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Efficacyand Safetyof Huashi Baidu Granules in Treating Patients with SARS-CoV-2Omicron Variant: A Single-Center Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2024年第2期30卷 107-114页

作者： CHEN Cai-yu ZHANG Wen XU Xiang-ru PU Yu-ting tu ya-dan PENG Wei yaO Xuan ZHOU Shuang FANG Bang-jiang Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China Department of Classical Traditional Chinese Medicine Chongqing Hospital of Traditional Chinese MedicineChongqing(400021)China Acupuncture and Massage College Shanghai University of Traditional Chinese MedicineShanghai(201203)China Institute of Emergency and Critical Care Medicine Shanghai University of Traditional Chinese MedicineShanghai(200032)China

Objective:To evaluate the efficacy and safety of Huashi Baidu Granules(HSBD)in treating patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant.Methods:A single-center retrospective cohort study was conducted during COVID-19 Omicron epidemic in the Mobile Cabin Hospital of Shanghai New International Expo Center from April 1st to May 23rd,2022.All COVID-19 patients with asymptomatic or mild infection were assigned to the treatment group(HSBD users)and the control group(non-HSBD users).After propensity score matching in a 1:1 ratio,496 HSBD users of treatment group were matched by propensity score to 496 non-HSBD users.Patients in the treatment group were administrated HSBD(5 g/bag)orally for 1 bag twice a day for 7 consecutive days.Patients in the control group received standard care and routine treatment.The primary outcomes were the negative conversion time of nucleic acid and negative conversion rate at day 7.Secondary outcomes included the hospitalized days,the time of the first nucleic acid negative conversion,and new-onset symptoms in asymptomatic patients.Adverse events(AEs)that occurred during the study were recorded.Further subgroup analysis was conducted in vaccinated(378 HSBD users and 390 non-HSBD users)and unvaccinated patients(118 HSBD users and 106 non-HSBD users).Results:The median negative conversion time of nucleic acid in the treatment group was significantly shortened than the control group[3 days(IQR:2-5 days)vs.5 days(IQR:4-6 days);P<0.01].The negative conversion rate of nucleic acid in the treatment group were significantly higher than those in the control group at day 7(91.73%vs.86.90%,P=0.014).Compared with the control group,the hospitalized days in the treatment group were significantly reduced[10 days(IQR:8-11 days)vs.11 days(IQR:10.25-12 days);P<0.01].The time of the first nucleic acid negative conversion had significant differences between the treatment and control groups[3 days(IQR:2-4 days)vs.5 days(IQR:4-6 days);P<0.01].The incidence of new-onset sym

关键词： Huashi Baidu Granule severe acute respiratory syndrome coronavirus 2 Omicron variant retrospective cohort trial Chinese medicine

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Large-scale real-world radio signal recognition with deep learning

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Chinese Journal of Aeronautics 2022年第9期35卷 35-48页

作者： ya tu Yun LIN Haoran ZHA Ju ZHANG Yu WANG Guan GUI Shiwen MAO College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China College of Electronic Science and Engineering National University of Defense TechnologyChangsha 410073China College of Telecommunications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China Department of Electrical and Computer Engineering Auburn UniversityAuburn 36849USA

In the past ten years, many high-quality datasets have been released to support the rapid development of deep learning in the fields of computer vision, voice, and natural language processing. Nowadays, deep learning has become a key research component of the Sixth-Generation wireless systems(6G) with numerous regulatory and defense applications. In order to facilitate the application of deep learning in radio signal recognition, in this work, a large-scale real-world radio signal dataset is created based on a special aeronautical monitoring system-Automatic Dependent Surveillance-Broadcast(ADS-B). This paper makes two main contributions. First, an automatic data collection and labeling system is designed to capture over-the-air ADS-B signals in the open and real-world scenario without human participation. Through data cleaning and sorting, a high-quality dataset of ADS-B signals is created for radio signal recognition. Second, we conduct an in-depth study on the performance of deep learning models using the new dataset, as well as comparison with a recognition benchmark using machine learning and deep learning methods.Finally, we conclude this paper with a discussion of open problems in this area.

