检索结果-南通市图书馆

Insulin-like signaling pathway functions in integrative response to an olfactory and a gustatory stimuli in Caenorhabditis elegans

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2010年第1期1卷 75-81页

作者： Ya-Ming Jiu Yang yue Song Yang lin liu jun-Wei Yu Zheng-xing Wu Tao xu Key Laboratory of Molecular Biophysics Ministry of Educationand Institute of Biophysics and BiochemistryHuazhong University of Science and TechnologyWuhan 430074China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Animals integrate various environmental stimuli within the nervous system to generate proper behavioral ***,the underlying neural circuits and molecular mechanisms are largely *** insulinlike signaling pathway is known to regulate dauer formation,fat metabolism,and longevity in Caenorhabditis elegans(***).Here,we show that this highly conserved signaling pathway also functions in the integrative response to an olfactory diacetyl and a gustatory Cu^(2+) *** of wild-type N2 Bristol displayed a strong avoidance to the Cu^(2+) barrier in the migration pathway to the attractive *** of daf-2(insulin receptor),daf-18(PTEN lipid phosphatase),pdk-1(phosphoinositide-dependent kinase),akt-1/-2(Akt/PKB kinase)and sgk-1(serum-and glucocorticoidinducible kinase)show severe defects in the elusion from the Cu^(2+) .Mutations in DAF-16,a forkhead-type transcriptional factor,suppress the integrative defects of daf-2 and akt-1/-2 *** further report that neither cGMP nor TGFβpathways,two other dauer formation regulators,likely plays a role in the integrative *** results suggest that the insulin-like signaling pathway constitutes an essential component for sensory integration and decision-making behavior plasticity.

关键词： C.elegans insulin signaling pathway sensory integration decision making behavior

Interfacial Oxides Evolution of High-Speed Steel Joints by Hot-Compression Bonding

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2022年第11期35卷 1837-1848页

作者： Wei-Feng liu Bi-jun Xie Ming-yue Sun Bin xu Yan-Fei Cao Dian-Zhong li Shenyang National Laboratory for Materials Science Instituteof Metal ResearchChineseAcademyof SciencesShenyang 110016China School of Materials Scienceand Engineering University of Science and Technology of ChinaShenyang 110016China

The interfacial oxidation behavior of Cr_(4)Mo_(4) V high-speed steel(HSS)joints undergoing hot-compression bonding was investigated by using optical microscopy(OM),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).In the heating and holding processes,dispersed rod-like and granularδ-Al_(2)O_(3) oxides were formed at the interface and in the matrix near the interface due to the selective oxidation and internal oxidation of Al,while irregular Si-Al-O compounds and spheroidal SiO_(2) particles were formed at the *** the post-holding treatment,SiO_(2) oxides and Si-Al-O compounds were dissolved into the matrix,andδ-Al_(2)O_(3) oxides were transformed into nanoscaleα-Al_(2)O_(3) particles,which did not deteriorate the mechanical properties of the *** formation and migration of newly-formed grain boundaries by plastic deformation and post-holding treatment were the main mechanism for interface *** tensile test results showed that the strength of the healed joints was comparable to that of the base material,and the in-situ tensile observations proved that the fracture was initiated at the grain boundary of the matrix rather than at the *** clarification of interfacial oxides and microstructure is essential for the application of hot-compression bonding of HSSs.

关键词： Hot-compression bonding High-speed steel Interfacial oxides Interface healing Mechanical properties

Preparation of flexible rubber composites with high contents of tungsten powders for gamma radiation shielding

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第7期41卷 2243-2248页

作者： Xiang-Rong xu jun-qing Wu Jian xu Feng liu An Xie jun-liang liu Ming Zhang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Environmental Engineering Center China Nuclear Power Research Institute Co.LtdShenzhen 518034China

To prepare tungsten/rubber composites with good gamma-ray shielding performances and fine mechanical properties,a composite surface modifier is employed to make surface modification of the tungsten powders.

关键词： composites composite rubber

Influence of carbonization temperature on cobalt-based nitrogendoped carbon nanopolyhedra derived from ZIF-67 for nonoxidative propane dehydrogenation

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2023年第1期20卷 559-568页

作者： Yu-Ming li Zi-Ye liu Qi-Yang Zhang Ya-jun Wang guo-qing Cui Zhen Zhao Chun-Ming xu Gui-Yuan Jiang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China

Propylene is a significant basic material for petrochemicals such as polypropylene,propylene oxide,*** abundant propane supply from shale gas,propane dehydrogenation(PDH)becomes extensively attractive as an on-purpose propylene production route in recent ***-doped carbon(NC)nanopolyhedra supported cobalt catalysts were synthesized in one-step of ZIF-67 pyrolysis and investigated further in ***,TEM and N_(2) adsorption-desorption were used to study the influence of carbonization temperature on as-prepared NC supported cobalt *** temperature is found to affect the cobalt phase and nitrogen species of the *** the positive correlation was established between Co0 proportion and space time yield of propylene,indicating that the modulation of carbonization temperature could be important for catalytic performance.

