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The inflammation influence on corneal surface after frontalis suspension surgery

International Journal of Ophthalmology(English edition) 2018年第9期11卷 1489-1495页

作者： Kang Li Xin-Chun Zhang Xian-Xian Cai ya-dan quan Rong Lu State Key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceZhongshan Ophthalmic CenterSun Yat-sen University Department of Prosthodontics Hospital of StomatologyGuangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen University

AIM： To study the influence of frontalis muscle flap suspension on ocular surface by analyzing the clinical features and inflammatory ***： A prospective, observational case series. Thirty-one eyes of 25 patients with severe congenital blepharoptosis who underwent frontalis muscle flap suspension surgery with at least 6 mo of follow-up were included in the study. The main outcome measures were margin reflex distance 1（MRD_1）, degree of lagophthalmos, ocular surface disease index（OSDI）, fluorescein staining（Fl）, tear break-up time（BUT）, Schirmer I test, and inflammatory cytokine ***： The degrees of lagophthalmos significantly increased after surgery. The OSDI scores significantly increased 1wk postoperatively and then decreased 4wk after operation. The Fl scores reflected corneal epithelial defects in sixteen patients at early stage postoperatively. The BUT and Schirmer I test values remained stable and did not show change compared to those before surgery. The inflammatory cytokines in conjunctival epithelial cells（including IL-1β, IL-6, IL-8, TNF-α, and IL-17A） significantly increased 1wk after the surgery（P〈0.001）, then returned to the normal level at 24wk postoperatively. The levels of inflammatory cytokine IL-1β, IL-6, IL-8, TNF-α, and IL-17A elevated significantly and were positively correlated with OSDI and Fl ***： Frontalis muscle flap suspension surgery results in lagophthalmos in early period of post-operation and relieved after months. The elevation of inflammatory cytokines level may participate in the occurrence of corneal epithelial defects at the early postoperative stage.

关键词： congenital blepharoptosis frontalis muscle flap suspension corneal epithelial defects inflammation

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Pterygial body epithelium domination of pterygial proliferation with TCF4 as a potential key factor

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1467-1474页

作者： Cong Nie Xin-Chun Zhang Si-Ying Xu ya-dan quan Zhi-Xin Tang Rong Lu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University Department of Prosthodontics Hospital of StomatologyGuangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen University

AIM： To characterize the proliferative capacity of pterygial epithelium in different regions（head, neck and body） of pterygium and explore the function of transcription factor 4（TCF4） in pterygium ***： Thirty pterygium tissues and 10 normal conjunctival tissues were obtained from Zhongshan Ophthalmic Center（ZOC） and Guangdong Eye Bank, respectively. Proliferative capacity of head, neck and body in pterygial epithelium was measured using clonal analysis, fold growth analysis and expression profile of proliferative markers revealed by immunofluorescent staining and real-time PCR. The expression of TCF4 was highlighted by double immunofluorescent staining with other proliferation related markers such as proliferating cell nuclear antigen（PCNA） and ATP-binding cassette subfamily G member 2（ABCG2）.RESULTS： The proliferative potential of pterygial epithelium was higher than that of normal conjunctival epithelium. High expression levels of proliferative markers（P63α, PCNA and ABCG2） in pterygial body epithelium were observed in immunofluorescent staining and real-time PCR（P〈0.05）. Also, epithelial cells isolated from pterygial body demonstrated higher proliferative capacity in clonal analysis and fold growth analysis, than those isolated from the head and neck regions. The TCF4 expression in pterygial epithelium was similar to other proliferative markers（P63α, PCNA and ABCG2）, as higher in pterygial body than head and neck. Moreover, TCF4 showed coexpression with other proliferation-related markers（PCNA and ABCG2） in the double immunofluorescent staining ***： The proliferative capacity in pterygial body epithelium is prominent than the head and neck regions, and upregulated TCF4 may be associated with enhanced proliferation in the pterygium.