关键词： Signal recognition Radio signal dataset Automatic Dependent Surveillance-Broadcast(ADS-B) Deep learning Recognition benchmark

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Antidepressant effect of electroacupuncture regulates signal targeting in the brain and increases brain- derived neurotrophic factor levels

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Neural Regeneration Research 2016年第10期11卷 1595-1602页

作者： Dong-mei Duan ya tu Ping Liu Shuang Jiao Department of Health Care of South Building Chinese PLA General Hospital Beijing China Acupuncture College of Beijing University of Chinese Medicine Beijing China Department of Clinical Pharmacology Chinese PLA General Hospital Beijing China Journal of Traditional Chinese Medicine Beijing China

Electroacupuncture improves depressive behavior faster and with fewer adverse effects than antidepressant medication. However, the antidepressant mechanism of electroacupuncture remains poorly understood. Here, we established a rat model of chronic unpredicted mild stress, and then treated these rats with electroacupuncture at Yintang （EX-HN3） and Baihui （DU20） with sparse waves at 2 Hz and 0.6 mA for 30 minutes, once a day. We found increased horizontal and vertical activity, and decreased immobility time, at 2 and 4 weeks after treatment. Moreover, levels of neurotransmitters （5-hydroxytryptamine, glutamate, and y-aminobutyric acid） and protein levels of brain-derived neurotrophic factor and brain-derived neurotrophic factor-related proteins （TrkB, protein kinase A, and phosphorylation of cyclic adenosine monophosphate response element binding protein） were increased in the hippocampus. Similarly, protein kinase A and TrkB mRNA levels were increased, and calcium-calmodulin-dependent protein kinase lI levels decreased. These findings suggest that electroacupuncture increases phosphorylation of cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor levels by regulating multiple targets in the cyclic adenosine rnonophosphate response element binding protein signal- ing pathway, thereby promoting nerve regeneration, and exerting an antidepressive effect.

关键词： nerve regeneration depression chronic unexpected mild stress electroacupuncture brain-derived neurotrophic factor neurotransmitter cyclic adenosine monophosphate response element binding protein signal pathway protein kinase A TrKB fluoxetine neural regeneration

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Electroacupuncture regulates the stress-injury-repair chain of events after cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2017年第6期12卷 925-930页

作者： Peng Shi Lin-lin Sun Yi-shuo Lee ya tu School of Acupuncture-Moxibustion and tuina Beijing University of Chinese Medicine

Inflammation after stroke is the main cause of cerebral ischemia/reperfusion injury. Cascading events after injury can lead to cell death. Heat shock protein 70 and other endogenous injury-signaling molecules are released by damaged cells, which can lead to systemic stress reactions. Protecting the brain through repair begins with the stress-injury-repair signaling chain. This study aimed to verify whether acupuncture acts through this chain to facilitate effective treatment of ischemic stroke. Rat models of cerebral ischemia/reperfusion injury were established by Zea Longa＇s method, and injury sites were identified by assessing neurological function, 2,3,5-triphenyltetrazolium chloride staining, and hematoxylin-eosin staining. Electroacupuncture at acupoints Baihui（DU20） and Zusanli（ST36） was performed in the model rats with dilatational waves, delivered for 20 minutes a day at 2–100 Hz and an amplitude of 2 m A. We analyzed the blood serum from the rats and found that inflammatory cytokines affected the levels of adrenotrophin and heat shock protein 70, each of which followed a similar bimodal curve. Specifically, electroacupuncture lowered the peak levels of adrenocorticotrophic hormone and heat shock protein 70. Thus, electroacupuncture was able to inhibit excessive stress, reduce inflammation, and promote the repair of neurons, which facilitated healing of ischemic stroke.

关键词： repair acupuncture hematoxylin eosin minutes endogenous Acupuncture neurological inflammation staining

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中波广播发射机远程控制系统设计及应用

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电视技术 2024年第5期48卷 13-16页

作者：图雅甘肃省广播电视局肃北广播转播台甘肃酒泉736300

为了有效提升中波广播安全播出能力,加快中波广播发射台站的智能化建设以及中波广播发射机远程控制系统的设计与应用是重要环节。提出基于浏览器/服务器(Browser/Server,B/S)架构的系统设计思路,详细论证系统各功能平台的设计内容和实... 详细信息

为了有效提升中波广播安全播出能力,加快中波广播发射台站的智能化建设以及中波广播发射机远程控制系统的设计与应用是重要环节。提出基于浏览器/服务器(Browser/Server,B/S)架构的系统设计思路,详细论证系统各功能平台的设计内容和实现方法,并对远程控制系统的应用情况进行深入探讨,以期在实现发射机等设备自动化管控的同时,为智慧台站建设奠定技术基础和硬件支撑。

关键词：智慧台站中波广播发射机远程控制

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Semi-Supervised Learning with Generative Adversarial Networks on Digital Signal Modulation Classification

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Computers, Materials & Continua 2018年第5期55卷 243-254页