关键词： Propane dehydrogenation ZIF-67 Nitrogen-doped carbon Cobalt

One-step controlled electrodeposition nickel sulfides heterointerfaces favoring the desorption of hydroxyl groups for efficient hydrogen generation

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4377-4386页

作者： Ru-Chun li Xin-yue Zhang Ze-yue Qu Feng-Yi liu Quan-qing xu Zhao-Xia Hu Jing-Wei li Mohamed-Nawfal Ghazzal Jin-li Yu Faculty of Chemistry and Chemical Engineering Yunnan Normal UniversityKunming 650500China Foshan Gaoke Hechuang Technology Co. Ltd.Foshan 528200China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China Universite Paris-Saclay UMR 8000 CNRSInstitut de Chimie PhysiqueOrsay 91405France Department of Chemistry City University of Hong KongHong Kong 999077China

The heterointerface engineering involving different components or phases represents a desirable strategy for enhancing the sluggish kinetics of hydrogen evolution reaction(HER).However,constructing desired heterointerfaces and elucidating the reaction mechanisms on the interface remains a considerable *** this work,we propose a straightforward electrochemical synthesis strategy to prepare the nickel sulfide-based heterointerfaces for *** mechanism of electrochemical synthesis is revealed,wherein metal-thiourea species can be formed at the cathode potential and subsequently oxidized to nickel sulfides at the anode *** this mechanism,a range of nickel sulfides,including NiS,Ni_(3)S_(2)/NiS,Ni/Ni_(3)S_(2)and Ni_(3)S_(2),have been successfully synthesized by tuning the potential range of cyclic *** these,the obtained Ni_(3)S_(2)/NiS@CC(CC:carbon cloth)exhibits the smallest overpotential of84 mV at 10 mA·cm^(-2)and high *** calculations further reveal that the combination of NiS and Ni_(3)S_(2)induces electron redistribution at the interface,and thus the Volmer process is effectively promoted with faster water dissociation and OH desorption ***,the simplicity method coupled with a clear synthesis mechanism and outstanding HER performance highlights its promising potential for practical applications.

关键词： Hydrogen evolution reaction Heterointerfaces OH desorption kinetics Electrochemical synthesis

Generation of elliptical isolated attosecond pulse from oriented H_(2)^(+)in a linearly polarized laser field

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2022年第4期31卷 281-286页

作者： Yun-He xing jun Zhang Xiao-Xin Huo qing-Yun xu xue-Shen liu Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

We investigate the ellipticity of the high-order harmonic generation from the oriented H_(2)^(+)exposed to a linearly polarized laser field by numerically solving the two-dimensional time-dependent Schrodinger equation(2 D TDSE).Numerical simulations show that the harmonic ellipticity is remarkably sensitive to the alignment *** harmonic spectrum is highly elliptically polarized at a specific alignment angleθ=30°,which is insensitive to the variation of the laser *** position of the harmonic intensity minima indicates the high ellipticity,which can be attributed to the two-center interference *** high ellipticity can be explained by the phase difference of the *** result facilitates the synthesis of a highly elliptical isolated attosecond pulse with duration down to 65 as,which can be served as a powerful tool to explore the ultrafast dynamics of molecules and study chiral light-matter interaction.

关键词： high harmonic generation linearly polarized laser fields elliptical isolated attosecond pulse alignment angle two-center interference effect

Sensitive detection of microRNAs using polyadenine-mediated fluorescent spherical nucleic acids and a microfluidic electrokinetic signal amplification chip

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2022年第5期12卷 808-813页

作者： jun xu qing Tang Runhui Zhang Haoyi Chen Bee Luan Khoo xinguo Zhang yue Chen Hong Yan Jincheng li Huaze Shao lihong liu NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou510515China The Second Clinical Medical School Southern Medical UniversityGuangzhou510515China Department of Biomedical Engineering City University of Hong KongHong Kong999077China

The identification of tumor-related microRNAs(miRNAs)exhibits excellent promise for the early diagnosis of cancer and other bioanalytical ***,we developed a sensitive and efficient biosensor using polyadenine(polyA)-mediated fluorescent spherical nucleic acid(FSNA)for miRNA analysis based on strand displacement reactions on gold nanoparticle(AuNP)surfaces and electrokinetic signal amplification(ESA)on a microfluidic *** this FSNA,polyA-DNA biosensor was anchored on AuNP surfaces via intrinsic affinity between adenine and *** upright conformational polyA-DNA recognition block hybridized with 6-carboxyfluorescein-labeled reporter-DNA,resulting in fluorescence quenching of FSNA probes induced by AuNP-based resonance energy *** DNA was replaced in the presence of target miRNA,leading to the recovery of reporter-DNA ***,reporter-DNAs were accumulated and detected in the front of with Nafion membrane in the microchannel by *** method showed high selectivity and sensitivity with a limit of detection of 1.3 *** method could also be used to detect miRNA-21 in human serum and urine samples,with recoveries of 104.0%-113.3% and 104.9%-108.0%,***,we constructed a chip with three parallel channels for the simultaneous detection of multiple tumor-related miRNAs(miRNA-21,miRNA-141,and miRNA-375),which increased the detection *** universal method can be applied to other DNA/RNA analyses by altering recognition sequences.

