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Overview of Wound Features and Treatment in Wenchuan Earthquake Victims

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Open Journal of Earthquake Research 2014年第2期3卷 100-107页

作者： Yuanzhang Yao Lianyang Zhang Xiaobin Cheng yue Shen yong He The Center of War Wound and Trauma PLA Research Institute of Surgery Daping Hospital The Third Military Medical University Chongqing China

Objective: “5.12” Wenchuan Earthquake killed 70,000 people and left more than 90,000 people injured seriously. This study was to analyze the wound features and early treatments in Wenchuan earthquake victims and investigate treatment strategies in major disasters, to provide a reference to future disaster rescue. Methods: Total of 1420 earthquake patients who were admitted to Deyang People’s Hospital, Sichuan Province from May 12-30, 2008 were enrolled in the study. The wound features and early treatment were retrospectively analyzed. Results: Among 1420 patients, there were total 1821 injuries. In which, there were 1089 cases with single site injury (76.69%) and 331 cases with multiple injury (23.31%);injuries of limb, body surface and soft tissue were more than that of other sites;injury of single site was larger than that of multi-site (P < 0.01);most of the earthquake patients were admitted to hospital within 2 days after earthquake (68.80%), whose number was more than those at other times (P < 0.01);the number of the earthquake patients in 19 - 45 age group was more than that of other groups (P < 0.01);most of patients were treated within 12 hours after injury (P < 0.01). Conclusion: In disaster rescue, rescue speed is the key point. And the “golden time” and emphases of rescue should be within 2 days after earthquake;the principle of damage control surgery should be followed in the rescue. Enhancing mutual and self help practice and first-aid training at usual times may save more lives.

关键词： Wenchuan Earthquake Disaster Medicine Injury Rescue First Aid Strategy

The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women

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Biomedical and Environmental Sciences 2016年第1期29卷 1-11页

作者： Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng yue Zhao Xia Ge Sheng Jing Hong Jiang Yang yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang yong Wang Jin Zhang Xin Sheng Xue Chang yong Lu Yan Ping Department of Nutrition Chinese PLA General HospitalBejjing 100853China Department of Gynaecology and Obstetrics Chinese PLA General HaspitalBeijing 100853China Sihai Huachen Technology Co LtdBeijing 102629China Department of Nutrition Beijing HospialBeijing 100730China Department of Nutrition Beijing Tongren HospialBeijing 100005China Haidian District Health Center for Women and Children Beijing 100080China Department of Nutrition Jishuitan HospitalBeijing 100035China Department of Nutrition Sixth People's HospitalShanghai 200233China Department of Nutrition Chinese Air Force General HospitalBejjing 100036China Department of Nurition People's Hospital of Sichuan ProvinceChengdu 610072SichuanChina Department of Nutrition Bethune International Peace HospitalShijiazhuang 130100HebeiChina Department of Nutrition No.304 Chinese PLA HospitalBeijing100037China

Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus （GDM）. Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks＇ gestation （WG）. Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDIVl morbidity. Results Age, pre-pregnant body weight （BW）, and body mass index （BMI） were associated with increased risk of GDM. Fat mass （FM）, fat mass percentage （FMP）, extracellular water （ECW）, BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass （FFM）, muscular mass （MM）, and intracellular water （ICW） were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity.

关键词： Gestational diabetes mellitus Body composition Dietary intake

奶牛乳房炎源金黄色葡萄球菌的分离鉴定及耐药性分析

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黑龙江畜牧兽医 2024年第9期 53-59页

作者：张小玉杨洁张晗楚高玉李彦芳徐晶晶屈勇刚梁晏侯宫明珠杨舒涵魏勇金庭辉石河子大学动物科技学院新疆石河子832003 新疆生产建设兵团第十二师畜牧兽医工作站乌鲁木齐830013 新疆天澳牧业有限公司乌鲁木齐830022

为了了解新疆石河子地区奶牛乳房炎源金黄色葡萄球菌的耐药表型及耐药基因携带情况,试验对采自石河子地区2个规模化奶牛场患乳房炎奶牛的乳样进行细菌分离,使用种特异性引物对分离株进行鉴定,并采用纸片琼脂扩散法、最小抑菌浓度(MIC)... 详细信息

