Current and Potential Roles of Ferroptosis in Bladder Cancer
作者机构：Department of UrologyHarbin Medical University Cancer HospitalHarbin 150081China Department of Internal Medical OncologyHarbin Medical University Cancer HospitalHarbin 150081China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2024年第44卷第1期
页 面：51-63页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the Postdoctoral Scientific Research Developmental Fund of Heilongjiang(No.LBH-Q21130) the Beijing Medical Award Foundation(No.YXJL-2020-1207-0811)
主 题：ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer
摘 要：Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.
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