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Harnessing Interactional Sensory Genes for Rationally Reprogramming Chaotic Metabolism

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Research 2023年第3期2022卷 295-308页

作者： Chunlin Tan ping xu Fei Tao State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental Sciencesand School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

Rationally controlling cellular metabolism is of great importance but challenging owing to its highly complex and chaotic *** existing sensory proteins like histidine kinases(HKs)are understood as“sensitive nodes”of biological networks that can trigger disruptive metabolic reprogramming(MRP)upon perceiving environmental ***,the“sensitive node”genes were adopted to devise a global MRP platform consisting of a CRISPR interference-mediated dual-gene combinational knockdown toolbox and survivorship-based metabolic interaction decoding *** platform allows users to decode the interfering effects of n×n gene pairs while only requiring the synthesis of n pairs of primers.A total of 35 HK genes and 24 glycine metabolic genes were selected as the targets to determine the effectiveness of our platform in a Vibrio *** platform was applied to decode the interfering impact of HKs on antibiotic resistance in strain FA2.A pattern of combined knockdown of HK genes(sasA_8 and 04288)was demonstrated to be capable of reducing antibiotic resistance of Vibrio by *** of combined knockdown of glycine pathway genes(e.g.,gcvT and ltaE)and several HK genes(e.g.,cpxA and btsS)were also revealed to increase glycine *** platform may enable an efficient and rational approach for global MRP based on the elucidation of high-order gene interactions.A web-based 1-stop service(https://***)is also provided to simplify the implementation of this smart strategy in a broad range of cells.

关键词： metabolism Rational programming

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang Wang Wenyong Zhou Yu xu Jianchun Duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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辱虐管理何时以及如何促进员工关系经营

管理工程学报 2025年第1期39卷 1-14页

作者：徐钊胥思齐郝凯冰席酉民西安交通大学管理学院西交利物浦大学和谐管理研究中心

管理实践中,员工在经历了领导者的辱虐管理后仍可能采取对领导者的关系经营行为。本文针对这一现象,顺应探究辱虐管理积极影响的研究趋势,从矛盾关系认同的视角构建了在领导者专业能力调节下,辱虐管理通过矛盾关系认同影响员工关系经营... 详细信息

管理实践中,员工在经历了领导者的辱虐管理后仍可能采取对领导者的关系经营行为。本文针对这一现象,顺应探究辱虐管理积极影响的研究趋势,从矛盾关系认同的视角构建了在领导者专业能力调节下,辱虐管理通过矛盾关系认同影响员工关系经营的两阶段调节中介模型。矛盾关系认同指个体在关系层面进行自我定义时产生的矛盾认知与情感,表现为个体既愿意又排斥以这段关系定义自己。这种源于对重要他人在互动中表现的不一致评估能激发个体采取应对不适感的行为。基于对专业知识员工及其同事的334份匹配调研数据,研究发现:领导者专业能力正向调节辱虐管理对矛盾关系认同的影响;领导者专业能力正向调节矛盾关系认同对关系经营的影响;领导者专业能力正向调节辱虐管理通过矛盾关系认同对关系经营的间接影响,即当且仅当领导者专业能力较强时,辱虐管理能够通过矛盾关系认同激发员工的关系经营。研究主要扩展了辱虐管理带来积极组织行为结果的机制类型。

关键词：矛盾关系认同辱虐管理领导者专业能力关系经营

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H lder Continuity of Weak Solutions for Parabolic Equations with Nonstandard Growth Conditions

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Acta Mathematica Sinica,English Series 2006年第3期22卷 793-806页

作者： Meng xu ya Zhe CHEN School of Mathematical Sciences Peking University Department of Applied Mathematics Nanjing University of Science and Technology

In this paper, we investigate the interior regularity including the local boundedness and the interior HSlder continuity of weak solutions for parabolic equations of the p（x, t）-Laplacian type. We improve the Moser iteration technique and generalize the known results for the elliptic problem to the corresponding parabolic problem.

关键词： Boundedness Hoelder continuity Parabolic equations Nonstandard growth conditions

A bibliometric analysis of core articles ofinternational nursing research frontiersbased on the Web of Science database

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Frontiers of Nursing 2020年第1期7卷 31-38页

作者： Shi-Fan Han Jin-Lian Cheng ya-ping Wang Qiong Chen Zhu-ya xu Hospital of Shanxi Medical University TaiyuanShanxi 030001China Shanxi Medical University TaiyuanShanxi 030001China Shanxi Medical Periodical Press TaiyuanShanxi 030001China

Objective:To review and analyze the basic information and distribution of core articles in the global research frontier of nursing,so as to ascertain the current trend in the ***:A total of 37 highly cited essential science indicator(ESI)papers in the nursing discipline were retrieved,which were compared with the core article collection of the ESI research frontier in January 2019 to understand the current nursing research ***,a statistical analysis of the core articles that constituted the nursing research frontiers was performed using a bibliometric *** analysis was conducted with multiple aspects including the number of core articles,total number of citations,average publication year,issuing country,participating institution,citing paper,journal distribution,and core ***:At present,the two international research frontiers of nursing are patient-centered care(Research Frontier 1)and missed care(Research Frontier 2).These two frontiers include a total of 12 core articles,6 of which are highly cited Web of Scienceindexed nursing *** Frontier 1 includes three core articles that were cited 389 *** Frontier 2 includes nine core articles that were cited 841 *** in the two frontiers were cited by 454 and 841 papers,respectively,most of which are in the United *** addition,the 12 core articles were published across eight journals,the impact factors of which are all relatively ***,Research Frontier 1 involves 11 authors,whereas Research Frontier 2 involves 49 authors,of which seven authors have published more than two ***:The core articles in the frontier of international nursing research demonstrate distinctive features in their issuing country/region,journal distribution,and participating *** and analysis of the core articles of international nursing research frontiers can help nursing staff understand the current research hotspots and conseq

