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Diagnosis and management of benign recurrent intrahepatic cholestasis and psychosocial stressors in an adolescent:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4427-4433页

作者： ya-xin xu Xiao-xuan Niu Bei-Li xu Yuan Ji Qun-yan yao Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200032China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastroenterology and Hepatology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Benign recurrent intrahepatic cholestasis(BRIC)is a rare autosomal recessive disorder,characterized by episodes of intense pruritus,elevated serum levels of alkaline phosphatase and bilirubin,and near-normal-glutamyl *** episodes may persist for weeks to months before spontaneously resolving,with patients typically remaining asymptomatic between *** entails the evaluation of clinical symptoms and targeted genetic *** BRIC is recognized as a benign genetic disorder,the triggers,particularly psychosocial factors,remain poorly *** SUMMARY An 18-year-old Chinese man presented with recurrent jaundice and pruritus after a cold,which was exacerbated by self-medication involving vitamin B and *** and laboratory evaluations revealed elevated levels of bilirubin and liver enzymes,in the absence of viral or autoimmune liver *** excluded biliary and pancreatic abnormalities,and liver biopsy demonstrated centrilobular cholestasis,culminating in a BRIC diagnosis confirmed by the identification of a novel ATP8B1 gene *** assessment of the patient unveiled stress attributable to academic and familial pressures,regarded as potential triggers for *** relief was observed with ursodeoxycholic acid and cetirizine,followed by an adjustment of the treatment regimen in response to elevated liver *** patient's condition significantly improved following a stress-related episode,thanks to a comprehensive management approach that included psychosocial support and medical *** Our research highlights genetic and psychosocial influences on BRIC,emphasizing integrated diagnostic and management strategies.

关键词： Benign recurrent intrahepatic cholestasis Genetic testing Psychosocial factors ATP8B1 gene mutation Cholestasis Jaundice Pruritus Case report

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Association between childhood obesity and gut microbiota:16S rRNA gene sequencing-based cohort study

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World Journal of Gastroenterology 2024年第16期30卷 2249-2257页

作者： xu-Ming Li Qing Lv ya-Jun Chen Lu-Biao yan xin Xiong Laboratory Department Nanjing Medical University Affiliated Obstetrics and Gynecology Hospital(Nanjing Maternal and Child Health Hospital)Nanjing 210004Jiangsu ProvinceChina Department of Pediatrics Shenzhen University General HospitalShenzhen 518055Guangdong ProvinceChina Department of Inspection Division Women’s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital)Nanjing 210004Jiangsu ProvinceChina Department of Pediatrics Women’s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital)Nanjing 210004Jiangsu ProvinceChina Department of Neonatology Chenzhou First People’s HospitalChenzhou 423000Hunan ProvinceChina

BACKGROUND This study aimed to identify characteristic gut genera in obese and normal-weight children(8-12 years old)using 16S rDNA *** research aimed to provide insights for mechanistic studies and prevention strategies for childhood *** normal-weight and thirty age-and sex-matched obese children were *** and body measurements were collected,and fecal samples underwent 16S rDNA *** differences in body mass index(BMI)and body-fat percentage were observed between the *** of gut microbiota diversity revealed lowerα-diversity in obese *** in gut microbiota composition were found between the two *** and Firmicutes were more abundant in the obese group,while Bacteroides and Sanguibacteroides were more prevalent in the control *** To identify the characteristic gut genera in obese and normal-weight children(8-12-year-old)using 16S rDNA sequencing,and provide a basis for subsequent mechanistic studies and prevention strategies for childhood *** Thirty each normal-weight,1:1 matched for age and sex,and obese children,with an obese status from 2020 to 2022,were included in the control and obese groups,*** information was collected through questionnaires and body measurements were obtained from both obese and normal-weight *** samples were collected from both groups and subjected to 16S rDNA sequencing using an Illumina MiSeq sequencing platform for gut microbiota diversity *** Significant differences in BMI and body-fat percentage were observed between the two *** Ace and Chao1 indices were significantly lower in the obese group than those in the control group,whereas differences were not significant in the Shannon and Simpson ***-Wallis tests indicated significant differences in unweighted and weighted UniFrac distances between the gut microbiota of normal-weight and obese children(P<0.01),suggest

关键词： Childhood obesity Gut microbiota 16S rDNA sequencing Diversity analysis Genus identification Body mass index

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Current and Potential Roles of Ferroptosis in Bladder Cancer

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Current Medical Science 2024年第1期44卷 51-63页

作者： Wen-xin AN Radheshyam Gupta Kun ZHAI ya-ru WANG Wan-hai xu yan CUI Department of Urology Harbin Medical University Cancer HospitalHarbin 150081China Department of Internal Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

关键词： ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer

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The RFI Fast Mitigation Algorithm Based on Block LMS Filter

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Research in Astronomy and Astrophysics 2024年第1期24卷 265-272页

作者： Han Wu Hai-Long Zhang ya-Zhou Zhang Jie Wang xu Du Ting Zhang xin-Chen Ye xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China

The radio telescope possesses high sensitivity and strong signal collection *** receiving celestial radiation signals,it also captures Radio Frequency Interferences(RFIs)introduced by human ***,as signals originating from sources other than the astronomical targets,significantly impacts the quality of astronomical *** paper presents an RFI fast mitigation algorithm based on block Least Mean Square(LMS)*** enhances the traditional adaptive LMS filter by grouping L adjacent time-sampled points into one block and applying the same filter coefficients for filtering within each *** transformation reduces multiplication calculations and enhances algorithm efficiency by leveraging the time-domain convolution *** algorithm is tested using baseband data from the Parkes 64 m radio telescope's pulsar observations and simulated *** results confirm the algorithm's effectiveness,as the pulsar profile after RFI mitigation closely matches the original pulsar profile.

