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Journal of Bionic Engineering 2016年第1期13卷 108-114页

作者： Yonggang Jiang Jianchao Fu Deyuan Zhang yahui zhao School of Mechanical Engineering and Automation Beihang University Beij'ing 100191 China International Research Institute for Multidisciplinary Science Beihang University Beijing 100191 China Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing 1 O0 l 01 China.

Cavefish, with sensitive lateral lines, can swim freely and locate preys in invisible and complex cave environments, though their eyes are greatly degenerated. Investigations on the morphology and distribution characteristics of their lateral line systems would benefit our understanding of the high-sensitivity mechanism of the fish. In this study, the arrangement and morphology of the lateral lines are described for two species ofSinocyclocheilus： S. macrophthalmus and S. microphthalmus, which live in the karst caves in Guangxi, China. The behavior experiments indicate that the lateral line system of the S. macrophthalmus is more sensitive at a low vibration frequency range from 20 Hz to 70 Hz. The cephalic and trunk lateral line systems both contribute to the efficient object-locating capability. For both of the two species of cavefish, the diameter of the lateral canal nearby the neuromasts is narrower than that nearby the canal pores. This variation can increase the normal pressure to the surface of the cupula, and increase the sensitivity of the canal lateral line system.

关键词： lateral line system cavefish neuromast bionic sensing

Exquisite structure of the lateral line system in eyeless cavefish Sinocyclocheilus tianlinensis contrast to eyed Sinocyclocheilus macrophthalmus(Cypriniformes:Cyprinidae)

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Integrative Zoology 2020年第4期15卷 314-328页

作者： Zhiqiang MA Hendrik HERZOG Yonggang JIANG yahui zhao Deyuan ZHANG Institute of Bionic and Micro-Nano Systems Beihang UniversityBeijingChina Institute of Zoology University of BonnBonnGermany Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijingChina

In this study,the lateral line systems in Chinese cavefish eyeless Sinocyclocheilus tianlinensis and eyed Sinocyclocheilus macrophthalmus were investigated to reveal their morphological changes to survive in harsh environ*** with the eyed cavefish ***(atypical),the lateral line system in the eyeless cave-fish ***(typical)has certain features to adapt to the dark cave environments:the superficial lateral line system in the eyeless species possesses a higher number of superficial neuromasts and more hair cells within an individual neuromast,and the trunk lateral line canal system in *** exhibits larger canal pores,higher canal diameter and more pronounced ***–structure interaction analysis suggested that the trunk lateral line canal system in the eyeless *** should be more sensitive than that in the eyed ****** morphological features of the lateral line system in the eyeless *** probably enhance the functioning of the lateral line system and compensate for the lack of *** revelation of the form–function relationship in the cavefish lateral line system provides inspiration for the design of sensitive artificial flow sensors.

关键词： cavefish flow sensor form-function lateral line neuromast

Phylogenetic analysis and expression differences of eye-related genes in cavefish genus Sinocyclocheilus

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Integrative Zoology 2021年第3期16卷 354-367页

作者： yahui zhao Zushi HUANG Jinqing HUANG Chunguang ZHANG Fanwei MENG State Key Laboratory of Membrane Biology State Key Laboratory of Integrated Pest ManagementKey Laboratory of ZoologicalSystematics and EvolutionInstitute of ZoologyChinese Academy of SciencesBeijingChina Faculty of Basic Medical Sciences Guilin Medical UniversityGuilinChina

The adaptive evolution of visual systems has been observed in many ***,little is known about the molecular mechanisms underlying these adaptations,which include regressive changes such as eye ***,we analyzed phylogenetic and expression patterns of 6 eye-related genes(crx,foxg1b,opn1sw2,otx2,rho and sox2)in 12 Sinocyclocheilus species from China,including 8 stygobionts and 4 stygophiles,and examined photoreceptor cell morphology of these *** eye-degenerated species of Sinocyclocheilus were polyphyletic and showed different degrees of photoreceptor defects in responses to cave *** eye loss and degeneration are the result of convergent *** *** grouped with the eye-normal species,it displayed not only a high degree of eye degeneration but also significant expression differences in eyerelated genes compared with the eye-normal *** gene foxg1b,which was determined to be under positive selection,might play an important role in the process of eye degeneration in *** based on differential ***-related gene expression and selection may have contributed to the polyphyly of the cave *** examined gene expression and duplication in 6 eye-related genes and revealed that these genes displayed considerable diversity in relative expression in Sinocyclocheilus ***2 and sox2 were significantly up-regulated in individual cave species,while the other 4 genes(crx,foxg1b,opn1sw2 and rho)were significantly *** findings provide a valuable resource for elucidating molecular mechanisms associated with visual system evolution in cavefish.