为了了解新疆石河子地区奶牛乳房炎源金黄色葡萄球菌的耐药表型及耐药基因携带情况,试验对采自石河子地区2个规模化奶牛场患乳房炎奶牛的乳样进行细菌分离,使用种特异性引物对分离株进行鉴定,并采用纸片琼脂扩散法、最小抑菌浓度(MIC)测定法和PCR方法对分离得到的金黄色葡萄球菌的耐药表型和耐药基因进行检测。结果表明:从患乳房炎奶牛的138份乳样中共分离出74株金黄色葡萄球菌,镜检为阳性球菌,经PCR扩增确定为金黄色葡萄球菌,分离率为53.62%(74/138)。所有分离株均有不同程度的耐药性,对万古霉素、甲氧西林、磺胺甲口恶唑、林可霉素、青霉素、恩诺沙星的耐药率分别为97.30%、82.43%、79.73%、71.62%、67.57%、67.57%,其他9种药物的耐药率为16.22%~59.46%;对庆大霉素和多西环素两种药物的敏感性较高,分别为52.70%、74.32%。耐3种及以上抗生素的菌株占90.54%,耐9种及以上抗生素的菌株占56.75%,其中1个分离株对所有检测的抗生素均耐受。74株分离株中共检测到blaZ、linA、ermB、aacA-aphD、aac6-aph2、aph(3′)-a和tetM 7种耐药基因,其中氨基糖苷类耐药基因aacA-aphD检出率最高,为8.10%,其余耐药基因的检出率在2.70%~4.05%之间。说明新疆石河子地区奶牛乳房炎源金黄色葡萄球菌普遍耐药,且多重耐药现象较为严重,建议临床上根据药敏试验结果科学治疗奶牛乳房炎。

关键词：石河子地区奶牛乳房炎金黄色葡萄球菌耐药性耐药基因

Analysis of the clinical efficacy of two-stage revision surgery in the treatment of periprosthetic joint infection in the knee:A retrospective study

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World Journal of Clinical Cases 2022年第36期10卷 13239-13249页

作者： yong-jie Qiao Feng Li Lv-Dan Zhang Xin-Yuan Yu Hao-Qiang Zhang Wen-Bin Yang Xiao-Yang Song Rui-Ling Xu Sheng-Hu Zhou Department of Joint Surgery The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Orthopedics The 943rd Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyWuwei 733000Gansu ProvinceChina Department of Respiratory Medicine The 940^(th) Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina

BACKGROUND Periprosthetic joint infection(PJI)is a catastrophic complication that can occur following total knee arthroplasty(TKA).Currently,the treatment for PJI mainly includes the use of antibiotics alone,prosthetic debridement lavage,primary revision,secondary revision,joint fusion,amputation,*** To explore the clinical effect of two-stage revision surgery for the treatment of PJI after *** The clinical data of 27 patients(3 males and 24 females;age range,47–80 years;mean age,66.7±8.0 years;27 knees)with PJI treated with two-stage revision surgery in our hospital between January 1,2010 and December 31,2020 were analyzed *** following outcomes were compared for changes between preoperative and last follow-up results:Erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),visual analogue scale(VAS)scores,Hospital for Special Surgery(HSS)scores,knee range of motion(ROM),and infection cure *** All 27 patients were followed up(range,13–112 mo).The ESR(14.5±6.3 mm/h)and CRP(0.6±0.4 mg/dL)of the patients at the last follow-up were significantly lower than those at admission;the difference was statistically significant(P<0.001).The postoperative VAS score(1.1±0.7),HSS score(82.3±7.1),and knee ROM(108.0°±19.7°)were significantly improved compared with those before the surgery;the difference was statistically significant(P<0.001).Of the 27 patients,26 were cured of the infection,whereas 1 case had an infection recurrence;the infection control rate was 96.3%.CONCLUSION Two-stage revision surgery can effectively relieve pain,control infection,and retain good joint function in the treatment of PJI after TKA.

