The role of cholesterol metabolism in lung cancer
作者机构：Department of Thoracic Oncology and State Key Laboratory of Biotherapy Cancer Center West China Hospital Sichuan University Chengdu 610041 China West China School of Medicine Sichuan University Chengdu 610041 China Department of Postgraduate Students West China School of Medicine Chengdu 610041 China Department of Biotherapy Cancer Center West China Hospital Sichuan University Chengdu 610041 China
出 版 物：《Oncology Research》 (肿瘤学研究（英文）)
年 卷 期：2024年第32卷第10期
页 面：1613-1621页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Cancer Psychology and Health Management Committee of the Sichuan Cancer Society
主 题：Cholesterol metabolism Immune cells Lung cancer Targeted strategies
摘 要：Elevated serum cholesterol metabolism is associated with a reduced risk of lung cancer. Disrupted cholesterol metabolism is evident in both lung cancer patients and tumor cells. Inhibiting tumor cell cholesterol uptake or biosynthesis pathways, through the modulation of receptors and enzymes such as liver X receptor and sterol-regulatory element binding protein 2, effectively restrains lung tumor growth. Similarly, promoting cholesterol excretion yields comparable effects. Cholesterol metabolites, including oxysterols and isoprenoids, play a crucial role in regulating cholesterol metabolism within tumor cells, consequently impacting cancer progression. In lung cancer patients, both the cholesterol levels in the tumor microenvironment and within tumor cells significantly influence cell growth, proliferation, and metastasis. The effects of cholesterol metabolism are further mediated by the reprogramming of immune cells such as T cells, B cells, macrophages, myeloid-derived suppressor cells, among others. Ongoing research is investigating drugs targeting cholesterol metabolism for clinical treatments. Statins, targeting the cholesterol biosynthesis pathway, are widely employed in lung cancer treatment, either as standalone agents or in combination with other drugs. Additionally, drugs focusing on cholesterol transportation have shown promise as effective therapies for lung cancer. In this review, we summarized current research regarding the rule of cholesterol metabolism and therapeutic advances in lung cancer. © 2024 The Authors.
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