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Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： Bing-Bing Liu Yi-Hui Liu You-Bin zhang Zhen-Guo Qi Guo-Hui qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

Price Mechanism,Government Constraints and Carbon Trading Pilot Policy for Emission Reduction

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Data Intelligence 2024年第3期6卷 621-648页

作者： Wei Huang Haili Xue qin zhang Haoguang Liang University of Chinese Academy of Sciences 100190China National Science Library Chinese Academy of Sciences100190China China Center for Modernization Research 100190China Beijing Key Laboratory of National Belt and Road Data Analysis and Decision Support 100024China

Based on the data of 247 cities at the prefecture level in China from 2007 to 2019,this paper analyzes the impact of the carbon emissions trading(CET)pilot policy on carbon emission reduction from the perspective of the price mechanism and government *** results show that the carbon emissions and carbon intensity in the pilot areas are significantly reduced by adjusting the industrial structure and promoting green technology *** terms of regions,the emission reduction effect of the pilot policy in regions with a high proportion of industry is obviously weaker than that in other *** aim of the carbon emission trading policy in China that achieve carbon emission reduction is by coordinating the carbon emission trading price that fail to fulfill this aim independently and the degree of government punishment for enterprises.

关键词： Carbon emission reduction Double difference Price incentive mechanism Government restraint mechanism

O_(2)-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma

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Chinese Chemical Letters 2024年第7期35卷 394-399页

作者： Yu qin Mingyang Huang Chenlu Huang Hannah LPerry Linhua zhang Dunwan Zhu Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Molecular Sciences Research Hub Department of ChemistryWhite City CampusImperial College LondonLondon W120BZUnited Kingdom

Photothermal therapy(PTT)and photodynamic therapy(PDT)have received tremendous attention owing to their great potential for tumor ***,two main issues hamper the antitumor performance of PDT:overexpression of glutathione(GSH)in tumors,which consumes PDT-induced reactive oxygen species(ROS),and hypoxia within the tumor *** drawbacks of PTT include uneven temperature distribution and the upregulation of the heat-shock proteins in tumors,both of which result in ineffective *** address these issues,a MnO_(2)doped nano-delivery system(HTIM-PMs)was synthesized by one-step self-assembly of disulfide bond bridged copolymers for indocyanine green(ICG)and MnO_(2)*** surface of polymeric micelles was layered with hyaluronan(HA)and transactivator(TAT)peptides to improve active targeting and increase cell *** internalization,HTIM-PMs showed responsiveness to the tumor microenvironment(acid pH,high glutathione,high H_(2)O_(2)).Breaking the disulfide bond reduced the intratumoral GSH level and simultaneously released the MnO_(2)and *** released MnO_(2)further reduced the GSH level and promoted O_(2)generation,thus enhancing the PDT *** PTT-mediated hyperthermia accelerated blood flow,which is beneficial for O_(2)distribution,and promotes ROS *** PTT-mediated adjuvant effects further overcame the limitations of PDT and the robust PDT effect in turn compensated for the deficiency of *** promising platform exhibited a significant improvement in the PTT-PDT cancer treatment strategy compared to previously reported nanostructures.

关键词： Photodynamic therapy Photothermal therapy Oxygen generating One-step self-assembly Stimuli-responsive nanoparticles

Multi-Scale Design and Optimization of Composite Material Structure for Heavy-Duty Truck Protection Device

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1961-1980页

作者： yanhui zhang Lianhua Ma Hailiang Su Jirong qin Zhining Chen Kaibiao Deng School of Mechanical and Automotive Engineering Guangxi University of Science and TechnologyLiuzhou545006China Commercial Vehicle Technology Center Dongfeng Liuzhou Automobile Co.Ltd.Liuzhou545005China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510641China