关键词： pterygium epithelium proliferation transcription factor 4

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Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush

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Neural Regeneration Research 2023年第4期18卷 913-921页

作者： Zong-Yi Zhan Yi-Ru Huang Lu-Wei Zhao ya-dan quan Zi-Jing Li Di-Fang Sun ya-Li Wu Hao-Yuan Wu Zi-Tian Liu Kai-Li Wu Yu-Qing Lan Min-Bin Yu Department of Ophthalmology Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Light Innovation Technology Ltd. Hong Kong Special Administrative RegionChina Department of Ophthalmology&Visual Science Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghaiChina Department of Ophthalmology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Successful establishment of reconnection between retinal ganglion cells and retinorecipient regions in the brain is critical to optic nerve ***,morphological assessments of retinorecipient regions are limited by the opacity of brain *** this study,we used an innovative tissue cleaning technique combined with retrograde trans-synaptic viral tracing to observe changes in retinorecipient regions connected to retinal ganglion cells in mice after optic nerve ***,we performed light-sheet imaging of whole brain tissue after a clearing *** found that pseudorabies virus 724(PRV724)mostly infected retinal ganglion cells,and that we could use it to retrogradely trace the retinorecipient regions in whole tissue-cleared ***,PRV724-traced neurons were more widely distributed compared with data from previous *** found that optic nerve injury could selectively modify projections from retinal ganglion cells in the hypothalamic paraventricular nucleus,intergeniculate leaflet,ventral lateral geniculate nucleus,central amygdala,basolateral amygdala,Edinger-Westphal nucleus,and oculomotor nucleus,but not the superior vestibular nucleus,red nucleus,locus coeruleus,gigantocellular reticular nucleus,or facial nerve *** findings demonstrate that the tissue clearing technique,combined with retrograde trans-synaptic viral tracing,can be used to objectively and comprehensively evaluate changes in mouse retinorecipient regions that receive projections from retinal ganglion cells after optic nerve ***,our approach may be useful for future estimations of optic nerve injury and regeneration.

关键词： histology image analysis light-sheet imaging optic nerve crush pseudorabies virus retinal ganglion cells three-dimensional imaging tissue clearing viral tracing whole brain study

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Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-Yu Jiang dan-dan Cui Kun-Rong Du Hong-Run Zhang Sheng-Jie Xu ya-Qi Li Zhi-Zhen Ren Liang Wang Wei-Chang Hao Yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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双轴应变对NbSe_(2)/MoSi_(2)N_(4)肖特基势垒的调控

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原子与分子物理学报 2025年第5期42卷 182-188页

作者：张宇哲安梦雅谢泉贵州大学大数据与信息工程学院新型光电子材料与技术研究所贵阳550025

最近一种高质量的二维(Two-dimensional,2D)半导体材料MoSi_(2)N_(4)(MSN)在实验上被成功合成,具有优异的电气和机械性能.尽管最近有大量的研究致力于揭示MSN的材料特性,但到目前为止,对MSN的电接触物理特性的探索还比较少.在这项工作中... 详细信息

最近一种高质量的二维(Two-dimensional,2D)半导体材料MoSi_(2)N_(4)(MSN)在实验上被成功合成,具有优异的电气和机械性能.尽管最近有大量的研究致力于揭示MSN的材料特性,但到目前为止,对MSN的电接触物理特性的探索还比较少.在这项工作中,构建了金属-半导体NbSe_(2)/MSN肖特基结并使用第一性原理密度泛函理论计算研究了该肖特基结的材料特性.发现NbSe_(2)/MSN接触具有超低肖特基势垒高度(Schottky barrier height,SBH),这有利于纳米电子学应用.SBH可以通过施加双轴应变的方式进行有效的调控.当施加拉伸应变时能实现NbSe_(2)/MSN肖特基结由p型肖特基接触转变为p型欧姆接触,而当施加较大的压缩应变时能实现p型肖特基接触和n型肖特基接触之间的转换.我们的研究结果为MSN的2D电触点的物理特性提供了见解,并将为设计基于MSN的2D纳米器件的高性能电触点提供关键的一步.

关键词： MoSi_(2)N_(4) NbSe_(2) 肖特基结欧姆接触

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Micromagnetic simulation of FeCo write head in perpendicular recording hard disk drives

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Rare Metals 2006年第Z1期25卷 502-508页

作者： quan Liang WEI dan Lab of Advanced Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China Lab of Advanced Materials Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

The single-pole tip (SPT) heads made of the high saturation FeCo ferromagnetic metals are crucial for the actualization of ultrahigh density perpendicular recording. The effective head field distribution in the medium is of key importance for the design of the SPT head, which would be analyzed by micromagnetic simulations in this work. Two 3D micromagnetic models of the SPT head were established to select a more appropriate method of modeling, with a magnetostatic image effect or a real soft magnetic material to model the image of the SPT head in soft under layer (SUL). The results from these two designs were tested and compared to the ideal head field calculated by the Jacobi finite element method (FEM); and the design with the real soft magnetic material as image was proved suitable for simulating the ultrahigh density perpendicular recording write head.