关键词： methods:data analysis techniques:interferometric (stars:)pulsars:individual(J0437-4715)

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Hawking-Page transition and the dual relations of anti-de Sitter black holes surrounded by dark energy in general dimensions

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Communications in Theoretical Physics 2024年第7期76卷 94-104页

作者： Zhang xin xu Wei School of Mathematics and Physics China University of GeosciencesWuhan 430074China

Recently,a dual relation T_(0)(n+1)=T_(HP)(n)between the minimum temperature(T_(0)(n+1))black hole phase and the Hawking-Page transition(T_(HP)(n))black hole phase in two successive dimensions was introduced by Wei et al(2020 ***.D10210411);this was reminiscent of the anti-de Sitter/conformal field theory(AdS/CFT)correspondence,as the Hawking-Page transition temperature could be treated as the temperature of the dual physical quantity on the boundary and the latter corresponds to that in the *** this paper,we discuss the Hawking-Page transition and the dual relations in Ads black holes surrounded by dark energy in general *** findings reveal the occurrence of the Hawking-Page transition between the thermal AdS radiation and thermodynamically stable large AdS black holes,in both the spacetime surrounded by phantom dark energy and the spacetime surrounded by quintessence dark *** discuss the effects of the phantom dark energy and quintessence dark energy on the Hawking-Page transition *** the dual relation in particular,it works well for the case of an AdS black holes surrounded by phantom dark *** the case of an Ads black hole surrounded by quintessence dark energy,the dual relation should be modified under an open assumption that the state parameter and the density parameter of the quintessence dark energy depend on the dimensions of the spacetime.

关键词： Hawking-Page transition dark energy black hole thermodynamics

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Characteristics and geological significance of the stress state of the lithosphere in the Qinghai-Tibetan Plateau and its neighboring areas

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Science China Earth Sciences 2024年第6期67卷 1836-1855页

作者： Qianwen ZHANG ya xu Wei CHU Shupeng LU Key Lab of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The present-day lithospheric stress state of the Qinghai-Tibetan Plateau and neighboring areas is controlled by both the lithosphere itself and the underlying *** other words,the stress is affected by the gravitational potential energy(GPE)difference caused by the change in the density distribution within the lithosphere and the drag force on the base of the lithosphere caused by mantle *** study of the lithospheric stress state plays an important role in further understanding the dynamic background and mechanism for the evolution of the Qinghai-Tibetan *** this study,the Crust1.0 crustal density model combined with the S40RTS mantle shear wave velocity variation model was used to calculate the *** EGM2008gravity field model was used to calculate the drag force from mantle convection at the base of the *** lithospheric and joint stress fields of the two sources were obtained by solving the force balance under the thin sheet *** way,we could comprehensively analyze the characteristics of the stress state within the *** regions were classified according to the GPE stress field,mantle drag force stress field,the relative magnitude of the two stress fields,and correlation between the two stress fields and surface *** lithospheric stress fields of the Tarim Basin and other stable blocks are mainly controlled by the GPE *** lithospheric stress field in the collision zone between the Indian Plate and the QinghaiTibetan Plateau is predominantly controlled by the deep mantle drag *** lithospheric stress field in the interior of the Plateau is controlled by both GPE and mantle *** correlation between the lithospheric stress field and surface deformation at the southeast margin of the Qinghai-Tibetan Plateau is *** is hypothesized that the presence of lower crustal flow with lower effective viscosity leads to crust-mantle decoupling,and the mantle drag force has a weaker influe

关键词： Qinghai-Tibetan Plateau Gravitational potential energy Mantle convection Lithospheric deviatoric stress field GPS strain rate field

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Effect of hot isostatic pressure on the microstructure and tensile properties of γ'-strengthened superalloy fabricated through induction-assisted directed energy deposition

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 1089-1097页

作者： Jianjun xu Hanlin Ding xin Lin Feng Liu Analytical&Testing Center Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China

The microstructure characteristics and strengthening mechanism of Inconel738LC(IN-738LC) alloy prepared by using induction-assisted directed energy deposition(IDED) were elucidated through the investigation of samples subjected to IDED under 1050℃ preheating with and without hot isostatic pressing(HIP,1190℃,105 MPa,and 3 h).Results show that the as-deposited sample mainly consisted of epitaxial columnar crystals and inhomogeneously distributed γ’ phases in interdendritic and dendritic core *** HIP,grain morphology changed negligibly,whereas the size of the γ’ phase became increasingly *** further heat treatment(HT,1070℃,2 h + 845℃,24 h),the γ’ phase in the as-deposited and HIPed samples presented a bimodal size distribution,whereas that in the as-deposited sample showed a size that remained *** comparison of tensile properties revealed that the tensile strength and uniform elongation of the HIP + HTed sample increased by 5% and 46%,respectively,due to the synergistic deformation of bimodal γ’phases,especially large cubic γ’ ***,the relationship between phase transformations and plastic deformations in the IDEDed sample was discussed on the basis of generalized stability theory in terms of the trade-off between thermodynamics and kinetics.