作者： ya tu Yun Lin Jin Wang Jeong-Uk Kim College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China School of Computer&Communication Engineering Changsha University of Science&TechnologyChangsha 410114China School of Information Engineering Yangzhou UniversityYangzhou 225009China Department of Energy Grid Sangmyung UniversitySeoulKorea

Deep Learning(DL)is such a powerful tool that we have seen tremendous success in areas such as Computer Vision,Speech Recognition,and Natural Language Processing.Since Automated Modulation Classification(AMC)is an important part in Cognitive Radio Networks,we try to explore its potential in solving signal modulation recognition problem.It cannot be overlooked that DL model is a complex model,thus making them prone to over-fitting.DL model requires many training data to combat with over-fitting,but adding high quality labels to training data manually is not always cheap and accessible,especially in real-time system,which may counter unprecedented data in dataset.Semi-supervised Learning is a way to exploit unlabeled data effectively to reduce over-fitting in DL.In this paper,we extend Generative Adversarial Networks(GANs)to the semi-supervised learning will show it is a method can be used to create a more dataefficient classifier.

关键词： Deep Learning automated modulation classification semi-supervised learning generative adversarial networks

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Combined effects of electroacupuncture and anti-depression drugs on the hippocampus and frontal lobe

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Neural Regeneration Research 2010年第22期5卷 1723-1727页

作者： Dongmei Duan ya tu Shuang Jiao Liping Chen Department of TCM of Nan Lou Chinese PLA General Hospital Beijing 100853 China School of Acupuncture and Moxibustion Beijing University of Chinese Medicine Beijing 100029 China

Electroacupuncture （EA） has been clinically used to treat depression and has resulted in favorable effects in China. However, results from animal studies and pathology do not reflect the influence of electroacupuncture treatment on in vivo physiological functions. To thoroughly and dynamically observe pathological changes during depression, the present study established EA ＋ fluoxetine and fluoxetine groups to observe depression in patients. 1H-magnetic resonance spectroscopy was utilized to determine the correlation between hippocampal frontal lobe metabolite changes and mental disorder scale. Results revealed significantly increased N-acetylaspartate （NAA）/creatine （Cr） in the bilateral hippocampus and right frontal lobe of depression patients treated with EA compared with fluoxetine. Changes in NAA/Cr in bilateral hippocampus and right frontal lobe in both groups, before and after treatment, negatively correlated with severity and curative effects. Choline/Cr changes in the bilateral frontal lobes of both groups were significant before and after treatment, but negatively correlated with curative effects. Choline/Cr changes in the bilateral hippocampus were significant in the EA ＋ fluoxetine group before and after treatment, but negatively correlated with severity and the curative effects of depression. These results demonstrate abnormal biochemical metabolism in bilateral frontal lobes and hippocampus of depression patients, and show that EA significantly altered biochemical indices in the frontal lobes and hippocampus compared with fluoxetine.

关键词： depression electroacupuncture fluoxetine hippocampus frontal lobe traditional Chinese medicine magnetic resonance spectroscopy neural regeneration

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Hippocampal activation of c-Jun N-terminal kinase,protein kinase B,and p38 mitogen-activated protein kinase in a chronic stress rat model of depression

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Neural Regeneration Research 2010年第19期5卷 1486-1490页

作者： Wei Dai Weidong Li Jun Lu Yingge A ya tu College of Acupuncture and Moxibustion Beijing University of Chinese Medicine Beijing 100029 China North China Coal Medical College Tangshan 063000 Hebei Province China

Recent studies have shown that varied stress stimuli activate c-Jun N-terminal kinase （JNK）, protein kinase B （Akt）, and p38 mitogen-activated protein kinase （p38） signal transduction pathway, and also regulate various apoptotic cascades. JNK and p38 promote apoptosis, but Akt protects against apoptosis, in hippocampal neurons. However, changes in the transduction pathway in different regions of brain tissues in a chronic stress rat model of depression remain poorly understood. Results from this study showed that JNK phosphorylation levels were significantly greater in the stress group hippocampus compared with the control group （P 〈 0.05）. No significant difference in JNK phosphorylation levels was detected in the rat cerebral cortex between stress and control groups, and no significant difference in Akt and p38 phosphorylation levels was detected in the rat hippocampus and cerebral cortex between stress and control groups （P 〉 0.05）. These results suggested that the JNK signal pathway is activated by JNK phosphorylation and participates in pathophysiological changes in rat models of depression.