关键词： cavefish convergent evolution eye degeneration gene duplication retina

Toxic effects of enrofloxacin on Scenedesmus obliquus

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Frontiers of Environmental Science & Engineering 2012年第1期6卷 107-116页

作者： Hongwei QIN Liufang CHEN Nan LU yahui zhao Xing YUAN School of Urban and Environmental Science Northeast Normal UniversityChangchun 130024China

In this article, the toxic effects of Enrofloxacin （ENFX） on Scenedesmus obliquus were studied, through investigating the growth, photosynthetic pigments, and protein contents. The possible toxic mechanisms of ENFX were analyzed by determining the superoxide dismutase （SOD） activity, malondialdehyde （MDA） content, proline content, and superoxide anion （O2） generation rate. Results showed that the growth of algae was inhibited by ENFX and the 50% effective concentration （EC50） values for 24, 48, 72, and 96 h of ENFX were 88.39, 63.86, 45.10, and 59.16 mg .L^-1, respectively. After treated with ENFX for 96h, the contents of photosynthetic pigments decreased with the increase of ENFX concentration, the content of soluble protein and the activity of SOD increased and then decreased, and the generation rate of superoxide anion （O2^-） increased continually. The contents of MDA and proline changed little in lower ENFX concentration groups, but increased rapidly when treated with higher concentration groups. These results suggested that ENFX affected the growth ofS. obliquus, and the main toxicity mechanism was that algal cells generated the reactive oxygen species under ENFX stress, and then the reactive oxygen species （ROS） induced the oxidation damages of biologic macromolecules and changed the biomembrane permeability further.

关键词： enrofloxacin Scenedesmus obliquus toxic effects

Differentially-expressed opsin genes identified in Sinocyclocheilus cavefish endemic to China

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Current Zoology 2013年第2期59卷 170-174页

作者： Fanwei MENG yahui zhao John H. POSTLETHWAIT Chunguang ZHANG Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Institute of Neuroscience University of Oregon Eugene OR 97403 USA

Eye degeneration is a common troglomorphic character of cave-dwelling organisms. Comparing the morphology and molecular biology of cave species and their close surface relatives is a powerful tool for studying regressive eye evolution and other adaptive phenotypes. We compared two co-occurring and closely-related species of the fish genus Sinocyclocheilus, which is endemic to China and includes both surface- and cave-dwelling species. Sinocyclocheilus tileihornes, a cave species, had smaller eyes than Sinocyclocheilus angustiporus, a surface species. Histological and immunohistochemical analyses revealed that the cave- fish had shorter cones and more disorderly rods than did the surface-dwelling species. Using quantitative PCR and in situ hybri- dization, we found that rhodopsin and a long-wavelength sensitive opsin had significantly lower expression levels in the cavefish. Furthermore, one of two short-wavelength-sensitive opsins was expressed at significantly higher levels in the cavefish. Changes in the expression ofopsin genes may have played a role in the degeneration of cavefish eyes [Current Zoology 59 （2）： 170-174, 2013].

关键词： Sinocyclocheilus Cavefish Eye Retina Opsin.

Killing two birds with one stone:Constructing tri-elements doped and hollow-structured carbon sphere by a single template for advanced potassium-ion hybrid capacitors

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Journal of Energy Chemistry 2022年第2期31卷 556-564页

作者： Jiafeng Ruan yahui zhao Sainan Luo Jiaming Hu Yuepeng Pang Fang Fang Shiyou Zheng School of Materials Science and Engineering University of Shanghai for Science&TechnologyShanghai 200093China Department of Materials Science Fudan UniversityShanghai 200433China

