulted in the insufficient secretion of adrenocortical *** hormone test,skin biopsy,T cell spot test of TB,and adrenal computed tomography scan were used to confirm the *** patient’s condition improved after hormone replacement therapy and TB *** Given the current status of TB in high-burden countries,outpatient doctors should be aware of and pay attention to TB and understand the early symptoms of AD.

关键词： primary adrenal insufficiency Adrenal tuberculosis Fatigue Hypotension Hyperkalemia Hyponatremia Depression Case report

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Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy:A case report

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1436-1442页

作者： Guo-Feng Chen Jun Wang Yu yan Song xu Jian Chen department of Gastroenterology Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina department of pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGrOUND pulmonary lymphoepithelioma-like carcinoma(pLELC)is a rare type of nonsmall-cell lung *** lymphoepithelioma-like carcinoma(LELC)metastasis secondary to pLELC has not been reported *** SUMMArY A 64-year-old female was admitted to our hospital for a regular gastroscopy examination with a 6-year history of surgical resection for left *** emission tomography/computed tomography suggested high accumulation of 18F-fludeoxyglucose in the gastric cardia *** gastrointestinal endoscopy confirmed a large mass at the stomach ***(IHC)of the biopsy suggested metastatic stomach *** gastrectomy showed that this 6.5 cm×5.0 cm mass was located in the stomach fundus near the *** examination showed a poorly differentiated carcinoma with prominent lymphoplasmacytic *** demonstrated that the tumor was positive for CK(AE1/AE3),p63,p40,p53,Ki-67(70%),and EGFr(3+)and negative for CK7,CK20,Her2,and *** situ hybridization analysis showed positive staining Epstein-Barr virus-encoded *** programmed cell death ligand 1(pD-L1)expression score was 98%,and the combined positive score was 100,with no evidence of microsatellite ***,the patient was unequivocally diagnosed with metastatic stomach LELC secondary to pulmonary *** discharge,this patient underwent pD-1 inhibitor treatment(toripalimab,240 mg)every 3 wk for ten cycles,and she has had no tumor *** For gastric LELC metastasis,pD-1 inhibitor therapy could become a new therapeutic approach,though there is still no evidence from large data sets to support this.

关键词： Stomach neoplasm pulmonary lymphoepithelioma-like carcinoma Metastasis Immune checkpoint inhibitor Case report

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Current and potential roles of Ferroptosis in Bladder Cancer

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Current Medical Science 2024年第1期44卷 51-63页

作者： Wen-xin AN radheshyam Gupta Kun ZHAI Ya-ru WANG Wan-hai xu yan CUI department of Urology Harbin Medical University Cancer HospitalHarbin 150081China department of Internal Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,rAS-rAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

关键词： ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer

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Contrasting response of rice rhizosphere microbiomes to in situ cadmium-contaminated soil remediation

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Soil Ecology Letters 2024年第2期6卷 149-162页

作者： Zhongyi Cheng Qinyu Han yan He Jiachun Shi Laosheng Wu Jianming xu Zhejiang provincial Key Laboratory of Agricultural resources and Environment Institute of Soil and Water Resources and Environmental ScienceCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou310058China Key Laboratory of Environment remediation and Ecological Health Ministry of EducationHangzhou310058China department of Environmental Sciences University of CaliforniaRiversideCA92521USA

Changes in soil properties and microbial communities regulated rhizosphere protistan assemblages. • Bacterial community was more sensitive to soil amendments than protists and fungi. • Soil amendments trigger the role of specific protistan taxa Cercozoa on microbial interactions. Understanding the responses of different rhizosphere microbial lineages to soil amendments during in situ remediation of Cd-contaminated soil is of great importance in the assessment of the restoration and crop health. Here, we evaluated the effects of lime (LM), biochar (BC), pig manure (pM), and a commercial Mg-Ca-Si conditioner (CMC) on the rice rhizosphere soil physicochemical properties and community assembly of bacteria, fungi, and protists in a six-year consecutive application of soil amendments field trial. Our results indicated that among the four amendments, the BC and CMC had the best efficiency in increasing soil pH, which were 5.2% and 16.2%, respectively. Despite the differences in soil Cd concentrations is not noticeable, all the soil amendment treatments significantly decreased the proportion of available Cd in total Cd compared to the control. Soil amendments significantly altered the diversity of bacterial community, while they had no effect on fungal and protistan communities. Linear discriminant analysis effect size (LEfSe) showed that the bacteria was more sensitive to soil amendment-induced changes. For protists, treatments with LM and BC changed the groups of protistan consumers, while treatments with pM and CMC significantly increased the relative abundances of protistan phototrophs. Co-occurrence network analysis revealed that soil amendments increased microbial network complexity and triggered the role of protists, especially for the predatory protists Cercozoa, on microbial trophic interactions. Further variation partitioning analysis revealed that edaphic properties, bacterial and fungal communities compositions together explained the 77% of the total variation i

关键词： cadmium soil amendments soil protist community microbial interactions

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A Tiny Example Based procedural Model for real-Time Glinty Appearance rendering

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Journal of Computer Science & Technology 2024年第4期39卷 771-784页

作者： You-Xin Xing Hao-Wen Tan yan-Ning xu Lu Wang School of Software Shandong UniversityJinan 250101China NetEase(Hangzhou)Network Co. LtdHangzhou 310052China

The glinty details from complex microstructures significantly enhance rendering ***,the previous methods use high-resolution normal maps to define each micro-geometry,which requires huge memory *** paper observes that many self-similarity materials have independent structural characteristics,which we define as tiny example *** propose a procedural model to represent microstructures implicitly by performing spatial transformations and spatial distribution on tiny ***,we precompute normal distribution functions(NDFs)by 4D Gaussians for tiny examples and store them in multi-scale NDF *** with a tiny example based NDF evaluation method,complex glinty surfaces can be rendered simply by texture *** experimental results show that our tiny example based the microstructure rendering method is GpU-friendly,successfully reproducing high-frequency reflection features of different microstructures in real time with low memory and computational overhead.

关键词： real-time rendering reflectance modeling glinty material photorealistic rendering microstructure

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