关键词： Total knee arthroplasty Periprosthetic joint infection Two-stage Revision Antibiotic therapy

基于网络药理学和细胞实验探讨华蟾素注射液抗结直肠癌的作用机制

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中国中药杂志 2024年第17期49卷 4755-4767页

作者：孟昭阳赵娟朱琴芳向丹凤孟晶晶陈君君姜波胡玉洁徐玲艳张湘奇邹欢韩永龙上海海洋大学上海201306 江西中医药大学江西南昌330004 上海交通大学医学院附属第六人民医院上海200030

采用网络药理学、分子对接技术和细胞实验探究华蟾素注射液(Huachansu Injection,HCSI)抗结直肠癌(colorectal cancer,CRC)的作用机制。课题组前期采用LC-MS/MS检测HCSI中16种蟾蜍内酯类成分的含量,以大于10 ng·mL-1为标准,筛选出10种... 详细信息

采用网络药理学、分子对接技术和细胞实验探究华蟾素注射液(Huachansu Injection,HCSI)抗结直肠癌(colorectal cancer,CRC)的作用机制。课题组前期采用LC-MS/MS检测HCSI中16种蟾蜍内酯类成分的含量,以大于10 ng·mL-1为标准,筛选出10种蟾蜍内酯类成分,通过SwissTargetPrediction数据库收集其潜在作用靶点;利用GeneCards、OMIM、TTD、PharmGKB数据库预测CRC相关靶点,通过Venny获得HCSI治疗CRC的交集靶点,并使用Cytoscape软件构建“活性成分-靶点-疾病”网络及靶点蛋白-蛋白相互作用(PPI)网络,根据度值筛选关键靶点;对关键靶点进行基因本体论(Gene Ontology,GO)功能和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,并通过AutoDock软件对主要蟾蜍内酯活性成分和关键靶点进行分子对接;检测不同浓度的HCSI、伪异沙蟾毒精(psi-bufarenogin,BUF)和蟾毒它灵(bufotalin,BFT)对结直肠癌HCT116细胞的细胞活力、迁移能力和凋亡率的影响,蛋白免疫印迹法(Western blot)检测HCT116细胞PI3K/Akt/mTOR信号通路相关蛋白的表达。筛选出HCSI的主要活性成分沙蟾毒精(arenobufagin)、BUF和BFT等8种,HCSI抗CRC的关键靶点EGFR、IL6和mTOR等20个,结合KEGG通路富集分析和分子对接结果,选择PI3K/Akt/mTOR信号通路进行验证。细胞实验结果表明,HCSI、BUF和BFT对HCT116细胞的增殖能力和迁移能力具有显著抑制作用,可诱导HCT116细胞凋亡,下调PI3K/Akt/mTOR通路相关蛋白表达,说明HCSI、BUF和BFT可通过mTOR和PIK3CA等靶点调控PI3K/Akt/mTOR信号通路,发挥抗CRC的作用。该研究为探究HCSI的抗肿瘤活性成分和作用机制提供理论依据。

关键词：华蟾素注射液结直肠癌网络药理学伪异沙蟾毒精蟾毒它灵 PI3K/Akt/mTOR信号通路

多中心横断面研究炎症性肠病患者感染新型冠状病毒的临床表现及因素分析

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中华炎性肠病杂志（中英文） 2024年第4期8卷 267-273页

作者：黄天璐彭春艳梁洁陈焰王梅欧阳春晖王晓蕾李晴晴王宏刚李玥刘文佳郝艳萍张晓琦南京大学医学院附属鼓楼医院消化内科南京210008 空军军医大学西京医院消化内科西安710032 浙江大学医学院附属第二医院消化内科杭州310009 扬州大学附属医院消化内科扬州225012 中南大学湘雅二医院消化内科长沙410011 同济大学附属第十人民医院消化内科上海200072 常州市中医医院消化内科常州213003 淮安市第一人民医院消化内科淮安223300 中国医学科学院北京协和医学院北京协和医院消化内科北京100730 南京医科大学附属第三医院(常州市第二人民医院)消化内科常州213003 盐城市第一人民医院消化内科盐城224006

目的研究炎症性肠病(IBD)患者在新型冠状病毒感染(COVID-19)流行期间感染新型冠状病毒后的症状变化以及IBD治疗用药的情况。方法采用横断面调查研究方法。2022年12月1-31日通过自愿抽样对全国多中心的IBD患者进行问卷调查,收集通过核酸... 详细信息