Integrating the merits of long lifespan and excellent energy as well as power densities,potassium-ion hybrid capacitors(PIHCs)exhibit great prospects for future energy storage *** boost comprehensive performance of PIHCs,heteroatom-doping and morphology-tuning as two comprehensive strategies have been devoted to designing uniquely structural carbon-based materials with favorable *** ideal strategy for simultaneous atomic doping and structural regulation is expected to be ***,we propose a novel"Killing Two Birds with One Stone"strategy to prepare a tri-elements doped hollow carbon sphere(TED-HCS)as PIHCs anodes,that is,a single template of spherical CoP particles is rationally adopted,which not only provides both a P source for heteroatom-doping but also acts as a selfsacrificial template for hollow-structure *** multifunctional TED-HCS presents a high capacity of 473.0 mAh g^(-1) and excellent rate performance of 212.5 mAh g^(-1) at 5.0 A g^(-1).Remarkably,the as-assembled PIHCs show outstanding energy/power density(40.4 Wh kg^(-1)/10500 W kg^(-1))and remain high-capacity retention of 89.15%even cycling 12,000 ***"Killing Two Birds with One Stone"strategy offers new insight into the search for the preparation of carbon-based materials with multi-elements doping and specific morphology structure.

关键词： Capacitors Potassium-ion Doping Carbon material Anode

Brain of the blind:transcriptomics of the golden-line cavefish brain

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Current Zoology 2018年第6期64卷 765-773页

作者： Fanwei MENG yahui zhao Tom TITUS Chunguang ZHANG John H.POSTLETHWAIT State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Neuroscience University of OregonEugeneOR 97403USA

The genus Sinocyclocheilus (golden-line barbel) includes 25species of cave-dwelling blind fish (cavefish)and more than 30 surface-dwelling species with normal *** environments are dark and generally nutrient-poor with few *** of several genera evolved convergent morphological adaptations in visual,pigmentation,brain,olfactory,and digestive systems. We compared brain morphology and gene expression patterns in a cavefish Sinocyclocheilus anophthalmus with those of a closely related surface-dwelling species *** showed that cavefish have a longer olfactory tract and a much smaller optic tectum than surface *** by RNA-seq revealed that many genes upregulated in cavefish are related to lysosomes and the degradation and metabolism of proteins,amino acids,and *** down- regulated in cavefish tended to involve "activation of gene expression in cholesterol biosynthesis" and cholesterol degradation in the *** encoding Srebfs (sterol regulatory element- binding transcription factors)and Srebf targets,including enzymes in cholesterol synthesis,were downregulated in cavefish brains compared with surface fish *** gene encoding Cyp46a1, which eliminates cholesterol from the brain,was also downregulated in cavefish brains,while the total level of cholesterol in the brain remained *** brains misexpressed several genes encoding proteins in the hypothalamus-pituitary axis,including Trh,Sst,Crh,Pomc,and *** results suggest that the rate of lipid biosynthesis and breakdown may both be depressed in golden-line cavefish brains but that the lysosome recycling rate may be increased in cavefish;properties that might be related to differences in nutrient availability in caves.

关键词： cavefish cholesterol cyp46a optic tectum Sinocyclocheilus transcriptomics

Sodium butyrate alleviates deoxynivalenol-induced hepatic cholesterol metabolic dysfunction via RORγ-mediated histone acetylation modification in weaning piglets

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Journal of Animal Science and Biotechnology 2023年第2期14卷 792-805页

作者： Qiufang Zong Huan Qu yahui zhao Haoyu Liu Shenglong Wu Shuai Wang Wenbin Bao Demin Cai College of Animal Science and Technology Yangzhou UniversityYangzhou 225009PR China Joint International Research Laboratory of Agriculture&Agri‑Product Safety Yangzhou UniversityYangzhou 225009PR China Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070PR China.

