Analysis of the clinical efficacy of two-stage revision surgery in the treatment of periprosthetic joint infection in the knee:A retrospective study

作     者：Yong-Jie Qiao Feng Li Lv-Dan Zhang Xin-Yuan Yu Hao-Qiang Zhang Wen-Bin Yang Xiao-Yang Song Rui-Ling Xu Sheng-Hu Zhou 

作者机构：Department of Joint SurgeryThe 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of OrthopedicsThe 943rd Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyWuwei 733000Gansu ProvinceChina Department of Respiratory MedicineThe 940^(th) Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第36期

页      面：13239-13249页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Total knee arthroplasty Periprosthetic joint infection Two-stage Revision Antibiotic therapy 

摘      要：BACKGROUND Periprosthetic joint infection(PJI)is a catastrophic complication that can occur following total knee arthroplasty(TKA).Currently,the treatment for PJI mainly includes the use of antibiotics alone,prosthetic debridement lavage,primary revision,secondary revision,joint fusion,amputation,*** To explore the clinical effect of two-stage revision surgery for the treatment of PJI after *** The clinical data of 27 patients(3 males and 24 females;age range,47–80 years;mean age,66.7±8.0 years;27 knees)with PJI treated with two-stage revision surgery in our hospital between January 1,2010 and December 31,2020 were analyzed *** following outcomes were compared for changes between preoperative and last follow-up results:Erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),visual analogue scale(VAS)scores,Hospital for Special Surgery(HSS)scores,knee range of motion(ROM),and infection cure *** All 27 patients were followed up(range,13–112 mo).The ESR(14.5±6.3 mm/h)and CRP(0.6±0.4 mg/dL)of the patients at the last follow-up were significantly lower than those at admission;the difference was statistically significant(P0.001).The postoperative VAS score(1.1±0.7),HSS score(82.3±7.1),and knee ROM(108.0°±19.7°)were significantly improved compared with those before the surgery;the difference was statistically significant(P0.001).Of the 27 patients,26 were cured of the infection,whereas 1 case had an infection recurrence;the infection control rate was 96.3%.CONCLUSION Two-stage revision surgery can effectively relieve pain,control infection,and retain good joint function in the treatment of PJI after TKA.