关键词： SPT head perpendicular recording micromagnetic simulation image

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Fully enclosed hybrid electromagnetic-triboelectric nanogenerator to scavenge vibrational energy

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Nano Research 2016年第8期9卷 2226-2233页

作者： Ting quan ya yang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences National Center for Nanoscience and Technology Beijing 100083 China

We propose a fully enclosed hybrid nanogenerator consisting of five elec- tromagnetic generators （EMGs） and four triboelectric nanogenerators （TENGs）. Under a vibration frequency of 15.5 Hz, one TENG can deliver a high output voltage of approximately 24 V and a low output current of approximately 24 μA, whereas one EMG can deliver a low output voltage of approximately 0.8 V and a high output current of approximately 0.5 mA. By integrating five rectified EMGs in series and four rectified TENGs in parallel, the hybrid nanogenerator can be used to charge a home-made Li-ion battery from 1 to 1.9 V in 6.3 h. By using the hybrid nanogenerator to scavenge the vibrational energy produced by human hands, a temperature-humidity sensor can be sustainably powered by the nanogenerator, which is capable of charging the 200 ~F system power capacitor from 0 to 2 V in 15 s, and sustainably power the sensor in 29 s.

关键词： hybrid nanogenerator electromagnetic triboelectric vibration energy Li-ion battery

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Utilizing comprehensive decision analysis methods to determine an optimal planting pattern and nitrogen application for winter oilseed rape

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Journal of Integrative Agriculture 2020年第9期19卷 2229-2238页

作者： DU ya-dan CUI Bing-jing ZHANG Qian SUN Jun WANG Zhen NIU Wen-quan Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Area of Ministry of Education/Northwest A&F University Yangling 712100P.R.China

Oilseed rape is one of the most important oil crops *** the appropriate cultivation method(planting pattern and nitrogen level)is necessary to achieve high yield,quality and resource utilization ***,the optimal method for oilseed rape varies across countries and *** objective of the present study was to determine an appropriate cultivation method,including planting pattern and nitrogen application,for winter oilseed rape in northwestern *** planting patterns:ridge film mulching and furrow planting(RFMF)and flat planting(FP),and six nitrogen(N)amounts:0(N0),60(N60),120(N120),180(N180),240(N240),and 300(N300)kg N ha–1 were applied across three growing seasons(2014–2017).Three comprehensive decision analysis methods:principal component analysis,grey correlation degree analysis and the combined entropy weight and dynamic technique for order preference by similarity to ideal solution method were used to evaluate the growth and physiological indicators,nutrient uptake,yield,quality,evapotranspiration,and water use efficiency of winter oilseed *** pattern,nitrogen amount and their interaction significantly affected the indicators *** RFMF pattern significantly increased all indicators over the FP *** of N also markedly increased all the indicators except for seed oil content,but the yield,oil production and water use efficiency were decreased when N fertilizer exceeded 180 kg N ha–1 under FP and 240 kg N ha–1 under *** evaluation results of the three comprehensive decision analysis methods indicated that RFMF planting pattern with 240 kg N ha–1 is an appropriate cultivation method for winter oilseed rape in northwestern *** findings are of vital significance to maximize yield,optimize quality and improve resource use efficiencies of winter oilseed rape.

关键词： appropriate cultivation method comprehensive decision analysis method northwestern China winter oilseed rape

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New insights on serodiagnosis of trichinellosis during window period:early diagnostic antigens from Trichinella spiralis intestinal worms

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Infectious Diseases of Poverty 2017年第1期6卷 368-371页

作者： Zhong-quan Wang ya-Li Shi Rou-dan Liu Peng Jiang ya-Yi Guan Ying-dan Chen Jing Cui Department of Parasitology Medical CollegeZhengzhou UniversityZhengzhou 450052China National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025China

The clinical diagnosis of trichinellosis is difficult because its clinical manifestations are *** of anti-Trichinella IgG by ELISA using *** muscle larval excretory-secretory(ES)antigens is the most commonly used serological method for diagnosis of trichinellosis,but the main disadvantage is false negativity during the early stage of *** is an obvious window period between Trichinella infection and antibody *** the intestinal stage of Trichinella infection,the ES antigens of intestinal worms(intestinal infective larvae and adults)are exposed to host’s immune system at the earliest time and elicit the production of specific anti-Trichinella ***-Trichinella IgG antibodies in infected mice were detectable by ELISA with ES antigens of intestinal worms as soon as 8-10 days post infection(dpi),but ELISA with muscle larval ES antigens did not permit detection of infected mice before 12 ***,the new early antigens from *** intestinal worms should be screened,identified and characterized for early serodiagnosis of trichinellosis.

关键词： Trichinellosis Early serodiagnosis Intestinal infective larvae Adult worms

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