目的研究炎症性肠病(IBD)患者在新型冠状病毒感染(COVID-19)流行期间感染新型冠状病毒后的症状变化以及IBD治疗用药的情况。方法采用横断面调查研究方法。2022年12月1-31日通过自愿抽样对全国多中心的IBD患者进行问卷调查,收集通过核酸/抗原检测确诊为COVID-19患者的临床资料。根据患者是否自觉IBD症状加重(包括腹部不适、便血加重或出现脓血便、腹泻次数增多等),分为症状加重组和无症状加重组,比较两组年龄、性别、体质量指数(BMI)、基础疾病、新型冠状病毒疫苗(简称新冠疫苗)接种、IBD类型、疾病活动度、COVID-19症状、治疗用药等差异。结果共纳入497例患者,男317例,女180例;年龄(35.27±11.54)岁;克罗恩病355例,溃疡性结肠炎142例;超过50%患者出现发热、肌肉酸痛、乏力、咳嗽、咳痰、鼻塞等呼吸系统症状,部分IBD患者出现消化系统症状和神经系统症状。症状加重组104例(20.93%),无症状加重组393例(79.07%)。两组患者在性别、年龄、BMI、基础疾病、IBD类型及新冠疫苗接种针次差异均无统计学意义(均P>0.05)。与无症状加重组相比,症状加重组处于疾病活动期的患者比例更高[47.12%(49/104)比24.68%(97/393),P<0.001],使用美沙拉嗪/柳氮磺吡啶的比例更高(35.58%比23.41%,P=0.012),出现腹泻、头痛、头晕等COVID-19症状比例均更高(均P<0.05)。237例使用生物制剂的IBD患者中,症状加重患者与无症状加重患者使用的生物制剂类型差异具有统计学意义(χ^(2)=9.351,P=0.031)。240例使用生物制剂患者中,症状加重患者延迟或中断生物制剂治疗的比例高于无症状加重患者,差异具有统计学意义[45.45%(20/44)比23.98%(47/196),χ^(2)=8.235,P=0.004]。47例使用免疫抑制剂的患者中,症状加重患者和无症状加重患者停用免疫抑制剂的比例差异不存在统计学意义(P=0.263)。结论IBD患者确诊COVID-19后的主要表现为呼吸道症状及全身症状,处于疾病活动期、延迟或者停用生物制剂者更容易在感染期间出现IBD症状加重。

关键词：炎症性肠病克罗恩病溃疡性结肠炎新型冠状病毒感染新型冠状病毒疾病活动停药症状加重

Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis

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World Journal of Gastroenterology 2018年第21期24卷 2300-2310页

作者： Qun-Qun Jiang Mei-Fang Han Ke Ma Guang Chen Xiao-Yang Wan Semvua Bukheti Kilonzo Wen-Yu Wu yong-Li Wang jie You Qin Ning Department and Institute of Infectious Disease Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

AIM To evaluate the differences in acute kidney injury(AKI) between acute-on-chronic liver failure(ACLF) and decompensated cirrhosis(DC) patients. METHODS During the period from December 2015 to July 2017, 280 patients with hepatitis B virus(HBV)-related ACLF(HBV-ACLF) and 132 patients with HBV-related DC(HBV-DC) who were admitted to our center were recruited consecutively into an observational study. Urine specimens were collected from all subjects and the levels of five urinary tubular injury biomarkers were detected,including neutrophil gelatinase-associated lipocalin(NGAL), interleukin-18(IL-18), liver-type fatty acid binding protein(L-FABP), cystatin C(CysC), and kidney injury molecule-1(KIM-1). Simultaneously, the patient demographics, occurrence and progression of AKI, and response to terlipressin therapy were recorded. All patients were followed up for 3 mo or until death after enrollment. RESULTS AKI occurred in 71 and 28 of HBV-ACLF and HBV-DC patients, respectively(25.4% vs 21.2%, P = 0.358). Among all patients, the levels of four urinary biomarkers(NGAL, CysC, L-FABP, IL-18) were significantly elevated in patients with HBV-ACLF and AKI(ACLF-AKI), compared with that in patients with HBV-DC and AKI(DC-AKI) or those without AKI. There was a higher proportion of patients with AKI progression in ACLF-AKI patients than in DC-AKI patients(49.3% vs 17.9%, P = 0.013). Fortythree patients with ACLF-AKI and 19 patients with DC-AKI were treated with terlipressin. The response rate of ACLFAKI patients was significantly lower than that of patients with DC-AKI(32.6% vs 57.9%, P = 0.018). Furthermore, patients with ACLF-AKI had the lowest 90 d survival rates among all groups(P < 0.001).CONCLUSION AKI in ACLF patients is more likely associated with structural kidney injury, and is more progressive, with a poorer response to terlipressin treatment and a worse prognosis than that in DC patients.