关键词： nursing core article research frontier bibliometrics highly cited paper

A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li yang Wei Kang Zhou Xin Huang Xing Zhou Jie xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

跟踪式家庭访视对改善居家失能老人生活自理能力的影响

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护理学报 2016年第18期32卷 74-76页

作者：朱雅萍许婷婷杨小谨方均华王君俏上海市静安区南京西路街道社区卫生服务中心 200041 复旦大学护理学院上海200433

目的探讨跟踪式家庭访视指导,对居家失能老人生活自理能力的效果评价。方法采用方便取样法,对84例社区居家护理的失能老人随机分为干预组和对照组各42例,对照组采用常规社区居家护理方式,干预组在常规社区护理的基础上针对失能老人生活... 详细信息

目的探讨跟踪式家庭访视指导,对居家失能老人生活自理能力的效果评价。方法采用方便取样法,对84例社区居家护理的失能老人随机分为干预组和对照组各42例,对照组采用常规社区居家护理方式,干预组在常规社区护理的基础上针对失能老人生活自理能力缺失的情况,进行跟踪式家庭访视指导。2组同时进行家庭访视3个月。分别在入组时,访视后1个月、2个月、3个月进行日常生活活动能力状况评估。结果实施干预3个月,2组日常生活活动能力自身对照差异有统计学意义(P<0.01);2组日常生活活动能力组间比较,差异具有统计学意义(P<0.01)。结论跟踪式家庭访视指导失能老人生活自理方法 ,有利于提高老人的自理能力,从而达到提高失能老人生活质量的目的。

关键词：跟踪式家庭访视失能老人生活自理能力

Strengthening poly(2-hydroxyethyl methacrylate) hydrogels using biochars and hydrophobic aggregations

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International Journal of Smart and Nano Materials 2022年第4期13卷 561-574页

作者： ping Zhang Ziyi xu Zhiying Wu ping xu Canhui yang Shenzhen Key Laboratory of Soft Mechanics&Smart Manufacturing Department of Mechanics and Aerospace EngineeringSouthern University of Science and TechnologyShenzhenP.R.China Department of Chemistry City University of Hong KongHong KongP.R.China Department of Respiratory and Critical Care Medicine Peking University Shenzhen HospitalShenzhenGuangdongP.R.China

As the first version of synthetic hydrogel,poly(2-hydroxyethyl methacrylate)hydrogels have found broad ***,their poor mechanical performances have been longstanding hurdles for practical ***,we report on strengthening the poly(2-hydroxyethyl methacrylate)hydro-gels with biochar nanoparticles and hydrophobic aggregations,which are induced by solvent exchange and reinforced by *** the vast anchoring points on the multifunc-tional surfaces of the biochar nanoparticles and the aggregates formed between poly(2-hydroxyethyl methacrylate)chains engender strong and dissipative physical *** result-ing hydrogels exhibit marked mechanical properties,encom-passing high stretchability~7,high fracture toughness~1360 J m−2,high elastic modulus~180 kPa,low friction coefficient~0.2,self-recovery,and ***,we demonstrate the versatility of the proposed strategy by using water/ionic liquid binary solvent as the sol-vent system,Laponite as the nano-reinforcement,and dryanneal as the hydrophobic aggregation enhancer to synthesize mechanically robust ***(2-hydroxyethyl methacry-late)hydrogels of superior mechanical properties are expected to enable previously inaccessible applications in biomedicine and engineering.

关键词： Hydrogel PHEMA mechanical properties biochar hydrophobic aggregation

Elastoplastic Analysis of Circular Tunnel in Saturated Ground Under Different Load Conditions

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Computers, Materials & Continua 2020年第1期62卷 179-197页

作者： Panpan Zhai ping xu College of Water Conservancy&Environmental Engineering Zhengzhou UniversityZhengzhou450001China National Local Joint Engineering Laboratory of Major Infrastructure Testing and Rehabilitation Technology Zhengzhou450001China

When a tunnel is excavated below the groundwater table,groundwater flows in through the excavated wall of the tunnel and seepage forces act on *** forces significantly affect the ground reaction curve,which is defined as the relationship between the internal pressure and radial displacement of the tunnel *** study investigates analytical solutions for seepage forces acting on the lining of a circular tunnel under steady-state groundwater *** the tunnel’s construction or service period and boundary conditions,the direction of maximum principal stress changes,and the input stress of the Mohr-Coulomb criterion *** stress distribution and yield range of the surrounding soils and linings are *** first,second,and third critical inner pressures are defined and *** influence of the seepage field on the plastic radius,first critical pressure,and stress distribution of the tunnel is *** is shown that during the construction period,the seepage force promotes the expansion of the yield area,whereas during the service period,the opposite is the *** first critical pressure increases nearly linearly with the distant water *** radial stress distribution decreases clearly in comparison with that when the seepage force is not considered,and the reduction is more prominent when internal pressure *** tangential stress distribution increases clearly compared with that when the seepage force is not considered.

关键词： Tunnel lining surrounding soils elastoplastic analysis critical pressure plastic radius seepage force