关键词： MicroRNAs Microfluidic chip Electrokinetic signal amplification Polyadenine-DNA Gold nanoparticle

Molecular cloning,expression pattern and phylogenetic analysis of Guanine nucleotide exchange factor Vav2 in lamprey,Lampetra japonica

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2017年第12期36卷 24-30页

作者： HAN Yinglun li jun xu Lei MA qinghua GOU Meng PANG yue liu Xin li qingwei College of life Science Liaoning Normal UniversityDalian 116029China Lamprey Research Center Liaoning Normal UniversityDalian 116029China Freshwater Fisheries Sciences Institute of liaoning Province Liaoyang 111000China

The Guanine nucleotide exchange factor Vav2（Vav2） is a member of the Vav family that serves as an important regulators for the Rho family of Ras-related GTPases. In the current study, an ortholog（Lj-Vav2） of Vav2 was identified in the lamprey（Lampetra japonica）. To elucidate the phylogenetic relationship of Vav2, the metazoan genome databases were analyzed to mine the ortholog of Vav. It was found that Vav2 genes were only existed in vertebrates and Lj-Vav2 was the original one found in agnathans. The evolutionary dynamics of conserved motifs of Vav2 were explored using combined amino acid sequence as markers, and it is revealed that the Calponin homology（CH） domain, Dbl-homologous（DH） domain, Pleckstrin homology（PH） domain, Cysteine-rich（C1）domains, Src homology 3（SH3） domains and Src homology 2（SH2） domain were conserved throughout the Vav2 gene family in vertebrates during gene evolution. Relative quantitative real-time PCR analysis showed that the LjVav2 was distributed in the heart, kidney, supraneural myeloid body, liver, gill and lymphocyte-like cells. The LjVav2 was found to be expressed in these tissues, and the level of which was upregulated in lymphocyte-like cells after the animal was stimulated with LPS. These results indicated that the Lj-Vav2 might be involved in the immune response of lymphocyte-like cells in lamprey. Meanwhile, our findings provided a foundation for further investigation of the function of Lj-Vav2 in the primary vertebrate.

关键词： guanine nucleotide exchange factor Vav2 Lampetra japonica phylogenetic relationship molecular cloning

Functional ceramic support as an independent catalyst layer for direct liquid fuel solid oxide fuel cells

在线全文

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2023年第3期12卷 474-486页

作者： Jie Luo Kai Zhao Jishi Zhao jun li Yihui liu Dongchu Chen qing xu Min Chen School of Materials Science and Hydrogen Energy Foshan UniversityFoshan 528000China Guangdong Key Laboratory for Hydrogen Energy Technologies Foshan UniversityFoshan 528000China Foshan Institute of Environment and Energy Technology Foshan 528000China R&D Center of Hydrogen Energy Standardization Yunfu 527300China Hubei Key Laboratory of Advanced Technology for Automotive Components&Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

A porous ceramic support is designed as a multi-functional independent catalyst layer for solid oxide fuel cells(SOFCs)running on liquid hydrocarbon *** layer consists of a highly porous Ce_(0.9)Ca_(0.1)O_(2−δ)ceramic backbone and active NiMo catalysts,which could be integrated into the conventional Ni metal containing the anode for internal reforming of the hydrocarbon *** to conventional catalyst layers sintered on the anodes,this independent catalyst layer could be simply assembled on top of the anode without additional sintering,thereby avoiding the mismatch of the thermal expansion coefficient between the catalyst layer and the anode and improving stability of a single ***,a current collector layer could be inserted between the catalyst and the anode to enhance current collection efficiency and electrochemical performance of the single *** 750℃,the independent catalyst layer displays high activity towards the catalytic decomposition of methanol,and the single cell could achieve the maximum power density of 400–500 mW·cm^(−2)in dry ***,by employing the independent catalyst layer,the single cell offers additional in-situ catalyst regeneration capability under the methanol operation *** 10 mL·min−1 air into an anode channel for 5 min is found to be effective to burn out carbon species in the catalyst layer,which reduces the degradation rate of the cell voltage by orders of magnitude from 2.6 to 0.024 mV·h−1 during the operation of 360 h in dry *** results demonstrate the significance of the independent catalyst layer design for direct internal reforming methanol fuel cells.

关键词： independent catalyst layer NiMo-Ce_(0.9)Ca_(0.1)O_(2−δ)catalyst internal reforming methanol solid oxide fuel cell(SOFC)