关键词： Decompensated cirrhosis Acute-on-chronic liver failure Acute kidney injury Biomarker Etiology Treatment Prognosis

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利用计算机辅助设计医用树脂假体重建外形

合成树脂及塑料 2016年第2期33卷 96-98页

作者：吴杰李悦唐山工业职业技术学院河北省唐山市063020 华北理工大学河北省唐山市063000

通过计算机开展采集技术,实现了计算机识别与人工识别的结合。让所需要进行设计的假体的轮廓曲线能够更好地进行拾取,且所拾取到的模型会表现出更清晰的边缘,呈现出完整的曲线轮廓,为后续的假体重建工作提供了良好的稳定性。再通过高新... 详细信息

通过计算机开展采集技术,实现了计算机识别与人工识别的结合。让所需要进行设计的假体的轮廓曲线能够更好地进行拾取,且所拾取到的模型会表现出更清晰的边缘,呈现出完整的曲线轮廓,为后续的假体重建工作提供了良好的稳定性。再通过高新技术及新材料,进行从三维立体模型到实体原型的加工,让假体制作能够更加快速地实现从设计到实体转化,排除了一些传统工艺中的复杂程序。在很大程度上满足了医生以及患者的设计需求。通过镜像技术,能够达到精准的设计效果。本文主要对利用计算机辅助设计医用树脂假体重建外形进行了探讨。

关键词：计算机辅助设计医用树脂假体外形

Efficacy and factors influencing treatment with peginterferon alpha-2a and ribavirin in elderly patients with chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 185-192页

作者： Jian-Wu Yu,Li-jie Sun,Peng Kang,Bing-Zhu Yan and yong-Hua Zhao Department of Infectious Diseases, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China Department of Infectious Diseases Second Affiliated Hospital Harbin Medical University Harbin 150086 China

BACKGROUND:In China,hepatitis C virus(HCV) infection is characterized by an increasing prevalence during *** study was undertaken to evaluate the efficacy of treatment with peginterferon alpha-2a and ribavirin in elderly chronic hepatitis C(CHC) patients and study the factors related to the sustained virologic response(SVR).METHODS:The medical records of 417 patients treated with peginterferon and ribavirin were retrospectively *** patients were divided into two groups according to age:patients aged ≥65 years(n=140) and patients aged <65 years(n=277).The rate of ribavirin reduction or discontinuation and virologic response rates of the two groups were *** factors influencing SVR were studied by multivariate ***:Ribavirin reduction or discontinuation was more frequent in patients aged ≥65 years than patients aged <65 years(37.1%,52/140 vs 20.2%,56/277;χ 2 =13.883,P<0.001).For genotype 1,patients aged ≥65 years had a higher relapse rate(50.0%,42/84 vs 29.2%,52/178;χ 2 =10.718,P=0.001) and a lower SVR rate(40.0%,42/105 vs 60.0%,126/210;χ 2 =11.250,P=0.001) than patients aged <65 *** were no significant differences in virologic response rates between the two groups for patients with genotype *** genotype 1,in patients aged ≥65 years,the SVR rate of females was lower than that of males(28.6%,12/42 vs 47.6%,30/63;χ 2 =8.150,P=0.004);in the high viral load group,patients aged ≥65 years had a lower SVR rate than patients aged <65 years(30.0%,18/60 vs 54.8%,69/126;χ 2 =10.010,P=0.002).In multivariate logistic regression analysis,the independent factors associated with SVR in patients aged ≥65 years were sex(P=0.020),genotype(P=0.005),ribavirin reduction or discontinuation(P=0.009) and presence of rapid virologic response(RVR)(P=0.001).CONCLUSIONS:The rate of ribavirin reduction or discontinuation and relapse rate of patients aged ≥65 years with genotype 1 are high,and the SVR rate is *** has no impact on virologic respons

关键词： chronic hepatitis C elderly patients sustained virologic response