In this paper,to present a lightweight-developed front underrun protection device(FUPD)for heavy-duty trucks,plain weave carbon fiber reinforced plastic(CFRP)is used instead of the original high-strength ***,the mechanical and structural properties of plain carbon fiber composite anti-collision beams are comparatively analyzed from a multi-scale *** studying the design capability of carbon fiber composite materials,we investigate the effects of TC-33 carbon fiber diameter(D),fiber yarn width(W)and height(H),and fiber yarn density(N)on the front underrun protective beam of carbon fiber *** on the investigation,a material-structure matching strategy suitable for the front underrun protective beam of heavy-duty trucks is ***,the composite material structure is optimized by applying size optimization and stack sequence optimization methods to obtain the higher performance carbon fiber composite front underrun protection beam of commercial *** results show that the fiber yarn height(H)has the greatest influence on the protective beam,and theH1matching scheme for the front underrun protective beamwith a carbon fiber composite structure exhibits superior *** proposed method achieves a weight reduction of 55.21% while still meeting regulatory requirements,which demonstrates its remarkable weight reduction effect.

关键词： Structural optimization front underrun protection device carbon fiber reinforced plastic multi-scale model lightweight design

The role of cholesterol metabolism in lung cancer

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Oncology Research 2024年第10期32卷 1613-1621页

作者： WEIGANG XIU XINGYU LIU KAIXIN HU qin zhang HUASHAN SHI Department of Thoracic Oncology and State Key Laboratory of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengdu610041China West China School of Medicine Sichuan UniversityChengdu610041China Department of Postgraduate Students West China School of MedicineChengdu610041China Department of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengdu610041China

Elevated serum cholesterol metabolism is associated with a reduced risk of lung *** cholesterol metabolism is evident in both lung cancer patients and tumor *** tumor cell cholesterol uptake or biosynthesis pathways,through the modulation of receptors and enzymes such as liver X receptor and sterolregulatory element binding protein 2,effectively restrains lung tumor ***,promoting cholesterol excretion yields comparable *** metabolites,including oxysterols and isoprenoids,play a crucial role in regulating cholesterol metabolism within tumor cells,consequently impacting cancer *** lung cancer patients,both the cholesterol levels in the tumor microenvironment and within tumor cells significantly influence cell growth,proliferation,and *** effects of cholesterol metabolism are further mediated by the reprogramming of immune cells such as T cells,B cells,macrophages,myeloid-derived suppressor cells,among *** research is investigating drugs targeting cholesterol metabolism for clinical ***,targeting the cholesterol biosynthesis pathway,are widely employed in lung cancer treatment,either as standalone agents or in combination with other ***,drugs focusing on cholesterol transportation have shown promise as effective therapies for lung *** this review,we summarized current research regarding the rule of cholesterol metabolism and therapeutic advances in lung cancer.

关键词： Cholesterol metabolism Lung cancer Immune cells Targeted strategies

Tmem39b promotes tumor progression and sorafenib resistance by inhibiting ferroptosis in hepatocellular carcinoma

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Oncology Research 2024年第8期32卷 1347-1357页

作者： MING ZHUANG XUE zhang LU LI LIMING WEN JIAMIN qin Department of Gastroenterology Sichuan Mianyang 404 HospitalMianyang621000China

Hepatocellular carcinoma(HCC)poses a signiﬁcant threat to human *** to sorafenib in the chemotherapy of HCC is a common and signiﬁcant issue that profoundly impacts clinical *** several members of the transmembrane(TMEM)protein family have been implicated in the occurrence and progression of HCC,the association between TMEM39b and HCC remains *** study revealed a signiﬁcant overexpression of TMEM39b in HCC,which correlated with a poor *** investigation revealed that RAS-selective lethal 3(RSL3)induced pronounced ferroptosis in HCC,and knocking down the expression of TMEM39b signiﬁcantly decreased its ***,following the induction of ferroptosis in HCC by sorafenib,knocking down the expression of TMEM39b also decreased the severity of ferroptosis,enhancing HCC tolerance to *** conclusion,we propose that TMEM39b promotes tumor progression and resistance to sorafenib by inhibiting ferroptosis in HCC.