关键词： directed energy deposition Ni-based superalloys high-temperature preheating hot isostatic pressing microstructure tensile properties

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Optimal proportioning of iron ore in sintering process based on improved multi-objective beluga whale optimisation algorithm

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Journal of Iron and Steel Research International 2024年第7期31卷 1597-1609页

作者： Zong-ping Li xu-dong Li xue-tong yan Wu Wen Xiao-xin Zeng Rong-jia Zhu ya-hui Wang Ling-zhi Yi Zhongye Changtian International Engineering Co. Ltd.Changsha 410205HunanChina College of Automation and Electronic Information Xiangtan UniversityXiangtan 411105HunanChina College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina

Proportioning is an important part of sintering,as it affects the cost of sintering and the quality of sintered *** address the problems posed by the complex raw material information and numerous constraints in the sintering process,a multi-objective optimisation model for sintering proportioning was established,which takes the proportioning cost and TFe as the optimisation ***,an improved multi-objective beluga whale optimisation(IMOBWO)algorithm was proposed to solve the nonlinear,multi-constrained multi-objective optimisation *** algorithm uses the con-strained non-dominance criterion to deal with the constraint problem in the ***,the algorithm employs an opposite learning strategy and a population guidance mechanism based on angular competition and two-population competition strategy to enhance convergence and population *** actual proportioning of a steel plant indicates that the IMOBWO algorithm applied to the ore proportioning process has good convergence and obtains the uniformly distributed Pareto ***,compared with the actual proportioning scheme,the proportioning cost is reduced by 4.3361¥/t,and the TFe content in the mixture is increased by 0.0367%in the optimal compromise ***,the proposed method effectively balances the cost and total iron,facilitating the comprehensive utilisation of sintered iron ore resources while ensuring quality assurance.

关键词： Sintering process Proportioning Iron ore Multi-objective beluga whale optimisation algorithm Proportioning cost

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Learning to sample initial solution for solving 0-1 discrete optimization problem by local search

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Science China Mathematics 2024年第6期67卷 1317-1340页

作者： xin Liu Jianyong Sun Zongben xu School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an710049China

Local search methods are convenient alternatives for solving discrete optimization problems(DOPs).These easy-to-implement methods are able to find approximate optimal solutions within a tolerable time *** is known that the quality of the initial solution greatly affects the quality of the approximated solution found by a local search *** this paper,we propose to take the initial solution as a random variable and learn its preferable probability *** aim is to sample a good initial solution from the learned distribution so that the local search can find a high-quality *** develop two different deep network models to deal with DOPs established on set(the knapsack problem)and graph(the maximum clique problem),*** deep neural network learns the representation of an optimization problem instance and transforms the representation to its probability *** results show that given the initial solution sampled from the learned probability distribution,a local search method can acquire much better approximate solutions than the randomly-sampled initial solution on the synthesized knapsack instances and the Erd?s-Rényi random graph ***,with sampled initial solutions,a classical genetic algorithm can achieve better solutions than a random initialized population in solving the maximum clique problems on DIMACS ***,we emphasize that the developed models can generalize in dimensions and across graphs with various densities,which is an important advantage on generalizing deep-learning-based optimization algorithms.

关键词： discrete optimization deep learning graph convolutional network local search

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Heterometallic Mg-Ni-Mg Complex Promoted Hydrosilylation of Alkenes: Catalytic Performance and Intermediates Characterization

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Chinese Journal of Chemistry 2024年第18期42卷 2133-2139页

作者： yanping Cai Shengjie Jiang xin xu Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochowUniversitySuzhouJiangsu215123China

Background and Originality Content The catalytic hydrosilylation of unsaturated hydrocarbons,facilitated by transition metal(TM),is widely recognized as a proficient technique for the synthesis of high-value organosilicon compounds'ti-4l over the past few decades,the most dominant *** in hydrosilylation processes have been constituted by pre-Ccious metar complexesroceinerecent vears omore sustainabile earth-abundant metal catalysts have received increased attentionj2-14l The classcal mechanism of transition metal-catalyzed hydrosilylation is generally accomplished through a series of fundamental processes(Scheme 1a),including(i)coordination and oxidative addition of Si-H bond to a low-valent metal center to form e.g.,o-complex or silyl metal hydride;(ii)insertion of.C-C multipe bonds intometal-hdridelsior metal-silicon bond;jiol and(ii)reductive elimination that forwards the hydrosilylated product with Markovnikov or anti-Markovnikov selectivity.

关键词： Heterometallic complex Cooperative effect Hydrosilylation Magnesium Nickel hydride

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