关键词： depression chronic stress phosphorylation stress-activated protein kinase protein kinase B p38 mitogen-activated protein kinase neural regeneration

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Effect of electroacupuncture on glial fibrillary acidic protein and nerve growth factor in the hippocampus of rats with hyperlipidemia and middle cerebral artery thrombus

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Neural Regeneration Research 2021年第1期16卷 137-142页

作者： Na-Ying Xue Dong-Yu Ge Rui-Juan Dong Hyung-Hwan Kim Xiu-Jun Ren ya tu School of Acupuncture-Moxibustion and tuina Beijing University of Chinese MedicineBeijingChina School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Neurovascular Research Laboratory Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA

Electroacupuncture(EA)has been shown to reduce blood lipid level and improve cerebral ischemia in rats with hyperlipemia complicated by cerebral ischemia.However,there are few studies on the results and mechanism of the effect of EA in reducing blood lipid level or promoting neural repair after stroke in hyperlipidemic subjects.In this study,EA was applied to a rat model of hyperlipidemia and middle cerebral artery thrombosis and the condition of neurons and astrocytes after hippocampal injury was assessed.Except for the normal group,rats in other groups were fed a high-fat diet throughout the whole experiment.Hyperlipidemia models were established in rats fed a high-fat diet for 6 weeks.Middle cerebral artery thrombus models were induced by pasting 50%FeCl3 filter paper on the left middle cerebral artery for 20 minutes on day 50 as the model group.EA1 group rats received EA at bilateral ST40(Fenglong)for 7 days before the thrombosis.Rats in the EA1 and EA2 groups received EA at GV20(Baihui)and bilateral ST40 for 14 days after model establishment.Neuronal health was assessed by hematoxylin-eosin staining in the brain.Hyperlipidemia was assessed by biochemical methods that measured total cholesterol,triglyceride,low-density lipoprotein and high-density lipoprotein in blood sera.Behavioral analysis was used to confirm the establishment of the model.Immunohistochemical methods were used to detect the expression of glial fibrillary acidic protein and nerve growth factor in the hippocampal CA1 region.The results demonstrated that,compared with the model group,blood lipid levels significantly decreased,glial fibrillary acidic protein immunoreactivity was significantly weakened and nerve growth factor immunoreactivity was significantly enhanced in the EA1 and EA2 groups.The repair effect was superior in the EA1 group than in the EA2 group.These findings confirm that EA can reduce blood lipid,inhibit glial fibrillary acidic protein expression and promote nerve growth factor expression in the hippocampal CA1 region after

关键词： astrocytes CA1 cerebral ischemia electroacupuncture glial fibrillary acidic protein hematoxylin-eosin staining hippocampus hyperlipidemia immunohistochemistry nerve growth factor

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Antidepressant Effect of Shenwei Ningyu Tablets on Rat Chronic Stress Model and Mouse Tail Suspension Model

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Medicinal Plant 2022年第2期13卷 21-25页

作者： yaxin WANG Shanshan GUO Yingjie GAO ya tu Xiaolan CUI Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China School of Acupuncture-moxibustion and tuina Beijing University of Chinese Medicine Beijing 100029 China

[Objectives]To explore the antidepressant effect of Shenwei Ningyu Tablet,a new antidepressant traditional Chinese medicine,on rat chronic stress depression model and mouse tail suspension models.[Methods]Rat chronic stress model:except for the normal group,the rats in other groups were given corresponding chronic stress,and administered by gavage 1 h before modeling,for a total of 21 d.The changes of each indicator before and after the experiment were observed through the body weight change,the sugar water test,and open field test.The relevant hormone levels were detected by radioimmunoassay.Mouse tail suspension depression model:after continuous administration for 7 d,the activity times was recorded with the mouse automatic recorder,and the mouse immobility time was recorded after tail suspension,to explore the effects of each administration group on the tail suspension immobility time of mice.[Results]Chronic stress depression model:21 d after modeling,compared with the normal group,rats in the model group exhibited significantly reduced body weight,sucrose preference index,and horizontal and vertical movement scores(P<0.05).Compared with the model group,the low-dose Shenwei Ningyu Tablets group had significant differences in the sugar water test,horizontal and vertical movement scores(P<0.05).In addition,all three dose groups of Shenwei Ningyu Tablets could effectively reduce the content of CRF in chronic stress model rats,and the low dose group could significantly reduce the ACTH level in model rats(P<0.05).Mouse tail suspension depression model:the immobility time after tail suspension in each administration group was significantly different from that in the model group(P<0.05).[Conclusions]Shenwei Ningyu Tablets has a certain anti-depression effect on both the rat chronic stress depression model and the mouse tail suspension depression model.

关键词： Depression Rat chronic stress model Mouse tail suspension model Open field experiment Sugar water preference Radioimmunoassay Shenwei Ningyu Tablets

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