关键词： TMEM39b Sorafenib Ferroptosis Hepatocellular carcinoma

Large-field objective lens for multi-wavelength microscopy at mesoscale and submicron resolution

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Opto-Electronic Advances 2024年第6期7卷 41-56页

作者： Xin Xu qin Luo Jixiang Wang yahui Song Hong Ye Xin zhang Yi He Minxuan Sun Ruobing zhang Guohua Shi School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Jiangsu Key Laboratory of Medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of ScienceSuzhou 215163China

Conventional microscopes designed for submicron resolution in biological research are hindered by a limited field of view,typically around 1 *** restriction poses a challenge when attempting to simultaneously analyze various parts of a sample,such as different brain *** addition,conventional objective lenses struggle to perform consistently across the required range of wavelengths for brain imaging in *** we present a novel mesoscopic objective lens with an impressive field of view of 8 mm,a numerical aperture of 0.5,and a working wavelength range from 400 to 1000 *** achieved a resolution of 0.74μm in fluorescent beads *** versatility of this lens was further demonstrated through high-quality images of mouse brain and kidney sections in a wide-field imaging system,a confocal laser scanning system,and a two-photon imaging *** mesoscopic objective lens holds immense promise for advancing multi-wavelength imaging of large fields of view at high resolution.

关键词： mesoscopic objective lens large field-of-view high resolution multi-wavelength wide-field microscopy confocal laser scanning microscopy

In-Vehicle Network Injection Attacks Detection Based on Feature Selection and Classification

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Automotive Innovation 2024年第1期7卷 138-149页

作者： Haojie Ji Liyong Wang Hongmao qin Yinghui Wang Junjie zhang Biao Chen Key Laboratory of Modern Measurement and Control Technology Ministry of EducationBeijing Information Science and Technology UniversityBeijing 100192China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Hefei Innovation Research Institute Beihang UniversityHefei 230012China

Detecting abnormal data generated from cyberattacks has emerged as a crucial approach for identifying security threats within in-vehicle *** transmission of information through in-vehicle networks needs to follow specific data for-mats and communication protocols ***,statistical algorithms are employed to learn these variation rules and facilitate the identification of abnormal ***,the effectiveness of anomaly detection outcomes often falls short when confronted with highly deceptive in-vehicle network *** this study,seven representative classification algorithms are selected to detect common in-vehicle network attacks,and a comparative analysis is employed to identify the most suitable and favorable detection *** consideration of the communication protocol characteristics of in-vehicle networks,an optimal convolutional neural network(CNN)detection algorithm is proposed that uses data field characteristics and classifier selection,and its comprehensive performance is *** addition,the concept of Hamming distance between two adjacent packets within the in-vehicle network is introduced,enabling the proposal of an enhanced CNN algorithm that achieves robust detection of challenging-to-identify abnormal *** paper also presents the proposed CNN classifica-tion algorithm that effectively addresses the issue of high false negative rate(FNR)in abnormal data detection based on the timestamp feature of data *** experimental results validate the efficacy of the proposed abnormal data detection algorithm,highlighting its strong detection performance and its potential to provide an effective solution for safeguarding the security of in-vehicle network information.

关键词： Classification algorithm Anomaly detection In-vehicle network Feature extraction Injecting attack

Regulable toehold lock for the effective control of strand displacement reaction sequence and circuit leakage

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Chinese Chemical Letters 2024年第7期35卷 372-376页

作者： Kuangdi Luo yang qin Xuehao zhang Hanxu Ji Heao zhang Jiangtian Li Xianjin Xiao Xinyu Wang Department of Breast Surgery Second Hospital of Jilin UniversityChangchun 130041China Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pancreatic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430023China

Strand displacement reaction enables the construction of enzyme-free DNA reaction networks,thus has been widely applied to DNA circuit and *** has the characteristics of high efficiency,universality and ***,the existing regulation tools cannot enable effective control of the reaction sequence,which undoubtedly limits the construction of complex nucleic acid ***,we developed a regulation tool,toehold lock,and achieved strict control of reaction sequence without loss of the main reaction signal ***,we applied the tool to scenarios such as seesaw circuits,AND/OR logic gates,and entropy-driven circuits,and respectively demonstrated its significant superiority compared to the original *** believe that the proposed toehold lock has greatly optimized the efficiency of DNA strand displacement-based networks,and we anticipate that the tool will be widely used in multiple fields.

关键词： DNA circuit Toehold lock DNA strand displacement Reaction sequence Seesaw circuit