Background:Cholesterol is an essential component of lipid rafts in cell plasma membrane,which exerts a hepatoprotective role against mycotoxin exposure in pigs,and cholesterol metabolism is vulnerable to epigenetic histone ***,our present study aimed to investigate whether a histone deacetylase inhibitor(sodium butyrate [NaBu]) could protect the porcine liver from deoxynivalenol(DON) exposure by modulating cholesterol ***,we randomly divided 28 pigs into four groups,which were fed an uncontaminated basal diet,contaminated diet(4 mg DON/kg),uncontaminated diet supplemented with 0.2% NaBu or 4 mg/kg DON contaminated diet(4 mg DON/kg) supplemented with 0.2% NaBu for 28 ***:We found that the serum alanine transaminase(ALT),aspartate transaminase(AST),and alkaline phosphatase(ALP) were all increased in pigs exposed to DON,indicative of significant liver ***,the cholesterol content in the serum of DON-exposed pigs was significantly reduced,compared to the healthy Vehicle *** analysis of porcine liver tissues revealed that the cholesterol homeostasis pathway was highly enriched due to DON *** which we validated by qRT-PCR and western blotting that the cholesterol program was markedly ***,NaBu effectively restored parameters associated with liver injury,along with the cholesterol content and the expression of key genes involved in the cholesterol biosynthesis ***,we performed a ChIP-seq analysis of H3K27ac and showed that NaBu strongly diminished DON-increased H3K27ac genome-wide *** further validated that the elevated H3K27ac and H3K9ac occupancies on cholesterol biosynthesis genes were both decreased by NaBu,as determined by ChIP-qPCR ***,nuclear receptor RORγ,a novel regulator of cholesterol biosynthesis,was found in the hyperacetylated ***,a remarkable increase of RORγ at both mRNA and protein levels in DON-exposed porcine l

关键词： Cholesterol biosynthesis DON Histone acetylation RORγ Sodium butyrate

XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3304-3317页

作者： yahui zhao Weina Zhang Miaomiao Huo Peng Wang Xianghe Liu Yu Wang Yinuo Li Zhixiang Zhou Ningzhi Xu Hongxia Zhu State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021BeijingChina Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021BeijingChina

Macrophages are among the most abundant immune cells in colorectal cancer (CRC). Re-educating tumor-associated macrophages (TAMs) to switch from protumoral to anti-tumoral activity is an attractive treatment strategy that warrants further investigation. However, little is known about the key pathway that is activated in TAMs. In this study, infitrating CD206^(+) TAMs in CRC were sorted and subjected to RNA-seq analysis. Differentially expressed genes were found to be enriched in unfolded protein response/endoplasmic reticulum stress response processes, and XBP1 splicing/activation was specifically observed in TAMs. XBP1 activation in TAMs promoted the growth and metastasis of CRC. Ablation of XBP1 inhibited the expression of the pro-tumor cytokine signature of TAMs, including IL-6, VEGFA, and IL-4. Simultaneously, XBP1 depletion could directly inhibit the expression of SIRPα and THBS1, thereby blocking “don’t eat me” recognition signals and enhancing phagocytosis. Therapeutic XBP1 gene editing using AAV2-sgXBP1 enhanced the anti-tumor activity. Together, XBP1 activation in TAMs drives CRC progression by elevating pro-tumor cytokine expression and secretion, as well as inhibiting macrophage phagocytosis. Targeting XBP1 signaling in TAMs may be a potential strategy for CRC therapy.

关键词： colorectal inhibited thereby

RNF114 suppresses metastasis through regulation of PARP10 in cervical cancer cells

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Cancer Communications 2021年第2期41卷 187-191页

作者： yahui zhao Xiao Liang Li Wei Yao Liu Juan Liu Huan Feng Fen Zheng Ying Wang Haijie Ma Jiaxue Wu State Key Laboratory of Genetic Engineering Zhongshan Hospital and School of Life SciencesFudan UniversityShanghai 200438P.R.China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032P.R.China Department of Oncology No.971 Hospital of PLA NavyQingdaoShandong 266071P.R.China Laboratory of Cytobiology and Molecular Biology the Affiliated Zhoushan Hospital of Wenzhou Medical UniversityZhoushanZhejiang 316000P.R.China

Dear editor,ADP-ribosylation is a post-translational modification catalysed by poly(ADP-ribose)polymerases(PARPs)and plays important roles in diverse biological processes,such as DNA repair,chromatin remodelling,telomere homeostasis,transcription,chromosome segregation,cell proliferation,and cell death[1,2].While much is known about the cellular roles of PARPs that catalyse polyADP ribosylation,the function of the PARPs that catalyse monoADP ribosylation is substantially less understood.

关键词： PARP1 editor homeostasis